CN102282176A - 由母体全血进行非侵入性胎儿RhD基因型分型 - Google Patents

由母体全血进行非侵入性胎儿RhD基因型分型 Download PDF

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Publication number
CN102282176A
CN102282176A CN2009801328735A CN200980132873A CN102282176A CN 102282176 A CN102282176 A CN 102282176A CN 2009801328735 A CN2009801328735 A CN 2009801328735A CN 200980132873 A CN200980132873 A CN 200980132873A CN 102282176 A CN102282176 A CN 102282176A
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Prior art keywords
seq
exon
rhd
primer
exons
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CN2009801328735A
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English (en)
Chinese (zh)
Inventor
W-H·范
R·蒂姆
K·科斯科
R·巴特
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Novartis Vaccines and Diagnostics Inc
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Novartis Vaccines and Diagnostics Inc
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Publication of CN102282176A publication Critical patent/CN102282176A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2009801328735A 2008-07-18 2009-07-17 由母体全血进行非侵入性胎儿RhD基因型分型 Pending CN102282176A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8216908P 2008-07-18 2008-07-18
US61/082,169 2008-07-18
PCT/US2009/051061 WO2010009440A2 (en) 2008-07-18 2009-07-17 Non-invasive fetal rhd genotyping from maternal whole blood

Publications (1)

Publication Number Publication Date
CN102282176A true CN102282176A (zh) 2011-12-14

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Family Applications (1)

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CN2009801328735A Pending CN102282176A (zh) 2008-07-18 2009-07-17 由母体全血进行非侵入性胎儿RhD基因型分型

Country Status (8)

Country Link
US (1) US20110262916A1 (enExample)
EP (1) EP2324063A4 (enExample)
JP (1) JP2011528554A (enExample)
CN (1) CN102282176A (enExample)
BR (1) BRPI0916617A2 (enExample)
CA (1) CA2731086A1 (enExample)
MX (1) MX2011000566A (enExample)
WO (1) WO2010009440A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107075582A (zh) * 2014-09-29 2017-08-18 富士胶片株式会社 胎儿的染色体非整倍性的非侵入性判别方法及判别系统
CN107254543A (zh) * 2017-08-09 2017-10-17 深圳市血液中心 用于检测RhD mRNA剪接体的PCR引物组合、试剂盒及实时荧光定量检测方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2576780C2 (ru) * 2014-04-25 2016-03-10 Общество с ограниченной ответственностью "Ген-технология" Набор с лиофилизированными праймерами для пцр-диагностики гена резус-фактора плода по крови беременной женщины
WO2018162516A1 (en) 2017-03-08 2018-09-13 Etablissement Francais Du Sang Rhd gene allele associated with a weak d phenotype and its uses
CN115927646B (zh) * 2022-06-07 2024-04-02 银丰基因科技有限公司 一种检测人类家系及孕妇胎儿游离DNA的Rh血型基因型的引物探针组、试剂盒及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1200767A (zh) * 1995-11-06 1998-12-02 纽约血液中心有限公司 用于确定Rh血型基因型的诊断方法与试剂盒
CN1413219A (zh) * 1999-11-02 2003-04-23 巴登-符腾堡-黑森Drk血库有限公司 Rhd阴性基因座的分子结构
US20080071076A1 (en) * 2003-10-16 2008-03-20 Sequenom, Inc. Non-invasive detection of fetal genetic traits

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE69723297D1 (de) * 1996-12-11 2003-08-07 Amersham Plc Little Chalfont Selektives verfahren zur lyse von zellen
EP1229128A1 (en) * 2001-01-31 2002-08-07 Boehringer Mannheim Gmbh New method for genotype determination
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20110143340A1 (en) * 2007-11-01 2011-06-16 Biocept, Inc. Non-invasive isolation of fetal nucleic acid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1200767A (zh) * 1995-11-06 1998-12-02 纽约血液中心有限公司 用于确定Rh血型基因型的诊断方法与试剂盒
CN1413219A (zh) * 1999-11-02 2003-04-23 巴登-符腾堡-黑森Drk血库有限公司 Rhd阴性基因座的分子结构
US20080071076A1 (en) * 2003-10-16 2008-03-20 Sequenom, Inc. Non-invasive detection of fetal genetic traits

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107075582A (zh) * 2014-09-29 2017-08-18 富士胶片株式会社 胎儿的染色体非整倍性的非侵入性判别方法及判别系统
CN107254543A (zh) * 2017-08-09 2017-10-17 深圳市血液中心 用于检测RhD mRNA剪接体的PCR引物组合、试剂盒及实时荧光定量检测方法
CN107254543B (zh) * 2017-08-09 2020-11-10 深圳市血液中心 用于检测RhD mRNA剪接体的PCR引物组合、试剂盒及实时荧光定量检测方法

Also Published As

Publication number Publication date
EP2324063A2 (en) 2011-05-25
BRPI0916617A2 (pt) 2019-09-24
US20110262916A1 (en) 2011-10-27
WO2010009440A3 (en) 2010-05-20
MX2011000566A (es) 2011-03-15
CA2731086A1 (en) 2010-01-21
JP2011528554A (ja) 2011-11-24
WO2010009440A2 (en) 2010-01-21
EP2324063A4 (en) 2012-01-18

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Application publication date: 20111214