CN102309511A - Application of drug composition in preparation of drugs for treating insomnia - Google Patents
Application of drug composition in preparation of drugs for treating insomnia Download PDFInfo
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- CN102309511A CN102309511A CN2011101253672A CN201110125367A CN102309511A CN 102309511 A CN102309511 A CN 102309511A CN 2011101253672 A CN2011101253672 A CN 2011101253672A CN 201110125367 A CN201110125367 A CN 201110125367A CN 102309511 A CN102309511 A CN 102309511A
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- inorganic acid
- acid salt
- trivalent
- vanadium
- tetravalence
- Prior art date
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Abstract
The invention relates to application of a drug composition in preparation of drugs for treating insomnia, belonging to the field of chemical drugs. The drug composition comprises the following active ingredient: inorganic acid salt of trivalent V. The clinical research indicates that after being used, the drug does not have obvious toxic or side effect, has an obvious effect on treating insomnia and takes an effect quickly. The invention provides a new option for treating insomnia, and the drug composition has broad market prospect.
Description
Technical field
The present invention relates to the purposes of a kind of pharmaceutical composition in the medicine of preparation Cure for insomnia, belong to the chemical medicine field.
Background technology
Insomnia is meant to fall asleep and maybe can't keeps sleep state, causes not having enough sleep.Be weighed into again and sleep and keep sleep disorder (DlMS); Be called again: be insomnia, insomnia, must not crouch, the unable to close the eyes; Be often can not obtain a kind of disease that ortho sleep is a characteristic; For a variety of causes causes that difficulty falling asleep, Depth of sleep or frequency are too short, early awakening and the length of one's sleep are not enough or of poor quality etc., the common reason that causes having a sleepless night mainly contains environment reason, individual factors, body reason, Nervous and Mental Factors, emotional factor etc.According to Traditional Chinese medical theory, the reason of insomnia is mainly the internal organs disorder, especially the YIN nourishing function of the warming YANG function of the heart and kidney can not coordination, deficiency of qi and blood, imbalance of YIN and YANG etc.
Vanadium is one of trace element necessary in the human body, and vanadium is extremely low at the intravital content of people, and insufficient total amount is 1 milligram in the body, mainly is distributed in internal organs, positions such as liver, kidney, thyroid especially, and content is also higher in the osseous tissue.Vanadium is merely 5% at the gastrointestinal absorbance, and its absorption site is mainly at upper digestive tract.About 95% vanadium combines with transferrins with ionic condition and carries in the blood, so vanadium and ferrum can interact in human body.Vanadium is a many-side in the intravital function of people, and the most approved vanadium lacks the research to goat and white mouse that performance comes from report in 1987, and the goat that vanadium lacks shows the abortion ratio increase and milk yield reduces.In the white mouse experiment, the vanadium shortage causes growth inhibited, and the reproduction function is weak, the ratio increase of thyroid weight and body weight and the variation of plasma thyroid hormones concentration.At present, still indeterminate for the research of human body vanadium deficiency disease.
Summary of the invention
Technical problem to be solved by this invention provides the purposes of a kind of pharmaceutical composition in the medicine of preparation Cure for insomnia.
The present invention provides the purposes of a kind of pharmaceutical composition in the medicine of preparation Cure for insomnia, and wherein, described pharmaceutical composition comprises the inorganic acid salt of following active component: trivalent V.
Further, better for the drug effect that makes medicine, the active component of aforementioned pharmaceutical compositions also comprises the inorganic acid salt of tetravalence V.
Wherein, better for the drug effect that makes medicine, the mol ratio of the inorganic acid salt of the inorganic acid salt of above-mentioned trivalent V and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.
Wherein, as preferred technical scheme, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the aforementioned pharmaceutical compositions and tetravalence V counts 0.9～1.1 with vanadium: 0.9～1.1.
Wherein, as most preferred technical scheme, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the aforementioned pharmaceutical compositions and tetravalence V is counted 1: 1 with vanadium.
Further, better for the drug effect that makes medicine, the active component of aforementioned pharmaceutical compositions also comprises the inorganic acid salt of pentavalent V.Wherein, the content of vanadium of the inorganic acid salt of pentavalent V be preferably trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.
Further, better for the drug effect that makes medicine, the active component of aforementioned pharmaceutical compositions also comprises proper inorganic acid, and wherein, said mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid.When active ingredient in pharmaceutical contained mineral acid, it was preferably solution dosage, and the consumption of mineral acid gets final product to guarantee that active component dissolves fully.
Further, better for the drug effect that makes medicine, the active component of aforementioned pharmaceutical compositions also comprises the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge.Wherein, the inorganic acid salt content of K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.
The active component of aforementioned pharmaceutical compositions can be merely the inorganic acid salt of trivalent V.
Wherein, the active component of aforementioned pharmaceutical compositions can also be inorganic acid salt and the proper inorganic acid of trivalent V; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid.When active ingredient in pharmaceutical contained mineral acid, it was preferably solution dosage, and the consumption of mineral acid gets final product to guarantee that active component dissolves fully.
Wherein, the active component of aforementioned pharmaceutical compositions can also be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge and the inorganic acid salt of trivalent V; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.The inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively trivalent V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, the active component of aforementioned pharmaceutical compositions can also be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V and proper inorganic acid; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.The inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively trivalent V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, the active component of aforementioned pharmaceutical compositions also can be the inorganic acid salt of trivalent V and the inorganic acid salt of tetravalence V.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.
Wherein, said active ingredient in pharmaceutical also can be the inorganic acid salt of trivalent V, inorganic acid salt and the proper inorganic acid of tetravalence V; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.
