CN102283939A - Chinese medicinal preparation for treating hypertension and preparation method thereof - Google Patents
Chinese medicinal preparation for treating hypertension and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal preparation, which is medicinal composition prepared by mixing devilpepper root, eucommia bark, notoginseng root, Chinese arborvitae twig, Chinese mugwort leaf, lotus leaf, gambir plant and rehmannia root which serve as active ingredients and pharmaceutically-acceptable auxiliary materials. The Chinese medicinal preparation has the effects of promoting blood circulation, invigorating pulse and reducing blood pressure, can be used for hypertension symptoms, and has the advantages of quick response, high bioavailability, convenience for carrying and the like.
Description
Technical field
The present invention relates to hypertensive Chinese medicine preparation of a kind of treatment and preparation method thereof, belong to medical technical field.
Background technology
Hypertension is a kind of chronic disease that serves as main performance with the lasting rising of arteriotony, often causes the pathological changes of vitals such as the heart, brain, kidney and corresponding consequence occurs.
The blood pressure standard of using according to World Health Organization (WHO) (Who) suggestion is: all normal adult systolic pressures should be less than or equal to 140mmHg (18.6kPa), and diastolic pressure is less than or equal to 90mmHg (12kPa).That is systolic pressure is between 141-159mmHg (18.9-21.2kPa), and diastolic pressure is borderline hypertension between 91-94mmHg (12.1-12.5kPa).
According to 2010 " Chinese health statistics summary " and " Chinese cardiovascular disease report ", only the hypertension cardiovascular disease death that causes comprising apoplexy every year is up to 2,330,000 people, and hypertension has become the main reason that China causes death, disables.
Hypertension belongs to the traditional Chinese medical science " dizzy ", " headache " category, with dizzy, headache, blood pressure increases, stringy pulse etc. be the dizzy class disease of main performance, lose because of the Liver and kidney yang hyperactivity is cloudy, wind-yang and up-boring, QI and blood contrary random due to.On modern medicine, hypertension is divided into constitutional (hypertension) and two kinds of Secondary cases (symptomatic hypertension).Main clinical manifestation has dizziness, headache, dim eyesight, tinnitus, cardiopalmus, insomnia, agitation, waist knee joint soft, very then twitches, vomiting, dysphonia, stupor, hemiplegia all diseases of incontinence of urination and defecation." element is asked. beautiful machine is really hidden opinion " say: " too then make us forgetful, dizziness with trance and the disorder of head, " spell out normal pulse in spring too due to, dizzy, headache, dim eyesight, tinnitus, head symptom such as forgetful." Ling Shu Miraculous Pivot or Divine Axis. mouth is asked a piece of writing " add: " QI of the upper portion of the body being insufficient, empty sensation in the brain, the bitter for it ring of ear, suffering from the head tilted down feebly, blurring of vision, " " element is asked. the most pure virginity will be discussed greatly " emphasize: " all wind trembling and dizziness all belong to liver " also is the endogenous wind theory." element is asked. the former sick formula of arcane truth " and what think primary disease is because wind-fire has " wind-fire all belongs to sun, mostly is doubleization, and sun is main moving ".
Chinese traditional treatment hypertension is paid attention to Coryza Treated by Syndrome Differentiation, emphasizes whole adjustment, makes the health negative and positive of qi and blood state that restores balance, complication prevention.When bringing high blood pressure down, the balance of each organ of protection health.The used medical material Radix Rauvolfiae of the present invention hardship, cold, fresh breeze heat, eliminating pathogen in the liver pathogenic fire reducing; The Cortex Eucommiae is sweet, temperature, invigorating the liver and kidney, bone and muscle strengthening; Sweet, the little hardship of Radix Notoginseng, temperature, dissipating blood stasis hemostasis, subduing swelling and relieving pain; Cacumen Platycladi hardship, puckery, cold, cooling blood for hemostasis; Folium Artemisiae Argyi suffering, hardship, temperature, warming the meridian for stopping bleeding; The Folium Nelumbinis hardship, flat, sending up the lucid YANG, cooling blood for hemostasis; Ramulus Uncariae Cum Uncis is sweet, cold, heat clearing away suppressing the hyperactive liver, endogenous wind stopping; Radix Rehmanniae is sweet, and is cold, clearing away heat and cooling blood, and yin nourishing is promoted the production of body fluid.All medicines share, and with blood circulation and channel invigorating, blood stasis dispersing and fresh blood promoting is main, can obtain good curative effect, be a kind of traditional Chinese medical science field effectively and the Chinese medicine preparation of the control high blood pressure disease of few side effects, broad market prospect and profit margin also have great social significance.
