CN102274291A - Chinese medicinal preparation for treating stroke and production method thereof - Google Patents
Chinese medicinal preparation for treating stroke and production method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal preparation for treating stroke. The Chinese medicinal preparation is characterized by comprising the following active ingredients: meadowrue corydalis root and musk. The Chinese medicinal preparation is an injection preparation or oral preparation of pharmaceutics, is mild in nature, high in pertinence and obvious in an effect, has the effects of promoting blood circulation, eliminating stasis, inducing diuresis and regulating the balance of functions of internal organs of human bodies, and by taking the Chinese medicinal preparation within 160 hours after stroke, patients can be recovered quickly within 24 hours and are restored to normal conditions after 5 to 7 days without sequelae.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of Chinese medicine preparation and production method thereof for the treatment of apoplexy.
Background technology
At present along with living standard raising and aged tendency of population, cardiovascular, particularly apoplexy (or claiming the brain collection) disease incidence is in rising trend, become one of dangerous sick kind of serious threat human health, apoplexy is a kind of common cardiovascular and cerebrovascular disease, and apoplexy is with sudden faint, unconsciousness, thirsty, speech is not smoothgoing, hemiplegia is primary symptom a kind of disease.Apoplexy comprises cerebral infarction (transient ischemic attack, Atherosclerosis and thrombosis and cerebral infarction, lacunar infarction, cerebral embolism), hemorrhagic apoplexy (cerebral hemorrhage, subarachnoid hemorrhage), hypertensive encephalopathy and vascular dementia four big classes.Clinical manifestation with suddenly pounce on dusk, syncope or take place suddenly that facial hemiparalysis, hemiplegia, stiff tongue speech are not smoothgoing, dysnoesia is a principal character.
According to relevant bibliographical information, the investigation of China 1998-2008 large-scale crowd shows that the apoplexy prevalence is 7,19/,100,000～745.6/10 ten thousand, and mortality rate is 1,16/,100,000～141.8/10 ten thousand, male's sickness rate is higher than the women, (man: women ratio is 1.3: 1～1.7: 1).Its increase with the age all was obvious increase trend in 45 years old later on, the most obvious more than 75 years old person's sickness rate be 5～8 times of 45～54 years old group, 50%～70% patient has left over handicaps such as paralysis, aphasia among the survivor, brings heavy burden for society and family.Along with improving constantly of China's population average life, old people's shared ratio in total population constantly increases, and this disease will be the principal disease that threatens human life's health.In recent years, existing lot of documents has been reported the easy trouble factor of thrombotic each side, about the research of cerebral thrombosis (apoplexy) aspect has become the focus of clinical and basic research, therefore, seek evident in efficacy, safe and reliable medicine is the problem that medical worker studies for a long period of time always.
Western medical treatment cerebral thrombosis or cerebral hemorrhage are to treat in time as early as possible at present.The Therapeutic Principle of acute stage be improve cerebral circulation, prevent and treat cerebral edema, the treatment complication.General present doctor trained in Western medicine is with following several therapeutic schemes: 1. anticoagulant: branch injection and oral formulations are arranged again, the injection dosage form as heparin and low molecular weight heparin, peroral dosage form as warfarin.2. thrombolytic agent:, have the selectivity of height for the fibrin of thrombosis, and further plasmin is taken off as streptokinase, urokinase, alteplase.3. antiplatelet coagulates agent: thrombosis is to suffer damage when tunica intima, platelet can adhere to collagen and other internal film tissue that comes out, and behind thrombocyte adhesiveness, can discharge the two Lin acid (ADP) of adenine, can impel platelet aggregation, be transformed into nonvolatil platelet fibrin sludged blood gradually.At present a lot of medicines all have antiplatelet activity as aspirin, dipyridamole, ticlopidine, clopidogrel or the like.4. fall the cerebral medicine: the blood vessel blockage after the apoplexy causes that cerebral raises or cerebral edema (causing cerebral to increase), and patient is remained unconscious, and at this moment medical personnel can give the injection that falls cerebral usually.As: glycerol, mannitol.5. Altace Ramipril: apoplexy is easy to cause hypertension, usually there is not hypertension, just blood pressure all may be very high during apoplexy, have plenty of hypertension and get up just to take place cerebral hemorrhage, therefore the doctor also often gives patient's Altace Ramipril, and the vasodilation that also has report is nicotinic acid or papaverin hydrochloride, glucose intravenous injection; The cranium pressing is fallen: morbidity just 3 days, 250 milliliters quick quiet in 20% mannitol; Anti-platelet aggregation agent: persantin 50mg merges aspirin 600mg, and is oral.The oral rich Soviet Union of the also employing that has, MENGNUO, nifedipine controlled release tablet joyfully; Yan acid, bendazol, Yan acid mesoinositol etc. can be made the tremulous pulse anastomosis if necessary.But, though Western medicine has effect faster to treatment hyperlipidemia and cholesterol, a lot of side effect are arranged, what have becomes safety issue the most troubling and concern.
The Chinese traditional treatment apoplexy mainly comprises: activating blood circulation to dissipate blood stasis treatment and the treatment of causing resuscitation with aromatic drugs door, for example Radix Salviae Miltiorrhizae injection, FUFANG DANSHEN PIAN, the spirit of promoting blood circulation, Rhizoma Gastrodiae Pilulae, day glad safe XUESHUANXINMAINING sheet and NAOLUOTONG JIAONANG etc., middle medical drugs mainly is: the Chinese medicine drug for invigorating blood circulation and eliminating stasis has the whole blood viscosity of reduction, plasma viscosity, Fibrinogen and erythrocyte and hematoblastic aggregation, expansion of cerebral vascular, coronary artery and peripheral vessels, reduce capillary permeability, effects such as microcirculation improvement.The employing therapy of combining Chinese and Western medicine that has, vasodilator with doctor trained in Western medicine, perhaps to brain, the heart and peripheral vessels particularly vertebral basilar system and internal carotid artery system the Western medicine and the Chinese medicine activating blood and removing stasis drug combined treatment of tangible dilating effect are arranged, curative effect is more remarkable.
The bibliographical information of relevant treatment apoplexy is very many, and below we also list part as background technology reference of the present invention:
1, Chinese patent, application number: CN93108859.3, publication number CN1085442, the medicine of a kind of prevention, treatment apoplexy, applicant: Li welcome guest, veteran cadre clinic, Nan Liang town, Yicheng County, Shanxi Province, summary: the medicine of prevention, treatment apoplexy is made up of Nidus Vespae, Radix Et Rhizoma Rhei, Fructus Trichosanthis, RHIZONA GASTRODIAE, XUEDANSHEN, Radix Gentianae, Rhizoma Acori Graminei, LUMBRICUS, Stigma Croci, Arisaema Cum Bile, Rhizoma Et Radix Notopterygii, worm, Hirudo, Moschus, Borneolum Syntheticum and radix smilacis sieboldi.This medicine can be treated the rescue of fulminant apoplexy, premonitory apoplexy forms patient and apoplexy patient, and its cure rate reaches more than 85%, and effective percentage reaches 99.5%.