Wherein, said active ingredient in pharmaceutical also can be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of the inorganic acid salt of trivalent V and tetravalence V; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.The inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, said active ingredient in pharmaceutical also can be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V and proper inorganic acid; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.The inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, the active component of aforementioned pharmaceutical compositions also can be the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V and the inorganic acid salt of pentavalent V.The content of vanadium of the inorganic acid salt of described pentavalent V be preferably trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.
Wherein, said active ingredient in pharmaceutical can also be the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V, inorganic acid salt and the proper inorganic acid of pentavalent V; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid.The content of vanadium of the inorganic acid salt of described pentavalent V be preferably trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.
Wherein, said active ingredient in pharmaceutical can also be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V, the inorganic acid salt of the inorganic acid salt of tetravalence V and pentavalent V; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.The content of vanadium of the inorganic acid salt of described pentavalent V be preferably trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.Further, the inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, said active ingredient in pharmaceutical can also be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V, the inorganic acid salt of pentavalent V and proper inorganic acid; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.The content of vanadium of the inorganic acid salt of described pentavalent V be preferably trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.Further, the inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, the inorganic acid salt of the V in the aforementioned pharmaceutical compositions is preferably sulfate, chlorate or phosphate.Further, when V was trivalent, the inorganic acid salt of V was preferably VCl
3, VOCl, V
2(SO
4)
3, VPO
4, V
2(HPO
4)
3Or V (H
2PO
4)
3When V was tetravalence, the inorganic acid salt of V was preferably: VCl
4, VOCl
2, VOSO
4, (VO)
3(PO
4)
2, VOHPO
4Or VO (H
2PO
4)
2When V was pentavalent, the inorganic acid salt of V was preferably VOCl
3, (VO
2)
2(SO
4)
3, VOPO
4, (VO)
2(HPO
4)
3Or VO (H
2PO
4)
3
Inventor of the present invention is through discovering that the vanadium cation that contains in the pharmaceutical composition of the present invention is a main active.Therefore, the present invention also provides the purposes of a kind of pharmaceutical composition in the medicine of preparation Cure for insomnia, and this pharmaceutical composition comprises following active component: the cation that contains trivalent vanadium; Wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+
Further, the active component of aforementioned pharmaceutical compositions also comprises VO
2+
Further, cation that contains trivalent vanadium and the VO in the aforementioned pharmaceutical compositions
2+Mol ratio be preferably 0.5～1.5: 0.5～1.5.Cation that contains trivalent vanadium and VO in the aforementioned pharmaceutical compositions
2+Mol ratio more preferably 0.9～1.1: 0.9～1.1.Cation that contains trivalent vanadium and VO in the aforementioned pharmaceutical compositions
2+Mol ratio most preferably be 1: 1.
Further, the active component of aforementioned pharmaceutical compositions also comprises VO
2 +Wherein, VO
2 +Content is preferably cation and the VO that contains trivalent vanadium
2+0.5%～5% of total vanadium mole.
Further, above-mentioned said active ingredient in pharmaceutical also comprises K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+Wherein, K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+, Ge
4+Content preferably be respectively V integral molar quantity 10
-6～10
-5Doubly.
Wherein, the active component of aforementioned pharmaceutical compositions can be for containing the cation of trivalent vanadium, and wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+And contain the cation of trivalent vanadium, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is cation and the VO that contains trivalent vanadium
2+, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+, contain the cation and the VO of trivalent vanadium
2+, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is cation, the VO that contains trivalent vanadium
2+And VO
2 +, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+, contain the cation of trivalent vanadium, VO
2+And VO
2 +, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Wherein, above-mentioned K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+, Ge
4+Content preferably be respectively V integral molar quantity 10
-6～10
-5Doubly.Above-mentioned VO
2 +Content is preferably cation and the VO that contains trivalent vanadium
2+0.5%～5% of total vanadium mole.Cation that contains trivalent vanadium and VO in the aforementioned pharmaceutical compositions
2+Mol ratio be preferably 0.5～1.5: 0.5～1.5.Cation that contains trivalent vanadium and VO in the aforementioned pharmaceutical compositions
2+Mol ratio more preferably 0.9～1.1: 0.9～1.1.Cation that contains trivalent vanadium and VO in the aforementioned pharmaceutical compositions
2+Mol ratio most preferably be 1: 1.
Said medicine can adopt conventional method that above-mentioned each activity is made according to mixed in molar ratio, according to concrete needs, also can add acceptable accessories.
Aforementioned pharmaceutical compositions can be the pharmaceutical dosage form of routine, and wherein, the dosage form of aforementioned pharmaceutical compositions is preferably transdermal formulation.Further, described transdermal formulation is preferably patch, varnish, liniment, aerosol, unguentum, solution or lotion.
When the dosage form of said medicine is lotion, when using, the patient can medicine of the present invention be added suitable quantity of water, and make the pH value of solution reach the acceptable faintly acid scope of human body; Soak then and use; General soak time 10～40min gets final product, and during immersion, soaks every day 1～6 time.
Medicine of the present invention has alleviated patient's financial burden.Show that through clinical research use medicine of the present invention not see that obvious toxic and side effects is arranged, the Cure for insomnia effect is remarkable, drug effect is fast.The present invention has vast market prospect for the treatment of insomnia provides a kind of new selection.
The specific embodiment
The present invention provides the purposes of a kind of pharmaceutical composition in the medicine of preparation Cure for insomnia, and wherein, described pharmaceutical composition comprises the inorganic acid salt of following active component: trivalent V.
