CN102321584B - 预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法 - Google Patents
预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法 Download PDFInfo
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- CN102321584B CN102321584B CN201110195193.7A CN201110195193A CN102321584B CN 102321584 B CN102321584 B CN 102321584B CN 201110195193 A CN201110195193 A CN 201110195193A CN 102321584 B CN102321584 B CN 102321584B
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Proteomics, Peptides & Aminoacids (AREA)
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- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
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- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53350503P | 2003-12-31 | 2003-12-31 | |
| US60/533,505 | 2003-12-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004800421486A Division CN1922332B (zh) | 2003-12-31 | 2004-12-30 | 预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102321584A CN102321584A (zh) | 2012-01-18 |
| CN102321584B true CN102321584B (zh) | 2014-01-08 |
Family
ID=34748910
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110195193.7A Expired - Fee Related CN102321584B (zh) | 2003-12-31 | 2004-12-30 | 预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法 |
| CN201210472073.1A Expired - Fee Related CN102989009B (zh) | 2003-12-31 | 2004-12-30 | 预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法 |
| CN2004800421486A Expired - Fee Related CN1922332B (zh) | 2003-12-31 | 2004-12-30 | 预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210472073.1A Expired - Fee Related CN102989009B (zh) | 2003-12-31 | 2004-12-30 | 预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法 |
| CN2004800421486A Expired - Fee Related CN1922332B (zh) | 2003-12-31 | 2004-12-30 | 预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US7700280B2 (https=) |
| EP (2) | EP1704250B1 (https=) |
| JP (3) | JP4682152B2 (https=) |
| CN (3) | CN102321584B (https=) |
| ES (1) | ES2394799T3 (https=) |
| TW (1) | TWI301066B (https=) |
| WO (1) | WO2005066371A2 (https=) |
Families Citing this family (45)
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| CN102321584B (zh) * | 2003-12-31 | 2014-01-08 | 宾夕法尼亚州研究基金会 | 预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法 |
| US8420603B2 (en) | 2004-05-14 | 2013-04-16 | Abraxis Bioscience, Llc | SPARC and methods of use thereof |
| EP3327031A1 (en) * | 2004-05-14 | 2018-05-30 | Abraxis BioScience, LLC | Disease site-delivering pharmaceutical compositions comprising paclitaxel |
| AU2006249235B2 (en) * | 2004-05-14 | 2010-11-11 | Abraxis Bioscience, Llc | Sparc and methods of use thereof |
| US7553496B2 (en) * | 2004-12-21 | 2009-06-30 | University Of Kentucky Research Foundation | VEGF-A as an inhibitor of angiogenesis and methods of using same |
| US8445198B2 (en) | 2005-12-01 | 2013-05-21 | Medical Prognosis Institute | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| CN101365806B (zh) * | 2005-12-01 | 2016-11-16 | 医学预后研究所 | 用于鉴定治疗反应的生物标记的方法和装置及其预测疗效的用途 |
| CA2651846C (en) * | 2006-06-13 | 2019-11-12 | The Rockefeller University | Use of p11 to diagnose a p11/5-ht related disorder |
| DE102006035393A1 (de) * | 2006-11-02 | 2008-05-15 | Signature Diagnostics Ag | Prognostische Marker für die Klassifizierung des dreijährigen progessionsfreien Überlebens von Patienten mit Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben |
| US20110178154A1 (en) * | 2007-02-06 | 2011-07-21 | Birrer Michael J | gene expression profile that predicts ovarian cancer subject response to chemotherapy |
| WO2008109519A2 (en) * | 2007-03-02 | 2008-09-12 | University Of South Florida | Micro-rna profiles associated with endometrial cancer development and response to cisplatin and doxorubicin chemotherapy |
| US8034792B2 (en) | 2007-09-11 | 2011-10-11 | University Of Massachusetts | Insulin-like growth factor binding protein 7 for treatment of cancer |
| JP5461201B2 (ja) * | 2008-01-31 | 2014-04-02 | 学校法人慶應義塾 | 抗がん剤感受性の判定方法 |
| US8093000B2 (en) * | 2008-05-09 | 2012-01-10 | The Regents Of The University Of California | Methods for predicting and treating tumors resistant to drug, immunotherapy, and radiation |
