CN102264733A - 新型多巴胺d3受体配体，其制备方法及其医药用途 - Google Patents
新型多巴胺d3受体配体，其制备方法及其医药用途 Download PDFInfo
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- CN102264733A CN102264733A CN2009801397773A CN200980139777A CN102264733A CN 102264733 A CN102264733 A CN 102264733A CN 2009801397773 A CN2009801397773 A CN 2009801397773A CN 200980139777 A CN200980139777 A CN 200980139777A CN 102264733 A CN102264733 A CN 102264733A
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- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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Abstract
本发明涉及具有多巴胺D3受体调节活性的通式I所示新型哌嗪衍生物、其立体异构体，其药用盐、其溶剂化物及含有这些化合物的药物组合物，其制备方法，及其在预防或治疗中枢神经系统紊乱相关的疾病如帕金森氏症、精神分裂症、药物成瘾与复吸等，及在肾脏保护和免疫调节中的用途，或作为工具药用于研究D3R功能及其D3R功能紊乱相关的疾病的用途。
Description
PCT国内申请，说明书已公开。
Claims (12)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200980139777.3A CN102264733B (zh) | 2008-10-10 | 2009-09-28 | 新型多巴胺d3受体配体，其制备方法及其医药用途 |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810167089.5 | 2008-10-10 | ||
| CN200810167089 | 2008-10-10 | ||
| CN200980139777.3A CN102264733B (zh) | 2008-10-10 | 2009-09-28 | 新型多巴胺d3受体配体，其制备方法及其医药用途 |
| PCT/CN2009/001096 WO2010040274A1 (zh) | 2008-10-10 | 2009-09-28 | 新型多巴胺d3受体配体，其制备方法及其医药用途 |
Publications (2)
| Publication Number | Publication Date |
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| CN102264733A true CN102264733A (zh) | 2011-11-30 |
| CN102264733B CN102264733B (zh) | 2014-07-30 |
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| US (1) | US8829001B2 (zh) |
| EP (1) | EP2354136B1 (zh) |
| JP (1) | JP5701213B2 (zh) |
| CN (1) | CN102264733B (zh) |
| WO (1) | WO2010040274A1 (zh) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9227944B2 (en) * | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
| CN103073524B (zh) * | 2013-01-25 | 2015-06-10 | 宁波市微循环与莨菪类药研究所 | 4-[4-(取代苯基)哌嗪基-1]-丁胺甲酸取代芳香酯衍生物及其制备方法 |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| US9828345B2 (en) | 2013-02-28 | 2017-11-28 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| CN105461608B (zh) * | 2015-11-23 | 2017-11-28 | 东南大学 | 二氢吲哚‑2‑酮类d3受体配体及其制备方法和用途 |
| EP3495363B1 (en) | 2016-07-28 | 2023-08-23 | Shionogi & Co., Ltd | Nitrogen-containing condensed ring compounds having dopamine d3 receptor antagonistic effect |
| CN109419802B (zh) * | 2017-08-28 | 2023-01-13 | 中国人民解放军军事医学科学院毒物药物研究所 | 具有多巴胺d3受体调节活性的化合物及其用途 |
| CN108329282B (zh) * | 2018-01-16 | 2022-01-07 | 新乡医学院 | 一种苯基哌嗪类衍生物及其制备方法和应用 |
| JPWO2019146739A1 (ja) | 2018-01-26 | 2021-01-07 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する縮環化合物 |
| WO2019146740A1 (ja) | 2018-01-26 | 2019-08-01 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する環式化合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR2613365B1 (fr) | 1987-04-01 | 1989-07-28 | Adir | Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| US5633377A (en) | 1990-12-28 | 1997-05-27 | Neurogen Corporation | 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands |
| DK0712387T3 (da) | 1993-08-06 | 2000-05-29 | Upjohn Co | 2-Aminoindaner som selektive dopamin-D3-ligander |
| US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| FR2742149B1 (fr) | 1995-12-11 | 1998-02-13 | Inst Nat Sante Rech Med | Nouveaux derives de 2-naphtamides et leurs applications therapeutiques |
| IL126747A0 (en) | 1996-05-11 | 1999-08-17 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives as modulators of dopamine D3 receptors |