Further, better for the drug effect that makes medicine, the active component of aforementioned pharmaceutical compositions also comprises the inorganic acid salt of tetravalence V.
Wherein, better for the drug effect that makes medicine, the mol ratio of the inorganic acid salt of the inorganic acid salt of above-mentioned trivalent V and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.
Wherein, as preferred technical scheme, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the aforementioned pharmaceutical compositions and tetravalence V counts 0.9～1.1 with vanadium: 0.9～1.1.
Wherein, as most preferred technical scheme, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the aforementioned pharmaceutical compositions and tetravalence V is counted 1: 1 with vanadium.
Further, better for the drug effect that makes medicine, the active component of aforementioned pharmaceutical compositions also comprises the inorganic acid salt of pentavalent V.Wherein, the content of vanadium of the inorganic acid salt of pentavalent V be preferably trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.
Further, better for the drug effect that makes medicine, the active component of aforementioned pharmaceutical compositions also comprises proper inorganic acid, and wherein, said mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid.When active ingredient in pharmaceutical contained mineral acid, it was preferably solution dosage, and the consumption of mineral acid gets final product to guarantee that active component dissolves fully.
Further, better for the drug effect that makes medicine, the active component of aforementioned pharmaceutical compositions also comprises the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge.Wherein, the inorganic acid salt content of K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.
The active component of aforementioned pharmaceutical compositions can be merely the inorganic acid salt of trivalent V.
Wherein, the active component of aforementioned pharmaceutical compositions can also be inorganic acid salt and the proper inorganic acid of trivalent V; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid.When active ingredient in pharmaceutical contained mineral acid, it was preferably solution dosage, and the consumption of mineral acid gets final product to guarantee that active component dissolves fully.
Wherein, the active component of aforementioned pharmaceutical compositions can also be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge and the inorganic acid salt of trivalent V; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.The inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively trivalent V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, the active component of aforementioned pharmaceutical compositions can also be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V and proper inorganic acid; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.The inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively trivalent V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, the active component of aforementioned pharmaceutical compositions also can be the inorganic acid salt of trivalent V and the inorganic acid salt of tetravalence V.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.
Wherein, said active ingredient in pharmaceutical also can be the inorganic acid salt of trivalent V, inorganic acid salt and the proper inorganic acid of tetravalence V; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.
Wherein, said active ingredient in pharmaceutical also can be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of the inorganic acid salt of trivalent V and tetravalence V; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.The inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, said active ingredient in pharmaceutical also can be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V and proper inorganic acid; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.The inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, the active component of aforementioned pharmaceutical compositions also can be the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V and the inorganic acid salt of pentavalent V.The content of vanadium of the inorganic acid salt of described pentavalent V be preferably trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.
Wherein, said active ingredient in pharmaceutical can also be the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V, inorganic acid salt and the proper inorganic acid of pentavalent V; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid.The content of vanadium of the inorganic acid salt of described pentavalent V be preferably trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.
Wherein, said active ingredient in pharmaceutical can also be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V, the inorganic acid salt of the inorganic acid salt of tetravalence V and pentavalent V; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.The content of vanadium of the inorganic acid salt of described pentavalent V be preferably trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.Further, the inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, said active ingredient in pharmaceutical can also be the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V, the inorganic acid salt of pentavalent V and proper inorganic acid; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.The content of vanadium of the inorganic acid salt of described pentavalent V be preferably trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.Further, the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.5～1.5 in vanadium: 0.5～1.5.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is in vanadium more preferably 0.9～1.1: 0.9～1.1.The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V most preferably is 1: 1 in vanadium.Further, the inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge preferably be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
Wherein, the inorganic acid salt of the V in the aforementioned pharmaceutical compositions is preferably sulfate, chlorate or phosphate.Further, when V was trivalent, the inorganic acid salt of V was preferably VCl
3, VOCl, V
2(SO
4)
3, VPO
4, V
2(HPO
4)
3Or V (H
2PO
4)
3When V was tetravalence, the inorganic acid salt of V was preferably: VCl
4, VOCl
2, VOSO
4, (VO)
3(PO
4)
2, VOHPO
4Or VO (H
2PO
4)
2When V was pentavalent, the inorganic acid salt of V was preferably VOCl
3, (VO
2)
2(SO
4)
3, VOPO
4, (VO)
2(HPO
4)
3Or VO (H
2PO
4)
3
Inventor of the present invention is through discovering that the vanadium cation that contains in the pharmaceutical composition of the present invention is a main active.Therefore, the present invention also provides the purposes of a kind of pharmaceutical composition in the medicine of preparation Cure for insomnia, and this pharmaceutical composition comprises following active component: the cation that contains trivalent vanadium; Wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+
Further, the active component of aforementioned pharmaceutical compositions also comprises VO
2+
Further, cation that contains trivalent vanadium and the VO in the aforementioned pharmaceutical compositions
2+Mol ratio be preferably 0.5～1.5: 0.5～1.5.Cation that contains trivalent vanadium and VO in the aforementioned pharmaceutical compositions
2+Mol ratio more preferably 0.9～1.1: 0.9～1.1.Cation that contains trivalent vanadium and VO in the aforementioned pharmaceutical compositions
2+Mol ratio most preferably be 1: 1.
Further, the active component of aforementioned pharmaceutical compositions also comprises VO
2 +Wherein, VO
2 +Content is preferably cation and the VO that contains trivalent vanadium
2+0.5%～5% of total vanadium mole.
