CN102266483B - Chinese medicinal composition for treating coronary heart diseases and preparation method thereof - Google Patents
Chinese medicinal composition for treating coronary heart diseases and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition for treating coronary heart diseases and a preparation method thereof. The composition is prepared from the following Chinese medicinal raw materials: antler glue, white paeony root, mulberry leaf, madder root, bupleurum, cassia bark, spiny jujube kernel, thinleaf milkwort root-bark and liriope graminifolia bak. The invention also relates to a preparation method for the composition and application of the preparation of the composition for treating the coronary heart diseases. The Chinese medicinal composition has an obvious treatment effect on the coronary heart diseases.
Description
Technical field
The present invention relates to Chinese medicine composition that is used for the treatment of coronary heart disease and preparation method thereof, also relate to the application of said composition in treatment coronary heart disease.
Background technology
The Coronary vein atherosclerotic heart disease is called for short coronary heart disease, and coronary heart disease is to cause coronary artery to produce speckle by blood fat height in the body to cause soon the narrow of lumen of vessels or obstruction; Angina pectoris occurs in the lighter, show as behind pareordia or the breastbone paroxysmal pain or with uncomfortable in chest, feel suffocated, cardiopalmus, the symptom such as be in a cold sweat; The severe one coronary artery is inaccessible suddenly, causes myocardial ischemia, ischemia, necrosis, and show as persistence and have an intense pain, pale complexion or livid purple, the critical disease such as be in a cold sweat, upper cold of the limbs is cold is if sudden death can occur in untimely rescue.
On August 12nd, 2011 is according to Beijing Evening News: 2.3 hundred million Chinese suffer from the cardiovascular diseases, dead 6 people of per second, and morbidity and mortality rate still show a rising trend.
China comprises that the cardiovascular disease people of the hypertension of coronary heart disease, apoplexy, heart failure estimates to have reached 2.3 people at present." Chinese cardiovascular diseases reports 2010 " be formal the publication at present, and the expert represents that China has 3,000,000 people to die from the cardiovascular diseases every year when understanding report, and it is the cardiovascular diseases that per 3 people's death just have 1 people, and cardiovascular diseases's morbidity and mortality rate still show a rising trend.
Report shows that China male total force activity has reduced 27.8% between 10 years, and the women has reduced 36.9%." people that physical exertion intensity is low, overweight or fat incidence rate is higher, and the ill risk of metabolism syndrome also raises along with the minimizing of physical exertion.”
Over nearly 30 years, the whole meals of China resident have had obvious improvement, but more original irrational meals characteristics still exist.Substantially exceed the every day of guide recommendation less than the standards of 6 grams comprising edible salt intake, the intake of fruit and vegetable is lower, and cereal is taken in obviously and descended, and the fat intake increase obviously.
The situation of China's Nicotiana tabacum L. prevention and control is still severe.Male doctor and teacher's high smoking rate makes people worried, and non-smokers' passive smoking rate is up to 72.4% more than 15 years old, and the half teenager suffers the harm of passive smoking.
Report is pointed out, the factors such as the variation of life style and aged tendency of population make the risk factor of China resident's the cardiovascular and cerebrovascular diseases such as obesity, diabetes, hyperlipemia and hypertension all be lasting ascendant trend.The Overweight and obesity person reaches respectively 2.5 hundred million and 7,000 ten thousand, 7 to 18 years old teenager more than 18 years old has 21,370,000 overweight or fat approximately.The prevalence 18.6% of crowd's dyslipidemia more than 18 years old, number of patients is estimated as 200,000,000.Adult hypertension prevalence 18.8%, about 200,000,000 people of hyperpietic's number.The annual cardiovascular death relevant with hypertension reaches 2,330,000 people.
According to estimates, China at present per 5 people just has 1 people to suffer from the cardiovascular diseases, and every day is because of cardiovascular death 8200 people, cardiovascular death 340 people per hour, about 6 people of per second.The patient who left hospital take coronary heart disease as diagnosis in 1980 is as 15.03 ten thousand, and 2008 then is 240.93 ten thousand; 2008 then was 200.44 ten thousand take apoplexy as the patient that leaves hospital of diagnosis only 10.29 10000 in 1980.