2; Chinese patent; application number: CN96115480.2; publication number CN1171248; the Chinese medicinal capsule that is used for the treatment of apoplexy; applicant: Zhao Guangjun; No. 3 out-patient departments of the Red Cross in Tai'an road, Meihekou City Peace Street, Jilin Province; summary: a kind of Chinese medicinal capsule that is used for the treatment of apoplexy; by Realgar; Rhizoma Chuanxiong; Radix Notoginseng; the Radix Astragali; Agkistrodon; Radix Paeoniae Rubra; Radix Angelicae Sinensis; Pheretima; Flos Carthami; Bombyx Batryticatus; Olibanum; Myrrha; Scorpio; Ganoderma; Herba Cynomorii; Herba Cistanches; Radix Polygoni Multiflori Preparata; Colla Corii Asini; the Radix Rehmanniae; Os Draconis; Concha Ostreae; Rhizoma Gastrodiae; Caulis Akebiae; Fructus Chaenomelis Herba Siegesbeckiae; Radix Achyranthis Bidentatae; Ramulus Cinnamomi; Folium Ginkgo; Flos Lonicerae; Flos Chrysanthemi; Radix Et Rhizoma Rhei; the artificial Moschus; the artificial Calculus Bovis; the Radix Aucklandiae and Cornu Bubali in the prescription ratio through being prepared from; it is to institute's indication instant effect; short treating period; the lasting healing of curative effect is difficult for recurrence, and the effective percentage height is the choice drug of treatment apoplexy.
3, Chinese patent, CN95104639.X, publication number CN1112441, a kind of Chinese medicine (ball) and method for making thereof for the treatment of apoplexy, applicant: Yang Ji's goods, Yang Liqing village, Ji Yi township, Qingxu County, Shanxi Province, summary: a kind of Chinese medicine (ball) for the treatment of apoplexy, adopt Chinese medicine assembly such as Moschus, Cinnabaris, Realgar, Galla Chinensis, the Radix Euphorbiae Pekinensis, Pseudobulbus Cremastrae Seu Pleiones to form.Its method for making is that each flavor Chinese medicine is cleaned roguing, is ground into fine powder, mixing, and reuse Oryza glutinosa extract transfers to soft or hard and suits, and smashes to smoothness degree of being with pestle, makes pill again.Product of the present invention is mainly used in treatment apoplexy, hemiplegia.Taking convenience, determined curative effect.
4, Chinese patent, application number: CN00124528.7, publication number CN1293049, Shexingkeyu capsule of treatment cardiovascular and cerebrovascular disease and preparation method thereof, applicant: Ma Jilong, No. 4, the East St in the county town, Fenxi, Shanxi Province, the summary: a kind of Shexingkeyu capsule for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof, capsule Chinese medicine include efflorescence Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Fructus Crataegi, Rhizoma Arisaematis, Radix Notoginseng, Borneolum Syntheticum, Hirudo, Moschus.With treatment apoplexy such as blood fat reducing, blood pressure lowering, blood circulation promoting and blood stasis dispelling, hemiplegia, cerebral thrombosis, the excessive sequela of brain, coronary heart disease, patient with angina pectoris, effective percentage reaches 95.2%.For some cerebral thrombosiss, the heavier person of the myocardial infarction state of an illness, but also adapted decoction Cornu Saigae Tataricae, Radix Polygalae, give birth to the Semen Cassiae Ramulus Uncariae Cum Uncis, perhaps Radix Ginseng, Rhizoma Pinelliae Preparata, Poria increase the capsular pharmacology of Moschus moschiferous star, effect.
5, Chinese patent, application number: CN02100146.4 publication number CN1364617, a kind of traditional Chinese medical science medicine applicant who treats cardiovascular and cerebrovascular disease: Sha Yingfu, 1 in Building 7, No. 22 3 unit, Nangang District Black Hills, Harbin City, Heilongjiang Province city street, summary: a kind of traditional Chinese medical science medicine for the treatment of cardiovascular and cerebrovascular disease, by Radix Ginseng, Radix Aconiti Lateralis Preparata, Poria, process Radix Glycyrrhizae, Herba Plantaginis in, Stigma Croci, XUERONG PIAN, pearl sand, Moschus, Margarita powder, Carapax Eretmochelydis, Cornu Saigae Tataricae, Rhizoma Zingiberis, Pheretima, Hirudo drying crushing screening is mixed and made into, to the various cerebral thrombosiss that cause by cardiovascular and cerebrovascular disease, myocarditis, angina pectoris, hemiplegia, cerebral arteriosclerosis, early-heart-beating, brain atrophy, hypertension, diseases such as hyperlipidemia have fabulous curative effect, simultaneously to prevention of cerebral hemorrhage, apoplexy, the strong middle-aged and elderly people of heart senilism is healthy significant effect.
6, Chinese patent, application number: CN03110967.5, the Moschus thrombus-resisting capsules, publication number CN1430974, kingdom's gift, No. 40 cities, street, six roads, Liaoyang City, Liaoning Province Wensheng District east institute of Traditional Chinese Medicine and materia medica Moschus thrombus-resisting capsules is a kind of Chinese medicine preparation.Summary: choose 500 of artificial Moschus 3.5-5.5g, Borneolum Syntheticum 4.5-5.5g, Hirudo 350-550g, Scolopendras, earlier Hirudo and Scolopendra drying and crushing are reached 100 orders, be blended into Moschus and Borneolum Syntheticum, fully behind the mixing, reinstall capsule and get final product, the about 0.3g of every capsules pastille.Beneficial effect of the present invention is waking up the patient from unconsciousness and subduing endogenous wind, dredge the meridian passage, and blood circulation promoting and blood stasis dispelling can be used for the headache and dizzy that cerebral ischemia causes, stiff tongue and retardation in speech, numb limbs and tense tendons, hemiplegia and stroke prevention are concentrated one's efforts grand to the sick merit of treatment cerebral infarction.In addition, this medicine is applicable to that also phlebothrombosis disease person takes, and also has significant curative effect.
