CN106420865A - Pharmaceutical composition and application thereof - Google Patents
Pharmaceutical composition and application thereof Download PDFInfo
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- CN106420865A CN106420865A CN201611181733.5A CN201611181733A CN106420865A CN 106420865 A CN106420865 A CN 106420865A CN 201611181733 A CN201611181733 A CN 201611181733A CN 106420865 A CN106420865 A CN 106420865A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Alternative & Traditional Medicine (AREA)
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- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a pharmaceutical composition. The pharmaceutical composition is prepared from a liquid component and a solid component, wherein the liquid component is prepared from the following components in parts by volume: 450 to 550 parts of an alcohol water solution, 5 to 15 parts of a lidocaine solution and 2 to 6 parts of a Chinese angelica injection solution; the solid component is prepared from the following components in parts by weight: 5 to 15 parts of borax and 10 to 20 parts of dried alum; the mass concentration ratio of the solid component to the liquid component is 40g/L to 50g/L. The invention further provides application of the pharmaceutical composition on preparation of painkillers; preferably, the painkillers can be used for alleviating herpes zoster pains or cancer pains.
Description
Technical field
The present invention relates to drug world, in particular to a kind of pharmaceutical composition and its application.
Background technology
Pain is incident symptom in numerous disease, and neuropathic pain is often difficult to eradicate, and has a strong impact on patient
Quality of life.
Cancerous pain (abbreviation cancer pain) is one of most common symptom being most difficult to stand of malignant tumor patient, and it is from psychology, life
The many aspects such as reason, spirit reduce the life quality of patient.Therefore analgesia is one of major measure for the treatment of cancer.WHO will
The effectively treatment of cancer pain is as one of four emphasis in cancer unified plan.Though third order convergence is internationally recognized Pain Treatment
Method, but still fail ideally to control all of cancer pain.And opioid drug has the untoward reaction such as additive, toleration.Warp
Cross years of researches and practice, effect in Pain Treatment for the Chinese medicine gets the nod, as medical science important composition portion of motherland
Point, external treatment of Chinese medicine compares with Western medicine, and pain relieving has that curative effect is reliable, and using safety, toxic and side effects are few, and no additive with give up
The advantages of property, clinically it is widely used.Part cancer patient spleen and stomach function is poor, and it is bad that effect digested and assimilated by Chinese medicine for oral administration,
In place of now being compensated its defect using external treatment.Plaster is the conventional dosage forms of Chinese medicine external, and it is corresponding that it is pasted on local tumor
Body surface or sore spot body surface, using medicine effect, reach reducing swelling and alleviating pain, suppression cancer contracting tumor purpose.
Herpes zoster is caused by varicella zoster viruss, and this virus is typically hidden in spinal cord dorsal root ganglia.But
Abwehrkraft des Koepers are low or tired, infection, cat fever, anger gets angry, and virus can regrow breeding, and along nerve fiber
Move to skin, make the nerve invaded and skin produce fierce inflammation.Erythra typically has Unilateral and is distributed by nerve segment
Feature, be made up of the herpess of cluster, and with pain；Age is bigger, and neuralgia is heavier.This sick modern medicine is referred to as banding
Herpess, referred to as Fel Serpentis skin ulcer among the people, skirt-roof dragon etc. claims.As long as Patients with Herpes Zoster active treatment, rapidly will viral in vivo and sensing
Virus sweep to peripheral nerve is not have sequela to occur in vitro, otherwise may form post herpetic neuralgia.
In addition, other are too numerous to enumerate with the disease of neuropathic pain.Alleviating pain, not only can improve patient
Quality of life, it is also possible that the mental status of patient is improved, by pain relieving make patient identification antagonism the serious illness letter
The heart, gives the optimistic phychology of patient and the resolution of brave life.Therefore pain relieving has great importance for treatment.
In view of this, the special proposition present invention.
Content of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition, and described pharmaceutical composition passes through the combination of Chinese and Western medicine
Mode Chinese medicine extract injection and Western medicine are organically combined, be aided with micro solid constituent, reach multiple-aspect control pain,
Fast and effeciently pain relieving and effect a radical cure pain because effect.
The second object of the present invention is to provide a kind of application of described pharmaceutical composition, the application of described pharmaceutical composition
Scope is quite varied, all has good analgesic effect for various neuropathic pains, for some treatable pain, this
Bright compositionss can play the effect of radical cure, does not recur after treatment.
In order to realize the above-mentioned purpose of the present invention, spy employs the following technical solutions：
One aspect of the present invention is related to a kind of pharmaceutical composition, and described pharmaceutical composition includes liquid component and solid group
Point, described liquid component includes alcohol water blend 450-550 part based on parts by volume, lidocaine solution 5-15 part and Radix Angelicae Sinensis note
Penetrate liquid 2-6 part；Described solid constituent includes Borax 5-15 part and dried Alumen 10-20 part by weight；Described solid constituent phase
Mass concentration ratio for described liquid component is 40-50g/L.