Meanwhile, the anxious residence of the hospitalization cost of China's cardiovascular and cerebrovascular disease risen, from over 2004, take acute myocardial infarction, cerebral hemorrhage and cerebral infarction as diagnosis patient hospitalization cost, after impact on inflation-adjusted basis, average annual growth is respectively 34.6%, 26.85% and 31.05%.Have immediate effect pills for curing heart disease, the heart of living, sorbitrate, persantin, Radix Salviae Miltiorrhizae, Tongxinluo, arteria coronaria of the medicine of existing treatment coronary heart disease is peaceful etc.
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of coronary heart disease, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
Colla cornus cervi 15-30, Radix Paeoniae Alba 12-25, Folium Mori 1-5, Radix Rubiae 1-3, Radix Bupleuri 15-35, Cortex Cinnamomi 1-5, Semen Ziziphi Spinosae 10-20, Radix Polygalae 5-15, Radix Ophiopogonis 1-5.
Preferably, said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
Colla cornus cervi 22, Radix Paeoniae Alba 18, Folium Mori 3, Radix Rubiae 2, Radix Bupleuri 26, Cortex Cinnamomi 2, Semen Ziziphi Spinosae 15, Radix Polygalae 9, Radix Ophiopogonis 3.
Another object of the present invention provides a kind of preparation method of the present composition, the method comprise with above nine the flavor raw material of Chinese medicine be ground into coarse powder, add in the extraction pot, add raw medicinal herbs quality 6-8 purified water doubly, open the vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and be heated to and boil, keep slight boiling condition, economic benefits and social benefits concentrating return-flow, dynamic extraction 2-4 hour; Collect extracting solution and be evaporated to relative density 1.5-1.6; Close heater, return to gradually atmospheric pressure.Carry out spray drying, with 160 ℃ of preheating 10-20 of drying tower minutes, inlet temperature is set as 150-200 ℃ first, leaving air temp is set 50-100 ℃, pan feeding flow 1.2L/ divides, and after all having sprayed, continues to keep air intake to open the discharge bucket discharging after 5 minutes and obtains dry powder.
Subsequently, can according to the ordinary skill in the art, compositions of the present invention be prepared into various dosage forms.For example dry powder if need to add flavoring agent and/or antiseptic, and is adjusted total amount with 100 times of pure water dilutions, embedding, and sterilization, packing namely gets oral liquid; Or with No. 0 capsule fill, or dry powder added a small amount of dextrin, sugar as excipient, with No. 0 capsule of fill behind the granulator granulation; Sterilization, packing namely gets capsule; Or make pill according to the ordinary skill in the art, and such as the watered pill, honeyed pill.
Need to prove that method of the present invention is a kind of preferred preparation technology but is not limited to this.Product by the inventive method preparation has good stability.
For many years, adopt the Chinese medicine composition for the treatment of coronary heart disease of the present invention, this Chinese medicine composition is used in combination by multiple Chinese herbal medicine, has the effect of blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, can improve coronary artery circulation, increase blood flow, reduce cardiac load and oxygen consumption, promote appetite, health invigorating, tranquilization and refreshment, cure mainly coronary heart diseases and angina pectoris due to the stagnation of heart-blood, have no any toxic and side effects.
The present invention is according to the differential diagnosis in tcm theoretical principle, " heart monarch is subjected to the patient; female deficiency of liver-blood also " and " medicine for the treatment of the liver is more than controlling heart flavor, and lid heart monarch is quiet, and liver blood is not empty; what is to aroused in interest; so this treating the liver is just being controlled the heart, thus control the heart namely treating the liver also, so-called conscience Xiang Ji " theory, improve coronary artery circulation, increase blood flow, reduce cardiac load and oxygen consumption, and have no side effect.
Usage and consumption: oral, medicine of the present invention is taken 3 times every day, and each 2 balls are bfore meals as an example of pill example, and ten days is 1 course for the treatment of.