| WO1998006699A1 (en) | 1996-08-14 | 1998-02-19 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives and their pharmaceutical use |
| PL336628A1 (en) | 1997-05-03 | 2000-07-03 | Smithkline Beecham Plc | Derivatives of tetrahydroisoquinoline as modulators of d3 dopamine receptors |
| GB9821978D0 (en) | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
| AR022229A1 (es) | 1999-01-12 | 2002-09-04 | Abbott Gmbh & Co Kg | Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion |
| NZ526226A (en) | 2000-11-30 | 2004-05-28 | Ranbaxy Lab Ltd | 1,4-disubstituted piperazine derivatives useful as uro-selective alpha1-adrenoceptor blockers |
| KR100394083B1 (ko) | 2000-12-04 | 2003-08-06 | 학교법인 성신학원 | 도파민 ｄ3 및 ｄ4 수용체의 선택적 활성을 지닌 신규4,5-디히드로이소옥사졸릴알킬피페라진 유도체와, 이의제조방법 |
| HUP0103987A3 (en) | 2001-09-28 | 2004-11-29 | Richter Gedeon Vegyeszet | Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates |
| GB0130219D0 (en) | 2001-12-18 | 2002-02-06 | Pfizer Ltd | Compounds for the treatment of sexual dysfunction |
| DE10232020A1 (de) | 2002-07-04 | 2004-02-26 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Neurorezeptoraktive Heteroarencarboxamide |
| JP2005538974A (ja) | 2002-07-04 | 2005-12-22 | シュバルツ ファルマ アクチェンゲゼルシャフト | 中枢神経系の病気を治療するドーパミン−ｄ３リガンドとして使用するためのヘテロアレーンカルボキサミド |
| US20040204422A1 (en) | 2003-04-14 | 2004-10-14 | Abbott Gmbh & Co. Kg. | N-[(Piperazinyl)hetaryl]arylsulfonamide compounds |
| EP1778684B1 (en) | 2004-08-09 | 2009-12-16 | Abbott GmbH & Co. KG | 4-PIPERAZINYL-PYRIMIDINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D<sb>3</sb> RECEPTOR |
| CA2585857A1 (en) * | 2004-11-26 | 2006-06-01 | Janssen Pharmaceutica N.V. | Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic activity |
| FR2878524B1 (fr) | 2004-12-01 | 2007-01-19 | Bioprojet Soc Civ Ile | Nouveaux derives d'arylpiperazine |
| DE102004063797A1 (de) * | 2004-12-30 | 2006-07-13 | Schwarz Pharma Ag | Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide |
| GB0517187D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| JP2008115175A (ja) * | 2006-10-13 | 2008-05-22 | Otsuka Pharmaceut Co Ltd | 複素環化合物 |
| AR063302A1 (es) * | 2006-10-13 | 2009-01-21 | Otsuka Pharma Co Ltd | Derivados de 4-benzo[b]tiofen-4-il-piperazin-1-il con accion antagonista del receptor 5-ht2a de serotonina y receptor de adrenalina alfa1 y agonista parcial del receptor d2, una composicion farmaceutica que lo comprende y un proceso para producirla. |
| US20110251212A1 (en) * | 2007-08-21 | 2011-10-13 | Shionogi & Co., Ltd. | Piperazine derivatives |
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- 2009-09-28 WO PCT/CN2009/001096 patent/WO2010040274A1/zh active Application Filing
- 2009-09-28 CN CN200980139777.3A patent/CN102264733B/zh active Active
- 2009-09-28 EP EP09818738.8A patent/EP2354136B1/en active Active
- 2009-09-28 US US13/123,368 patent/US8829001B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5701213B2 (ja) | 2015-04-15 |
| US8829001B2 (en) | 2014-09-09 |
| US20110319423A1 (en) | 2011-12-29 |
| EP2354136A4 (en) | 2012-04-18 |
| CN102264733B (zh) | 2014-07-30 |
| JP2012505165A (ja) | 2012-03-01 |
| EP2354136B1 (en) | 2016-02-24 |
| WO2010040274A1 (zh) | 2010-04-15 |
| EP2354136A1 (en) | 2011-08-10 |
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