CN100558908C - 在母体样品中鉴定胎儿dna的诊断方法 - Google Patents
在母体样品中鉴定胎儿dna的诊断方法 Download PDFInfo
- Publication number
- CN100558908C CN100558908C CNB018153542A CN01815354A CN100558908C CN 100558908 C CN100558908 C CN 100558908C CN B018153542 A CNB018153542 A CN B018153542A CN 01815354 A CN01815354 A CN 01815354A CN 100558908 C CN100558908 C CN 100558908C
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- CN
- China
- Prior art keywords
- dna
- sample
- foetal
- telomere
- digestion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Abstract
Description
Claims (20)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0016742.9A GB0016742D0 (en) | 2000-07-10 | 2000-07-10 | Diagnostic method |
GB0016742.9 | 2000-07-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1452665A CN1452665A (zh) | 2003-10-29 |
CN100558908C true CN100558908C (zh) | 2009-11-11 |
Family
ID=9895241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018153542A Expired - Fee Related CN100558908C (zh) | 2000-07-10 | 2001-07-09 | 在母体样品中鉴定胎儿dna的诊断方法 |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1301630B1 (zh) |
JP (1) | JP2004502466A (zh) |
CN (1) | CN100558908C (zh) |
AT (1) | ATE351923T1 (zh) |
AU (2) | AU6932301A (zh) |
CA (1) | CA2414986A1 (zh) |
DE (1) | DE60126090D1 (zh) |
GB (1) | GB0016742D0 (zh) |
HK (1) | HK1060156A1 (zh) |
WO (1) | WO2002004672A2 (zh) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006523082A (ja) | 2002-03-01 | 2006-10-12 | ラブジェン, インコーポレイテッド | ゲノム内の変異の迅速分析 |
US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
GB0214842D0 (en) * | 2002-06-27 | 2002-08-07 | Simeg Ltd | Diagnostic method |
CA2517017A1 (en) * | 2003-02-28 | 2004-09-16 | Ravgen, Inc. | Methods for detection of genetic disorders |
US8394582B2 (en) * | 2003-03-05 | 2013-03-12 | Genetic Technologies, Inc | Identification of fetal DNA and fetal cell markers in maternal plasma or serum |
US20100216153A1 (en) * | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
AU2006224971B2 (en) * | 2005-03-18 | 2009-07-02 | Boston University | A method for the detection of chromosomal aneuploidies |
ATE557105T1 (de) | 2005-06-23 | 2012-05-15 | Keygene Nv | Strategien für eine hohe durchsatzidentifikation und erkennung von polymorphismen |
US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US10083273B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US10316364B2 (en) | 2005-09-29 | 2019-06-11 | Keygene N.V. | Method for identifying the source of an amplicon |
WO2007037678A2 (en) | 2005-09-29 | 2007-04-05 | Keygene N.V. | High throughput screening of mutagenized populations |
JP6121642B2 (ja) * | 2005-11-26 | 2017-04-26 | ナテラ, インコーポレイテッド | 予測を行うための、遺伝子データを清浄化し、そして、そのデータを使用するためのシステムおよび方法 |
CA2645045A1 (en) * | 2006-03-06 | 2007-09-13 | The Trustees Of Columbia University In The City Of New York | Specific amplification of fetal dna sequences from a mixed, fetal-maternal source |
EP3406736B1 (en) * | 2006-06-14 | 2022-09-07 | Verinata Health, Inc. | Methods for the diagnosis of fetal abnormalities |
EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
US20100112590A1 (en) | 2007-07-23 | 2010-05-06 | The Chinese University Of Hong Kong | Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment |
EP3067807A1 (en) * | 2007-07-23 | 2016-09-14 | The Chinese University of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