Lidocaine solution has the effect of local anesthesia, lignocaine component is used as only in the compositionss of the present invention
The main component of pain, dissolves pathologic pain by its anesthetic action；Radix Angelicae Sinensis injection has blood circulation promoting and blood stasis dispelling, hemopoietic of enriching blood
Effect, adds a small amount of Radix Angelicae Sinensis injection as accessory drugss, can fundamentally remove the cause of disease of pain in component.Borax and dried Alumen are equal
It is placed in compositionss for solid constituent, the two micro constitutent being dissolved in ethanol has sterilization, hemostasis, the effect of sterilization.Above-mentioned
The proportioning that component provides according to the present invention carry out in the ethanol compounding after, each group also has the effect of Synergistic between dividing.
Preferably, described liquid component includes alcohol water blend 480-520 part based on parts by volume, lidocaine solution 8-
12 parts and Radix Angelicae Sinensis injection 3-5 part.
Preferably, described solid constituent includes Borax 8-12 part by weight and dried Alumen 12-18 part.
Preferably, described solid constituent is 45-50g/L with respect to the mass concentration ratio of described liquid component.
Preferably, the alcohol concentration of described alcohol water blend is more than 90%.
Preferably, the concentration of described lidocaine solution is 1-3%.
Preferably, described compositionss also include the Chinese medicine mixed extract by parts by volume 20-50 part, and described Chinese medicine mixing carries
Take liquid mainly by weight than position 1：(0.5-1)：(0.5-1)：(1-2) Herba speranskiae tuberculatae, Radix Bupleuri, Radix Salviae Miltiorrhizae and Rhizoma Pinelliae extract and obtain.
Chinese crude drug extracting solution can also be applied in above-mentioned composition for the present invention, Herba speranskiae tuberculatae, Radix Bupleuri, Radix Salviae Miltiorrhizae and Rhizoma Pinelliae
All there is pain relieving, generally, Radix Salviae Miltiorrhizae, Radix Bupleuri and Rhizoma Pinelliae are used for taking orally, but, the method for the present invention is by its active component
After the pain-easing spray made extracting solution and provided with the present invention is compounded again, its effect can be inhaled by external transdermal
Receive.Use the extracting solution of above four kinds of Chinese crude drugs according to the compositionss proportioning that the present invention provides, have between its component significantly
Synergistic function.
Preferably, the preparation method of described Chinese medicine mixed extract includes, by described Herba speranskiae tuberculatae, Radix Bupleuri, Radix Salviae Miltiorrhizae and raw half
After summer crushes, boil 1-2h using 8-10 times of decocting of weight meter, filter to take filtrate, repeatedly after above procedure 1-3 time, filtrate is closed
And and obtain extracting solution after being concentrated into relative density 1.10-1.20.
Preferably, the dosage form of described pharmaceutical composition be spray it is preferable that in described pharmaceutical composition, Borax and withered
The granularity of vitriol is less than 150 mesh.
Another aspect of the present invention is related to application in preparing analgesic for the described pharmaceutical composition, preferably described pain relieving
Medicine is used for alleviating banding spore rash pain or cancerous pain.
Compared with prior art, beneficial effects of the present invention are：
(1) pharmaceutical composition of the present invention is alleviated by the way of the combination of Chinese and Western medicine and is treated neuropathic pain, rapid-action,
Good effect, the pain that can cure for some, the medicament of the present invention can eradicate pain because not recurring after curing；
(2) effect of Synergistic is played between each group is divided in the pharmaceutical composition of the present invention by specific proportioning；
(3) the pharmaceutical composition using method of the present invention is simple, gets final product onset by spraying, is easy to patient and uses；
(4) pharmaceutical composition of the present invention has wide range of applications, and is particularly well-suited to alleviate cancerous pain, treats banding spore rash
Neuralgia causing etc..
Specific embodiment
Below in conjunction with embodiment, embodiment of the present invention is described in detail, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and be not construed as limiting the scope of the present invention.Unreceipted concrete in embodiment
Condition person, the condition according to normal condition or manufacturer's suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, are
Can be by the commercially available conventional products bought and obtain.
Embodiment 1
Prepare pain-easing spray according to following steps
1. prepare following liquid component by volume：
450 parts of alcohol water blend；
5 parts of lidocaine solution；
2 parts of Radix Angelicae Sinensis injection；
2. prepare following solid constituent by weight：
5 parts of Borax；
10 parts of dried Alumen；
Both at particulate form, grain graininess is less than 150 mesh.
Wherein, described solid constituent is 40g/L with respect to the mass concentration ratio of described liquid component.