7, Chinese patent, application number: CN03113901.9 publication number CN1438018, a kind of medicine and production method Qixing Pharmaceutical Co., Ltd., Guangzhou thereof for the treatment of apoplexy, Zhu Baihua, No. 33, Chi Gang North Road, XinGang Middle Road, GuangZhou City, GuangDong Province, summary: a kind of medicine and production method thereof for the treatment of apoplexy, adopt seven flavor medicine things such as Rhizoma Chuanxiong, artificial Moschus, Fructus Gleditsiae Abnormalis, Hirudo, Radix Panacis Quinquefolii, Pericarpium Citri Reticulatae, Borneolum Syntheticum, through effective component extracting and be processed into exterior-applied formulation.Medicine that is somebody's turn to do and nimodipine compare, and cure rate, obvious effective rate, total effective rate all are better than matched group, and its production method is simple.
8, relative analysis [author] Ren Dewang [1] Han Haijun [2] Sun Qingping [1] of [autograph] ginseng trematodiasis Xinnaotong capsule for treating blood vessel of heart and brain and low-dosage aspirin prevention heart and brain thrombus disease appoints virtue [1] Ren Zhongyi [3] Ren Zhongyu [3] Ren Zhongjie [3] to appoint the funny the People's Hospital, [4] Wang Xiaoqian [5] [mechanism] [1] Jishan County, Shanxi Province of Liang Gang [1] Huang Mingjie [3] Yang Che [4] Ning Xuan [5] Wang Yangyun, [2] Beijing 95968 Army Hospitals, [3] middle school, Jishan County, Shanxi Province, [4] The Medical College of Changzhi, Shanxi, [5] Colleges Of Traditional Chinese Medicine Of Shanxi, [periodical name] internal medicine .2008,3 (6) .-872-873[digests] in recent years, low-dosage aspirin has been widely used in the prevention of heart and brain thrombus disease in the whole world.Most of doctors and patient think that it is safe, effective, inexpensive.But we observe a lot of because of taking the massive hemorrhage that low-dosage aspirin causes in clinical.At present, domestic and foreign literature has also proposed query to safety, the effectiveness of low-dosage aspirin.In order to solve the difficult problem that low-dosage aspirin causes hemorrhage this poor stability, we are to being in hospital and the heart and brain thrombus disease patient of outpatient service in my institute year June in January, 2000 to 2008, adopt homemade traditional Chinese drug preparation ginseng trematodiasis Xinnaotong capsule for treating blood vessel of heart and brain and low-dosage aspirin that the heart and brain thrombus disease is prevented, and do clinical observation and relative analysis.
9, [autograph] Chinese medicine XINGNAOJING is to the treatment and quiet red rosy clouds king two quick Ni bright-coloured Lee Pan Hong Asia Longnan hospital of [mechanism] Daqing Oilfield General Hospital Group (the 5th Affiliated Hospital of Qiqihar Medical College) of nursing [author] of cerebral trauma, [periodical name] China practical medical .2010 (6) .-185-186[digest] XINGNAOJING ZHUSHEYE is a kind of Chinese traditional compound medicine, main component is made up of artificial Moschus, Fructus Gardeniae, Flos Tulipae Gesnerianae, Borneolum Syntheticum etc., has heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, inducing resuscitation etc. to cure mainly function.It is clinical that to be usually used in QI and blood contrary disorderly, apoplectic coma due to the resistance of the brain arteries and veins stasis of blood, and the hemiplegia mouth, the wound headache, coma, alcoholism is made a psychological attack, the headache vomiting and nausea, stupor is twitched, cerebral thrombosis acute phase, craniocerebral trauma, acute alcoholism is seen above-mentioned disease person.
10, [autograph] Chinese medicine XINGNAOJING is to the treatment and quiet red rosy clouds king two quick Ni bright-coloured Lee Pan Hong Asia Longnan hospital of [mechanism] Daqing Oilfield General Hospital Group (the 5th Affiliated Hospital of Qiqihar Medical College) of nursing [author] of cerebral trauma, [periodical name] China practical medical .2010 (6) .-185-186[digest] XINGNAOJING ZHUSHEYE is a kind of Chinese traditional compound medicine, main component is made up of artificial Moschus, Fructus Gardeniae, Flos Tulipae Gesnerianae, Borneolum Syntheticum etc., has heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, inducing resuscitation etc. to cure mainly function.It is clinical that to be usually used in QI and blood contrary disorderly, apoplectic coma due to the resistance of the brain arteries and veins stasis of blood, and the hemiplegia mouth, the wound headache, coma, alcoholism is made a psychological attack, the headache vomiting and nausea, stupor is twitched, cerebral thrombosis acute phase, craniocerebral trauma, acute alcoholism is seen above-mentioned disease person.
From above-mentioned data searching, they respectively have characteristics the doctor trained in Western medicine and the traditional Chinese medical science, its major function be improve cerebral circulation, prevent and treat cerebral edema, the treatment complication, also need to reduce blood viscosity, vessel softening, around improving and the circulation of cardiovascular and cerebrovascular vessel.But, in general,, just may produce sequela if apoplexy take place to surpass 3 days, promptly limbs may not voluntary movement, and it is skinny then to suffer from limb for a long time, and apathy is so the doctor trained in Western medicine or the traditional Chinese medical science are to above there being the apoplexy of sequela all not have good way in 3 days.
Summary of the invention
The inventor is at the generation of existing cerebral hemorrhage, cerebral thrombosis, cerebral embolism, transient ischemic attack disease, the utilization Chinese medical theory more preferred Chinese medicines, make a kind of waking up the patient from unconsciousness and subduing endogenous wind, dredge the meridian passage, the medicine of blood circulation promoting and blood stasis dispelling, can when paralysis due to windstroke, rise behind 160 hours innerlich anwendens and recover rapidly in 24 hours, recover normal person's no sequel after 5～7 days.
The present invention treats the effective ingredient of the Chinese medicine preparation of apoplexy and is made by following parts by weight of traditional Chinese medicines raw material:
80～150 parts of Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae)s;
2～8 parts in Moschus.
This Chinese medicine preparation is ejection preparation or the oral formulations on the pharmaceutics; Described ejection preparation is an intravenous fluid; Described oral formulations is tablet, capsule, pill, granule, oral liquid etc.
The production method of intravenous fluid is:
(1) with after exsiccant Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) (herb) pulverizing, every 100g gram Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) is with the ethanol percolate extraction of the weight concentration 60～85% of 500ml, and the storage of percolation solution is standby, medicinal residues add 2～3 times clear water again and boiled 10-30 minute, filter, and preserve with percolation solution to merge, transfer PH to 3～4 with the HCl aqueous solution, leave standstill half an hour, the elimination precipitate, reuse NaOH aqueous solution transfers to 6.5～7.5, reclaim ethanol, simmer down to 300ml filters subsequently, cool to 4～10 ℃ of stored refrigerated, obtain solution A.
