CN102302442B - 一种大蒜素阴道栓剂及其制备方法 - Google Patents
一种大蒜素阴道栓剂及其制备方法 Download PDFInfo
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- CN102302442B CN102302442B CN 201110211022 CN201110211022A CN102302442B CN 102302442 B CN102302442 B CN 102302442B CN 201110211022 CN201110211022 CN 201110211022 CN 201110211022 A CN201110211022 A CN 201110211022A CN 102302442 B CN102302442 B CN 102302442B
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- China
- Prior art keywords
- allicin
- polyethylene glycol
- vaginal suppository
- substrate
- adopts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 title claims abstract description 52
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 235000010081 allicin Nutrition 0.000 title claims abstract description 52
- 239000006216 vaginal suppository Substances 0.000 title claims abstract description 51
- 229940120293 vaginal suppository Drugs 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 57
- 239000000758 substrate Substances 0.000 claims abstract description 46
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229920001661 Chitosan Polymers 0.000 claims abstract description 30
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 29
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 29
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940093430 polyethylene glycol 1500 Drugs 0.000 claims abstract description 13
- 108010010803 Gelatin Proteins 0.000 claims abstract description 11
- 239000008273 gelatin Substances 0.000 claims abstract description 11
- 229920000159 gelatin Polymers 0.000 claims abstract description 11
- 235000019322 gelatine Nutrition 0.000 claims abstract description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 11
- 229920000136 polysorbate Polymers 0.000 claims abstract description 8
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 7
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 7
- 229920001214 Polysorbate 60 Polymers 0.000 claims abstract description 6
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 20
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims description 20
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 20
- 239000000499 gel Substances 0.000 claims description 14
- IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 claims description 12
- 229950009789 cetomacrogol 1000 Drugs 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 9
- 239000000839 emulsion Substances 0.000 claims description 8
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- 229940113116 polyethylene glycol 1000 Drugs 0.000 abstract 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 abstract 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 21
- 230000035876 healing Effects 0.000 description 15
- 230000008929 regeneration Effects 0.000 description 15
- 238000011069 regeneration method Methods 0.000 description 15
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- 241000283973 Oryctolagus cuniculus Species 0.000 description 12
- 230000007794 irritation Effects 0.000 description 9
- 210000004877 mucosa Anatomy 0.000 description 7
- 238000010579 first pass effect Methods 0.000 description 6
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- 238000002474 experimental method Methods 0.000 description 5
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- 241000233866 Fungi Species 0.000 description 3
- 208000006374 Uterine Cervicitis Diseases 0.000 description 3
- 201000008100 Vaginitis Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 206010008323 cervicitis Diseases 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 208000003322 Coinfection Diseases 0.000 description 2
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- 208000004926 Bacterial Vaginosis Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
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- 241000606161 Chlamydia Species 0.000 description 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 1
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 1
- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
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- 229940121375 antifungal agent Drugs 0.000 description 1
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- 239000002662 enteric coated tablet Substances 0.000 description 1
- 229940014062 garlic preparation Drugs 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000013138 pruning Methods 0.000 description 1
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- 210000003462 vein Anatomy 0.000 description 1
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Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 201110211022 CN102302442B (zh) | 2011-07-26 | 2011-07-26 | 一种大蒜素阴道栓剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN 201110211022 CN102302442B (zh) | 2011-07-26 | 2011-07-26 | 一种大蒜素阴道栓剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN102302442A CN102302442A (zh) | 2012-01-04 |
CN102302442B true CN102302442B (zh) | 2013-02-20 |
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CN 201110211022 Expired - Fee Related CN102302442B (zh) | 2011-07-26 | 2011-07-26 | 一种大蒜素阴道栓剂及其制备方法 |
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CN (1) | CN102302442B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102600456B (zh) * | 2012-03-22 | 2014-05-07 | 兰州大学第二医院 | 一种治疗阴道炎、宫颈炎的生物黏附阴道栓及其制备方法 |
CN113975358A (zh) * | 2021-12-03 | 2022-01-28 | 贵州长生药业有限责任公司 | 百草妇炎清栓组合物及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1565430A (zh) * | 2003-06-22 | 2005-01-19 | 毛友昌 | 大蒜素环糊精包合物、制剂及制备方法 |
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2011
- 2011-07-26 CN CN 201110211022 patent/CN102302442B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1565430A (zh) * | 2003-06-22 | 2005-01-19 | 毛友昌 | 大蒜素环糊精包合物、制剂及制备方法 |
Non-Patent Citations (2)
Title |
---|
卢贺起.《中药剂型研究现代化》.《医学与哲学》.1991,第26页左栏第3段. * |
魏清芳.《大蒜的临床新用》.《中国医药导报》.2007,第4卷(第6期),第86页右栏. * |
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CN102302442A (zh) | 2012-01-04 |
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CB03 | Change of inventor or designer information |
Inventor after: Min Guangning Inventor after: Min Guangtao Inventor after: Zhu Jinsong Inventor after: Wu Xinan Inventor after: Zhang Xiaoyun Inventor before: Min Guangning Inventor before: Zhang Xiaoyun Inventor before: Zhu Jinsong Inventor before: Wu Xinan Inventor before: Min Guangtao |
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Free format text: CORRECT: INVENTOR; FROM: MIN GUANGNING ZHANG XIAOYUN ZHU JINSONG WU XINAN MIN GUANGTAO TO: MIN GUANGNING MIN GUANGTAO ZHU JINSONG WU XINAN ZHANG XIAOYUN |
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