CN102293986A - Coating agent with efficacy of antiphlogosis, itching relief, disinfection and sterilization and preparation method thereof - Google Patents
Coating agent with efficacy of antiphlogosis, itching relief, disinfection and sterilization and preparation method thereof Download PDFInfo
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Abstract
The invention particularly relates to a coating agent with the efficacy of antiphlogosis, itching relief, disinfection and sterilization and a preparation method thereof. The technical problem solved by the invention is to improve Binghuangfule ointment and increase compliance of patients. Particularly, the invention is realized by the following technical scheme that: Binghuangfule ointment is modified and prepared into a coating agent. The coating agent has the efficacy of antiphlogosis, itching relief, disinfection and sterilization. The weight ratios of raw material herbs of the coating agent are: 20-68 parts of rheum officinale, 1-40 parts of curcuma longa, 1-10 parts of scutellaria, 3-10 parts of licorice, 20-40 parts of sulfur, 0.1-6.5 parts of borneol, 0.1-4.5 parts of menthol. After the herbs are prepared into a coating agent, the using amount of the raw material of sulfur is reduced; the preparation process is simple and is easy to operate; the prepared coating agent has significant curative effect clinically, is superior to ointment, does not contaminate clothing, is light yellow or transparent, and has good compliance of patients.
Description
Technical field
The invention belongs to the field, be specifically related to have antiinflammatory, the liniment of antipruritic and disinfection effect and preparation method thereof.
Background technology
Neurodermatitis, eczema, tinea pedis, psoriasis etc. are common, the frequently-occurring disease of cardinal symptom with the skin pruritus.Treat the external preparation such as ointment, emulsifiable paste and disinfectant preparation that the medicine of above-mentioned disease is made more, based on antipruritic.
Chinese patent publication number CN1939522A, application number 200510107769.4, treat dermopathic external preparation and preparation method thereof: disclosing a kind of is the dermopathic external preparation of treatment of active drug composition by natural drug Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, sulfur, Radix Scutellariae, Radix Glycyrrhizae, Borneolum Syntheticum, Mentholum, it is that Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, sulfur, Radix Scutellariae, Radix Glycyrrhizae are pulverized or it is decocted with water, filter, concentrate, behind dry the extract powder, add the auxiliary adding ingredient of external medicine preparation acceptable with the Borneolum Syntheticum and the Mentholum of porphyrize, mix homogeneously promptly.In using clinically, the rarely seen ointment of making of the marketed drugs that adopts the disclosed prescription of above-mentioned external preparation to make, promptly ice the happy ointment of yellow skin, but find that in application process ointment easily is infected with clothes, be difficult to clean, it is obvious with the normal skin colouring discrimination to smear the back, though therapeutic effect is remarkable, inconvenient because of smearing the back, plain, patient's poor compliance.
The invention human desires is improved the happy ointment of the yellow skin of ice in clinical practice, the defective of patient's poor compliance.
Summary of the invention
Technical problem solved by the invention is to improve at the happy ointment of the yellow skin of ice, improves patient's compliance.
Be achieved through the following technical solutions for solving the technology of the present invention problem: will ice the happy ointment of yellow skin and change agent and make liniment.
Particularly, this liniment has antiinflammatory, antipruritic and disinfection effect.The weight proportion of the crude drug of this liniment is: Radix Et Rhizoma Rhei 20-68 part, Rhizoma Curcumae Longae 1-40 part, Radix Scutellariae 1-10 part, Radix Glycyrrhizae 3-10 part, sulfur 20-40 part, Borneolum Syntheticum 0.1-6.5 part, Mentholum 0.1-4.5 part.Adopt the above-mentioned raw materials medicine, be prepared as follows liniment:
A, with after Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Radix Scutellariae, Radix Glycyrrhizae water or the alcohol extraction, make the organic solvent solution of extract;
B, filmogen is dissolved in the organic solvent;
C, the organic solvent solution with extract, the organic solvent that is dissolved with filmogen, sulfur, Borneolum Syntheticum, Mentholum mix, promptly.
In order to guarantee curative effect of medication, the weight proportion of crude drug is preferred: Radix Et Rhizoma Rhei 30-40 part, Rhizoma Curcumae Longae 20-30 part, Radix Scutellariae 3-7 part, Radix Glycyrrhizae 3-7 part, sulfur 20-25 part, Borneolum Syntheticum 0.1-3.5 part, Mentholum 2-3.5 part.