Period in a medicine is informed patient's points for attention: asthma and anemia of pregnant woman forbid taking in case cause adverse consequences.
A kind of Chinese medicine composition for the treatment of coronary heart disease of the present invention, the raw material of Chinese medicine of employing is according to the record of " Chinese medicine voluminous dictionary ", wherein:
Colla cornus cervi, function cures mainly: enrich blood, benefit is smart.Control deficiency of kidney-QI, lumbago.
Radix Paeoniae Alba, function cures mainly: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.
Folium Mori, function cures mainly: expelling wind and clearing away heat, cooling blood for improving eyesight.The dispelling the wind and dampness pathogens heating, headache, conjunctival congestion, thirsty, cough due to lung-heat, migratory arthralgia.
Radix Rubiae (Abacopteris penangiana (Hook.) Ching, HUOXUEDAN (" detailed outline is picked up any lost article from the road "), red imperial fibrous root (" Guizhou side's medicine among the people collection "), husky alizarin seedling root (" Henan Chinese medicine handbook), Herba Ipomoeae Cairicae, Herba azollae imbricatae, Radix Bauhihiae Championii (" medicine will is planted in Jiangsu "), red stalk root, child's fist, Radix grewiae bilobae, the daughter root of uprooting plants after their edible portions have been harvested (" Shandong Chinese medicine "), Radix Rubiae Yunnanensis dragon (" Zhejiang traditional herbal medicine "), Salvia kiaometiensis Levl.f.pubescens Stib., cubic Arisaema balansae Engl. (" east, Fujian book on Chinese herbal medicine "), red rubia (" Jiangsu medical material will ").Root and rhizome for the Maguireothamnus speciosus Radix Rubiae.) effect of Radix Rubiae [function cures mainly-] promoting the circulation of blood hemostasis, dredge the meridian passage, eliminating phlegm and stopping cough.Control haematemesis, epistaxis, hematuria is had blood in stool, snowslide, amenorrhea, rheumatic arthralgia, traumatic injury, the stasis of blood stagnates and swells and ache jaundice, chronic tracheitis.
1. " herbal classic ": main cold-damp migratory arthralgia, jaundice, invigorating middle warmer.
2. " not Lu ": hemostasis, the metrorrhagia hematochezia, the not enough ， Wei of bladder falls.
Main numbness and pining for is hindered and is fallen folding.
3. " property of medicine opinion ": control the sad lung of six types of severe debility disease, spit blood, rush down blood.
4. " Japan hanako materia medica ": end serious epistaxis, leukorrhagia, puerperal blood faints, the breast knot, menstruation is more than, hemorrhoidal hamorrhage anal fistula, evacuation of pus; Control furuncle, let out essence, hematuria is pounced on damage congestion.
5. " the typhoid fever class is wanted ": control heart illness, vexatious, hot feeling in the epigastrium.
6. " pearl sac ": remove all dead blood.
7. " detailed outline ": qualcomm meridian, control joint wind pain.
Promoting blood circulation and hemostasis.
8. Du Wen mediate " medicine mirror ": merit is specially invigorated blood circulation, and control to fall and pounce on the carbuncle poison, lump in the abdomen, amenorrhea is had blood in stool, the metrorrhagia leukorrhagia, anal fistula, migratory arthralgia expands jaundice, insect bite.
9. " detailed outline is picked up any lost article from the road "; " Ge Zufang " controls crazy pain due to disorder of QI, tire under the dysmenorrhea, jaundice, abdominal mass painful abdominal mass, snakebite.
10. " book on Chinese herbal medicine brief points ": treat syphilis.
(11) " modern Practical Chinese medicinal ": strong effect is arranged.
Be applicable to children's and anemia of pregnant woman's osteomalacia.
[usage and consumption] is for oral administration: fry in shallow oil soup, 2～3 money; Or enter ball, loose.
Radix Bupleuri (another name: Asia puecon recklessly, smoke Shennong's Herbal, mountain dish, eat grass " WU Pu Bencao ", faggot " product converge smart will ".Nature and flavor: hardship, be slightly cold) function: evacuate and bring down a fever, yang invigorating is soothing the liver.Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the uterus comes off, menoxenia.