EP2245195B1 (en) * | 2008-01-30 | 2012-06-20 | Novartis AG | Two stage enrichment of cell-free fetal dna in maternal plasma |
ES2620431T3 (es) | 2008-08-04 | 2017-06-28 | Natera, Inc. | Métodos para la determinación de alelos y de ploidía |
US10017812B2 (en) | 2010-05-18 | 2018-07-10 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US20120185176A1 (en) | 2009-09-30 | 2012-07-19 | Natera, Inc. | Methods for Non-Invasive Prenatal Ploidy Calling |
EA034241B1 (ru) * | 2009-11-06 | 2020-01-21 | Те Чайниз Юниверсити Ов Гонконг | Способ пренатальной диагностики дисбаланса последовательности |
US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
CA2798758C (en) | 2010-05-18 | 2019-05-07 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
WO2012088456A2 (en) | 2010-12-22 | 2012-06-28 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
US9499870B2 (en) | 2013-09-27 | 2016-11-22 | Natera, Inc. | Cell free DNA diagnostic testing standards |
RU2717641C2 (ru) | 2014-04-21 | 2020-03-24 | Натера, Инк. | Обнаружение мутаций и плоидности в хромосомных сегментах |
KR20220127359A (ko) | 2014-07-25 | 2022-09-19 | 유니버시티 오브 워싱톤 | 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법 |
US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
AU2018225348A1 (en) | 2017-02-21 | 2019-07-18 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
WO2019136427A1 (en) * | 2018-01-08 | 2019-07-11 | Cradle Genomics, Inc. | Methods and kits for nucleic acid isolation |
US11525159B2 (en) | 2018-07-03 | 2022-12-13 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU647741B2 (en) * | 1989-12-01 | 1994-03-31 | Regents Of The University Of California, The | Methods and compositions for chromosome-specific staining |
JPH07509136A (ja) * | 1992-07-17 | 1995-10-12 | バイシス,インク. | インサイチュ(in situ)・ハイブリダイゼーションのための母体血液中の胎児細胞の富化と同定 |
GB9704444D0 (en) * | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
GB0009784D0 (en) * | 2000-04-20 | 2000-06-07 | Simeg Limited | Methods for clinical diagnosis |
-
2000
- 2000-07-10 GB GBGB0016742.9A patent/GB0016742D0/en not_active Ceased
-
2001
- 2001-07-09 JP JP2002509525A patent/JP2004502466A/ja active Pending
- 2001-07-09 CA CA002414986A patent/CA2414986A1/en not_active Abandoned
- 2001-07-09 AU AU6932301A patent/AU6932301A/xx active Pending
- 2001-07-09 DE DE60126090T patent/DE60126090D1/de not_active Expired - Lifetime
- 2001-07-09 EP EP01947676A patent/EP1301630B1/en not_active Expired - Lifetime
- 2001-07-09 CN CNB018153542A patent/CN100558908C/zh not_active Expired - Fee Related
- 2001-07-09 WO PCT/GB2001/003092 patent/WO2002004672A2/en active IP Right Grant
- 2001-07-09 AT AT01947676T patent/ATE351923T1/de not_active IP Right Cessation
- 2001-07-09 AU AU2001269323A patent/AU2001269323B2/en not_active Ceased
-
2004
- 2004-04-23 HK HK04102885.0A patent/HK1060156A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2414986A1 (en) | 2002-01-17 |
ATE351923T1 (de) | 2007-02-15 |
WO2002004672A2 (en) | 2002-01-17 |
DE60126090D1 (de) | 2007-03-08 |
WO2002004672A3 (en) | 2002-09-06 |
JP2004502466A (ja) | 2004-01-29 |
EP1301630B1 (en) | 2007-01-17 |
GB0016742D0 (en) | 2000-08-30 |
CN1452665A (zh) | 2003-10-29 |
HK1060156A1 (en) | 2004-07-30 |
EP1301630A2 (en) | 2003-04-16 |
AU2001269323B2 (en) | 2006-08-03 |
AU6932301A (en) | 2002-01-21 |
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