CN102292456A - 用于诊断和治疗卵巢癌的基于microRNA 的方法和组合物 - Google Patents
用于诊断和治疗卵巢癌的基于microRNA 的方法和组合物 Download PDFInfo
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- CN102292456A CN102292456A CN2009801553409A CN200980155340A CN102292456A CN 102292456 A CN102292456 A CN 102292456A CN 2009801553409 A CN2009801553409 A CN 2009801553409A CN 200980155340 A CN200980155340 A CN 200980155340A CN 102292456 A CN102292456 A CN 102292456A
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/207—Modifications characterised by siRNA, miRNA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
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- Microbiology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12012308P | 2008-12-05 | 2008-12-05 | |
| US61/120,123 | 2008-12-05 | ||
| PCT/US2009/038214 WO2010065156A1 (en) | 2008-12-05 | 2009-03-25 | Microrna-based methods and compositions for the diagnosis and treatment of ovarian cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102292456A true CN102292456A (zh) | 2011-12-21 |
Family
ID=42233538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801553409A Pending CN102292456A (zh) | 2008-12-05 | 2009-03-25 | 用于诊断和治疗卵巢癌的基于microRNA 的方法和组合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20110275534A1 (enExample) |
| EP (1) | EP2373815A4 (enExample) |
| JP (1) | JP2012510813A (enExample) |
| CN (1) | CN102292456A (enExample) |
| AU (2) | AU2009322907B2 (enExample) |
| CA (1) | CA2745746A1 (enExample) |
| WO (1) | WO2010065156A1 (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103952465A (zh) * | 2013-12-10 | 2014-07-30 | 长沙赢润生物技术有限公司 | 一种基于血浆microRNA分析的卵巢癌肿瘤诊断方法 |
| CN104619353A (zh) * | 2011-12-13 | 2015-05-13 | 俄亥俄州国家创新基金会 | 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移 |
| CN105177173A (zh) * | 2015-11-02 | 2015-12-23 | 崔长友 | 用于卵巢癌诊断的miRNA生物标志物及检测试剂盒 |
| CN105695612A (zh) * | 2016-04-19 | 2016-06-22 | 中南大学 | microRNA-126-5p在心肌损伤中的表达检测方法 |
| CN104123480B (zh) * | 2013-04-27 | 2017-03-08 | 中国科学院上海生命科学研究院 | 新型微rna筛选方法、验证系统及其应用 |
| CN106520924A (zh) * | 2016-10-14 | 2017-03-22 | 浙江大学 | 一种用于检测卵巢癌的引物组及检测方法 |
| CN108348547A (zh) * | 2015-08-28 | 2018-07-31 | 纽约市哥伦比亚大学信托人 | 用于匹配肿瘤学特征的系统和方法 |
| CN112626209A (zh) * | 2020-12-22 | 2021-04-09 | 绵竹市人民医院 | 用于卵巢癌诊断的miRNA标志物、其应用及诊断试剂盒 |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5489459B2 (ja) | 2005-08-01 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 乳癌の診断、予後及び治療のためのマイクロrnaに基づいた方法及び組成物 |
| CN101296702B (zh) | 2005-09-12 | 2012-11-28 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
| WO2007081680A2 (en) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna expression abnormalities in pancreatic endocrine and acinar tumors |
| ES2553442T3 (es) | 2006-01-05 | 2015-12-09 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| ES2536423T3 (es) | 2006-01-05 | 2015-05-25 | The Ohio State University Research Foundation | Métodos basados en microARN para el diagnóstico de cáncer de próstata |
| EP2369012A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Micro-RNA fingerprints during human megakaryocytopoiesis |
| ES2442890T3 (es) | 2006-07-13 | 2014-02-14 | The Ohio State University Research Foundation | Métodos y composiciones basados en micro-ARN para el diagnóstico y el tratamiento de enfermedades relacionadas con el colon |
| ES2374446T3 (es) | 2006-09-19 | 2012-02-16 | The Ohio State University Research Foundation | Expresión de tcl1 en la leucemia linfocítica crónica (llc) regulada por mir-29 y mir-181. |