| WO2010135786A1 (en) * | 2009-05-29 | 2010-12-02 | Clinical Genomics Pty. Ltd. | A method for diagnosing neoplasms and molecules for use therein |
| CN102625839A (zh) * | 2009-07-09 | 2012-08-01 | 阿布拉西斯生物科学有限责任公司 | Sparc反义组合物和其用途 |
| DK177532B1 (en) | 2009-09-17 | 2013-09-08 | Bio Bedst Aps | Medical use of sPLA2 hydrolysable liposomes |
| KR20120092597A (ko) * | 2009-09-18 | 2012-08-21 | 아브락시스 바이오사이언스, 엘엘씨 | 암 치료에 있어 sparc 미세환경 시그니처의 용도 |
| US8765713B2 (en) | 2009-10-30 | 2014-07-01 | Keio University | Method for determination of sensitivity to anti-cancer agent |
| CA2800557A1 (en) | 2010-04-29 | 2011-11-03 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy |
| DK2576638T3 (da) | 2010-05-25 | 2021-03-15 | Syndevrx Inc | Polymerkonjugerede metap2-inhibitorer og terapeutiske fremgangsmåder til anvendelse deraf |
| CA2801190A1 (en) | 2010-06-03 | 2011-12-08 | Abraxis Bioscience, Llc | Use of the sparc microenvironment signature in the treatment of cancer |
| WO2012110425A1 (en) * | 2011-02-14 | 2012-08-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for monitoring the response to treatment and for treating colorectal cancer |
| BR112013031019A2 (pt) * | 2011-06-02 | 2017-03-21 | Almac Diagnostics Ltd | teste diagnóstico molecular para câncer |
| US9409978B2 (en) * | 2011-09-09 | 2016-08-09 | University Of Massachusetts | Modulation of midbody derivatives |
| MX2015006955A (es) | 2012-12-03 | 2016-01-25 | Almac Diagnostics Ltd | Prueba de diagnostico molecular para cancer. |
| CN105431426A (zh) | 2013-04-10 | 2016-03-23 | 新德发制药有限公司 | Metap2抑制剂和治疗肥胖症的方法 |
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| CN103893763B (zh) * | 2014-04-10 | 2016-05-11 | 武汉大学 | Vinexin-β基因在心肌梗死中的应用 |
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| US10570457B2 (en) | 2014-09-26 | 2020-02-25 | Medical Prognosis Institute A/S | Methods for predicting drug responsiveness |
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| CN108697807B (zh) * | 2016-01-11 | 2021-11-26 | 辛德弗雷克斯公司 | 代谢功能障碍引起的肿瘤的治疗 |
| US9725769B1 (en) | 2016-10-07 | 2017-08-08 | Oncology Venture ApS | Methods for predicting drug responsiveness in cancer patients |
| AU2017258901A1 (en) | 2016-12-30 | 2018-07-19 | Allarity Therapeutics Europe ApS | Methods for predicting drug responsiveness in cancer patients |
| EP3714896A4 (en) * | 2017-11-21 | 2021-08-04 | Miwa, Naofumi | MEANS FOR INHIBITING METASTASISATION OF HUMAN CANCER CELLS AND MEANS FOR DETERMINING HUMAN CANCER CELLS |
| CN113196055B (zh) | 2018-10-15 | 2025-06-27 | 马克斯·普朗克科学促进协会 | 用于治疗疾病的化合物及其筛选方法 |
| CN113453721B (zh) | 2018-10-26 | 2025-09-16 | 辛德弗雷克斯公司 | Metap2抑制剂的生物标志物及其应用 |
| CA3127237A1 (en) | 2019-02-08 | 2020-08-13 | Dewpoint Therapeutics, Inc. | Methods of characterizing condensate-associated characteristics of compounds and uses thereof |
| CA3140651A1 (en) * | 2019-05-15 | 2020-11-19 | Whitehead Institute For Biomedical Research | Methods of characterizing and utilizing agent-condensate interactions |
| CN110331203B (zh) * | 2019-07-30 | 2023-04-18 | 中南大学湘雅三医院 | 泛素连接酶chaf1b作为靶位点在制备肺腺癌顺铂增敏药物中的应用 |
| KR20220084047A (ko) | 2019-09-18 | 2022-06-21 | 듀포인트 테라퓨틱스, 인크. | 응축물 관련 특이성에 대한 스크리닝 방법 및 이의 용도 |
| EP4329778A4 (en) * | 2021-04-26 | 2025-02-19 | Crititech, Inc. | CISPLATIN PARTICLES AND THEIR USES |
| WO2023196540A1 (en) * | 2022-04-06 | 2023-10-12 | Vanderbilt University | Articles and methods for inhibiting methionine aminopeptidase activity |
| WO2025057928A1 (ja) * | 2023-09-11 | 2025-03-20 | 国立大学法人大阪大学 | 細胞外小胞内rna修飾による卵巣癌プラチナ製剤抵抗性を判別するための検査方法 |
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| US6146886A (en) * | 1994-08-19 | 2000-11-14 | Ribozyme Pharmaceuticals, Inc. | RNA polymerase III-based expression of therapeutic RNAs |
| CA2207593A1 (en) | 1994-12-13 | 1996-06-20 | John Gustofson | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses |
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| CA2301166A1 (en) | 1997-07-24 | 1999-02-04 | Yuan-Peng Zhang | Liposomal compositions for the delivery of nucleic acid catalysts |
| TW589189B (en) | 1997-08-04 | 2004-06-01 | Scras | Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis |
| JP2003528024A (ja) | 1997-12-16 | 2003-09-24 | バレンティス・インコーポレーテッド | 製剤化された核酸分子の無針注入 |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
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| EP1451343B1 (en) * | 2001-11-02 | 2012-10-17 | Dana-Farber Cancer Institute | Methods and compositions for the diagnosis of cancer susceptibilities and defective dna repair mechanisms and treatment thereof |
| AU2002357017A1 (en) * | 2001-11-28 | 2003-06-10 | Mediomics, Llc | Anti-angiogenesis methods, compositions and uses therefor |
| WO2003078603A2 (en) * | 2002-03-15 | 2003-09-25 | Board Of Regents, The University Of Texas System | Strong gene sets for glioma classification |
| US20040097452A1 (en) * | 2002-11-19 | 2004-05-20 | Isis Pharmaceuticals Inc. | Modulation of kallikrein 6 expression |
| CN102321584B (zh) * | 2003-12-31 | 2014-01-08 | 宾夕法尼亚州研究基金会 | 预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法 |
| WO2006044017A2 (en) * | 2004-08-13 | 2006-04-27 | Jaguar Bioscience Inc. | Systems and methods for identifying diagnostic indicators |
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2004
- 2004-12-30 CN CN201110195193.7A patent/CN102321584B/zh not_active Expired - Fee Related
- 2004-12-30 CN CN201210472073.1A patent/CN102989009B/zh not_active Expired - Fee Related
- 2004-12-30 JP JP2006547537A patent/JP4682152B2/ja not_active Expired - Fee Related
- 2004-12-30 EP EP04815833A patent/EP1704250B1/en not_active Expired - Lifetime
- 2004-12-30 ES ES04815833T patent/ES2394799T3/es not_active Expired - Lifetime
- 2004-12-30 EP EP11163049.7A patent/EP2395112B1/en not_active Expired - Lifetime
- 2004-12-30 US US11/026,734 patent/US7700280B2/en not_active Expired - Lifetime
- 2004-12-30 WO PCT/US2004/043837 patent/WO2005066371A2/en not_active Ceased
- 2004-12-30 CN CN2004800421486A patent/CN1922332B/zh not_active Expired - Fee Related
- 2004-12-31 TW TW093141829A patent/TWI301066B/zh not_active IP Right Cessation
-
2010
- 2010-02-23 US US12/711,036 patent/US20100221729A1/en not_active Abandoned
- 2010-02-23 US US12/711,056 patent/US20100221730A1/en not_active Abandoned
- 2010-02-23 US US12/711,068 patent/US8192935B2/en not_active Expired - Fee Related
- 2010-03-31 JP JP2010081265A patent/JP5285012B2/ja not_active Expired - Fee Related
-
2012
- 2012-12-12 JP JP2012271426A patent/JP5789591B2/ja not_active Expired - Fee Related
-
2016
- 2016-02-24 US US15/052,422 patent/US20160348180A1/en not_active Abandoned
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| Analysis of molecular profile data using generative and discriminative methods;E.J.Moler et al.;《Physiological Genomics》;20000101;第4卷;109-126 * |
| E.J.Moler et al..Analysis of molecular profile data using generative and discriminative methods.《Physiological Genomics》.2000,第4卷109-126. |
| Lu PY et al..siRNA-mediated antitumorigenesis for drug target validation and therapeutics.《Europe PubMed Central》.2003,第5卷(第3期),225-234. |
| siRNA-mediated antitumorigenesis for drug target validation and therapeutics;Lu PY et al.;《Europe PubMed Central》;20030630;第5卷(第3期);225-234 * |
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|---|---|
| US20100221731A1 (en) | 2010-09-02 |
| ES2394799T3 (es) | 2013-02-05 |
| CN102989009A (zh) | 2013-03-27 |
| EP2395112B1 (en) | 2017-02-15 |
| CN1922332B (zh) | 2013-06-12 |
| US7700280B2 (en) | 2010-04-20 |
| EP1704250A2 (en) | 2006-09-27 |
| CN1922332A (zh) | 2007-02-28 |
| US20100221729A1 (en) | 2010-09-02 |
| JP5789591B2 (ja) | 2015-10-07 |
| JP2010209076A (ja) | 2010-09-24 |
| JP5285012B2 (ja) | 2013-09-11 |
| TWI301066B (en) | 2008-09-21 |
| JP2007517058A (ja) | 2007-06-28 |
| CN102321584A (zh) | 2012-01-18 |
| JP2013079261A (ja) | 2013-05-02 |
| US20050176669A1 (en) | 2005-08-11 |
| WO2005066371A3 (en) | 2006-04-20 |
| JP4682152B2 (ja) | 2011-05-11 |
| EP2395112A1 (en) | 2011-12-14 |
| EP1704250B1 (en) | 2012-09-19 |
| WO2005066371A2 (en) | 2005-07-21 |
| CN102989009B (zh) | 2015-06-03 |
| TW200531682A (en) | 2005-10-01 |
| US20100221730A1 (en) | 2010-09-02 |
| US8192935B2 (en) | 2012-06-05 |
| US20160348180A1 (en) | 2016-12-01 |
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