CN102293251B - Cornus officinalis fruit milk - Google Patents
Cornus officinalis fruit milk Download PDFInfo
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- CN102293251B CN102293251B CN 201110205918 CN201110205918A CN102293251B CN 102293251 B CN102293251 B CN 102293251B CN 201110205918 CN201110205918 CN 201110205918 CN 201110205918 A CN201110205918 A CN 201110205918A CN 102293251 B CN102293251 B CN 102293251B
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Abstract
The invention relates to Cornus officinalis fruit milk, which can solve the problems of Cornus officinalis health care drinks for nourishing liver and kidney, enhancing the immunity and resisting aging. The invention has the following technical scheme that the Cornus officinalis fruit milk comprises the following ingredients by weight: 1-3 parts of Cornus officinalis polysaccharide particles, 15-30 parts of milk, 0.1-0.3 part of xylitol and 0.3-0.5 part of maltodextrin. The invention has the advantages of scientific and reasonable compatibility, easy production and good product quality, and has functions of nourishing liver and kidney, enhancing the immunity and resisting aging, and is effectively used for health product drinks, the Cornus officinalis fruit milk is beneficial to the body health and has large economical and social benefit.
Description
Technical field
The present invention relates to health drink, particularly a kind of cornel fruit milk.
Background technology
Fructus Corni has another name called dogwood fruit, cornus, fructus corni etc., be Cornaceae plant Fructus Corni (
Cornus officinalisSieb.et Zucc.) remove the drying and ripening pulp of removal core, have tonify the liver and kidney, effect that puckery essence is taken off admittedly, be the traditional Chinese medicine material of China.Fructus Corni contains multiple compositions such as polysaccharide, tannin, iridoid glycoside and organic acid, and wherein, its effect of tonifying the liver and kidney of skunk bush polysaccharide is outstanding, is considered to one type of important active material.Pharmaceutical research proves that skunk bush polysaccharide has raise immunity, removes free radical, non-oxidizability and anti-aging effects, and the health products DEVELOPMENT PROSPECT is good.
Skunk bush polysaccharide astringent taste so that water extraction and alcohol precipitation method extracts is heavier, and dissolubility is very poor, easy oxidation discoloration in air.It is sour and astringent directly to be dissolved in the water mouthfeel, is difficult for being accepted by popular.Given this, the deep processing Processing Technology of skunk bush polysaccharide is the required content of the new health products of exploitation Fructus Corni.
Though relevant for the product of skunk bush polysaccharide, do not see so far that as the health products that tonify the liver and kidney public reported is arranged on the current market.
Summary of the invention
To above-mentioned situation, for overcoming the defective of prior art, the object of the invention just provides a kind of cornel fruit milk, can effectively solve nourishing the liver and kidney, the problem of enhance immunity power, antidotal Fructus Corni health beverages.
The technical scheme that the present invention solves is that this cornel fruit is suckled by the weight meter: skunk bush polysaccharide particle 1-3 part, milk 15-30 part, xylitol 0.1-0.3 part, maltodextrin 0.3-0.5 part are processed, and described skunk bush polysaccharide particle is; Fructus Corni pulp is placed apparatus,Soxhlet's; The mass concentration that adds 4 times of amounts of Fructus Corni pulp weight is 95% alcohol reflux extraction 2-3h, filters reject filtrating; Residue is dry under 20-25 ℃ normal temperature; Get degreasing Fructus Corni meat, volatilize ethanol in the air, subsequent use; Add its weight 10-12 decocting doubly and boiled 1 hour volatilizing Fructus Corni meat 500g behind the alcohol degreasing, the filtrating 1 of gauze coarse filtration is subsequent use; The degreasing Fructus Corni meat dregs of a decoction after the gauze coarse filtration are added its weight 10-12 decocting doubly again boiled 1 hour, filter, must filtrate 2, subsequent use, discard the dregs of a decoction; Merging filtrate 1 and filtrating 2, decocting and concentrating be to 300-500ml, and adding mass concentration and be 95% ethanol to ethanol content is between the 80-85%, leaves standstill 15-20h under 20-25 ℃ the normal temperature, filters, and discards filtrating, sediment 1; Sediment 1 drying under reduced pressure to there not being the alcohol flavor, is got sediment 2; Sediment 2 leaves standstill 5-10h after adding 15-20 water-soluble the separating doubly of weight of precipitate under 20-25 ℃ normal temperature, get supernatant; Be evaporated to the medicinal extract that proportion is 1.3-1.5, add the maltodextrin that the 8-10 of medicinal extract weight doubly measures, the mixed powder of Icing Sugar again, the weight ratio of maltodextrin and Icing Sugar is 1:1; Process and hold the softwood that agglomerating, light pressure is promptly loose; Process particle, 60 ℃ of freeze-day with constant temperature get the skunk bush polysaccharide particle.