| EP2087135B8 (en) | 2006-11-01 | 2013-07-24 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| CN105256004A (zh) | 2007-01-31 | 2016-01-20 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| ES2537349T3 (es) | 2007-06-08 | 2015-06-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar un subtipo de carcinoma hepatocelular |
| CN101918424A (zh) | 2007-06-15 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白 |
| JP2010535782A (ja) | 2007-07-31 | 2010-11-25 | ズィ、オハイオウ、ステイト、ユーニヴァーサティ、リサーチ、ファウンデイシャン | Dnmt3a及びdnmt3bを標的にすることによるメチル化を元に戻す方法 |
| ES2562077T3 (es) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Regiones ultraconservadas que codifican ARNnc |
| EP2183593B1 (en) | 2007-08-22 | 2016-01-13 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| EP2201112A4 (en) | 2007-10-26 | 2011-02-02 | Univ Ohio State Res Found | METHOD FOR IDENTIFYING FHIT INTERACTION AND USE |
| US20110034538A1 (en) * | 2008-02-28 | 2011-02-10 | The Ohio State University Research Foundation | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Gastric Cancer |
| US9125923B2 (en) | 2008-06-11 | 2015-09-08 | The Ohio State University | Use of MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy |
| US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| JP6081798B2 (ja) * | 2010-02-26 | 2017-02-15 | メモリアル スローン−ケタリング キャンサー センター | miRNAに関連する癌を検出および処置するための方法および組成物およびmiRNAインヒビターおよび標的 |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
| BR112013011942A2 (pt) | 2010-11-15 | 2016-11-01 | Univ Michigan | formulação, forma de dosagem de droga para administração transmucosa oral, sistema transmucoso de fornecimento de droga, método de tratamento e profilaxia de uma doença ou distúrbio, método de tratamento, formulação, método para tratamento ou prevenção de carcinoma de célula escamosa de cabeça e pescoço (hnscc), método para quimioprevenção de um câncer oral ou condição pré-cancerosa, método para aumentar a concentração de uma composição de retinida, método de tratamento e profilaxia de uma doença ou condição, método de ratamento de um sujeito apresentando uma condição médica sintomática, método de tratamento de um câncer oral ou condição pré-cancerosa num paciente, método para fazer um sistema de fornecimento de droga bucal, método para aumentar a liberação e permeação de uma composição de retinida. |
| EP2683387A4 (en) | 2011-03-07 | 2014-09-03 | Univ Ohio State | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
| WO2012135814A2 (en) * | 2011-03-31 | 2012-10-04 | University Of Houston | Microrna29a,b,c as a tumor suppressor and sensitizing agent for chemotherapy |
| CN104364390B (zh) * | 2011-10-14 | 2016-08-24 | 俄亥俄州立大学 | 与卵巢癌相关的方法和材料 |
| CA2866052A1 (en) | 2012-01-20 | 2013-07-25 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| WO2014071226A1 (en) | 2012-11-02 | 2014-05-08 | The Regents Of The University Of California | Methods and systems for determining a likelihood of adverse prostate cancer pathology |
| KR101508580B1 (ko) | 2013-05-14 | 2015-04-07 | 연세대학교 산학협력단 | 재발성 난소암의 예측 또는 진단 방법 |
| KR101784714B1 (ko) | 2014-08-19 | 2017-10-12 | 주식회사 엠모니터 | 재발 난소암 진단 또는 난소암 재발 예측용 mirna 마커 및 그 용도 |
| EP3147370A1 (en) | 2015-09-28 | 2017-03-29 | Rheinische Friedrich-Wilhelms-Universität Bonn | Exosomal microrna in serum as an indicator for the activation of brown and beige fat tissue (bat) |
| BR112018068866B1 (pt) | 2016-03-17 | 2022-11-29 | Bd Biosciences | Classificação de células utilizando um citômetro de fluxo de fluorescência de alto rendimento |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| US11236337B2 (en) | 2016-11-01 | 2022-02-01 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| US11214839B2 (en) | 2017-01-09 | 2022-01-04 | Dana-Farber Cancer Institute, Inc. | Circulating microRNA signatures for ovarian cancer |