Through checking for many years, when the weight proportion of crude drug was 1.8 parts of 30 parts of Radix Et Rhizoma Rhei, 20 parts in Rhizoma Curcumae Longae, 4 parts of Radix Scutellariaes, 4 parts in Radix Glycyrrhizae, 10 parts of sulfurs, 2 parts of Borneolum Syntheticums, Mentholum, curative effect is the most stable, and was definite.
The happy ointment prescribed dose of the yellow skin of field ice is: Radix Et Rhizoma Rhei 30g, Rhizoma Curcumae Longae 20g, Radix Scutellariae 4g, Radix Glycyrrhizae 4g, sulfur 20g, Borneolum Syntheticum 2g, Mentholum 1.8g.After the present invention adopted liniment, sulphur dosage can be reduced to 10g.
The technology of preparation liniment is simple, need not mount the backing material, need not special installation, and this dosage form is easy to use, can form thin film protection wound surface after the time spent solvent evaporates, reaches the effect that discharges gradually.
Second technical problem solved by the invention provides the preparation method of this liniment, and method is as follows:
A, weighting raw materials
B, with after Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Radix Scutellariae, Radix Glycyrrhizae water or the alcohol extraction, make the organic solvent solution of extract;
C, filmogen is dissolved in the organic solvent;
The organic solvent solution of D, mixed extract, the organic solvent that is dissolved with filmogen and sulfur, Borneolum Syntheticum, Mentholum, promptly.
Wherein, after described water of step B or the alcohol extraction, make alcoholic solution, acetone soln, ethyl acetate solution, the diethyl ether solution of extract, or its at least two kinds of solution mix.As make the ethanol-acetone soln of extract; Or make the ethanol-ethyl acetate solution of extract.
As, when step B adopted water extraction: water decocted 1-5 time, merged decocting liquid.For the decocting liquid that obtains with water extraction, adding ethanol transfers to and contains ethanol 60-80%, gets clear liquor after leaving standstill, and concentrates.
Wherein, filmogen is cellulose derivative, polyvinyl formal-acetal, polyvinyl butyral resin, pyroxylin, polyvinyl alcohol-124 among the step C.
Particularly, cellulose derivative adopts cellulose acetate (CA), hydroxypropyl cellulose (HPC), ethyl cellulose (EC), hydroxypropyl emthylcellulose (HPMC).
Composite technology screening and medicine efficacy screening, last inventor finds to prepare liniment the best with following method:
A, weighting raw materials;
B, with Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Radix Scutellariae, Radix Glycyrrhizae with 60-80% (v/v) ethanol extraction, concentrate;
C, filmogen is dissolved in the ethanol;
D, the ethanol concentrated solution with extract, the ethanol that is dissolved with filmogen, sulfur, Borneolum Syntheticum, Mentholum mix, promptly.
Wherein, step B adopts 60-80% (v/v) ethanol extraction.Particularly, extraction, spissated method are:
Extract 1-5 time, adopt 60-80% (v/v) ethanol extraction 1-2 hour that 4-8 doubly measures at every turn, merge extractive liquid, is concentrated into the 10-25% of extracting liquid volume.
Further preferably extract, simmer down to: extract 3 times, adopt 60-80% (v/v) ethanol extraction 1-2 hour of 6 times of amounts at every turn, merge extractive liquid, is concentrated into the 10-25% of extracting liquid volume.
The filmogen preferred, ethyl.
After step D mixed the ethanol concentrated solution of extract, the ethanol that is dissolved with filmogen, sulfur, Borneolum Syntheticum, Mentholum, it was 70-80% (v/v) that adding ethanol makes its concentration.
To sum up, can reduce the raw material sulphur dosage after making liniment, preparation technology is easy, and is easy to operate, and the liniment for preparing is evident in efficacy clinically, and is excellent than ointment, and is not infected with medicated clothing, and it is light yellow or transparent that color is, good patient compliance.
The specific embodiment
Below by specific description of embodiments of the present invention the explanation but do not limit the present invention.
Prior art is: ice the happy ointment of yellow skin.Though it is evident in efficacy aspect treatment dermatitis, wet disease to ice the happy ointment of yellow skin, because the happy ointment of the yellow skin of ice is smeared the back on using plain, easily be infected with medicated clothing, not too accepted by extensive patients.
The technology of the present invention is: will ice the happy ointment of yellow skin and change agent, and make liniment.After improving liniment, patient Geng Yi accepts.