Summary of the invention
The present invention is hypertensive Chinese medicine preparation of a kind of treatment and preparation method thereof, it is characterized in that, it is to be active component by Radix Rauvolfiae, the Cortex Eucommiae, Radix Notoginseng, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae, the preparation made from mixing acceptable accessories.
It is characterized in that the consumption of described Radix Rauvolfiae, the Cortex Eucommiae, Radix Notoginseng, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae is a per unit dosage
Radix Rauvolfiae 100-1000 part Cortex Eucommiae 50-500 part Radix Notoginseng 10-100 part
Cacumen Platycladi 50-500 part Folium Artemisiae Argyi 200-1000 part Folium Nelumbinis 50-500 part
Ramulus Uncariae Cum Uncis 80-800 part Radix Rehmanniae 10-100 part.
Per unit dosage is preferably
36 parts of 260 portions of Radix Notoginseng of 910 parts of Cortexs Eucommiae of Radix Rauvolfiae
100 parts on 650 parts of Folium Nelumbinis of 260 portions of Folium Artemisiae Argyis of Cacumen Platycladi
26 parts of 180 portions of Radix Rehmanniae of Ramulus Uncariae Cum Uncis.
The method of being used as medicine of Radix Rauvolfiae, the Cortex Eucommiae, Radix Notoginseng, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae is:
Technology A: Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae, the Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, and drying is pulverized.
Technology B: Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae, the Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae add 20-95% ethanol water reflux, extract,, filter, and filtrate is condensed into extractum, and drying is pulverized.
Technology C: Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae adds 20-95% ethanol water reflux, extract,, filters, and filtrate is condensed into extractum, and drying is pulverized.The Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, and drying is pulverized.
Described preparation comprises drop pill, coated tablet, thin membrane coated tablet, chewable tablet, effervescent tablet, dispersible tablet, soft capsule, granule.
It is characterized in that described acceptable accessories is selected from drop pill substrate, filler, effervescent (acid source and alkali source), correctives, disintegrating agent, binding agent and lubricant.
The preparation process of described drop pill is as follows: extract obtained and volatile oil and substrate suspendible or fusion, and through the system of dripping, ball is washed in cooling, and drying is selected ball, quality inspection, packing forms.The preparation process of described coated tablet is as follows: with above-mentioned extract obtained, add a certain amount of filler, disintegrating agent, binding agent, granulate, drying adds volatile oil, lubricant, tabletting, and sugar coating promptly gets coated tablet.The preparation process of described thin membrane coated tablet is as follows: with above-mentioned extract obtained, add a certain amount of filler, disintegrating agent, binding agent, granulate, drying adds volatile oil, lubricant, tabletting, and the bag film-coat promptly gets thin membrane coated tablet.The preparation process of described chewable tablet is as follows: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, granulate, drying adds volatile oil, lubricant, and tabletting promptly gets chewable tablet.The preparation process of described effervescent tablet is as follows: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, effervescent, granulate, drying adds volatile oil, lubricant, and tabletting promptly gets effervescent tablet.The preparation process of described dispersible tablet is as follows: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, disintegrating agent, granulate, drying adds volatile oil, lubricant, and tabletting promptly gets dispersible tablet.Described preparation of soft capsule step is as follows: the castor oil hydrogenated heating is dissolved in the medicinal soybean oil, adds extract, volatile oil mix homogeneously, be rolled into soft capsule.The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, granulation, drying adds volatile oil, promptly gets granule.
Described drop pill substrate be selected from but be not limited only to PEG-6000, PEG-4000, sodium stearate, glycerin gelatine, stearic acid arranged, one or more the mixture in the glyceryl monostearate, hexadecanol, octadecanol, insect wax, hydrogenated vegetable wet goods; Described filler is selected from but is not limited only to one or more mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, xylitol, the Semen sojae atricolor wet goods; Described correctives is selected from but one of is not limited only in Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture; Suitable lubricant is selected from but is not limited only to wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel; Acid source is selected from but is not limited only to citric acid (aqueous or anhydride) in the described effervescent, and alkali source is selected from but is not limited only to sodium bicarbonate.Suitable disintegrating agent is selected from but is not limited only to dried starch, carboxymethyl starch sodium, low substituted hydroxy-propyl methylcellulose, crospolyvinylpyrrolidone.Described binding agent is selected from but is not limited only to one or more mixture in starch slurry, hydroxypropyl cellulose, methylcellulose, gelatin, sucrose, the polyvinylpyrrolidone etc.