Cortex Cinnamomi, function cures mainly: complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, the cold extremities faint pulse, the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Semen Ziziphi Spinosae (latin name: Semen Ziziphi Spinosae; English name: Spine Date Seed; Another name Semen Ziziphi Spinosae Lei Gong's Treatise on Preparation and Broiling of Materia Medica, Semen Ziziphi Spinosae " medicine instrument ", jujube nucleus " Jiangsu value medicine will ".Ziziphi Spinosae " herbal classic " has another name called: sour jujube " Book of Songs ", " elegant ", Fructus Choerospondiatis (TAO Hong-Jing), wild Fructus Jujubae (appointing fat " stating different note "), function cures mainly: nourish heart, calm the nerves, arresting sweating.Be used for neurasthenia, insomnia, dreaminess, night sweat.
Radix Polygalae, function cures mainly: the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm detumescence.Be used for the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Radix Ophiopogonis, function cures mainly: nourishing YIN and moistening the lung, the relieving restlessness that clears away heart-fire, reinforcing stomach reg fluid.Control dryness of the lung dry cough, spit blood ...
The inventor is the traditional Chinese medical science from generation to generation, leaves the secret prescription handed down in the family from generation to generation for the treatment of heart Viscera, and the teacher of the older generation did the pill head in Tongrentang, passes on performance through the inventor and adopt multiple Chinese herbal medicine to be used in combination, and is evident in efficacy; Medicine of the present invention has been treated patients with coronary heart disease 3,000 many cases since the 1980s, be 96.5% to treatment coronary heart disease total effective rate, be 98.2% to the angina pectoris total effective rate, and can obviously improve thoracic obstruction blood stasis type patient's the many index such as hemorheology whole blood viscosity, plasma viscosity, packed cell volume, to improving the every symptom of the thoracic obstruction, the total effective rate such as chest pain, uncomfortable in chest, cardiopalmus, shortness of breath and fatigue, die Blausucht is more than 90%.
Model case
1, Shen XX, chest pain, uncomfortable in chest is coronary heart disease to the Boai County hospital diagnosis, diagnosis and treatment in Boai County hospital through 3 years, do not feel any better, increase the weight of on the contrary, disability, look for inventor's diagnosis and treatment in June, 2006, take the Chinese medicine composition pill of the treatment coronary heart disease of inventor's preparation, by the inventor's instrucion, three times on the one, each two balls, take continuously three courses for the treatment of, ten days each courses for the treatment of, afterwards, Shen XX chest pain, the symptom such as uncomfortable in chest is eliminated, so far not recurrence, and can work, Shen XX and his household are very glad; followingly send silk banner here to the inventor, the praise inventor is the highly skilled man highly skilled doctor, the such patient of similar Shen XX, and practising medicine the inventor three has hundreds of examples during the last ten years.
2, Lee X, the woman, 45 years old, area just outside a city gate, Boai County village people was angina pectoris at the Boai County hospital diagnosis, took medicine of the present invention and can normally work down after a course for the treatment of, fully recovered after continuing to take 3 courses for the treatment of.
3, open X, the man, 45 years old, Jiaozuo City Zhongzhan District people, the People's Hospital is diagnosed as coronary heart disease at Jiaozuo City, takes and fully recovers after medicine of the present invention continues to take 3 courses for the treatment of.
4, remaining X, the man, 65 years old, people from Qinyang City was diagnosed as coronary heart disease in the People's Hospital, Qinyang City, took medicine of the present invention and felt after course for the treatment of to take a turn for the better, and afterwards, fully recovered after continuing to take 2 courses for the treatment of
5, Dong XX, the woman, 52 years old, area just outside a city gate, Xiuwu County village people, pain can't do housework, and is angina pectoris at the Xiuwu County hospital diagnosis, takes medicine of the present invention and can do housework after a course for the treatment of, afterwards, fully recovers after continuing to take 2 courses for the treatment of.