(2) get Moschus, pulverize, every 10g adds water 2000ml, is divided into 2 distillations (at every turn adding water 1000ml), steams distillate 1800ml, obtains solution B.
(3) merge solution A and solution B, ratio is A: B=1: 2, and with the normal saline dilution, the A of every 1000ml, B solution add injection surfactant 5～10ml, mix thoroughly, transfer PH to 8.5, filter, potting, leak detection, 100% sterilization obtained the intravenous injection liquid product in 30 minutes.
If by standard, best intravenous fluid concentration is the crude drug in whole that every milliliter of intravenous fluid is equivalent to 0.33mg Moschus, 0.33g Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).
Described injection surfactant is tween, span, lecithin etc.
[usage and dosage] intravenous drip, each 10ml mixes instillation in 5% glucose sodium chloride 250ml.Once a day, 7 days is a course of treatment.
The production method of oral formulations is:
(1) after exsiccant Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) (herb) is pulverized, cross 80 mesh sieves, the clear water that adds 2～3 times boiled 10～30 minutes, filtered, and obtained solution C;
(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55～70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part D;
(3) C and D mixing are concentrated, get the fluid extract of 1.05～1.20/55～60 ℃ of relative densities, drying gets intermediate products dried cream powder E;
(4) get Moschus, pulverize, E mixes with dried cream powder, adds appropriate amount of auxiliary materials (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, according to pharmaceutical technology film-making agent, granule, capsule or pill, gets the oral formulations product.
[usage and dosage] is for oral administration, each 0.2～0.5g, and once a day, 7～10 days is a course of treatment.
The raw material of the Chinese medicine preparation of above-mentioned treatment apoplexy can be from " finding its another name, latin name and the place of production, usage Chinese pharmacopoeia and other Chinese medicine handbook, in order to understand the mechanism that the present invention treats disease, existing effect and pharmacology thereof to the prescription Chinese medicine describes:
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Latin formal name used at school: Corydalis saxicola Bunting, belong to the Papaverales Papaveraceae, another name: rock Hu, rock company, Radix corydalis pallidae, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), herbaceos perennial, high 15-40cm, main root prosperity, be born in the border rock slot of mountain region, be distributed in ground such as Gansu, Hubei, Guangxi, Sichuan, Guizhou, Yunnan.Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) is a kind of Chinese medicine also, has multiple curative effects such as heat-clearing and toxic substances removing, treatment hepatitis, attending effectiveness: heat-clearing and toxic substances removing; Dampness removing; Analgesic hemostatic; Cure mainly hepatitis; Aphthous stomatitis; Acute catarrhal conjunctivitis; Cough, corneal nebula; Dysentery; Diarrhoea; Stomachache; Bleeding hemorrhoids also has certain antitumaous effect.It is documented, the chemical constituent of Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae): herb contains berberine (berberine), alkali (cavidine) is decided in the racemization Cavan, alkali (dehydrocavidine) is decided in the dehydrogenation Cavan, racemization Corydalis Saxicolae (thalictrifoline), left-handed-13 β hydroxyl stylopines (13 β hydroxystylopine), dextrorotation tetrahydropalmatine (tetrahydropalmatine), left-handed tetrahydrocolumbamine (tetrahydrocolumbamine), protopine (protopine), scoulerine (scoulerine), chelerythrine alkaloids such as (chelerytrine).
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) is owing to have above-mentioned heat-clearing and toxic substances removing, dampness removing, analgesic hemostatic function and chemical constituent, it is found that it has special efficacy to the liver disease, the multi-efficiency that has anti-hepatitis virus simultaneously and protect the liver, thereby be widely used in the treatment of hepatitis, liver cirrhosis, hepatocarcinoma, and obtain beyond thought special effect, Guangxi, some pharmaceutical factories, Guizhou have produced some for oral administration and ejection preparations with Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) at present, through taking for a long time and toxic and side effects is not found in intravenous injection, so Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) is as the important drugs of treatment hepatic disease.But do not see to have Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) is used for the treatment of apoplexy.
Moschus, Latin are learned civilian Moschus, for the umbilicus of male Moschus moschiferous and the secretions of the glandular sac between the genitals, are graininess or bulk after the drying, and special fragrance is arranged, and bitterness is arranged, and can make spice, also can be used as medicine.Be the central nervous excitation agent, external can be eased pain, be subsided a swelling.Be called for short " Moschus moschiferous ".
Function cures mainly: the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, pain relieving, hasten parturition, the heart, brain, blood vessel are had decisive stronger effect.
Chemical constituent: Moschus core master contains muscone (muscone), and content is about 0.9%～3%, is colourless liquid, the distinctive fragrance of tool Moschus; And contain muscopyridine, 11 kinds of androstanes (androstane) Xing biological species such as androsterone (androsterone), epiandrosterone (epiandrosterone) etc.In addition, contain cholesterol class, fat, protein, wax and inorganic salt (ammonium salt, calcium salt).
Moschus is very famous and precious medical material, contains abundant nutrition.Moisture 22.66%, ash 8.62% (wherein containing potassium, sodium, calcium, magnesium, chlorine, sulfate radical, phosphate radical etc.), chlorine-containing compound (in contain ammonia 1.89% in ammonium carbonate 1.1%, the ammonium salt.Carbamide 0.4%, amino acid nitrogen 1.077%, total nitrogen 6.16%), cholesterol 2.19%, crude fibre 0.59%, fatty acid 5.15%, muscone 1.2%.Moschus suffering, temperature, nontoxic, bitter in the mouth.Go into the heart, spleen, Liver Channel, the function of having one's ideas straightened out, warding off dirty, collateral dredging, loosing silt is arranged.Cure mainly apoplexy, syncope due to accumulation of phlegm, infantile convulsion, attacked by pestiferous factors unhappiness, trusted subordinate's sudden pain, traumatic injury, swollen ulcer drug.Many clinical materials show, during the patients with coronary heart disease angina pectoris attacks, or are in when fainting shock, and taking with the Moschus is that ball closes in the Soviet Union of main component, and the state of an illness can be eased.Talk in the ancient book " Elementary Medicine ", Moschus, the key of being open to the custom, on reach muscle.In go into bone marrow ...The Compendium of Material Medica cloud: ... the lid Moschus is walked to scurry, and can lead to the unfavorable of all keys, opens the heap soil or fertilizer over and around the roots of meridians and holds back.Its meaning is to say that Moschus can enter muscle and bone marrow very soon, can give full play to the property of medicine.During the treatment sore, the Moschus of adding some points in right amount in the medicine, drug effect is obvious especially.Western medicine is made first aid medicines such as cardiac tonic analeptic with Moschus.