Compatibility of the present invention is scientific and reasonable, is prone to produce, and good product quality has nourishing the liver and kidney, enhance immunity power and the anti-ageing function of waiting for a long time, and the health products that can be effective to people are drunk, and are beneficial to the healthy of people, and economic and social benefit is huge.
The specific embodiment
Below in conjunction with embodiment, specific embodiments of the invention elaborates.
The present invention can be provided by following examples in practical implementation:
Embodiment 1
The present invention is processed by the component of following weight meter: 1 part of skunk bush polysaccharide particle, 15 parts in milk, 0.1 part of xylitol, 0.3 part of maltodextrin, mixing adopts the routine techniques sterilization packaging, re-pasteurization, dress box.
Embodiment 2
The present invention can also be processed by the component of following weight meter: 2 parts of skunk bush polysaccharide particles, 17 parts in milk, 0.2 part of xylitol, 0.4 part of maltodextrin, mixing adopts the routine techniques sterilization packaging, re-pasteurization, dress box.
Embodiment 3
The present invention can also be processed by the component of following weight meter: 3 parts of skunk bush polysaccharide particles, 30 parts in milk, 0.3 part of xylitol, 0.5 part of maltodextrin, mixing adopts the routine techniques sterilization packaging, re-pasteurization, dress box.
Embodiment 4
The present invention can also be processed by the component of following weight meter: 1 part of skunk bush polysaccharide particle, 20 parts in milk, 0.3 part of xylitol, 0.3 part of maltodextrin, mixing adopts the routine techniques sterilization packaging, re-pasteurization, dress box.
Embodiment 5
The present invention can also be processed by the component of following weight meter: 3 parts of skunk bush polysaccharide particles, 18 parts in milk, 0.25 part of xylitol, 0.35 part of maltodextrin, mixing adopts the routine techniques sterilization packaging, re-pasteurization, dress box.
Embodiment 6
The present invention can also be processed by the component of following weight meter: 2.5 parts of skunk bush polysaccharide particles, 19 parts in milk, 0.15 part of xylitol, 0.45 part of maltodextrin, mixing adopts the routine techniques sterilization packaging, re-pasteurization, dress box.
Embodiment 7
The present invention can also be processed by the component of following weight meter: skunk bush polysaccharide particle 20g, milk 200g, xylitol 2g, maltodextrin 6g, mixing adopts the routine techniques sterilization packaging, re-pasteurization, dress box.
Embodiment 8
The present invention can also be processed by the component of following weight meter: skunk bush polysaccharide particle 20g, milk 300g, xylitol 4g, maltodextrin 8g, mixing adopts the routine techniques sterilization packaging, re-pasteurization, dress box.
Embodiment 9
The present invention can also be processed by the component of following weight meter: skunk bush polysaccharide particle 20g, milk 400g, xylitol 6g, maltodextrin 10g, mixing adopts the routine techniques sterilization packaging, re-pasteurization, dress box.
Product of the present invention is a primary raw material with skunk bush polysaccharide extract and milk, has nourishing the liver and kidney, strengthens the epidemic disease function, removes free radical, non-oxidizability and antidotal effect, and obtained fully proving through experiment, and relevant experimental data is following:
Experiment material
1. immunological stimulation
Medicine: endoxan (CY); The mushroom polysaccharide sheet; Cornel fruit milk of the present invention is got 50g, and it is subsequent use to add water 100ml dissolving.
Animal: mouse, the Kunming kind is provided by Henan Province's medical experiment animal center.
50 of mouse are got in experiment, are divided into 5 groups, 10 every group; 4 groups of endoxan (CY) wherein respectively at the new preparation of the 1st, 2,3 day lumbar injection 80mg/kg; And irritate clothes cornel fruit milk, lentinan film suspension respectively and with volume physiological saline, 1 group is the blank group in addition, administration every day 1 time; Continuous 8d, the 8th day observation each item index.Groundwater increment is amounted to into polysaccharide dosage and is calculated.
The 8th day morning, every mouse lumbar injection 5% chicken red blood cell normal saline suspension, 6h after giving chicken red blood cell, 2h after the last administration; Put to death mouse, the sterilization belly injects Han Shi liquid 215ml, gently rubs mouse web portion; Get peritoneal fluid and place on the slide, auxilliary wet gauze under the slide is hatched 30min for 37 ℃, and physiological saline washes away floating cell; The dyeing of Rui Shi liquid, microscopically is observed, and calculates phagocytic percentage and phagocytic index, and the result sees table 1.
Can find out from table 1, with the blank control group ratio, all obviously reductions of model group phagocytic percentage and phagocytic index (P 0.01), the success of modeling type is described.With the model group ratio, large and small dosage skunk bush polysaccharide group all can make phagocytic percentage and phagocytic index significantly improve (P < 0.01).