| CN111278844B (zh) | 2017-09-13 | 2023-12-19 | 贝克顿·迪金森公司 | 用于使用氧化铁颗粒提取核酸的方法和组合物 |
| EP3818180B1 (en) * | 2018-07-05 | 2025-09-10 | Université de Caen Normandie | Predictive and prognostic use of a mirna for high grade serous ovarian carcinoma therapeutic care |
| KR20210137828A (ko) * | 2020-05-11 | 2021-11-18 | 의료법인 성광의료재단 | 기계학습 예측모델을 이용한 난소암 진단 방법 및 이를 적용하는 시스템 |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007016548A2 (en) * | 2005-08-01 | 2007-02-08 | The Ohio State University Research Foundation | Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer |
| WO2007081740A2 (en) * | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers |
| WO2008029295A2 (en) * | 2006-06-30 | 2008-03-13 | Rosetta Genomics Ltd | A method for detecting nucleic acids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050182005A1 (en) * | 2004-02-13 | 2005-08-18 | Tuschl Thomas H. | Anti-microRNA oligonucleotide molecules |
-
2009
- 2009-03-25 US US13/132,583 patent/US20110275534A1/en not_active Abandoned
- 2009-03-25 CA CA2745746A patent/CA2745746A1/en not_active Abandoned
- 2009-03-25 JP JP2011539528A patent/JP2012510813A/ja active Pending
- 2009-03-25 EP EP09830750A patent/EP2373815A4/en not_active Withdrawn
- 2009-03-25 CN CN2009801553409A patent/CN102292456A/zh active Pending
- 2009-03-25 AU AU2009322907A patent/AU2009322907B2/en not_active Ceased
- 2009-03-25 WO PCT/US2009/038214 patent/WO2010065156A1/en not_active Ceased
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2014
- 2014-05-22 US US14/284,992 patent/US9499869B2/en not_active Expired - Fee Related
-
2016
- 2016-06-25 AU AU2016204376A patent/AU2016204376A1/en not_active Abandoned
- 2016-10-17 US US15/294,867 patent/US20170037412A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007016548A2 (en) * | 2005-08-01 | 2007-02-08 | The Ohio State University Research Foundation | Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer |
| WO2007081740A2 (en) * | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers |
| WO2008029295A2 (en) * | 2006-06-30 | 2008-03-13 | Rosetta Genomics Ltd | A method for detecting nucleic acids |
Non-Patent Citations (8)
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104619353A (zh) * | 2011-12-13 | 2015-05-13 | 俄亥俄州国家创新基金会 | 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移 |
| CN104123480B (zh) * | 2013-04-27 | 2017-03-08 | 中国科学院上海生命科学研究院 | 新型微rna筛选方法、验证系统及其应用 |
| CN103952465A (zh) * | 2013-12-10 | 2014-07-30 | 长沙赢润生物技术有限公司 | 一种基于血浆microRNA分析的卵巢癌肿瘤诊断方法 |
| CN108348547A (zh) * | 2015-08-28 | 2018-07-31 | 纽约市哥伦比亚大学信托人 | 用于匹配肿瘤学特征的系统和方法 |
| CN108348547B (zh) * | 2015-08-28 | 2023-09-22 | 纽约市哥伦比亚大学信托人 | 用于匹配肿瘤学特征的系统和方法 |
| CN105177173A (zh) * | 2015-11-02 | 2015-12-23 | 崔长友 | 用于卵巢癌诊断的miRNA生物标志物及检测试剂盒 |
| CN105695612A (zh) * | 2016-04-19 | 2016-06-22 | 中南大学 | microRNA-126-5p在心肌损伤中的表达检测方法 |
| CN106520924A (zh) * | 2016-10-14 | 2017-03-22 | 浙江大学 | 一种用于检测卵巢癌的引物组及检测方法 |
| CN112626209A (zh) * | 2020-12-22 | 2021-04-09 | 绵竹市人民医院 | 用于卵巢癌诊断的miRNA标志物、其应用及诊断试剂盒 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010065156A1 (en) | 2010-06-10 |
| AU2009322907B2 (en) | 2016-05-05 |
| JP2012510813A (ja) | 2012-05-17 |
| AU2016204376A1 (en) | 2016-07-14 |
| US20170037412A1 (en) | 2017-02-09 |
| CA2745746A1 (en) | 2010-06-10 |
| EP2373815A4 (en) | 2012-09-26 |
| EP2373815A1 (en) | 2011-10-12 |
| US20110275534A1 (en) | 2011-11-10 |
| US9499869B2 (en) | 2016-11-22 |
| AU2009322907A1 (en) | 2011-07-28 |
| US20140256591A1 (en) | 2014-09-11 |
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