So the present invention mainly is the refreshment of having one's ideas straightened out, a promoting blood circulation to restore menstrual flow effect of having utilized Moschus with the ingredient of Moschus as the treatment apoplexy.
The mechanism of action that the present invention treats apoplexy is:
Except operating pressure and factor of environmental, the urbanization of the higher fatty acid and modern inhabitation of food at present, make the sickness rate of person in middle and old age's apoplexy in rising trend, for example serious threat human health, therefore, the sequela that caused in several days after treatment apoplexy and the apoplexy thereof, it is an outstanding feature of the present invention, the inventor studies Traditional Chinese medical theory, on the basis of secret prescription handed down in the family from generation to generation, replenished and put in order, excavate and develop and a kind of Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) and Moschus are share, based on suppressing the hyperactive liver to relieve the wind syndrome, eleminating phlegm and freeing channels.The expectorant stasis of blood is handed over resistance person, and assistant is with blood circulation promoting and blood stasis dispelling.In the internal organs person, excess syndrome of stroke when relieve inflammation or internal heat to relieve dizziness, high fever, infantile convulsions, epilepsy, etc., eliminating heat pathogen by purging the bowels, blood stasis dispelling eliminate phlegm for resuscitation; The suitable rescuing YIN recuperating the depleted YANG to cure collapse-syndrome as emergency treatment of the depletion syndrome.If excess syndrome of stroke begins to transfer in the depletion syndrome, can close, take off treatment ginseng usefulness mutually.Gradually wake up as stupor, close, take off remission, can be according to the state of an illness, treating both the principal and the secondary aspects of a disease at the same time, as suppressing the hyperactive liver to relieve the wind syndrome, removing heat-phlegm, while nourishing the liver and kidney or benefiting qi and nourishing blood.The deficiency of vital energy can be mended, blood stasis can loose, wind-phlegm can be dispelled, suppressing the hyperactive liver and subsiding YANG, play benefiting QI for activating blood circulation altogether, the eliminating phlegm that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., disperse blood stasis and dredge collateral, treating both the principal and secondary aspects of a disease it, it can improve myocardial function, blood vessel dilating, blood fat reducing alleviates atherosclerosis, reach enhancing human body cell metabolism number of times prolonged human body life time, delay cerebral tissue function imbalance, the effect that regains the function.
The present invention compared with prior art, its outstanding substantive distinguishing features and obvious improvement is:
(1) medicine slightly warm in nature of the present invention, promoting blood circulation to remove blood stasis, diuresis, each organ function equilibrium of conditioning human body viscera, can when paralysis due to windstroke, rise behind 160 hours innerlich anwendens and recover rapidly in 24 hours, recover normal person's no sequel after 5～7 days, and the general paralysis due to windstroke of doctor trained in Western medicine is treated very difficult the recovery after 2 days at present.
(2) induce the activity of the antioxidase system of organism inside; The anti-stress of enhancing body and anti-fatigue ability improve memory ability.
(3) protect the liver, tomorrow, blood pressure lowering, blood fat reducing, promote the human body metabolism to make human nerve, endocrine operational network normal.Improve myocardial function, blood vessel dilating brings high blood pressure down, and promotes hemopoietic function, and blood fat reducing alleviates atherosclerosis, blood circulation promoting and blood stasis dispelling.
(4) Chinese medicine preparation of treatment apoplexy of the present invention has been followed whole existing the thought and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle of motherland's medical science, the rule of development takes place in research and inquirement apoplexy theoretically and sequela thereof, and adopt blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, heat-clearing and toxic substances removing, the body resistance strengthening and constitution consolidating etc. to have " operation " means of Chinese medicine characteristic, accomplish " medication is as using military forces ", ability " To know one's own strength and the enemy's is the sure way to victory ".
(5) prescription science, production technology advanced person, workable, moderate product price is fit to suitability for industrialized production.
(6) produce in according to the effective ingredient character and the preparation requirement of each flavor raw material of Chinese medicine, adopt or alcohol extraction, or water carries, or the production technology of pulverizing and corresponding sterilizing methods, thereby product active constituent content height, and not perishable long shelf-life.
(7) result of product studies on acute toxicity of the present invention and long term toxicity research shows, by intending using the daily dose injection course of treatment or oral, it is safe using product of the present invention.
The specific embodiment
Below be embodiments of the invention:
Embodiment 1,
The production of injection, raw material: Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 1000g, Moschus 40g;
(1) Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) (dry herb), the processing coarse powder is used 75% ethanol percolate extraction, percolation solution storage is standby, and medicinal residues add 2～3 times clear water again and boiled 10-30 minute, filter, preserve merging with percolation solution, transfer PH to 3～4, leave standstill half an hour with the HCl aqueous solution, the elimination precipitate, reuse NaOH aqueous solution transfers to 6.5～7.5, reclaims ethanol, simmer down to 300ml subsequently, filter, cool to 4～10 ℃ of stored refrigerated, obtain solution A.
(1) with after exsiccant Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) (herb) pulverizing, every 100g gram Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) ethanol percolate extraction of the weight concentration 60～85% of 500ml,
(2) Moschus adds 50 times in water, and distillation meets distillate 2000ml, obtains injection B liquid.
(3) A, B liquid merge, and adding distil water is adjusted to 0.9% sodium chloride to 6000ml, add the 10ml Tween 80 and mix thoroughly, transfer PH to 8.5, filter, and potting, leak detection, 100% sterilization 30 minutes makes 1000 (6ml/ props up) " brain is upright logical " injection altogether.
Embodiment 2,
The production of tablet, raw material: Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 1500g, Moschus 40g;
The production method of oral formulations is:
(1) after exsiccant Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) (herb) is pulverized, cross 80 mesh sieves, the clear water that adds 2～3 times boiled 10-30 minute, filtered, and obtained solution C;
(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55～70%, each 2-3 hour, extracting solution reclaimed ethanol and gets alcohol extraction part D;
(3) C and D mixing are concentrated, get the fluid extract of 1.05～1.20/55～60 ℃ of relative densities, drying gets intermediate products dried cream powder E;
(4) get Moschus, grind, E mixes with dried cream powder, adds an amount of methylcellulose and starch (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, granulate according to pharmaceutical technology, and tabletting, packing gets finished product " brain is upright logical " tablet.