6, Liu XX, the man, 46 years old, people from Mengzhou City can not Go to ground activity, is angina pectoris at Mengzhou City's hospital diagnosis, and taking medicine of the present invention can Go to ground activity after course for the treatment of, afterwards, fully recovers after continuing to take 2 courses for the treatment of, and activity is freely.
7, Dong X, the woman, 39 years old, people from Wen County, hospital diagnosis is coronary heart disease, takes medicine of the present invention and fully recovers after 2 courses for the treatment of.
For this reason, another object of the present invention provides a kind of application of Chinese medicine composition in preparation treatment medicaments for coronary disease for the treatment of coronary heart disease.
The specific embodiment
Embodiment 1: oral liquid
Raw material of Chinese medicine weighing: 22 kilograms of Colla cornus cervis, 18 kilograms of Radix Paeoniae Alba, 3 kilograms on Folium Mori, 2 kilograms of Radix Rubiae, 26 kilograms of Radix Bupleuri, 2 kilograms of Cortex Cinnamomis, 15 kilograms of Semen Ziziphi Spinosaes, 9 kilograms of Radix Polygalaes, 3 kilograms of Radix Ophiopogonis.
Method for making: 1. above nine flavor raw material of Chinese medicine are cleaned, drying is ground into coarse powder, adds in the extraction pot, carries out respectively conventional water or alcohol extraction, and concentrate drying obtains dry powder;
Perhaps 2. is clean through 2-3 stirring and washing with above Chinese medicine composition, adds in the extraction pot, adds the purified water of 8 times of raw medicinal herbs quality, open the vacuum automatic switch, be decompressed to negative pressure 0.67MP, and be heated to and boil, keep slight boiling condition, economic benefits and social benefits concentrating return-flow, dynamic extraction 3 hours.Collect extracting solution and be evaporated to relative density 1.5.Close heater, return to gradually atmospheric pressure.Carry out spray drying, with 160 ℃ of preheatings of drying tower 15 minutes, inlet temperature is set as 170 ℃ first, leaving air temp is set 80 ℃, and pan feeding flow 1.2L/ divides, and after all spray, continues the maintenance air intake and opens the discharge bucket discharging after 5 minutes and obtain dry powder and get final product.
Get dry powder 20 grams, add the 1800ml pure water, if need to add flavoring agent and/or antiseptic, oral liquid, treatment coronary heart disease, drink for each person every day 200ml, took continuously 10 days, 10 days is a course for the treatment of, takes continuously three courses for the treatment of, can cure coronary heart disease, effective percentage is more than 95%.
Embodiment 2: capsule
Raw material of Chinese medicine and consumption: 30 kilograms of Colla cornus cervis, 12 kilograms of Radix Paeoniae Alba, 3 kilograms on Folium Mori, 2 kilograms of Radix Rubiae, 15 kilograms of Radix Bupleuri, 2 kilograms of Cortex Cinnamomis, 10 kilograms of Semen Ziziphi Spinosaes, 8 kilograms of Radix Polygalaes, 3 kilograms of Radix Ophiopogonis.
Method for making is with embodiment 1;
Get dry powder with No. 0 capsule fill, or dry powder is added a small amount of dextrin, sugar as excipient, with No. 0 capsule of fill behind the granulator granulation; Treatment coronary heart disease is taken the 6-12 grain for each person every day, takes continuously 10 days, and 10 days is a course for the treatment of, takes continuously three courses for the treatment of, can cure coronary heart disease, and effective percentage is more than 95%.
Embodiment 3: pill
Raw material of Chinese medicine and consumption: 15 kilograms of Colla cornus cervis, 25 kilograms of Radix Paeoniae Alba, 5 kilograms on Folium Mori, 3 kilograms of Radix Rubiae, 35 kilograms of Radix Bupleuri, 5 kilograms of Cortex Cinnamomis, 20 kilograms of Semen Ziziphi Spinosaes, 15 kilograms of Radix Polygalaes, 5 kilograms of Radix Ophiopogonis.
