CN102318746A - 一种用于细菌性畜禽疾病的动物保健品 - Google Patents
一种用于细菌性畜禽疾病的动物保健品 Download PDFInfo
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Abstract
本发明涉及一种用于细菌性畜禽疾病的动物保健品，由黄连、黄柏、银杏叶、车前子、陈皮、枸杞子、蒲公英、金银花炒炭、醋炒鸡内金、石膏、壳多糖、茶多酚制成。可以制成颗粒剂。
Description
技术领域
本发明涉及一种用于细菌性畜禽疾病的动物保健品，属于饲料添加剂领域。
背景技术
食品工业的最终目标是满足人们对食物营养摄人的需要，绿色食品在生产过程中充分注意了食物营养的变化，绿色食品的优质生产，包括了食物品质的改善和营养价值的提高，绿色食品满足了人们选择高营养食品的需要。绿色食品是绿色健康养殖的结果和标志。但是，随着规模化养殖业的发展，畜禽疾病越来越复杂，单一发生的疾病很少，多以混合感染的形式出现，2006年以来流行的高致病性猪蓝耳病，由于常以多种病原的混合感染出现，曾一度被认为是“无名高热”，这些疾病严重地危害到绿色食品的生产。西药在治疗畜禽疾病有一定的效果，但是，现在出现越来越多的西药残留，耐药性等问题无法解决。
中药具有广谱的抗菌抗病毒作用，针对机体整体机能的恢复，用于治疗畜禽疾病比较好，以复方制剂来使用，在临床上效果更好，如治疗猪的病毒性疾病混合感染就用清瘟败毒散配合白虎汤。但是，目前我国的中兽药动物保健品还处于发展阶段，药物配伍缺少系统研究、产品剂型粗糙、产品质量不稳定的低水平状态，不利于我国畜禽产业的持续性发展。
发明内容
本发明的目的是提供：一种用于细菌性畜禽疾病的动物保健品，用于治疗畜禽细菌性疾病。
一种用于细菌性畜禽疾病的动物保健品，由黄连20-40g、黄柏20-40g、银杏叶5-10g、车前子5-10g、陈皮2-8g、枸杞子5-10g、蒲公英5-10g、金银花炒炭5-10g、醋炒鸡内金2-4g、石膏2-8g、壳多糖2-8g、茶多酚1-2g制成。
A、取黄连20-40g、黄柏20-40g、银杏叶5-10g、车前子5-10g、陈皮2-8g、枸杞子5-10g、蒲公英5-10g、混匀，采用乙醇提取，用水沉淀，过滤，滤液真空干燥，粉碎，得到粉末A备用；
B、金银花炒炭5-10g、醋炒鸡内金2-4g、石膏2-8g、壳多糖2-8g、茶多酚1-2g，粉碎，得到粉末B备用；
C、将粉末A和粉末B，混合。
一种用于前列腺的保健品：
C、将混合粉末，加入糊精8-16g，羟丙基甲基纤维素2-4g，木糖醇2-4g，蔗糖1-2g，混匀，加入适量乙醇，制成颗粒。
取干净的金银花适量，置于平盘中，摊匀，厚度为20mm，放入烘箱内，在150℃烘25分钟，外显焦褐色，内显焦黄色，取出，放凉，得到金银花炒炭；
醋炒鸡内金：杀鸡后，取出鸡肫，趁热立即剥下内壁，洗净，干燥，清炒烫法炒至鼓起，表面暗黄褐色至焦黄色，喷醋，取出，干燥。
本发明采用颗粒剂，掩盖了药物辛辣的苦味，解决了动物不愿意服用的问题，本发明还可以制成口服液，喷雾剂等剂型。
具体实施方式
实施例1
A、取黄连20g、黄柏20g、银杏叶5g、车前子5g、陈皮2g、枸杞子5g、蒲公英5g，混匀，采用乙醇提取，用水沉淀，过滤，滤液真空干燥，粉碎，得到粉末A备用；
B、金银花炒炭5g、醋炒鸡内金2g、石膏2g、壳多糖2g、茶多酚1g，粉碎，得到粉末B备用；
C、将粉末A和粉末B，混合。
实施例2
将实施例1混合粉末，加入糊精8g，羟丙基甲基纤维素2g，木糖醇2g，蔗糖1g，混匀，加入适量乙醇，制成颗粒。
实施例3
A、取黄连40g、黄柏40g、银杏叶10g、车前子10g、陈皮8g、枸杞子10g、蒲公英10g，混匀，采用乙醇提取，用水沉淀，过滤，滤液真空干燥，粉碎，得到粉末A备用；
B、金银花炒炭10g、醋炒鸡内金4g、石膏8g、壳多糖8g、茶多酚2g，粉碎，得到粉末B备用；
C、将粉末A和粉末B，混合。
实施例4
将实施例3混合粉末，加入糊精16g，羟丙基甲基纤维素4g，木糖醇4g，蔗糖2g，混匀，加入适量乙醇，制成颗粒。
实施例5
试验动物
7日龄雏鸡60只。鸡试验前经血清学检测为阴性。用不含其他任何抗菌药物的全价饲料饲喂至30日龄。
菌种，将保存的鸡大肠杆菌(O78)接种于普通平板，培养24h后挑取典型菌落接种于营养肉汤中，37℃培养18h取出，肉汤培养物经接种鸡复壮后，从鸡肝脏分离出大肠杆菌并接种于平板培养，最后挑选典型菌落用营养肉汤培养制备染毒菌液。
将30日龄60只鸡，试验前单羽称重，随机分组，共6组，每组10只，即分别为实施例4高、低剂量治疗组、红霉素对照组、磺胺嘧啶/甲氧苄啶对照组、健康对照组、感染对照组。