Further, above-mentioned said active ingredient in pharmaceutical also comprises K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+Wherein, K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+, Ge
4+Content preferably be respectively V integral molar quantity 10
-6～10
-5Doubly.
Wherein, the active component of aforementioned pharmaceutical compositions can be for containing the cation of trivalent vanadium, and wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+And contain the cation of trivalent vanadium, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is cation and the VO that contains trivalent vanadium
2+, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+, contain the cation and the VO of trivalent vanadium
2+, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is cation, the VO that contains trivalent vanadium
2+And VO
2 +, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+, contain the cation of trivalent vanadium, VO
2+And VO
2 +, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Wherein, above-mentioned K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+, Ge
4+Content preferably be respectively V integral molar quantity 10
-6～10
-5Doubly.Above-mentioned VO
2 +Content is preferably cation and the VO that contains trivalent vanadium
2+0.5%～5% of total vanadium mole.Cation that contains trivalent vanadium and VO in the aforementioned pharmaceutical compositions
2+Mol ratio be preferably 0.5～1.5: 0.5～1.5.Cation that contains trivalent vanadium and VO in the aforementioned pharmaceutical compositions
2+Mol ratio more preferably 0.9～1.1: 0.9～1.1.Cation that contains trivalent vanadium and VO in the aforementioned pharmaceutical compositions
2+Mol ratio most preferably be 1: 1.
Said medicine can adopt conventional method that above-mentioned each activity is made according to mixed in molar ratio, according to concrete needs, also can add acceptable accessories.
Aforementioned pharmaceutical compositions can be the pharmaceutical dosage form of routine, and wherein, the dosage form of aforementioned pharmaceutical compositions is preferably transdermal formulation.Further, described transdermal formulation is preferably patch, varnish, liniment, aerosol, unguentum, solution or lotion.
When the dosage form of said medicine is lotion, when using, the patient can medicine of the present invention be added suitable quantity of water, and make the pH value of solution reach the acceptable faintly acid scope of human body; Soak then and use; General soak time 10～40min gets final product, and during immersion, soaks every day 1～6 time.
Do further description below in conjunction with the embodiment specific embodiments of the invention, therefore do not limit the present invention among the described scope of embodiments.
The preparation of embodiment 1 medicine
Medicine according to mol ratio preparation table 1.
The set of dispense of table 1 medicine is than (mol/L)
The drug prepared dosage form is a lotion, adds water during use and is mixed with pH value and is about and soaks behind 5.5 the solution or insert and wash use, and soak time is 10～40min.
The test of Test Example 1 Transdermal absorption
Experimental technique and step: the Transdermal absorption appearance TT-8 that adopts the just logical Science and Technology Ltd. in Tianjin to produce carries out percutaneous and absorbs diffusion experiment.Adopt Chengdu to reach the qualified adult wistar rat of large biological company limited quarantine, body weight 200～220g is as laboratory animal.With the cropping of rat elder generation, use 5wt%Na then
2The processing of losing hair or feathers of S solution, the depilation back was put to death rat on the 2nd day, and bark fetching is removed subcutaneus adipose tissue, carries out transdermal experiment.Press from both sides rat skin between diffusion cell lid and the diffusion cell during experiment, the diffusion cell lid adds test solution, and diffusion cell adds the PBS buffer of pH7.4, and buffer adopts ultra-pure water (containing vanadium less than 0.01ug/ml) preparation.After experiment finishes; Get buffer in the diffusion cell with 50ml volumetric flask standardize solution (volumetric flask in advance through ultra-pure water clean repeatedly); Detect content of vanadium in the PBS buffer (promptly absorb contain vanadium ion concentration) with ICP; Or other ion concentration (ion concentration that promptly absorbs), if the content of vanadium in the buffer or other ion concentration have raising, prove that then this ion can pass through Transdermal absorption.According to assay, the result is carried out the secondary experiment with the big test group of expection difference, if result of the test is then averaged as a result of with result of the test is approaching for the first time for the second time; If for the second time result of the test differs greatly with result of the test for the first time, then test for the third time, get two groups of the most close data result meansigma methodss as experimental result according to three experimental results.
Sulfate preparation with vanadium contains VO
+, VO
2+, VO
2 +, Fe
2+, Al
3+, K
+, Na
+, Se
4+, Li
+Isoionic solution is measured its percutaneous assimilation effect respectively with step according to the method described above.Specific as follows:
1, VO
+The percutaneous absorption data:
Cation in the testing liquid is VO
+, anion is SO
4 2-PBS buffer V＜0.01ug/ml, Fe＜0.01ug/ml, Ge＜0.01ug/ml, Al＜0.01ug/ml, Ti＜0.01ug/ml, Se＜0.01ug/ml, K
+=134.9ug/ml, Na
+=1336ug/ml.Transdermal absorption time 15min, stock solution (being the testing liquid of not diluted) pH value is 1.5, the VO in the stock solution
+Concentration is counted 100g/L with vanadium, 40 ℃ of temperature, and the Transdermal absorption data of testing liquid are as shown in table 2, wherein, the VO of absorption
+Concentration is the concentration in vanadium.
(the VO of table 2 testing liquid
+) Transdermal absorption result
2, VO
+, Fe
2+, Al
3+, K
+, Na
+, Se
4+The percutaneous absorption data:
Cation in the testing liquid is VO
+, Fe
2+, Al
3+, K
+, Na
+, Se
4+, anion is SO
4 2-PBS buffer V＜0.01ug/ml, Fe
2+＜0.01ug/ml, Al
3+＜0.01ug/ml, Se
4+＜0.01ug/ml, K
+=134.9ug/ml, Na
+=1336ug/ml.