Following data declaration beneficial effect of the present invention by experiment:
24 of healthy male SD rats, body constitution amount (225 ± 25) g.
Reagent Chinese medicine DW dilutes drop pill to desired concn with purified water; Norepinephrine (NE); Acetylcholine (Ach); Krebs-Henseleit (K-H) liquid includes (mmol/L): NaCl 118.0, and KCl 4.7, KH2PO41.2, and MgSO4 1.2, and NaHCO3 25.0, CaCl21.25, glucose 10.0 (pH 7.4).
The preparation of thoracic aortic ring is with stable
Rat is hit unconsciously with blunt, and dislocation of cervical vertebra is put to death, and opens the thoracic cavity rapidly, gets its thoracic aorta, moves the people and fills 4 ℃, gaseous mixture [VO
2: VCO
2=95: 5], the culture dish of saturated K-H liquid.Carefully divest connective tissue around the blood vessel, the flushing vessel inner blood is cut into 2 sections of the vascular rings of long 3～4mm, and one section be experimental group, and another section is matched group; Test needs factually, in the endothelium-denuded experiment, 2 sections vascular rings rub blood vessel to destroy blood vessel endothelium gently with pincet, are assigned in the group the same; Vascular strip one end vertically is suspended in the vascular smooth muscle bath with the rustless steel hook, and the other end is connected in tension pick-up, and its rest tension is 2g, uses many physiology bio signal acquisition system record vascular ring tension variation.Body lotion is a K-H liquid, passes to gaseous mixture [VO in the bath
2: VCO
2=95: 5], after 37 ℃ of balance 1h, every 15min change liquid 1 time, with KCl 6 * 10-2mol/L repetitive stimulation 2 times, to bring out the maximum shrinkage amplitude of blood vessel.After treating that vascular ring is stable, with NE 10-6mol/L preshrinking arterial ring, waiting to shrink the stable people Ach 10-5mol/L check vascular endothelial function that adds, is that endothelium is complete with diastole amplitude＞80%, is that endothelium is removed with diastole amplitude＜20%, carries out next step experiment.Bringing out maximum shrinkage amplitude with 10-6mol/L NE is 100%, brings out the variation of the ratio reflection antiotasis between the maximum shrinkage amplitude with antiotasis amplitude of variation behind the adding diastole medicine and NE.
DW is to the influence of isolated aortic ring
The vascular ring of the pre-shrunk aortic annulus group of NE endothelium complete (n=6) or endothelium-denuded (n=6) adds people NE (10-6mol/L), treat vascular ring shrink reach stablize 10min after, accumulation adding DW (3.1～30.5g/L).With the variation of the ratio reflection antiotasis between the maximum shrinkage amplitude that adds the vascular ring that antiotasis amplitude behind the DW and NE bring out, make the vasodilation curve.Corresponding matched group (n=6) replaces the DW accumulation to add with K-H liquid equal-volume.
The pre-shrunk aortic annulus group of KCl
The vascular ring of endothelium complete (n=6) or endothelium-denuded (n=6), add KCl (6 * 10-2mol/L), treat vascular ring shrink reach stablize 10min after, accumulation adding DW (3.1～30.5g/L).The variation of the ratio reflection antiotasis between the maximum shrinkage amplitude of the vascular ring that brings out with antiotasis amplitude and the KCl that adds behind the DW, making vasodilation curve.Corresponding matched group (n=6) replaces the DW accumulation to add with K-H liquid equal-volume.
The statistical procedures experimental result is represented with x ± s. handles with the SPSS13.0 statistical software.Adopt the t check, ANOVA and New-man-Keuls method are carried out significance test, and P＜0.05 is for difference has statistical significance, meaning that P＜0.01 is that there was a significant difference.
