CN102271508B - 含有刚性部分的吡啶并[4，3-b]吲哚类化合物 - Google Patents

含有刚性部分的吡啶并[4，3-b]吲哚类化合物 Download PDF

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Publication number
CN102271508B
CN102271508B CN200980153434.2A CN200980153434A CN102271508B CN 102271508 B CN102271508 B CN 102271508B CN 200980153434 A CN200980153434 A CN 200980153434A CN 102271508 B CN102271508 B CN 102271508B
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substituted
unsubstituted
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alkyl
formula
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CN102271508A (zh
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戴维.T.亨格
安德鲁.A.普罗特
拉詹德拉.P.贾因
萨瓦吉特.查克拉瓦蒂
马科.乔吉蒂
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Medivation Technologies LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200980153434.2A 2008-10-31 2009-10-30 含有刚性部分的吡啶并[4，3-b]吲哚类化合物 Expired - Fee Related CN102271508B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11051908P 2008-10-31 2008-10-31
US61/110,519 2008-10-31
US17396009P 2009-04-29 2009-04-29
US61/173,960 2009-04-29
US24515009P 2009-09-23 2009-09-23
US61/245,150 2009-09-23
PCT/US2009/062869 WO2010051501A1 (en) 2008-10-31 2009-10-30 Pyrido (4,3-b) indoles containing rigid moieties

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CN102271508A CN102271508A (zh) 2011-12-07
CN102271508B true CN102271508B (zh) 2015-04-29

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US (3) US8907097B2 (https=)
EP (1) EP2346332A4 (https=)
JP (2) JP5588991B2 (https=)
CN (1) CN102271508B (https=)
AR (1) AR073923A1 (https=)
AU (1) AU2009308706C1 (https=)
BR (1) BRPI0919948A2 (https=)
CA (1) CA2742320A1 (https=)
TW (1) TWI477503B (https=)
WO (1) WO2010051501A1 (https=)

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