Transdermal absorption time 30min, stock solution (being the testing liquid of not diluted) pH value is 1.5, the VO in the stock solution
+Concentration is counted 100g/L with vanadium, Fe
2+, Al
3+, Ks
+, Na
+, Se
4+Concentration be respectively 1.5*10
-5Mol/L, 10
-5Mol/L, 1.5*10
-5Mol/L, 1.5*10
-5Mol/L, 10
-5Mol/L, 40 ℃ of temperature, the Transdermal absorption data of testing liquid are as shown in table 3, wherein, the VO of absorption
+Concentration is the concentration in vanadium, and the ion concentration that absorbs described in the table is the ion concentration that increases in the buffer, down together.
(the VO of table 3 testing liquid
+, Fe
2+, Al
3+, K
+, Na
+, Se
4+) Transdermal absorption result
3, VO
+, VO
2+(mol ratio 1: 1) percutaneous absorption data
Cation in the testing liquid is VO
+, VO
2+, anion is SO
4 2-PBS buffer V＜0.01ug/ml, K
+=134.9ug/ml, Na
+=1336ug/ml.
Transdermal absorption time 30min, stock solution (being the testing liquid of not diluted) pH value is 1.0, the VO in the stock solution
+, VO
2+Total concentration is counted 100g/L with vanadium, 40 ℃ of temperature, and the Transdermal absorption data of testing liquid are as shown in table 4, wherein, the VO of absorption
+, VO
2+Concentration is the total concentration in vanadium.
(the VO of table 4 testing liquid
+, VO
2+) Transdermal absorption result
4, VO
+, VO
2+(VO
+, VO
2+Mol ratio 1: 1), Fe
2+, K
+, Na
+, Se
4+Cation in the percutaneous absorption data testing liquid is VO
+, VO
2+, Fe
2+, K
+, Na
+, Se
4+, anion is SO
4 2-PBS buffer V＜0.01ug/ml, Fe
2+＜0.01ug/ml, Se
4+＜0.01ug/ml, K
+=134.9ug/ml, Na
+=1336ug/ml.
Transdermal absorption time 15min, stock solution (being the testing liquid of not diluted) pH value is 1.0, the VO in the stock solution
+, VO
2+Total concentration is counted 100g/L with vanadium, Fe
2+, K
+, Na
+, Se
4+Concentration be respectively 1.5*10
-5Mol/L, 1.5*10
-5Mol/L, 1.5*10
-5Mol/L, 10
-5Mol/L, 40 ℃ of temperature, the Transdermal absorption data of testing liquid are as shown in table 5.
(the VO of table 5 testing liquid
+, VO
2+, Fe
2+, K
+, Na
+, Se
4+) Transdermal absorption result
5, VO
+, VO
2+, VO
2 +According to 100: 100: 3 proportioning liquid of mol ratio percutaneous data:
Cation in the testing liquid is VO
+, VO
2+, VO
2 +, anion is SO
4 2-PBS buffer V＜0.01ug/ml.
Transdermal absorption time 30min, stock solution (being the testing liquid of not diluted) pH value is 1.5, the VO in the stock solution
+, VO
2+, VO
2 +Total concentration is counted 100g/L with vanadium, 40 ℃ of temperature, and the Transdermal absorption data of testing liquid are as shown in table 6.
(the VO of table 6 testing liquid
+, VO
2+, VO
2 +) Transdermal absorption result
6, VO
+, VO
2+, VO
2 +, Fe
2+, K
+, Na
+Percutaneous absorption data (VO
+, VO
2+, VO
2 +Mol ratio be 150: 100: 1)
Cation in the testing liquid is VO
+, VO
2+, VO
2 +, Fe
2+, K
+, Na
+, anion is SO
4 2-PBS buffer V＜0.01ug/ml, Fe＜0.01ug/ml, K
+=134.9ug/ml, Na
+=1336ug/ml.Transdermal absorption time 30min, stock solution (being the testing liquid of not diluted) pH value is 1.0, the VO in the stock solution
+, VO
2+, VO
2 +Total concentration is counted 100g/L with vanadium, Fe
2+, K
+, Na
+Concentration be respectively 10
-5Mol/L, 10
-5Mol/L, 10
-5Mol/L, 40 ℃ of temperature, the Transdermal absorption data of testing liquid are as shown in table 7.
(the VO of table 7 testing liquid
+, VO
2+, VO
2 +, Fe
2+, K
+, Na
+) Transdermal absorption result
Can find out that from table 2～7 the Transdermal absorption effect of medicine of the present invention is better.
Test Example 2 adopts Drug therapy insomnia of the present invention
Pay * *, man, 36 years old.Often headache, dizzy, feeling of fullness in the head, insomnia 2 years, with agitation, sentimentality, depressed, feel run-down, soreness of the waist and knees, symptoms such as anorexia, tcm diagnosis: disease belongs to excessive rising of liver-YANG, deficiency of kidney yin.Use medicine of the present invention (embodiment 1, numbering 11) foot bath in March, 2010, each foot bath 30min treated 1 month every day 1 time, and insomnia is clearly better, and spiritual emotional status improves.Continue to use medicine of the present invention (embodiment 1, numbering 6) foot bath, each foot bath 30min, every day 1 time, after treatment 1 month, insomnia is eliminated fully, and the patient can normally fall asleep, and the deep sleep reaches normal level the time.