Embodiment 1
Get Radix Et Rhizoma Rhei 30g, Rhizoma Curcumae Longae 20g, Radix Scutellariae 4g, Radix Glycyrrhizae 4g put in the 500ml flask, add 70% ethanol 350ml reflux, extract, 1.5 hours, get extracting solution device preservation in addition, add 70% ethanol 350ml reflux, extract, 1.5 hours again, extracted twice liquid merges to be preserved, add 70% ethanol 300ml reflux, extract, again 1 hour, and got three extracting solution and merge, be evaporated to about 150ml.
Get ethyl cellulose 15g and add 95% ethanol 200ml and reflux after the dissolving, add in the above-mentioned concentrated solution and stir evenly, add sulfur 10g, Borneolum Syntheticum 2g, Mentholum 1.8g stir evenly, and add ethanol and make concentration become 75%, volume becomes 500ml, and fill promptly.
Embodiment 2
Get Radix Et Rhizoma Rhei 30g, Rhizoma Curcumae Longae 20g, Radix Scutellariae 4g, Radix Glycyrrhizae 4g put in the 500ml flask, add 70% ethanol 350ml reflux, extract, 1.5 hours, get extracting solution device preservation in addition, add 70% ethanol 350ml reflux, extract, 1.5 hours again, extracted twice liquid merges to be preserved, add 70% ethanol 300ml reflux, extract, again 1 hour, and got three extracting solution and merge, be evaporated to about 150ml.
Get ethyl cellulose 15g and add 95% ethanol 200ml and reflux after the dissolving, add in the above-mentioned concentrated solution and stir evenly, add sulfur 20g, Borneolum Syntheticum 2g, Mentholum 1.8g stir evenly, and add ethanol and make concentration become 75%, volume becomes 500ml, and fill promptly.
Embodiment 3
Get Radix Et Rhizoma Rhei 60g, Rhizoma Curcumae Longae 10g, Radix Scutellariae 10g, Radix Glycyrrhizae 3g put in the 1000ml flask, add 70% ethanol 670ml reflux, extract, 1.5 hours, get extracting solution device preservation in addition, add 70% ethanol 670ml reflux, extract, 1.5 hours again, extracted twice liquid merges to be preserved, add 70% ethanol 600ml reflux, extract, again 1 hour, and got three extracting solution and merge, be evaporated to about 300ml.
Get ethyl cellulose 30g and add 95% ethanol 400ml and reflux after the dissolving, add in the above-mentioned concentrated solution and stir evenly, add sulfur 40g, Borneolum Syntheticum 2g, Mentholum 0.8g stir evenly, and add ethanol and make concentration become 75%, volume becomes 1000ml, and fill promptly.
Embodiment 4
Get Radix Et Rhizoma Rhei 20g, Rhizoma Curcumae Longae 1g, Radix Scutellariae 1g, Radix Glycyrrhizae 3g put in the 500ml flask, add 70% ethanol 200ml reflux, extract, 1.5 hours, get extracting solution device preservation in addition, add 70% ethanol 200ml reflux, extract, 1.5 hours again, extracted twice liquid merges to be preserved, add 70% ethanol 150ml reflux, extract, again 1 hour, and got three extracting solution and merge, be evaporated to about 100ml.
Get ethyl cellulose 7.5g and add 95% ethanol 100ml and reflux after the dissolving, add in the above-mentioned concentrated solution and stir evenly, add sulfur 20g, Borneolum Syntheticum 2g, Mentholum 0.8g stir evenly, and add ethanol and make concentration become 75%, volume becomes 300ml, and fill promptly.
Embodiment 5
Get Radix Et Rhizoma Rhei 20g, Rhizoma Curcumae Longae 40g, Radix Scutellariae 10g, Radix Glycyrrhizae 10g put in the 1000ml flask, add 60% ethanol 650ml reflux, extract, 1.5 hours, get extracting solution device preservation in addition, add 60% ethanol 650ml reflux, extract, 1.5 hours again, extracted twice liquid merges to be preserved, add 60% ethanol 600ml reflux, extract, again 1 hour, and got three extracting solution and merge, be evaporated to about 350ml.
Get ethyl cellulose 30g and add 95% ethanol 300ml and reflux after the dissolving, add in the above-mentioned concentrated solution and stir evenly, add sulfur 20g, Borneolum Syntheticum 2g, Mentholum 0.8g stir evenly, and add ethanol and make concentration become 75%, volume becomes 750ml, and fill promptly.