3. by after aforesaid liquid component mix homogeneously, stir 15min, add solid constituent afterwards, and stand at room temperature
24h, obtains spray.
Embodiment 2
Prepare pain-easing spray according to following steps
1. prepare following liquid component by volume：
550 parts of alcohol water blend；
15 parts of lidocaine solution；
6 parts of Radix Angelicae Sinensis injection；
2. prepare following solid constituent by weight：
15 parts of Borax；
20 parts of dried Alumen；
Both at particulate form, grain graininess is less than 150 mesh.
Wherein, described solid constituent is 50g/L with respect to the mass concentration ratio of described liquid component.
3. by after aforesaid liquid component mix homogeneously, stir 15min, add solid constituent afterwards, and stand at room temperature
24h, obtains spray.
Embodiment 3
Prepare pain-easing spray according to following steps
1. prepare following liquid component by volume：
500 parts of alcohol water blend；
10 parts of lidocaine solution；
4 parts of Radix Angelicae Sinensis injection；
2. prepare following solid constituent by weight：
10 parts of Borax；
15 parts of dried Alumen；
Both at particulate form, grain graininess is less than 150 mesh.
Wherein, described solid constituent is 45g/L with respect to the mass concentration ratio of described liquid component.
3. take by weight 1：0.5：0.5：1 Herba speranskiae tuberculatae, Radix Bupleuri, Radix Salviae Miltiorrhizae and Rhizoma Pinelliae, add the water of 8 times amount, decoct
Filter to take filtrate after boiling 1h, repeatedly after above procedure 1 time, filtrate is combined and concentrated to after relative density 1.10 be extracted
Liquid.
4., by after aforesaid liquid component mix homogeneously, add Chinese medicine extraction liquid, the addition of Chinese medicine extraction liquid is by volume
20 parts of part meter, adds solid constituent after stirring 15min, and stands 24h at room temperature, obtain spray.
Embodiment 4
Prepare pain-easing spray according to following steps
1. prepare following liquid component by volume：
500 parts of alcohol water blend；
10 parts of lidocaine solution；
4 parts of Radix Angelicae Sinensis injection；
2. prepare following solid constituent by weight：
10 parts of Borax；
15 parts of dried Alumen；
Both at particulate form, grain graininess is less than 150 mesh.
Wherein, described solid constituent is 45g/L with respect to the mass concentration ratio of described liquid component.
3. take by weight 1：1：1：2 Herba speranskiae tuberculatae, Radix Bupleuri, Radix Salviae Miltiorrhizae and Rhizoma Pinelliae, add the water of 10 times amount, decoct 2h
After filter to take filtrate, repeatedly after above procedure 3 times, filtrate is combined and concentrated to after relative density 1.20 obtain extracting solution.
4., by after aforesaid liquid component mix homogeneously, add Chinese medicine extraction liquid, the addition of Chinese medicine extraction liquid is by volume
50 parts of part meter, adds solid constituent after stirring 15min, and stands 24h at room temperature, obtain spray.
Embodiment 5
Prepare pain-easing spray according to following steps
1. prepare following liquid component by volume：
500 parts of alcohol water blend；
10 parts of lidocaine solution；
4 parts of Radix Angelicae Sinensis injection；
2. prepare following solid constituent by weight：
10 parts of Borax；
15 parts of dried Alumen；
Both at particulate form, grain graininess is less than 150 mesh.
Wherein, described solid constituent is 45g/L with respect to the mass concentration ratio of described liquid component.
3. take by weight 1：0.8：1：1.5 Herba speranskiae tuberculatae, Radix Bupleuri, Radix Salviae Miltiorrhizae and Rhizoma Pinelliae, add the water of 10 times amount, decoct
Filter to take filtrate after boiling 2h, repeatedly after above procedure 2 times, filtrate is combined and concentrated to after relative density 1.20 be extracted
Liquid.
4., by after aforesaid liquid component mix homogeneously, add Chinese medicine extraction liquid, the addition of Chinese medicine extraction liquid is by volume
35 parts of part meter, adds solid constituent after stirring 15min, and stands 24h at room temperature, obtain spray.
Experimental example
500 patients suffering from neuropathic pain of collection, are equally divided into 5 groups, in affected part spraying embodiment of the present invention 1-5
The medicament of preparation, administering mode is that every 4-6 hour sprays once, every time under spraying 3-4, after one week, curative effect is investigated, system
Count (after wherein, spraying is fully recovered after one week and referred to deactivation, pain does not recur) as shown in the table：
It can be seen that, the compositionss of the present invention have good effect for the short-term pain relieving after spraying, but some pain classes
Disease be accompanied by disease main cause and exist it is impossible to radical cure, therefore some patients still cannot be discontinued after one week.