Method for making is with embodiment 1;
Get dry powder add honey be processed into pill according to honeyed pill preparation technology, ball weigh 3 the gram, the treatment coronary heart disease, take for each person every day the 3-6 ball, took continuously 10 days, 10 days is a course for the treatment of, takes continuously three courses for the treatment of, can cure coronary heart disease, effective percentage is more than 95%.
More than embodiments of the invention are had been described in detail, but described content only is preferred embodiment of the present invention, can not be considered to be used to limiting practical range of the present invention.All equalizations of doing according to the present patent application scope change and improve etc., all should still belong within the patent covering scope of the present invention.
Claims (7)
1. Chinese medicine composition for the treatment of coronary heart disease, it is characterized in that: said composition is prepared from by the raw material of Chinese medicine of following weight ratio:
Colla cornus cervi 15-30, Radix Paeoniae Alba 12-25, Folium Mori 1-5, Radix Rubiae 1-3, Radix Bupleuri 15-35, Cortex Cinnamomi 1-5, Semen Ziziphi Spinosae 10-20, Radix Polygalae 5-15, Radix Ophiopogonis 1-5.
2. a kind of Chinese medicine composition for the treatment of coronary heart disease according to claim 1 is characterized in that: said composition is that the raw material of Chinese medicine by following weight ratio is prepared from:
Colla cornus cervi 22, Radix Paeoniae Alba 18, Folium Mori 3, Radix Rubiae 2, Radix Bupleuri 26, Cortex Cinnamomi 2, Semen Ziziphi Spinosae 15, Radix Polygalae 9, Radix Ophiopogonis 3.
3. according to claim 1 and 2 arbitrary compositions, it is characterized in that: described compositions is oral liquid or capsule or pill.
4. according to claim 1 and 2 a kind of preparation method for the treatment of the Chinese medicine composition of coronary heart disease, it is characterized in that: the method comprise with above nine the flavor raw material of Chinese medicine be ground into coarse powder, add in the extraction pot, add raw medicinal herbs quality 6-8 purified water doubly, open the vacuum automatic switch, be decompressed to negative pressure 0.5-1MP, and be heated to and boil, keep slight boiling condition, economic benefits and social benefits concentrating return-flow, dynamic extraction 2-4 hour; Collect extracting solution and be evaporated to relative density 1.5-1.6; Close heater, return to gradually atmospheric pressure, carry out spray drying, first with 160 ℃ of preheating 10-20 of drying tower minutes, inlet temperature is set as 150-200 ℃, and leaving air temp is set 50-100 ℃, and pan feeding flow 1.2L/ divides, after all having sprayed, continue to keep air intake to open the discharge bucket discharging after 5 minutes and obtain dry powder.
5. a kind of preparation method for the treatment of the Chinese medicine composition of coronary heart disease according to claim 4, it is characterized in that: further dry powder is diluted 100 times with pure water, can add flavoring agent and/or antiseptic if need, and adjustment total amount, embedding, sterilization, packing namely gets oral liquid.
6. a kind of preparation method for the treatment of the Chinese medicine composition of coronary heart disease according to claim 4, it is characterized in that: further with dry powder with No. 0 capsule fill, or dry powder added a small amount of dextrin, sugar as excipient, with No. 0 capsule of fill behind the granulator granulation; Sterilization, packing namely gets capsule.
7. a kind of preparation method for the treatment of the Chinese medicine composition of coronary heart disease according to claim 4 is characterized in that: further dry powder is made the watered pill or honeyed pill according to the ordinary skill in the art.
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Non-Patent Citations (4)
| Title |
|---|
| 中医治疗女性更年期综合征;李清亚;《临床心身疾病杂志》;20080331;第14卷(第2期);184-185 * |
| 从肝论治高血压病;邵惠民;《浙江中医学院学报》;19900630;第14卷(第6期);17-19 * |
| 李清亚.中医治疗女性更年期综合征.《临床心身疾病杂志》.2008,第14卷(第2期),184-185. |
| 邵惠民.从肝论治高血压病.《浙江中医学院学报》.1990,第14卷(第6期),17-19. |
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