Test Example 3 adopts Drug therapy insomnia of the present invention
Liu * *, woman, 63 years old.In March, 2009, sleep quality seriously descends, long-term insomnia, tired, weak, headache on daytime, dizziness can't be fallen asleep again, begin to take the stable sleeping pill that waits, taking dose is increasing, in JIUYUE, 2009 reach 3/inferior, 3 times/day.Bring into use medicine of the present invention (embodiment 1, numbering 4) foot bath in JIUYUE, 2009, each foot bath 30min uses the back time for falling asleep to shorten every day 1 time, and sleep time prolongs, and wakes up with a start minimizing night, and daytime, mental status took a turn for the better.Because patient's medicine uses up and feel blood pressure, insomnia is effectively controlled, stop using washing liquid behind in the Decembers, 2009.In February, 2010, patient sleep begins to occur insomnia again, and it is bad to take stable effect, and still wake up with a start night, and time for falling asleep is short, carries out questionnaire survey according to Pittsburg sleep quality index scale [PSQI] scale, must be divided into 16 fens, poor sleeping quality.Brought into use medicine of the present invention (embodiment 1, numbering 2) foot bath on March 13rd, 2010, each foot bath 30min; Every day 1 time,, carry out questionnaire survey according to Pittsburg sleep quality index scale [PSQI] scale to daily inspection in April 5 in 2010; Must be divided into 9 fens; Sleep quality improves, and spiritual emotional status takes a turn for the better, and continues to strengthen in the treatment at present.
Test Example 4 adopts Drug therapy insomnia of the present invention
Yellow * *, woman, 18 years old, students.2009, the Huang of last Senior Two was in the period that senior middle school's study is formed a connecting link, and learning pressure is big especially.Begin in March, 2009 to toss and turn at night, always appear the homework of study on daytime in the brain in one's mind.Just having begun is insomnia, develops into afterwards that on class spirit was not enough, absent minded, emotion is impatient daytime, school grade decline.Found afterwards to begin stealthily to smoke and drink, it is irascible especially that temper becomes, and is weary of study, also silent with the classmate, desperate to school work and future, even attempt to eat sleeping pill and commit suiside.Go to see a doctor and be diagnosed as the anxiety-depression emotion and cause the insomnia syndrome.Bring into use medicine of the present invention (embodiment 1, numbering 1) foot bath in August, 2009, each foot bath 30min, every day 1 time; Used back 1 month, sleep quality improves, time for falling asleep and prolonged sleep time lengthening; The insomnia number of times reduces, and irascible, depressed emotion takes a turn for the better, and carries out questionnaire survey according to Pittsburg sleep quality index scale [PSQI] scale; Must be divided into 7 fens, continue to strengthen treatment 3 months, patient's insomnia is eliminated fully.
Claims (31)
1. the pharmaceutical composition purposes in the medicine of preparation Cure for insomnia, wherein, described pharmaceutical composition comprises the inorganic acid salt of following active component: trivalent V.
2. purposes according to claim 1 is characterized in that: said active ingredient in pharmaceutical also comprises the inorganic acid salt of tetravalence V.
3. purposes according to claim 2 is characterized in that: the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V counts 0.5～1.5 with vanadium: 0.5～1.5; The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V preferably counts 0.9～1.1 with vanadium: 0.9～1.1; The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is more preferably counted 1: 1 with vanadium.
4. according to each described purposes of claim 1～3, it is characterized in that: said active ingredient in pharmaceutical also comprises the inorganic acid salt of pentavalent V.
5. purposes according to claim 4 is characterized in that: the content of vanadium of the inorganic acid salt of pentavalent V be trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.
6. according to each described purposes of claim 1～5, it is characterized in that: said active ingredient in pharmaceutical also comprises proper inorganic acid, and wherein, said mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid.
7. according to each described purposes of claim 1～6, it is characterized in that: said active ingredient in pharmaceutical also comprises the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge.
8. purposes according to claim 7 is characterized in that: the inorganic acid salt content of K, Na, Fe, Al, Ti, Se, Li, Ge be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.
9. purposes according to claim 1 is characterized in that: said active ingredient in pharmaceutical is the inorganic acid salt of trivalent V; Or
Said active ingredient in pharmaceutical is inorganic acid salt and the proper inorganic acid of trivalent V; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; Or
Said active ingredient in pharmaceutical is the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge and the inorganic acid salt of trivalent V; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate; Or
Said active ingredient in pharmaceutical is the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V and proper inorganic acid; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.
10. purposes according to claim 9 is characterized in that: the inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge be respectively trivalent V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
11. purposes according to claim 1 is characterized in that: said active ingredient in pharmaceutical is the inorganic acid salt of trivalent V and the inorganic acid salt of tetravalence V; Or
Said active ingredient in pharmaceutical is the inorganic acid salt of trivalent V, inorganic acid salt and the proper inorganic acid of tetravalence V; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; Or
Said active ingredient in pharmaceutical is the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of the inorganic acid salt of trivalent V and tetravalence V; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate; Or
Said active ingredient in pharmaceutical is the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V and proper inorganic acid; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.
12. purposes according to claim 11 is characterized in that: the inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
13. purposes according to claim 1 is characterized in that: said active ingredient in pharmaceutical is the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V and the inorganic acid salt of pentavalent V; Or
Said active ingredient in pharmaceutical is the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V, inorganic acid salt and the proper inorganic acid of pentavalent V; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; Or
Said active ingredient in pharmaceutical is the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V, the inorganic acid salt of the inorganic acid salt of tetravalence V and pentavalent V; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate; Or
Said active ingredient in pharmaceutical is the inorganic acid salt of K, Na, Fe, Al, Ti, Se, Li and/or Ge, the inorganic acid salt of trivalent V, the inorganic acid salt of tetravalence V, the inorganic acid salt of pentavalent V and proper inorganic acid; Described mineral acid is hydrochloric acid, sulphuric acid or phosphoric acid; The inorganic acid salt of described K, Na, Fe, Al, Ti, Se, Li, Ge is chlorate, sulfate or phosphate.
