CN102325785B - 用于纯化脂肽的方法 - Google Patents

用于纯化脂肽的方法 Download PDF

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Publication number
CN102325785B
CN102325785B CN201080008292.3A CN201080008292A CN102325785B CN 102325785 B CN102325785 B CN 102325785B CN 201080008292 A CN201080008292 A CN 201080008292A CN 102325785 B CN102325785 B CN 102325785B
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daptomycin
solution
elution
column
elution buffer
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Chinese (zh)
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CN102325785A (zh
Inventor
马丁·蒙森
埃莉·卡林·戴尔
赛斯塞尔·豪格
卡斯滕·奥弗巴莱-彼得森
谢尔斯蒂·阿斯托普·希思
丹尼斯·布赖恩·汉森
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Xellia Pharmaceuticals ApS
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Xellia Pharmaceuticals ApS
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201080008292.3A 2009-02-19 2010-02-19 用于纯化脂肽的方法 Active CN102325785B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15366009P 2009-02-19 2009-02-19
US61/153,660 2009-02-19
PCT/NO2010/000066 WO2010095953A1 (en) 2009-02-19 2010-02-19 Process for purifying lipopeptides

Publications (2)

Publication Number Publication Date
CN102325785A CN102325785A (zh) 2012-01-18
CN102325785B true CN102325785B (zh) 2015-01-21

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CN201080008292.3A Active CN102325785B (zh) 2009-02-19 2010-02-19 用于纯化脂肽的方法

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Country Link
US (1) US9150894B2 (https=)
EP (1) EP2398817B2 (https=)
JP (1) JP5752609B2 (https=)
KR (1) KR101666144B1 (https=)
CN (1) CN102325785B (https=)
AU (1) AU2010216475B2 (https=)
BR (1) BRPI1008300B1 (https=)
CA (1) CA2748932C (https=)
DK (1) DK2398817T4 (https=)
ES (1) ES2543457T5 (https=)
HR (1) HRP20150761T4 (https=)
HU (1) HUE026818T2 (https=)
IL (1) IL214374A (https=)
MX (1) MX2011008621A (https=)
PL (1) PL2398817T5 (https=)
PT (1) PT2398817E (https=)
RU (1) RU2526391C2 (https=)
SI (1) SI2398817T2 (https=)
UA (1) UA105785C2 (https=)
WO (1) WO2010095953A1 (https=)
ZA (1) ZA201104848B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2398817T2 (sl) 2009-02-19 2021-09-30 Xellia Pharmaceuticals Aps Postopek čiščenja lipopeptidov
CN102690329B (zh) * 2011-03-25 2014-06-04 杭州九源基因工程有限公司 一种戈舍瑞林多肽的纯化生产方法
CN102875652A (zh) * 2011-07-13 2013-01-16 北大方正集团有限公司 一种分离纯化达托霉素的方法
CN103159829B (zh) * 2011-12-08 2014-11-05 北大方正集团有限公司 达托霉素的提取方法
CN102675426B (zh) * 2012-04-26 2013-12-11 杭州华东医药集团生物工程研究所有限公司 一种达托霉素的提取纯化方法
CN102924572B (zh) * 2012-11-12 2014-12-03 华北制药集团新药研究开发有限责任公司 一种高纯度达托霉素的制备方法
CN104387444B (zh) * 2014-11-13 2017-12-08 北大医药重庆大新药业股份有限公司 一种达托霉素杂质rs‑2高纯度样品的制备方法
EP3233230B1 (en) * 2014-12-15 2024-06-12 Merck Patent GmbH Target molecule capture from crude solutions
CN105001305A (zh) * 2015-04-29 2015-10-28 利穗科技(苏州)有限公司 利用层析技术提取高纯度达托霉素的方法
CN105481950B (zh) * 2016-01-28 2019-01-04 丽珠集团福州福兴医药有限公司 一种达托霉素提取方法
IT201600127655A1 (it) 2016-12-16 2018-06-16 Gnosis Spa Processo per la purificazione di antibiotici lipopolipeptidici
CN108250270A (zh) * 2016-12-29 2018-07-06 天津领世生物科技开发有限公司 一种从发酵液中富集提取达托霉素的方法
CN112979756B (zh) * 2019-12-13 2023-01-03 浙江昌海制药有限公司 达托霉素的提纯方法
CN113004373B (zh) * 2019-12-19 2024-08-13 鲁南制药集团股份有限公司 一种达托霉素的纯化方法
RU2762182C1 (ru) * 2020-12-08 2021-12-16 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения
CN113340691B (zh) * 2021-06-05 2023-12-12 清华大学 一种提取海洋沉积物中不同赋存形态磷的方法
CN119119201A (zh) * 2024-09-10 2024-12-13 丽珠集团福州福兴医药有限公司 一种达托霉素的生产方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
US6696412B1 (en) * 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
CN1592753A (zh) * 2000-12-18 2005-03-09 卡比斯特制药公司 制备纯化脂肽的方法