Embodiment 3,
The production of capsule, raw material: Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 3000g, Moschus 50g;
(1) after exsiccant Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) (herb) is pulverized, cross 80 mesh sieves, the clear water that adds 2～3 times boiled 10-30 minute, filtered, and obtained solution C;
(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55～70%, each 2～3 hours, extracting solution reclaimed ethanol and gets alcohol extraction part D;
(3) C and D mixing are concentrated, get the fluid extract of 1.05～1.20/55～60 ℃ of relative densities, drying gets intermediate products dried cream powder E;
(4) get Moschus, pulverizing, E mixes with dried cream powder, adds an amount of lactose (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, granulates according to pharmaceutical technology, and is encapsulated, and packing gets finished product " brain is upright logical " capsule.
Embodiment 4
The production method of pill: raw material: Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 2000g, Moschus 30g;
(1) after exsiccant Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) (herb) is pulverized, cross 80 mesh sieves, the clear water that adds 2～3 times boiled 10～30 minutes, filtered, and obtained solution C;
(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55～70%, each 2～3 hours, extracting solution reclaimed ethanol and gets alcohol extraction part D;
(3) C and D mixing are concentrated, get the fluid extract of 1.05～1.20/55～60 ℃ of relative densities, drying gets intermediate products dried cream powder E;
(4) get Moschus, pulverize, E mixes with dried cream powder, with Mel and adjuvant (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, stirs, and makes pill, and makes it dry, and coating promptly obtains " brain is upright logical " pill product.
Embodiment 5
The granule production method, raw material: Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 1200g, Moschus 50g;
(1) after exsiccant Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) (herb) is pulverized, cross 80 mesh sieves, the clear water that adds 2～3 times boiled 10～30 minutes, filtered, and obtained solution C;
(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55～70%, each 2～3 hours, extracting solution reclaimed ethanol and gets alcohol extraction part D;
(3) C and D mixing are concentrated, get the fluid extract of 1.05～1.20/55～60 ℃ of relative densities, drying gets intermediate products dried cream powder E;
(4) get Moschus, pulverize, E mixes with dried cream powder, adds sucrose and adjuvant (by the adjuvant of state-promulgated pharmacopoeia regulation) mixing, stirs, and makes " brain is upright logical " granule.
The present invention treat apoplexy tablet, capsule, granule, pill, instructions of taking:
[usage and dosage] is for oral administration, each 0.2～1.5g, and every day 2 times, 7～10 days is a course of treatment.
The present invention treats the clinical research report () of the Chinese medicine preparation of apoplexy:
This product is through proved recipe, and to 138 routine cerebral thrombosis patients' clinical practice, its effective percentage reaches more than 98% through in the past few years, cures to reach 95%.
The upright logical injection of brain begins clinical practice to 2010 year in nineteen ninety, and total clinical verification is as follows:
291 people within 1 to 7 day paralyse; 108 people in 8 to 9 days; 113 people in 10 to 12 days; 68 people more than 13 days.
Returning to no any sequela is respectively 290 people to reach 99.65%, 83 people is that 76.85%, 63 people are that 55.75%, 22 people are 32.35%.
Show that according to above clinical practice the upright logical injection of brain does not have under the dead resting state at the paralysis due to windstroke brain cell, medication can return to the no sequel, and person's effective percentage reaches more than 99.6%.
Remaining case stays sequela person, and is also not clearly on be paralyzed in bed, also far better than other medicine therapeutic effect.
Case 1:
Mother of Liuzhou city teacher Wei Zhijiao, Li Shi, woman 69 years old.Nineteen ninety-five JIUYUE 7 o'clock of 2 morning sudden faint, after lift back on the bed and be unable to leave the bed always, upper left, lower extremity paralysis is to JIUYUE 9 days (8 days).Be cerebral thrombosis (apoplexy) after diagnosing, instil once with 5% Dextrose and Sodium Chloride Inj. 250ml mixed venous in the JIUYUE upright logical injection 4 (8ml) that 9 23 o'clock evening began to require mental skill.9 o'clock of the next morning WA, seen that she separates urine from toilet and passes in and out toilet voluntarily.Medication was fully recovered after 6 days repeatedly continuously, no sequel.
Case 2:
Guilin city Wei, man, 65 years old, retired professor.In at 6 o'clock in afternoon on August 3rd, 2010, Wei is played when going home outside, is fainting from the entrance suddenly, both back upper right, lower extremity paralysis, and distortion of commissure is unable to leave the bed.The upright logical injection 4 (8ml) of requiring mental skill morning August 4 instils once with 5% Dextrose and Sodium Chloride Inj. 250ml mixed venous.The next morning Wei get up voluntarily the turnover toilet separate urine.Medication was fully recovered after 2 days, until not recurrence now, no sequel.
Case 3:
Nanning city Huang, woman, 70 years old.Be on March 5th, 2011 and be unable to leave the bed suddenly, feel upper left, numbness of lower limbs, imperception is paralyzed in bed.In at 12 o'clock at noon 5 month March the upright logical injection 4 (8ml) of requiring mental skill instil once with 5% Dextrose and Sodium Chloride Inj. 250ml mixed venous.Can get up voluntarily at 7 o'clock in the afternoon same day, can slowly walk to dining table and have dinner.Gradually recover one's health after second day.No sequel is fully recovered in medication after 5 days repeatedly.
The clinical research report (two) of Chinese medicine preparation treatment angina pectoris of the present invention:
The present invention treats the Chinese medicine preparation of apoplexy and entrusted certain hospital to carry out the angina pectoris clinical verification in 2009:
Clinical data:
One, physical data,
Job step and experimental result are as follows:
Coronary disease with angina pectoris 60 examples all are higher than normal value through blood check blood fat.Wherein 40 examples are organized in treatment, male's 25 examples, and women's 15 examples, 48～70 one full year of life of age, 62.16 ± 7.33 years old mean age (X ± SD).Matched group 20 examples, male's 12 examples, women's 8 examples, 45～70 years old age, average 59.31 ± 7.96 years old.Two groups of sexes, age distribution all do not have significant difference (P＞0.05).
Be and have thoracic obstruction main symptom; Chinese medical discrimination belongs to syndrome of blood stasis due to qi deficiency, and Western medicine diagnose meets the angina pectoris standard, and patient more than 2 times shows effect weekly.Wherein 30 examples are organized in treatment, male's 11 examples, and women's 19 examples, the age is at 40～70 years old, average 63.39 ± 6.73 years old (X ± S0).Matched group 30 examples, male's 16 examples, women's 14 examples, 40～70 years old age, average 58.734～8.84 years old (X ± SD).Two groups of sexes, age distribution all do not have significant difference (P＞0.05).
Two, diagnostic criteria
1, coronary heart disease:
(1) primary symptom: the apoplexy phenomenon is arranged, the hemiplegia that has, numbness.