The result
The pre-shrunk aortic annulus group of NE
To the complete vascular ring of NE preshrinking endothelium, DW produces the diastole effect but not remarkable (' vs matched group of effect at 5.8g/L, P＞0.05).Produce diastole effect (matched group P＜0.01) at 10.5～30.5g/L, dose dependent diastole effect is arranged; DW is to NE preshrinking endothelium-denuded vascular ring, produces the diastole effect but effect not significantly (vs matched group, P＞0.05) produces diastole effect (vs matched group, P＜0.05) at 20.8g/L at 10.5g/L; 10.5～30.5g/L NE is significantly higher than endothelium-denuded group (P＜0.01) to endothelium close set diastole degree under identical DW concentration, shows that DW has certain endothelium-dependent relaxation to the pre-shrunk vascular ring diastole of NE effect.
The pre-shrunk aortic annulus group of KCl
To the complete aortic annulus of KCl preshrinking endothelium, DW is in that (10.5～30.5g/L) are producing diastole effect (vs matched group, P＜0.01).Dose dependent diastole effect is arranged; KCl preshrinking endothelium-denuded aortic annulus .DW is produced diastole effect (vs matched group, P＜0.01) at 10.5～30.5g/L, dose dependent diastole effect is arranged; (10.5～30.5g/L) to KCl preshrinking endothelium close set similar with endothelium-denuded group diastole degree (P＞0.05) under identical DW concentration.
The specific embodiment
Come preparation of the present invention done further specifying by following example, but be not limited in following example.
Embodiment 1:
Method for making: Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae adds 95% ethanol water reflux, extract,, filters, and filtrate is condensed into extractum, and drying is pulverized.The Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, and drying is pulverized.Polyethylene glycol 6000 is heated to 90～100 ℃, treats to add water extraction extract powder, Radix Rauvolfiae extract powder, Radix Notoginseng powder mix homogeneously after whole fusions, keep 85～90 ℃, with the speed of 100 of per minutes, splash into and become ball in the simethicone, promptly.
Embodiment 2:
Method for making: Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae, the Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, and drying is pulverized.Polyethylene glycol 6000 is heated to 90～100 ℃, treats to add water extraction extract powder, Radix Notoginseng powder mix homogeneously after whole fusions, keeps 85～90 ℃, with the speed of 100 of per minutes, splashes in the liquid paraffin with thermograde and becomes ball, promptly.
Embodiment 3:
Method for making: Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae, the Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae add 20-95% ethanol water reflux, extract,, filter, and filtrate is condensed into extractum, and drying is pulverized.Polyethylene glycol 6000 is heated to 90～100 ℃, treats to add alcohol extraction extract powder, Radix Notoginseng powder mix homogeneously after whole fusions, keeps 85～90 ℃, with the speed of 100 of per minutes, splashes in the liquid paraffin with thermograde and becomes ball, promptly.
Embodiment 4: film coated tablet
Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae adds 20-95% ethanol water reflux, extract,, filters, and filtrate is condensed into extractum, and drying is pulverized.The Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, drying, pulverize,, granulate drying with Radix Notoginseng powder, dextrin, low substituted hydroxy-propyl methylcellulose mixing, add magnesium stearate, be pressed into 500, the bag film-coat, promptly.
Embodiment 5: effervescent tablet
Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae adds 20-95% ethanol water reflux, extract,, filters, and filtrate is condensed into extractum, and drying is pulverized.The Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, drying is pulverized, with Radix Notoginseng powder, dextrin, magnesium stearate, sodium bicarbonate, tartaric acid, orange flavor, PEG6000 mixing, airtight 2 hours, be pressed into 500, promptly.
Embodiment 6: coated tablet
Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae, the Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, drying, pulverize,, granulate drying with Radix Notoginseng powder, dextrin, low substituted hydroxy-propyl methylcellulose mixing, add magnesium stearate, be pressed into 500, sugar coating, promptly.
Embodiment 7: chewable tablet
Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae, the Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, and drying is pulverized, and with Radix Notoginseng powder, dextrin, sucrose mixing, granulate, and drying adds magnesium stearate, is pressed into 500, promptly.
Embodiment 8: dispersible tablet
Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae, the Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, be condensed into extractum, drying is pulverized, with Radix Notoginseng powder, cross-linking sodium carboxymethyl cellulose, microcrystalline Cellulose, low substituted hydroxy-propyl methylcellulose mixing, granulate, drying adds magnesium stearate, is pressed into 500, the bag film-coat, promptly.