14. purposes according to claim 13 is characterized in that: the inorganic acid salt content of described K, Na, Fe, Al, Ti, Se, Li, Ge be respectively V the inorganic acid salt integral molar quantity 10
-6～10
-5Doubly.
15., it is characterized in that according to claim 13 or 14 described purposes: the content of vanadium of the inorganic acid salt of described pentavalent V be trivalent V inorganic acid salt and tetravalence V the total vanadium mole of inorganic acid salt 0.5%～5%.
16. according to each described purposes of claim 11～15, it is characterized in that: the mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V counts 0.5～1.5 with vanadium: 0.5～1.5; The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is preferably 0.9～1.1 in vanadium: 0.9～1.1; The mol ratio of the inorganic acid salt of the inorganic acid salt of the trivalent V in the said pharmaceutical composition and tetravalence V is most preferably counted 1: 1 with vanadium.
17. according to each described purposes of claim 1～16, it is characterized in that: the inorganic acid salt of described trivalent V is sulfate, chlorate or the phosphate of trivalent V; The inorganic acid salt of described tetravalence V is sulfate, chlorate or the phosphate of tetravalence V; The inorganic acid salt of described pentavalent V is sulfate, chlorate or the phosphate of pentavalent V.
18. purposes according to claim 17 is characterized in that: when V was trivalent, the inorganic acid salt of V was VCl
3, VOCl, V
2(SO
4)
3, VPO
4, V
2(HPO
4)
3Or V (H
2PO
4)
3When V was tetravalence, the inorganic acid salt of V was: VCl
4, VOCl
2, VOSO
4, (VO)
3(PO
4)
2, VOHPO
4Or VO (H
2PO
4)
2When V was pentavalent, the inorganic acid salt of V was VOCl
3, (VO
2)
2(SO
4)
3, VOPO
4, (VO)
2(HPO
4)
3Or VO (H
2PO
4)
3
19. the purposes of a pharmaceutical composition in the medicine of preparation Cure for insomnia is characterized in that described pharmaceutical composition comprises following active component: the cation that contains trivalent vanadium; Wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+
20. purposes according to claim 19 is characterized in that: said active ingredient in pharmaceutical also comprises VO
2+
21. purposes according to claim 20 is characterized in that: cation that contains trivalent vanadium and VO in the said pharmaceutical composition
2+Mol ratio be 0.5～1.5: 0.5～1.5; Cation that contains trivalent vanadium and VO in the said pharmaceutical composition
2+Mol ratio be preferably 0.9～1.1: 0.9～1.1; Cation that contains trivalent vanadium and VO in the said pharmaceutical composition
2+Mol ratio most preferably be 1: 1.
22. according to each described purposes of claim 19～21, it is characterized in that: said active ingredient in pharmaceutical also comprises VO
2 +
23. purposes according to claim 22 is characterized in that: VO
2 +Content is cation and the VO that contains trivalent vanadium
2+0.5%～5% of total vanadium mole.
24. according to each described purposes of claim 19～23, it is characterized in that: said active ingredient in pharmaceutical also comprises K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+
25. purposes according to claim 24 is characterized in that: K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+, Ge
4+Content be respectively V integral molar quantity 10
-6～10
-5Doubly.
26. purposes according to claim 19 is characterized in that: said active ingredient in pharmaceutical is the cation that contains trivalent vanadium, and wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+And contain the cation of trivalent vanadium, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is cation and the VO that contains trivalent vanadium
2+, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+, contain the cation and the VO of trivalent vanadium
2+, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is cation, the VO that contains trivalent vanadium
2+And VO
2 +, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+Or
Said active ingredient in pharmaceutical is K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+And/or Ge
4+, contain the cation of trivalent vanadium, VO
2+And VO
2 +, wherein, the described cation that contains trivalent vanadium is VO
+Or [V (H
2O)
6]
3+
27. purposes according to claim 26 is characterized in that: described K
+, Na
+, Fe
2+, Al
3+, Ti
4+, Se
4+, Li
+, Ge
4+Content be respectively V integral molar quantity 10
-6～10
-5Doubly.
28., it is characterized in that: described VO according to claim 26 or 27 described purposes
2 +Content is cation and the VO that contains trivalent vanadium
2+0.5%～5% of total vanadium mole.
29. according to each described purposes of claim 26～28, it is characterized in that: cation that contains trivalent vanadium and VO in the said pharmaceutical composition
2+Mol ratio be 0.5～1.5: 0.5～1.5; Cation that contains trivalent vanadium and VO in the said pharmaceutical composition
2+Mol ratio be preferably 0.9～1.1: 0.9～1.1; Cation that contains trivalent vanadium and VO in the said pharmaceutical composition
2+Mol ratio most preferably be 1: 1.
30. according to each described purposes of claim 1～29, it is characterized in that: the dosage form of said pharmaceutical composition is a transdermal formulation.
31. purposes according to claim 30 is characterized in that: described transdermal formulation is patch, varnish, liniment, aerosol, unguentum, solution or lotion.