(2) Acute onset.
(3) crooked mouth and tongue, mind unconsciousness, stiff tongue and retardation in speech or in silence, hemianesthesia.
(3) sick sending out has inducement more, and premonitory symptom is often arranged before not sending out.
(4) how send out the age well more than 40 years old,
The selection coronary disease with angina pectoris is the object of observation.
Deficiency of vital energy blood match pattern of syndrome standard is, hemianesthesia, and pale complexion, shortness of breath and fatigue, mouthful sialorrhea is perspired, dimly pale tongue, thin white fur of tongue or white greasy, deep-thready pulse, slow or thin string carefully.
Wind-phlegm blood stasis, numbness resistance venation pattern of syndrome standard is: hemianesthesia, have a dizzy spell dimly pale tongue, thin white fur of tongue or white greasy.
2. the thoracic obstruction:
(1) the vexed Pu of chest, very then chest pain radiating to the back
(2) the lighter only becomes chest distress, hypopnea,
(3) Electrocardioscopy has the ischemic change or the exercise test positive,
Select in the thoracic obstruction deficiency of vital energy blood to examine the card patient and be the object of observation. its pattern of syndrome standard is: feeling of oppression and pain in the chest, breathe hard, cardiopalmus, dizzy, dark tongue quality or ecchymosis is arranged, deep and stringy pulse or heavy thin.
Observational technique
Observe 60 examples altogether, be divided into 2 groups at random.Thoracic obstruction patient treatment group 40 examples, matched group 20 examples. the treatment group " is treated the Chinese medicine preparation capsule of apoplexy " with medicine of the present invention, each 2, every day 3 times, serve on for 4 weeks, matched group Ginkgo oral liquid (production of the XX of Hebei province city pharmaceutical factory), each 10ml, every day 3 times, serve on for 4 weeks, routine is made detailed physical examination to the patient before the test, with relevant physico-chemical examination, as electrocardiogram, blood fat, hemorheology, waist is worn, CT scan etc. change of illness state is kept a close eye in the test back, make pathography weekly 1 time, as find that the state of an illness obviously worsens, and should stop test immediately and take other integrative therapy measures, therapeutic effect is evaluated with scoring method.The curative effect judgement is directly made by the observer. and viewing duration is withdrawn the Chinese and western drugs that influences the coronary heart disease curative effect in principle.Heavier to the state of an illness, withdraw the other drug person of having any problem, can be with the Western medicine application limitations at citicoline (paralytic) and nitroglycerin (thoracic obstruction patient), other Chinese medicines and Chinese patent medicine are withdrawn without exception. finish the relevant physico-chemical examination of back check the course of treatment,
Three, therapeutic outcome:
1. to the influence of various symptoms, sign: observe behind two kinds of treatment for diseases groups and the matched group patient treatment the various witness integrations equal highly significant that descends, illustrate that two kinds of medicines all have therapeutical effect to the apoplexy and the thoracic obstruction, treatment back paralytic's mind, language are blind, the motor function and the thoracic obstruction are patient's feeling of oppression and pain in the chest, and symptoms such as shortness of breath and palpitation, sign all have clear improvement.
2, two kinds of medicines to thoracic obstruction patient onset time relatively: treatment group paralytic is 2.SS+0.99 (X ± SD) onset time, obviously faster than to railway carriage or compartment group (30.5 ± 1.29 week), two groups of differences have significance (P＜0,05). treatment group thoracic obstruction person is 2.61 ± 1.13 weeks (X ± SD) onset time, be slower than matched group (2.48 ± 1.21, two groups of difference and significance (P＞0.05) slightly.
Before and after the thoracic obstruction patient physico-chemical examination treatment relatively, two groups of patient treatment after-contraction pressures, diastolic pressure, ch and TG all have obvious decline (P＜0,05), and HDL increases nonsignificance (P＞0,05), treatment group hemorheology improves obviously (P＜0,01).
4. treatment group and matched group curative effect are relatively, 60 examples are organized in paralytic's treatment, total effective rate is 89%, matched group 20 examples, and total effective rate is 76.7%, treatment group curative effect obviously is better than matched group (P＜0,01), see Table 4. thoracic obstruction patient treatment groups, 30 examples, its heart strand carbuncle curative effect, ECG curative effect, clinical card marquis curative effect total effective rate are respectively 90,0%, 60.0%, 83,4%.Matched group 30 examples, very main angor curative effect, Jb electrograph curative effect, clinical card marquis curative effect total effective rate is respectively 93.3%, 63.3%, 93,3%, two group of relatively more equal nonsignificance (P＞0,05) of curative effect, see Table 5, two groups of patients of side effect all do not find obvious adverse reaction and toxic and side effects at viewing duration.
Example 1, he XX, the man, 56 years old, (medical record number: 64463).
The patient because of " the companion's speech of falling forward dusk suddenly is unfavorable; the left limb moving obstacle is admitted to hospital in emergency treatment on February 8 in 2008 half a day. conscious having a dizzy spell; palpitation and night sweat; hemianesthesia. check and see: refreshing clear, crooked mouth and tongue sialorrhea; language performance owes complete; act can not done shoulder on the left shoulder joint, articulations digitorum manus only can be clenched fist, left side leftover bits and pieces hip joint still can be stretched and bend but a little less than the power, toe joint is stretched Qu Buquan, dark tongue quality, white and greasy fur, deep-thready pulse. diagnose through CT examination: right side temporal lobe cerebral infarction, tcm diagnosis: apoplexy (apoplex involving the channels and collaterals one wind-phlegm blood stasis type).Treat the Chinese medicine preparation of apoplexy with the present invention and treat every day three times, each 2.Take medicine only two weeks, hemiplegia, having a dizzy spell begins to alleviate, and shoulder joint has gone up lifts flat shoulder, and life can partial self-help.After all around, former symptom disappears substantially, and patient's life can be taken care of oneself, and June 9, recovery from illness was left hospital.
Example 2, an XX, woman, 50 years old, (medical record number: 94173).
The patient is admitted to hospital on May 12nd, 2009 because of " pain uncomfortable in chest, hypopnea 1 hour ", conscious pain uncomfortable in chest, shortness of breath and fatigue, cardiopalmus, has a dizzy spell. and check and see that lustreless complexion, asthenia lazyness are blind, dark tongue quality has speckle, white and thin fur, deep-thready pulse.Electrocardioscopy is shown: T1V3-6 is low flat, tcm diagnosis; Thoracic obstruction Qi deficiency blood stasis type, Western medicine diagnose: angina pectoris. Chinese medicine preparation treatment, the day for the treatment of apoplexy with the present invention obey 3 times, each 2. after, sensation of oppression over the chest with shortness of breath, the weak beginning of cardiopalmus alleviate, and are kept to 1 time for 2 times the every day of feeling of oppression and pain in the chest when being admitted to hospital, time is by being kept to 10 minutes half an hour, pain degree obviously alleviates, around the after, pain uncomfortable in chest is not reaccessed, only surplus slightly breathing hard and dizzy symptom, surplus disease disappears.