Embodiment 9: soft capsule
Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae, the Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, and drying is pulverized.The castor oil hydrogenated heating is dissolved in the medicinal soybean oil, adds extract, Radix Notoginseng powder mix homogeneously, be rolled into ball.
Embodiment 10: granule
Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae, the Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, and drying is pulverized, with Radix Notoginseng powder, dextrin, sucrose mixing, granulate, and drying, promptly.
Claims (8)
1. the present invention is hypertensive Chinese medicine preparation of a kind of treatment and preparation method thereof, it is characterized in that, it is to be active component by Radix Rauvolfiae, the Cortex Eucommiae, Radix Notoginseng, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae, the preparation made from mixing acceptable accessories.
2. a kind of Radix Rauvolfiae as claimed in claim 1, the Cortex Eucommiae, Radix Notoginseng, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae are formulations of active ingredients, it is characterized in that the consumption of described Radix Rauvolfiae, the Cortex Eucommiae, Radix Notoginseng, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae is a per unit dosage
Radix Rauvolfiae 100-1000 part Cortex Eucommiae 50-500 part Radix Notoginseng 10-100 part
Cacumen Platycladi 50-500 part Folium Artemisiae Argyi 200-1000 part Folium Nelumbinis 50-500 part
Ramulus Uncariae Cum Uncis 80-800 part Radix Rehmanniae 10-100 part.
3. the consumption of Chinese medicine ingredients as claimed in claim 2 is characterized in that, for per unit dosage is preferably
36 parts of 260 portions of Radix Notoginseng of 910 parts of Cortexs Eucommiae of Radix Rauvolfiae
100 parts on 650 parts of Folium Nelumbinis of 260 portions of Folium Artemisiae Argyis of Cacumen Platycladi
26 parts of 180 portions of Radix Rehmanniae of Ramulus Uncariae Cum Uncis.
4. preparation as claimed in claim 1 is characterized in that, the method for being used as medicine of Radix Rauvolfiae, the Cortex Eucommiae, Radix Notoginseng, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae is:
Technology A: Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae, the Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, and drying is pulverized;
Technology B: Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae, the Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae add 20-95% ethanol water reflux, extract,, filter, and filtrate is condensed into extractum, and drying is pulverized;
Technology C: Radix Notoginseng powder is broken into fine powder, sieves; Radix Rauvolfiae adds 20-95% ethanol water reflux, extract,, filters, and filtrate is condensed into extractum, and drying is pulverized.The Cortex Eucommiae, Cacumen Platycladi, Folium Artemisiae Argyi, Folium Nelumbinis, Ramulus Uncariae Cum Uncis, Radix Rehmanniae decoct with water, and collecting decoction filters, and is condensed into extractum, and drying is pulverized.
5. preparation as claimed in claim 1 is characterized in that described preparation comprises drop pill, coated tablet, thin membrane coated tablet, chewable tablet, effervescent tablet, dispersible tablet, soft capsule, granule.
6. preparation as claimed in claim 1 is characterized in that, described acceptable accessories is selected from drop pill substrate, filler, effervescent (acid source and alkali source), correctives, disintegrating agent, binding agent and lubricant.
7. the Chinese medicine preparation of claim 5, it is characterized in that: the preparation process of described drop pill is as follows: extract obtained and volatile oil and substrate suspendible or fusion, through the system of dripping, ball is washed in cooling, and drying is selected ball, quality inspection, packing forms;
The preparation process of described coated tablet is as follows: with above-mentioned extract obtained, add a certain amount of filler, disintegrating agent, binding agent, granulate, drying adds volatile oil, lubricant, tabletting, and sugar coating promptly gets coated tablet;
The preparation process of described thin membrane coated tablet is as follows: with above-mentioned extract obtained, add a certain amount of filler, disintegrating agent, binding agent, granulate, drying adds volatile oil, lubricant, tabletting, and the bag film-coat promptly gets thin membrane coated tablet;
The preparation process of described chewable tablet is as follows: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, granulate, drying adds volatile oil, lubricant, and tabletting promptly gets chewable tablet;
The preparation process of described effervescent tablet is as follows: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, effervescent, granulate, drying adds volatile oil, lubricant, and tabletting promptly gets effervescent tablet;
The preparation process of described dispersible tablet is as follows: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, disintegrating agent, granulate, drying adds volatile oil, lubricant, and tabletting promptly gets dispersible tablet;
Described preparation of soft capsule step is as follows: the castor oil hydrogenated heating is dissolved in the medicinal soybean oil, adds extract, volatile oil mix homogeneously, be rolled into soft capsule;
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, binding agent, correctives, granulation, drying adds volatile oil, promptly gets granule.