实施例4高剂量组为：30g实施例4生药/kg配制成含干粉浓度为30％的药液，大鼠的灌胃量为10ml/kg，3次/d
实施例4低剂量组为：10g实施例4生药/kg配制成含干粉浓度为10％的药液，大鼠的灌胃量为10ml/kg，
红霉素对照组：配制成2mg/ml的溶液.按照2ml/kg的用量，3次/d灌胃
磺胺嘧啶/甲氧苄啶：配制成(1mg磺胺嘧啶+1mg甲氧苄啶)/ml的溶液.按照1ml/kg的用量，3次/d灌胃
30日龄时，各给药组及感染对照组，每只鸡通过皮下注射接种大肠杆菌液体培养物(4.0×105CFU/ml)，剂量为0.1ml/100g。健康对照组注射无菌生理盐水。
各治疗组鸡于接种大肠杆菌后即以饮水途径给予药物治疗，每天配换药液一次，连续用药7天。健康及感染对照组给予常水。
停药后观察期14天，每天观察各组鸡的临床症状，记录死亡情况。病死鸡剖检并进行细菌学分离。
疗效评价指标
死亡率 在试验期间，鸡出现败血支原体和大肠杆菌混合感染的典型症状并死亡，剖检气囊、肺脏、心脏、肝脏有典型的病理变化特征，肝脏、心脏分离出大肠杆菌，判定感染死亡。根据死亡鸡数计算死亡率。
治愈率 在试验期间，经饮水给药后精神状况及食欲恢复正常，不再出现咳嗽、呼吸口罗音、打喷嚏、张口呼吸、流鼻涕等临床症状均属治愈。根据治愈鸡数计算治愈率。
有效率 用药后，试验鸡的精神、食欲、呼吸有明显好转，体重较用药前增加者，均判为有效，据此计算有效率。
病理剖检和病原分离：试验结束后将所有存活鸡捕杀，并进行大肠杆菌分离培养。据此计算各组大肠杆菌分离率。
| 组别 | 死亡率/％ | 治愈率％ | 有效率％ | 增重％ | 大肠杆菌分离率％ |
| 实施例4高剂量组 | 12.1 | 80.3 | 87.9 | 27.5 | 12.4 |
| 实施例4低剂量组 | 21.3 | 69.4 | 78.7 | 21.5 | 27.5 |
| 红霉素对照组 | 40.2 | 50.7 | 59.8 | 14.9 | 35.9 |
| 磺胺嘧啶/甲氧苄啶对照组 | 35.4 | 56.2 | 64.6 | 16.4 | 30.6 |
| 感染对照组 | 51.9 | 42.5 | 48.1 | 2.7 | 100.0 |
| 健康对照组 | 0 | - | - | 56.8 | 35.8 |
统计学分析表明，高、低剂量组与其他用药组及感染对照组差异均显著(P＜0.05)。本发明颗粒饮水给药使用方便，溶解迅速，对鸡无不良作用，饮、食欲正常，适口性良好，可作为大肠杆菌混合感染时治疗的有效药物。
实施例6、抗炎试验
角叉菜胶致大鼠足跖肿胀实验：
取昆明小鼠50只，随机分为空白对照组、模型对照组、阳性对照组、实施例4高剂量组、实施例4低剂量组，N＝10。
空白对照组：灌胃蒸馏水
模型对照组：灌胃蒸馏水
阳性对照组：100mg/kg阿司匹林药液。
实施例4高剂量组为：30g实施例4生药/kg，配制成药液，大鼠的灌胃量为10ml/kg，
实施例4低剂量组为：10g实施例4生药/kg，配制成药液，大鼠的灌胃量为10ml/kg，
用足容积测量器测量各组大鼠右后肢踝关节以下容积。阳性对照组、实施例4高剂量组、实施例4低剂量组分别灌服药物，对照组灌服等量生理盐水，每天给药2次，连续3d，末次给药30min，将1％角叉菜胶溶液0.1ml注入各组大鼠右后肢脚掌皮下致炎，分别记录致炎后1，2，4，6h各组大鼠右后肢踝关节以下容积。
在角叉菜胶致大鼠足跖肿胀的试验中，实施例1的干浸膏粉显著降低角叉菜胶性足肿胀度。
Claims (2)
1.一种用于细菌性畜禽疾病的动物保健品，其特征在于：
由黄连20—40g、黄柏20—40g、银杏叶5—10g、车前子5—10g、陈皮2—8g、枸杞子5—10g、蒲公英5—10g、金银花炒炭5—10g、醋炒鸡内金2—4g、石膏2—8g、壳多糖2—8g、茶多酚1—2g制成。
2.根据权利要求1所述的一种用于前列腺的保健品，其特征在于：
A、取黄连20—40g、黄柏20—40g、银杏叶5—10g、车前子5—10g、陈皮2—8g、枸杞子5—10g、蒲公英5—10g，混匀，采用乙醇提取，用水沉淀，过滤，滤液真空干燥，粉碎，得到粉末A备用；
B、金银花炒炭5—10g、醋炒鸡内金2—4g、石膏2—8g、壳多糖2—8g、茶多酚1—2g，粉碎，得到粉末B备用；
C、将粉末A和粉末B，混合。
3. 根据权利要求2所述的一种用于前列腺的保健品，其特征在于：
C、将混合粉末，加入糊精8—16g，羟丙基甲基纤维素2—4g，木糖醇2—4g，蔗糖1—2g，混匀，加入适量乙醇，制成颗粒。
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