The check electrocardiogram:
Normal ECG roughly. curative effect to treat angina pectoris, ECG curative effect and clinical card marquis efficacy evaluation are produce effects.
Conclusion:
Above clinical data discloses:
1. preparation of the present invention has the promote blood circulation effect of brain-strengthening suppressing the hyperactive liver of inrigorating qi and promoting blood circulation, dispelling pathogenic wind and eliminating phlegm, blood stasis dispelling, and cerebral infarction card, angina pectoris due to blood stasis due to qi deficiency, wind-phlegm blood stasis, the passages through which vital energy circulates impatency are had therapeutical effect.
2, the present invention has blood pressure lowering, effect for reducing blood fat, and hemorheology is also improved significantly, and prompting offsets except that symptom before the apoplexy, and reducing cerebrovascular disease has certain preventive and therapeutic effect.
3. the present invention treats paralytic's 100 examples, total effective rate is 89%, curative effect is better than the Ginkgo oral liquid that XX city, Hebei province pharmaceutical factory produces. the treatment thoracic obstruction 30 examples, the total effective rate of angina pectoris, electrocardiogram, symptom curative effect is for being respectively 90.0%, 60.0%, 83,4%, curative effect and ginkgo oral liquid no significant difference.
4. this product is safe and reliable, and 130 examples are not all found obvious adverse reaction and toxic and side effects at viewing duration.
Claims (6)
1. Chinese medicine preparation for the treatment of apoplexy, it is characterized in that: its effective ingredient is made by following parts by weight of traditional Chinese medicines raw material:
80～150 parts of Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae)s;
2～8 parts in Moschus;
Described Chinese medicine preparation is ejection preparation or the oral formulations on the pharmaceutics;
Described ejection preparation is an intravenous fluid; Described oral formulations is tablet, capsule, pill, granule or oral liquid.
2. the Chinese medicine preparation of the described treatment apoplexy of claim 1, it is characterized in that: the production method of intravenous fluid is:
(1) with exsiccant Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) herb, after the pulverizing, every 100g gram Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) ethanol percolate extraction of the weight concentration 60～85% of 500ml, the storage of percolation solution is standby, and the clear water that medicinal residues add 2-3 times of weight again boiled 10～30 minutes, filtered, preserve merging with percolation solution, transfer PH to 3～4, leave standstill half an hour with the HCl aqueous solution, the elimination precipitate, reuse NaOH aqueous solution transfers to 6.5～7.5, reclaims ethanol, simmer down to 300ml subsequently, filter, cool to 4～10 ℃ of stored refrigerated, obtain solution A;
(2) get Moschus, pulverize, every 10g adds water 2000ml, is divided into 2 distillations, adds water 1000ml at every turn, steams distillate 1800ml, obtains solution B;
(3) merge solution A and solution B, ratio is A: B=1: 2, and with the normal saline dilution, the A of every 1000ml, B solution add injection surfactant 5～10ml, mix thoroughly, transfer PH to 8.5, filter, potting, leak detection, 100% sterilization obtained the intravenous injection liquid product in 30 minutes;
Described injection surfactant is tween, span or lecithin.
3. the Chinese medicine preparation of treatment apoplexy according to claim 2 is characterized in that: the concentration of making intravenous fluid is the primary dose that every milliliter of injection contains 0.33mg Moschus, 0.33g Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).
4. the Chinese medicine preparation of the described treatment apoplexy of claim 1, it is characterized in that: the production method of oral formulations is:
(1) after exsiccant Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) herb is pulverized, cross 80 mesh sieves, the clear water that adds 2～3 times boiled 10～30 minutes, filtered, and obtained solution C;
(2) with the alcohol reflux twice of filtering residue with volume by volume concentration 55～70%, each 2～3 hours, extracting solution reclaimed ethanol and gets alcohol extraction part D;
(3) C and D mixing are concentrated, get the fluid extract of 1.05～1.20/55～60 ℃ of relative densities, drying gets intermediate products dried cream powder E;
(4) get Moschus, pulverizing, E mixes with dried cream powder, adds an amount of adjuvant by the state-promulgated pharmacopoeia regulation, and mixing according to pharmaceutical technology film-making agent, granule, capsule or pill, gets the oral formulations product.
5. the Chinese medicine preparation of the described treatment apoplexy of claim 1 is in the purposes of preparation treatment apoplexy and sequela medicine.
6. the Chinese medicine preparation of the described treatment apoplexy of claim 1 is in the purposes of preparation treatment myocardial infarction medicine.
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| CN106728001A (en) * | 2016-12-16 | 2017-05-31 | 柳州草子吉生物科技有限公司 | It is a kind of to promote composition of eyelashes growth and preparation method thereof |
| CN109966393A (en) * | 2019-05-13 | 2019-07-05 | 广西康丹夏裕医药科技有限公司 | It treats hypertension and hypertension causes Chinese materia medica preparation of apoplexy and preparation method thereof |
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| 《中华人民共和国药典》 20100131 国家药典委员会编 麝香 化学工业出版社 2010年版一部 , * |
| 《中药新药与临床药理》 19970331 管孝鞠等 中药促智药研究进展 第8卷, 第1期 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106728001A (en) * | 2016-12-16 | 2017-05-31 | 柳州草子吉生物科技有限公司 | It is a kind of to promote composition of eyelashes growth and preparation method thereof |
| CN109966393A (en) * | 2019-05-13 | 2019-07-05 | 广西康丹夏裕医药科技有限公司 | It treats hypertension and hypertension causes Chinese materia medica preparation of apoplexy and preparation method thereof |
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Addressee: Guangxi three grass Biological Technology Co.,Ltd. Document name: Notification of Passing Examination on Formalities |
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Address after: 545006 No. a1-27, 1st floor, standard workshop, building 1, No. 15, Gaoxin 1st Road, Liuzhou City, Guangxi Zhuang Autonomous Region Patentee after: Guangxi Yaozhen Traditional Chinese Medicine Research Co.,Ltd. Address before: 545006 No. a1-27, 1st floor, standard workshop, building 1, No. 15, Gaoxin 1st Road, Liuzhou City, Guangxi Zhuang Autonomous Region Patentee before: Guangxi three grass Biological Technology Co.,Ltd. |
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