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US4885243A (en) * 1984-10-09 1989-12-05 Eli Lilly And Company Process for producing A-21978C derivatives
US4667016A (en) 1985-06-20 1987-05-19 Kirin-Amgen, Inc. Erythropoietin purification
US4874843A (en) * 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
CA1315229C (en) * 1987-06-10 1993-03-30 Eli Lilly And Company Chromatographic purification process
JP2661790B2 (ja) * 1990-11-27 1997-10-08 電気化学工業株式会社 入尿トリプシンインヒビターの精製方法
CN1057534C (zh) * 1993-08-17 2000-10-18 柯瑞英-艾格公司 促红细胞生成素类似物
US5650496A (en) 1995-04-14 1997-07-22 Cephalon, Inc. IGF-I purification process
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
US8969532B2 (en) * 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
WO2009144739A1 (en) 2008-05-26 2009-12-03 Biocon Limited Amorphous daptomycin and a method of purification thereof
SI2398817T2 (sl) 2009-02-19 2021-09-30 Xellia Pharmaceuticals Aps Postopek čiščenja lipopeptidov
CN101899094B (zh) * 2009-06-01 2012-11-21 安徽丰原发酵技术工程研究有限公司 一种高纯达托霉素的制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696412B1 (en) * 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
CN101240013A (zh) * 2000-01-20 2008-08-13 卡比斯特制药公司 高纯度脂肽、脂肽胶束及其制备方法
CN1592753A (zh) * 2000-12-18 2005-03-09 卡比斯特制药公司 制备纯化脂肽的方法

Non-Patent Citations (1)

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Also Published As

Publication number Publication date
ZA201104848B (en) 2012-10-31
IL214374A (en) 2017-03-30
EP2398817A1 (en) 2011-12-28
AU2010216475B2 (en) 2015-07-09
RU2011137010A (ru) 2013-03-27
ES2543457T3 (es) 2015-08-19
CA2748932A1 (en) 2010-08-26
DK2398817T3 (en) 2015-07-27
IL214374A0 (en) 2011-09-27
DK2398817T4 (da) 2021-08-23
EP2398817B1 (en) 2015-04-29
BRPI1008300A2 (pt) 2016-03-15
KR20110134884A (ko) 2011-12-15
AU2010216475A1 (en) 2011-08-11
HRP20150761T1 (hr) 2015-08-14
HUE026818T2 (en) 2016-07-28
ES2543457T5 (es) 2021-12-22
MX2011008621A (es) 2011-09-15
WO2010095953A1 (en) 2010-08-26
UA105785C2 (uk) 2014-06-25
RU2526391C2 (ru) 2014-08-20
SI2398817T2 (sl) 2021-09-30
US20100228006A1 (en) 2010-09-09
CA2748932C (en) 2019-11-19
PT2398817E (pt) 2015-08-28
BRPI1008300A8 (pt) 2021-05-11
CN102325785A (zh) 2012-01-18
JP5752609B2 (ja) 2015-07-22
BRPI1008300B1 (pt) 2021-07-13
JP2012518034A (ja) 2012-08-09
KR101666144B1 (ko) 2016-10-13
HRP20150761T4 (hr) 2021-08-06
US9150894B2 (en) 2015-10-06
PL2398817T5 (pl) 2021-10-04
SI2398817T1 (sl) 2015-08-31
PL2398817T3 (pl) 2015-10-30
EP2398817B2 (en) 2021-06-23

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