Embodiment 6
Get Radix Et Rhizoma Rhei 20g, Rhizoma Curcumae Longae 40g, Radix Scutellariae 10g, Radix Glycyrrhizae 10g put in the 1000ml flask, decoct three times with 8,8,6 times of water gagings respectively, be respectively for three times 2,2,1.5 hours, merge decocting liquid, adding ethanol to concentration is 75%, gets clear liquor after staticly settling, and is evaporated to about 250ml, add acetone, be made into the solution of 350ml.
Get ethyl cellulose 30g and add 95% ethanol 300ml and reflux after the dissolving, add in the above-mentioned concentrated solution and stir evenly, add sulfur 20g, Borneolum Syntheticum 2g, Mentholum 0.8g stir evenly, and add ethanol and make concentration become 75%, volume becomes 750ml, and fill promptly.
The inventor is applied to clinical case with above-mentioned liniment and has investigated the compliance of patient to medicine, and liniment and ointment have been done the dosage form contrast after having developed above-mentioned liniment.Treatment clinical course and statistical data are as follows:
One, experiment medicine:
1, prescription and the method for making by embodiment 1 and 2 prepared two batches of liniment respectively, hereinafter to be referred as liniment embodiment 1 and liniment embodiment 2.
2, the happy ointment of the yellow skin of commercial ice.
Two, case distributes and the grouping situation:
All clinical the clarifying a diagnosis of selected case is subacute eczema, chronic eczema, contact dermatitis, neurodermatitis, tinea manus and pedis, uses liniment or emulsifiable paste at random, the contrast therapy effect.The grouping situation is asked for an interview table 1.
Table 1 clinical case distributes and grouping
| Group | Subacute eczema | Chronic eczema | Contact dermatitis | Neurodermatitis | Tinea manus and pedis |
| Liniment embodiment 1 | 42 examples | 64 examples | 22 examples | 36 examples | 37 examples |
| Liniment embodiment 2 | 40 examples | 60 examples | 20 examples | 30 examples | 30 examples |
| Ice the happy ointment of yellow skin | 40 examples | 60 examples | 20 examples | 30 examples | 30 examples |
Three, Therapeutic Method and observation of curative effect
1, Therapeutic Method
In three groups, morning, noon and afternoon every day each be coated with 1 corresponding medicine and put on the skin in the affected part, liniment smoothens in the affected part and gets final product, ointment need gently be rubbed to drug absorption, 1～3 week was 1 course of treatment, during the medication without other external used medicines.
2, observation of curative effect
Clinical indexes and score erythema, pimple, infiltration or lichenization, keratinization desquamation, pruritus etc.Undertaken by 4 grades of point systems during each assessment: 0=does not have, 1=slight, 2=moderate, 3=severe.
Therapeutic evaluation: the integrated value computing formula is: total mark * 100% before (integration before integrated value=treatment-treatment back integration)/treatment.
Cure: integrated value reduces＞95%;
Produce effects: integrated value reduces 61%～95%;
Take a turn for the better: integrated value reduces 20%～60%;
Invalid: integrated value reduces＜20%.
Four, therapeutic outcome sees Table 2-4.
Table 2 liniment embodiment 1 treatment dermatitis, eczema class dermatosis clinical efficacy
Table 3 liniment embodiment 2 treatment dermatitis, eczema class dermatosis clinical efficacy
The happy Ointment in Treatment dermatitis of the table 4 yellow skin of ice, eczema class dermatosis clinical efficacy
By above-mentioned clinical statistics data as seen: liniment embodiment 1 and liniment embodiment 2 total effective rates all are better than icing the happy ointment of yellow skin; Two liniment are when treatment subacute eczema, contact dermatitis, and total effective rate can improve 3-5 percentage point.The liniment of two kinds of prescriptions of contrast, the crude drug sulfur of the liniment embodiment 1 of unit dose has reduced the consumption of 10g than the crude drug sulfur of liniment embodiment 2, but the two can reach suitable therapeutic effect, and liniment embodiment 1 also has better therapeutic effect at neurodermatitis.
And the patient is more prone to use liniment in use, as long as because liniment smoothens, also can not be infected with medicated clothing, and it is light yellow or transparent that color is, and it is not obvious to smear the back color, does not very influence attractive in appearance.And ointment also needs massage until absorption after smearing, otherwise ointment can be infected with medicated clothing, and the ointment color is darker, and is obvious with the skin color contrast after smearing, and influences attractive in appearance.