Table 1 skunk bush polysaccharide causes the influence (x ± s) of immunosuppressed mice peritoneal macrophage phagocytic function to CY
| Group | n | Polyoses content (mg/ kg) | Phagocytic percentage (%) | Phagocytic index |
| The blank group | 10 | - | 41.3 ±2.1﹡﹡ | 0.52 ±0.04﹡﹡ |
| Model group | 10 | - | 27.8 ±3.3 | 0.42 ±0.03 |
| The lentinan group | 10 | 100 | 33.5 ±3.0﹡﹡ | 0.48 ±0.06﹡﹡ |
| Cornel fruit milk | 10 | 200 | 37.4 ±3.6﹡﹡ | 0.55 ±0.03﹡﹡ |
Annotate: * * represent with model group than P < 0.01
2. the removing free radical is anti-oxidant, Study of Anti-senility
Medicine: D-galactolipin; The SOD kit; Hydrogen peroxide; The mushroom polysaccharide sheet; Cornel fruit milk of the present invention is got 50g, and it is subsequent use to add water 100ml dissolving.
Animal: mouse, the Kunming kind is provided by Henan Province's medical experiment animal center.
50 of mouse are got in experiment, evenly are divided into 5 groups at random, and 10 every group, wherein the 4 groups of every mouse nape hypodermic injection D-of portion galactolipins (1.25g/kg) are made aging model, inject every day 1 time, and 40d gives the D-galactolipin continuously.1 group of neck hypodermic injection physiological saline is as blank in addition; Weighed 1 time in per 3 days; According to body weight adjustment D-galactolipin consumption, irritate clothes cornel fruit milk, lentinan film mixed liquor respectively and with physiological saline, the continuous medicine-filling 30d of volume from 4 groups on the tenth daystart model.Groundwater increment is amounted to into polysaccharide dosage and is calculated.
1h after 2h, last 1 perfusion behind last 1 injection of d-galactose, mouse orbit is got blood, and the blood anticoagulant heparin is subsequent use, gets Mouse Liver again, brain prepares LH and brain homogenate, and Data Processing in Experiment adopts the t check.
2.1 influence to aging model mouse blood SOD vigor
Get mouse blood 50 μ l, adding fills in the 5ml physiological saline graduated centrifuge tube centrifugal, abandons most supernatant, adds precooling DDW 0.2ml; Behind the haemolysis, add precooling 95% ethanol 0.1ml, jolting; Add precooling chloroform 0.1ml again, extracting 2min on the blender, the centrifugal extract that gets.Press the kit specification and survey extract SOD vigor, and by specification formula calculating SOD vigor, the result sees table 2.
2.2 influence to aging model mouse hemase (CAT) vigor
Get 30% hydrogen peroxidase 10 .52ml, add water to 50ml, therefrom take out 4ml; Adding pH value is 7.0 0.05mol/L phosphate buffer 26ml, surveys absorption value at the 230nm place, is 0.53; Can be used as catalatic substrate solution, calculate the hemase vigor, the result sees table 2.
2.3 to the active influence of aging model mouse blood gst enzyme (PSH-PX)
Get mouse blood 20 μ l, release to 10ml with DDW, the 422nm place surveys and respectively manages the OD value, and in order to remove the influence of non-enzyme system to GSH, other throws the non-enzyme reaction control tube, calculates the GSH-PX vigor, and the result sees table 2.
Obvious or the remarkable reduction than blank group of model group blood SOD, CAT, GSH-PX vigor (P 0.05, P 0.01), the success of modeling type is described.With the model group ratio, cornel fruit milk, Fructus Corni subtract sugared instant milk powder aqueous solution group can significantly improve aging model mouse blood SOD, CAT and GSH-PX vigor (P < 0.01).
Table 2 skunk bush polysaccharide is to the influence (
± s) of aging model mouse blood SOD, CAT and GSH-PX vigor
Annotate: n=10, * represent with model group than P 0.05, and * * represent with model group than P < 0.01.