8. adjuvant as claimed in claim 6, described drop pill substrate be selected from but be not limited only to PEG-6000, PEG-4000, sodium stearate, glycerin gelatine, stearic acid arranged, one or more the mixture in the glyceryl monostearate, hexadecanol, octadecanol, insect wax, hydrogenated vegetable wet goods; Described filler is selected from but is not limited only to one or more mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, xylitol, the Semen sojae atricolor wet goods; Described correctives is selected from but one of is not limited only in Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture; Suitable lubricant is selected from but is not limited only to wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel; Acid source is selected from but is not limited only to citric acid (aqueous or anhydride) in the described effervescent, and alkali source is selected from but is not limited only to sodium bicarbonate.Suitable disintegrating agent is selected from but is not limited only to dried starch, carboxymethyl starch sodium, low substituted hydroxy-propyl methylcellulose, crospolyvinylpyrrolidone.Described binding agent is selected from but is not limited only to one or more mixture in starch slurry, hydroxypropyl cellulose, methylcellulose, gelatin, sucrose, the polyvinylpyrrolidone etc.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102179027A CN102283939A (en) | 2011-08-01 | 2011-08-01 | Chinese medicinal preparation for treating hypertension and preparation method thereof |
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|---|---|---|---|
| CN2011102179027A CN102283939A (en) | 2011-08-01 | 2011-08-01 | Chinese medicinal preparation for treating hypertension and preparation method thereof |
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| CN102283939A true CN102283939A (en) | 2011-12-21 |
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| CN2011102179027A Pending CN102283939A (en) | 2011-08-01 | 2011-08-01 | Chinese medicinal preparation for treating hypertension and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103651975A (en) * | 2013-11-22 | 2014-03-26 | 安徽大平油脂有限公司 | Health-care oil capable of lowering blood pressure and containing rauvolfia verticillate |
| CN105168756A (en) * | 2015-10-29 | 2015-12-23 | 惠州市康祥生物技术开发有限公司 | Chewable tablets containing Chinese mugwort leaf extract |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1561862A (en) * | 2004-04-20 | 2005-01-12 | 韩继志 | Health pressure reducing drink |
| CN1565600A (en) * | 2003-06-30 | 2005-01-19 | 北京中孚天和医药科技有限公司 | Chinese medicinal composition for treating hypertension |
| CN1589833A (en) * | 2003-09-03 | 2005-03-09 | 熊安富 | Medicine for treating high blood pressure and its preparation method |
| CN1899427A (en) * | 2006-07-26 | 2007-01-24 | 吕宝俊 | Chinese medicine composition with blood pressure reducing and tranquilizing function and its preparing method |
-
2011
- 2011-08-01 CN CN2011102179027A patent/CN102283939A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565600A (en) * | 2003-06-30 | 2005-01-19 | 北京中孚天和医药科技有限公司 | Chinese medicinal composition for treating hypertension |
| CN1589833A (en) * | 2003-09-03 | 2005-03-09 | 熊安富 | Medicine for treating high blood pressure and its preparation method |
| CN1561862A (en) * | 2004-04-20 | 2005-01-12 | 韩继志 | Health pressure reducing drink |
| CN1899427A (en) * | 2006-07-26 | 2007-01-24 | 吕宝俊 | Chinese medicine composition with blood pressure reducing and tranquilizing function and its preparing method |
Non-Patent Citations (1)
| Title |
|---|
| 智慧生活编委会: "《科学食疗降"三高"全图典》", 31 January 2011, 中国纺织出版社, article "田七", pages: 98 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103651975A (en) * | 2013-11-22 | 2014-03-26 | 安徽大平油脂有限公司 | Health-care oil capable of lowering blood pressure and containing rauvolfia verticillate |
| CN105168756A (en) * | 2015-10-29 | 2015-12-23 | 惠州市康祥生物技术开发有限公司 | Chewable tablets containing Chinese mugwort leaf extract |
| CN105168756B (en) * | 2015-10-29 | 2019-02-22 | 惠州市康祥生物技术开发有限公司 | A kind of chewable tablets containing Folium Artemisiae Argyi extract |
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Application publication date: 20111221 |