Liniment of the present invention can realize therapeutical effect and have the characteristic of high advantage of effective percentage and liniment and employing filmogen bigger relation is arranged.At first, liniment can form thin film protection wound surface after the time spent solvent evaporates, clean cleaning, and patient's compliance is strong, is beneficial to the normal use of medicine; Secondly, the effective ingredient in the medicine volatilizees because of organic solvent, is detained in the filmogen, plays slow releasing function, guarantees the stable of blood drug level, is beneficial to medicine and plays a role, and improves curative effect.
To sum up, the invention provides a kind of liniment with antiinflammatory, antipruritic and disinfection effect, use dermatosiss such as this liniment treatment subacute eczema, chronic eczema, contact dermatitis, neurodermatitis, tinea manus and pedis, evident in efficacy, good patient compliance is for clinical practice provides a kind of brand-new selection.
Claims (10)
1. the liniment that has antiinflammatory, antipruritic and disinfection effect, the weight proportion of its crude drug is: Radix Et Rhizoma Rhei 20-68 part, Rhizoma Curcumae Longae 1-40 part, Radix Scutellariae 1-10 part, Radix Glycyrrhizae 3-10 part, sulfur 20-40 part, Borneolum Syntheticum 0.1-6.5 part, Mentholum 0.1-4.5 part is characterized in that: it is by following method preparation:
A, with after Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Radix Scutellariae, Radix Glycyrrhizae water or the alcohol extraction, make the organic solvent solution of extract;
B, filmogen is dissolved in the organic solvent;
C, the organic solvent solution with extract, the organic solvent that is dissolved with filmogen, sulfur, Borneolum Syntheticum, Mentholum mix, promptly.
2. the liniment with antiinflammatory, antipruritic and disinfection effect according to claim 1, it is characterized in that: the weight proportion of described crude drug is: Radix Et Rhizoma Rhei 30-40 part, Rhizoma Curcumae Longae 20-30 part, Radix Scutellariae 3-7 part, Radix Glycyrrhizae 3-7 part, sulfur 20-25 part, Borneolum Syntheticum 0.1-3.5 part, Mentholum 2-3.5 part.
3. have the liniment of antiinflammatory, antipruritic and disinfection effect, it is characterized in that: the weight proportion of described crude drug is:
Radix Et Rhizoma Rhei 20-40 part, Rhizoma Curcumae Longae 15-25 part, Radix Scutellariae 3-7 part, Radix Glycyrrhizae 3-7 part, sulfur 7.5-12.5 part, Borneolum Syntheticum 0.1-3.5 part, Mentholum 1.5-3.5 part;
It is by following method preparation:
A, with after Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Radix Scutellariae, Radix Glycyrrhizae water or the alcohol extraction, make the organic solvent solution of extract;
B, filmogen is dissolved in the organic solvent;
C, the organic solvent solution with extract, the organic solvent that is dissolved with filmogen, sulfur, Borneolum Syntheticum, Mentholum mix, promptly;
The weight proportion of preferred feedstock medicine is: 30 parts of Radix Et Rhizoma Rhei, 20 parts in Rhizoma Curcumae Longae, 4 parts of Radix Scutellariaes, 4 parts in Radix Glycyrrhizae, 10 parts of sulfurs, 2 parts of Borneolum Syntheticums, 1.8 parts of Mentholums.
4. each described preparation method of claim 1-3 with liniment of antiinflammatory, antipruritic and disinfection effect, it is characterized in that: it is by following method preparation:
A, weighting raw materials
B, with after Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Radix Scutellariae, Radix Glycyrrhizae water or the alcohol extraction, make the organic solvent solution of extract;
C, filmogen is dissolved in the organic solvent;
The organic solvent solution of D, mixed extract, the organic solvent that is dissolved with filmogen and sulfur, Borneolum Syntheticum, Mentholum, promptly.
5. the preparation method with liniment of antiinflammatory, antipruritic and disinfection effect according to claim 4 is characterized in that:
Among the step B: after described water or the alcohol extraction, make alcoholic solution, acetone soln, ethyl acetate solution, the diethyl ether solution of extract, or its at least two kinds of solution mix; Wherein, the described method with water extraction of step B is as follows: water decocts 1-5 time, merges decocting liquid; Behind water extraction, the water intaking decocting liquid, adding ethanol transfers to and contains ethanol 60-80%v/v, gets clear liquor after leaving standstill, and concentrates;
Among the step C: described filmogen is cellulose derivative, polyvinyl formal-acetal, polyvinyl butyral resin, pyroxylin, polyvinyl alcohol-124.