Claims (9)
1. cornel fruit milk is characterized in that, by the weight meter: skunk bush polysaccharide particle 1-3 part, milk 15-30 part, xylitol 0.1-0.3 part, maltodextrin 0.3-0.5 part are processed; Described skunk bush polysaccharide particle is, Fructus Corni pulp is placed apparatus,Soxhlet's, and the mass concentration that adds 4 times of amounts of Fructus Corni pulp weight is that 95% alcohol reflux extracts 2-3h; Filter, reject filtrating, residue is dry under 20-25 ℃ normal temperature; Get degreasing Fructus Corni meat, volatilize ethanol in the air, subsequent use; Add its weight 10-12 decocting doubly and boiled 1 hour volatilizing Fructus Corni meat 500g behind the alcohol degreasing, use the gauze coarse filtration, must filtrate 1, subsequent use; The degreasing Fructus Corni meat dregs of a decoction after the gauze coarse filtration are added its weight 10-12 decocting doubly again boiled 1 hour, filter, must filtrate 2, subsequent use, discard the dregs of a decoction; Merging filtrate 1 and filtrating 2, decocting and concentrating be to 300-500ml, and adding mass concentration and be 95% ethanol to ethanol content is between the 80-85%, leaves standstill 15-20h under 20-25 ℃ the normal temperature, filters, and discards filtrating, sediment 1; Sediment 1 drying under reduced pressure to there not being the alcohol flavor, is got sediment 2; Sediment 2 leaves standstill 5-10h after adding 15-20 water-soluble the separating doubly of weight of precipitate under 20-25 ℃ normal temperature, get supernatant; Be evaporated to the medicinal extract that proportion is 1.3-1.5, add the maltodextrin that the 8-10 of medicinal extract weight doubly measures, the mixed powder of Icing Sugar again, the weight ratio of maltodextrin and Icing Sugar is 1:1; Process and hold the softwood that agglomerating, light pressure is promptly loose; Process particle, 60 ℃ of freeze-day with constant temperature get the skunk bush polysaccharide particle.
2. cornel fruit milk according to claim 1 is characterized in that, is processed by the component of following weight meter: 1 part of skunk bush polysaccharide particle, 15 parts in milk, 0.1 part of xylitol, 0.3 part of maltodextrin; Mixing; Adopt the routine techniques sterilization packaging, re-pasteurization, dress box.
3. cornel fruit milk according to claim 1 is characterized in that, is processed by the component of following weight meter: 2 parts of skunk bush polysaccharide particles, 17 parts in milk, 0.2 part of xylitol, 0.4 part of maltodextrin; Mixing; Adopt the routine techniques sterilization packaging, re-pasteurization, dress box.
4. cornel fruit milk according to claim 1 is characterized in that, is processed by the component of following weight meter: 3 parts of skunk bush polysaccharide particles, 30 parts in milk, 0.3 part of xylitol, 0.5 part of maltodextrin; Mixing; Adopt the routine techniques sterilization packaging, re-pasteurization, dress box.
5. cornel fruit milk according to claim 1 is characterized in that, is processed by the component of following weight meter: 1 part of skunk bush polysaccharide particle, 20 parts in milk, 0.3 part of xylitol, 0.3 part of maltodextrin; Mixing; Adopt the routine techniques sterilization packaging, re-pasteurization, dress box.
6. cornel fruit milk according to claim 1 is characterized in that, is processed by the component of following weight meter: 3 parts of skunk bush polysaccharide particles, 18 parts in milk, 0.25 part of xylitol, 0.35 part of maltodextrin; Mixing; Adopt the routine techniques sterilization packaging, re-pasteurization, dress box.
7. cornel fruit milk according to claim 1 is characterized in that, is processed by the component of following weight meter: 2.5 parts of skunk bush polysaccharide particles, 19 parts in milk, 0.15 part of xylitol, 0.45 part of maltodextrin; Mixing; Adopt the routine techniques sterilization packaging, re-pasteurization, dress box.
8. cornel fruit milk according to claim 1 is characterized in that, is processed by the component of following weight meter: skunk bush polysaccharide particle 20g, milk 300g, xylitol 4g, maltodextrin 8g, mixing adopts the routine techniques sterilization packaging, re-pasteurization, dress box.
9. cornel fruit milk according to claim 1 is characterized in that, is processed by the component of following weight meter: skunk bush polysaccharide particle 20g, milk 400g, xylitol 6g, maltodextrin 10g, mixing adopts the routine techniques sterilization packaging, re-pasteurization, dress box.
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| CN 201110205918 CN102293251B (en) | 2011-07-21 | 2011-07-21 | Cornus officinalis fruit milk |
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| CN 201110205918 CN102293251B (en) | 2011-07-21 | 2011-07-21 | Cornus officinalis fruit milk |
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| CN102293251B true CN102293251B (en) | 2012-12-19 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102669272B (en) * | 2012-05-30 | 2013-05-08 | 徐爱华 | Preparation method of dogwood yoghourt |
| CN104686671B (en) * | 2015-03-19 | 2017-07-21 | 河南中医学院 | A kind of root of kudzu vine fruit milk |
| CN105558058A (en) * | 2016-02-18 | 2016-05-11 | 王俊杰 | Stomach invigorating and digestion helping fruit milk and making method thereof |
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| CN102127140A (en) * | 2010-11-25 | 2011-07-20 | 南京泽朗医药科技有限公司 | Method for combinedly extracting Morroniside, dogwood polysaccharide and ursolic acid from dogwood |
| CN102002109A (en) * | 2010-11-25 | 2011-04-06 | 南京泽朗医药科技有限公司 | Preparation method of dogwood polysaccharides |
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