It is noted that adding the compositionss of traditional Chinese medicine composition extract liquid, for short-term relief pain and radical cure pain
Pain all has good effect.
Case 1
Yan, man, 46 years old, Changzhi City Qin County Duan Liu township Yan Jiagou people from village
Left side breast, the side of body, backache, shirtfront, oxter, back are dispersed in red pimple and blister, are diagnosed as banding spore rash.After making a definite diagnosis
Take that ibuprofen curative effect is not good enough, and have the trend gradually increasing, night aggravates so that can not fall asleep.
Spray using the present invention sprays affected part, and 4-6 hour once, is sprayed three times every time, after one week, bitterly stopped, just like
Ordinary person.
Case 2
Lin, female, 77 years old, Changzhi City people
With cancerous pain, it is all invalid to carry out treating using various Conventional pain medicaments, and patient is worn out mentally and physically, and emotion is low
Fall, using the spray of the present invention, spray in place of pain, in 0.5h after sprinkling, pain can be significantly inhibited,
Spray 3-4 time daily, after cancerous pain is controlled, the emotion of Lin takes a turn for the better, and all has bright for the fitness treated and confidence
Show and increase.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
Many other changes can be made in the case of spirit and scope and change.It is, therefore, intended that in the following claims
Including all such changes and modifications belonging in the scope of the invention.
Claims (10)
1. a kind of pharmaceutical composition is it is characterised in that described pharmaceutical composition includes liquid component and solid constituent, described liquid
Component includes alcohol water blend 450-550 part based on parts by volume, lidocaine solution 5-15 part and Radix Angelicae Sinensis injection 2-6 part；
Described solid constituent includes Borax 5-15 part and dried Alumen 10-20 part by weight；Described solid constituent is with respect to described liquid
The mass concentration ratio of body component is 40-50g/L.
2. pharmaceutical composition according to claim 1 is it is characterised in that described liquid component includes the wine based on parts by volume
Smart aqueous solution 480-520 part, lidocaine solution 8-12 part and Radix Angelicae Sinensis injection 3-5 part.
3. pharmaceutical composition according to claim 1 is it is characterised in that described solid constituent includes boron by weight
Sand 8-12 part and dried Alumen 12-18 part.
4. pharmaceutical composition according to claim 1 is it is characterised in that described solid constituent is with respect to described liquid component
Mass concentration ratio be 45-50g/L.
5. the pharmaceutical composition according to any one in claim 1-4 is it is characterised in that the wine of described alcohol water blend
Smart concentration is more than 90%.
6. the pharmaceutical composition according to any one in claim 1-4 is it is characterised in that described lidocaine solution
Concentration is 1-3%.
7. pharmaceutical composition according to claim 1 is it is characterised in that described compositionss are also included by parts by volume 20-50
Part Chinese medicine mixed extract, described Chinese medicine mixed extract mainly by weight than position 1：(0.5-1)：(0.5-1)：(1-2) saturating
GUCAO, Radix Bupleuri, Radix Salviae Miltiorrhizae and Rhizoma Pinelliae extract and obtain.
8. pharmaceutical composition according to claim 7 is it is characterised in that the preparation method bag of described Chinese medicine mixed extract
Include, after described Herba speranskiae tuberculatae, Radix Bupleuri, Radix Salviae Miltiorrhizae and Rhizoma Pinelliae are crushed, the decocting using 8-10 times of weight meter boils 1-2h, filters to take filter
Liquid, repeatedly after above procedure 1-3 time, filtrate is combined and concentrated to after relative density 1.10-1.20 obtain extracting solution.
9. pharmaceutical composition according to claim 1 it is characterised in that described pharmaceutical composition dosage form be spray,
Preferably, in described pharmaceutical composition, the granularity of Borax and dried Alumen is less than 150 mesh.
10. application in preparing analgesic for the pharmaceutical composition described in any one in claim 1-8, preferably described only
Pain medicine is used for alleviating banding spore rash pain or cancerous pain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611181733.5A CN106420865A (en) | 2016-12-20 | 2016-12-20 | Pharmaceutical composition and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611181733.5A CN106420865A (en) | 2016-12-20 | 2016-12-20 | Pharmaceutical composition and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106420865A true CN106420865A (en) | 2017-02-22 |
Family
ID=58215071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611181733.5A Pending CN106420865A (en) | 2016-12-20 | 2016-12-20 | Pharmaceutical composition and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106420865A (en) |
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2016
- 2016-12-20 CN CN201611181733.5A patent/CN106420865A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 孙秀萍等: "穴位注射配合逍遥散治疗带状疱疹神经痛76例", 《陕西中医》 * |
| 李佩文 等: "《癌症疼痛中西医汇通》", 31 January 2002 * |
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Application publication date: 20170222 |