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| CN2010105415845A Active CN101961347B (en) | 2010-06-24 | 2010-11-12 | Medicinal composition for treating cancer and use thereof |
| CN2010105414518A Active CN101978965B (en) | 2010-06-24 | 2010-11-12 | Use of medicine in treating diabetes |
| CN2011101250956A Pending CN102309505A (en) | 2010-06-24 | 2011-05-16 | Application of drug composition in preparation of drugs for treating organic sexual dysfunction |
| CN2011101255659A Pending CN102309517A (en) | 2010-06-24 | 2011-05-16 | Application of drug composition in preparation of drugs for treating rheumatism |
| CN2011101254196A Pending CN102309514A (en) | 2010-06-24 | 2011-05-16 | Application of drug composition in preparation of drugs for treating hypertensive disease |
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| CN2011101250956A Pending CN102309505A (en) | 2010-06-24 | 2011-05-16 | Application of drug composition in preparation of drugs for treating organic sexual dysfunction |
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| CN106692546A (en) * | 2015-11-14 | 2017-05-24 | 张立 | Medicinal liquor for treating rheumatism and ostealgia |
| CN107375254A (en) * | 2017-08-30 | 2017-11-24 | 李炜 | A kind of external plaster and its application method for being used to treat diabetes |
| CN107485706A (en) * | 2017-09-01 | 2017-12-19 | 仲崇允 | A kind of Chinese medicine for treating breast cancer |
| CN114177196A (en) | 2020-09-14 | 2022-03-15 | 湖南方升泰医药科技有限公司 | Vanadium compounds for use in methods of treating pain |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843481A (en) * | 1994-01-18 | 1998-12-01 | Mount Sinai Hospital Corporation | Treatment of proliferative disorders, metastasaes, and drug resistant tumors with vanadate compounds and derivatives or analogues thereof |
| IL121748A0 (en) * | 1997-09-11 | 1998-02-22 | Yeda Res & Dev | Vanadium complexes of hydroxamates and pharmaceutical compositions comprising them |
| CN1118243C (en) * | 1999-12-17 | 2003-08-20 | 王将克 | Nutritive soybean-pumpkin powder |
| US6689385B2 (en) * | 2000-11-03 | 2004-02-10 | Chronorx Llc | Formulations for the treatment of insulin resistance and type 2 diabetes mellitus |
| CN1178946C (en) * | 2000-11-28 | 2004-12-08 | 昆明贵金属研究所 | Vanadium compound and its preparing process and usage |
| US6693094B2 (en) * | 2001-03-22 | 2004-02-17 | Chrono Rx Llc | Biguanide and sulfonylurea formulations for the prevention and treatment of insulin resistance and type 2 diabetes mellitus |
| CN1179659C (en) * | 2002-05-20 | 2004-12-15 | 郑军武 | Prep. of vanadium-enriched nutrient extender |
| CN1413727A (en) * | 2002-09-09 | 2003-04-30 | 凌一峰 | Composite medicine for radical curing AIDS |
| CN1187091C (en) * | 2002-09-24 | 2005-02-02 | 浙江大学 | Oral vanadium replenishing agent with bimetallic oxide as carrier and its prepn and usage |
| CN1460472A (en) * | 2003-06-06 | 2003-12-10 | 乐益 | Biquanide vanadium complex plaster preparation for curing diabetes and its application |
| FI121915B (en) * | 2004-02-06 | 2011-06-15 | Neurofood Ab Oy | Composition for the treatment of psoriasis |
| US20070066682A1 (en) * | 2005-07-01 | 2007-03-22 | Exposito Miriam R | Arylalkylamine vanadium (V) salts for the treatment and/or prevention of Diabetes mellitus |
| WO2007043606A1 (en) * | 2005-10-12 | 2007-04-19 | Genolac Bl Corporation | Antidiabetic agent comprising anionic polyamino acid-metal complex |
| DE602007006641D1 (en) * | 2006-02-21 | 2010-07-01 | Astrum Therapeutics Pty Ltd | COMPOSITIONS FOR REDUCING THE BLOOD GLUCOSE MIRROR AND TREATING DIABETES |
| CN1846711A (en) * | 2006-04-25 | 2006-10-18 | 苟仕金 | Balanced solution with trace elements for extracorporeal culture of bezoar and its prepn process |
| CN101033239A (en) * | 2007-01-31 | 2007-09-12 | 辽宁师范大学 | Preparation and structure of novel para-insulin pharmaceutical model compound |
| CN101362684A (en) * | 2008-07-23 | 2009-02-11 | 郑德龙 | Solution containing vanadium oxalate and preparation method thereof |
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| CN102309513A (en) | 2012-01-11 |
| CN102309505A (en) | 2012-01-11 |
| CN101947238A (en) | 2011-01-19 |
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| CN102309516A (en) | 2012-01-11 |
| CN101961347B (en) | 2011-12-21 |
| CN102309518A (en) | 2012-01-11 |
| CN102309512A (en) | 2012-01-11 |
| CN102309509A (en) | 2012-01-11 |
| CN102309517A (en) | 2012-01-11 |
| CN101953846B (en) | 2011-12-28 |
| CN102309507A (en) | 2012-01-11 |
| CN102309510A (en) | 2012-01-11 |
| CN102302511B (en) | 2015-06-03 |
| CN102309508A (en) | 2012-01-11 |
| CN102309506A (en) | 2012-01-11 |
| CN101978965B (en) | 2011-12-28 |
| CN101961347A (en) | 2011-02-02 |
| CN102309514A (en) | 2012-01-11 |
| CN102302510B (en) | 2014-04-23 |
| CN102302511A (en) | 2012-01-04 |
| CN101953846A (en) | 2011-01-26 |
| CN101947238B (en) | 2011-12-21 |
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| CN102309515A (en) | 2012-01-11 |
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