6. the preparation method with liniment of antiinflammatory, antipruritic and disinfection effect according to claim 5 is characterized in that: among the step B, add ethanol and transfer to and contain ethanol 70%v/v, get clear liquor after leaving standstill, concentrate.
7. the preparation method with liniment of antiinflammatory, antipruritic and disinfection effect according to claim 5, it is characterized in that: described cellulose derivative is cellulose acetate, hydroxypropyl cellulose, ethyl cellulose, hydroxypropyl emthylcellulose.
8. the preparation method with liniment of antiinflammatory, antipruritic and disinfection effect according to claim 4 is characterized in that:
A, weighting raw materials;
B, with Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Radix Scutellariae, Radix Glycyrrhizae with 60-80% (v/v) ethanol extraction, concentrate, wherein, preferably adopting concentration of alcohol is 70%v/v;
C, filmogen is dissolved in the ethanol;
D, the ethanol concentrated solution with extract, the ethanol that is dissolved with filmogen, sulfur, Borneolum Syntheticum, Mentholum mix, promptly.
9. the preparation method with liniment of antiinflammatory, antipruritic and disinfection effect according to claim 8, it is characterized in that: the described extraction of step B, spissated method are:
Extract 1-5 time, adopt 60-80%v/v ethanol extraction 1-2 hour that 4-8 doubly measures at every turn, merge extractive liquid, is concentrated into the 10-25% of extracting liquid volume;
The described extraction of step B, spissated method are preferred:
Extract 3 times, adopt 60-80%v/v ethanol extraction 1-2 hour of 6 times of amounts at every turn, merge extractive liquid, is concentrated into the 10-25% of extracting liquid volume.
10. the preparation method with liniment of antiinflammatory, antipruritic and disinfection effect according to claim 8 is characterized in that:
The described filmogen of step C is an ethyl cellulose;
After step D mixed the ethanol concentrated solution of extract, the ethanol that is dissolved with filmogen, sulfur, Borneolum Syntheticum, Mentholum, it was 70-80%v/v that adding ethanol makes its concentration.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102033025A CN102293986A (en) | 2010-07-20 | 2011-07-20 | Coating agent with efficacy of antiphlogosis, itching relief, disinfection and sterilization and preparation method thereof |
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| CN201010231539 | 2010-07-20 | ||
| CN201010231539.X | 2010-07-20 | ||
| CN2011102033025A CN102293986A (en) | 2010-07-20 | 2011-07-20 | Coating agent with efficacy of antiphlogosis, itching relief, disinfection and sterilization and preparation method thereof |
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| CN102293986A true CN102293986A (en) | 2011-12-28 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698816A (en) * | 2005-06-07 | 2005-11-23 | 广西花红药业有限责任公司 | Coating film preparation for dispelling swelling and relieving pain and its preparation method |
| CN1939522A (en) * | 2005-09-30 | 2007-04-04 | 曾雄辉 | Externally-applied medicinal composition for treating dermatosis and its making method |
| CN101152546A (en) * | 2007-10-09 | 2008-04-02 | 西藏芝芝药业有限公司 | Externally used preparations with functions of anti-inflammation, relieving itching and sterilization disinfection, and method for preparing the same |
| CN101361951A (en) * | 2008-09-19 | 2009-02-11 | 西藏芝芝药业有限公司 | Skin external preparation with anti-inflammation, itching-relieving and disinfection and sterilization function and preparation method thereof |
-
2011
- 2011-07-20 CN CN2011102033025A patent/CN102293986A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698816A (en) * | 2005-06-07 | 2005-11-23 | 广西花红药业有限责任公司 | Coating film preparation for dispelling swelling and relieving pain and its preparation method |
| CN1939522A (en) * | 2005-09-30 | 2007-04-04 | 曾雄辉 | Externally-applied medicinal composition for treating dermatosis and its making method |
| CN101152546A (en) * | 2007-10-09 | 2008-04-02 | 西藏芝芝药业有限公司 | Externally used preparations with functions of anti-inflammation, relieving itching and sterilization disinfection, and method for preparing the same |
| CN101361951A (en) * | 2008-09-19 | 2009-02-11 | 西藏芝芝药业有限公司 | Skin external preparation with anti-inflammation, itching-relieving and disinfection and sterilization function and preparation method thereof |
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Application publication date: 20111228 |