CN102258046A - Germicide composition with synergistic effect - Google Patents
Germicide composition with synergistic effect Download PDFInfo
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- CN102258046A CN102258046A CN2011101367160A CN201110136716A CN102258046A CN 102258046 A CN102258046 A CN 102258046A CN 2011101367160 A CN2011101367160 A CN 2011101367160A CN 201110136716 A CN201110136716 A CN 201110136716A CN 102258046 A CN102258046 A CN 102258046A
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Abstract
The invention relates to a germicide composition with a synergistic effect, particularly relates to a composition containing iprodione and hexaconazole, and is mainly used for preventing and controlling diseases of plants such as vegetables, fruit trees, cereals, flowers and the like, especially for preventing and controlling gray mold and powdery mildew. The composition contains a compound (A), a compound (B) and the balance of auxiliary components which are allowed to be used and accepted in pesticides, wherein the compound (A) is 3-(3,5-Dichlorophenyl)-2,4-dioxo-N-isopropylimidazolidine-1-carboxamide, the compound (B) is 2-(2,4-dichlorophenyl)-1-1,2,4-triazole-1-yl-hexan-2-ethanol, the weight ratio of the compound (A) to the compound (B) is (50:1)-(1:20), preferably (20:1)-(1:20).
Description
Technical field
The present invention relates to a kind of microbicide compositions, particularly contain the composition of iprodione and own azoles alcohol, be mainly used in the disease control of vegetables, fruit tree, cereal, flowers and other crops, particularly to the control of gray mold and powdery mildew with synergistic effect.
Background technology
Powdery mildew is to take place on many important crops generally, endanger seriously, difficult disease of preventing and treating.The Ascomycotina disease fungus all can cause powdery mildew, and the cause of disease crop species is a lot.Such germ arrives 10-30 in temperature
oSpore takes place and all can sprout in C, and not high to humidity requirement, normal condition can be finished and once infect circulation in following 10 days; Therefore caused season of growth of crop repeated multiple times to be infected, in case take place to cause irremediable massive losses to agricultural production under characteristics, especially the plastic greenhouse planting environment of very fast eruption and prevalence.On the agricultural, use inorganic sulfurs such as thiophanate methyl, mancozeb to the premorbid protection of crop in the time of the phase I, powdery mildew is not almost had result of treatment, sulphur preparation can not use many vegetable melon and fruit sensitivities simultaneously.In the time of second stage, be the triazole germicide series of representative, be greatly improved than the activity of first generation bactericide to powdery mildew with triazolone, nitrile bacterium azoles, alkene azoles alcohol, Difenoconazole, Flusilazole.But this compounds is single to the germ action site.Germ has cross resistance to such medicament.This compounds has excitant to plant simultaneously, and consumption will suppress plant growing slightly greatly, reduces output.Such pharmacy control efficacy is substantially at 70-80%, and effect is general.Phase III is the noval chemical compound kind of representative with the import kresoxim-methyl, mechanism of action uniqueness, and action site is more, and specially the property controlled is higher to powdery mildew, and effect can reach more than 90%; But because domestic long-term in recent years use has continuously produced obvious pesticide resistance, and effect descends to some extent, the reagent cost of import simultaneously is too high.
Since the last century the eighties, the gray mold of crops has and progressively increases the weight of the trend that takes place, especially on melon and fruit and vegetables.The economic loss that this disease causes is generally 20-30%, can reach more than 50% when serious.In the agricultural production, for a long time with benzimidazole germicide such as carbendazim, carboxylic acid imide fungicides such as iprodione, Sukeling etc. are main, prevent and treat such disease singlely, the variation frequency of pathogen self is big in addition, cause pathogen that these medicaments have been produced pesticide resistance in various degree, and its anti-medicine heredity is very stable.For example, the control efficiency when carbendazim uses the earliest can reach more than 90%, but has only below 30% now, even invalid substantially sometimes.
Iprodione (iprodione) is that molecular formula is C by the dicarboximide series bactericidal agent of Beyer Co., Ltd's exploitation
13H
13Cl
2N
3O
3, chemical name is 3-(3, the 5-dichlorophenyl)-N-isopropyl-2,4-dioxo imidazoline-1-carboxylic acid amides is disclosed among the US3823240.Iprodione is a kind of wide spectrum contact bactericide, is mainly used in the gray mold of crops such as control fruit tree, vegetables, melon and fruit class.Signal in the cell of its energy Profilin kinases, the many cell functions of control comprises that carbohydrate is in conjunction with the interference effect that enters the fungi component.Therefore it both can suppress fungus spore germination and generation, also can suppress mycelial growth.Promptly all influential to pathogen each developmental stage in the history of life, can prevent and treat the fungi that the benzimidazole systemic fungicide is had resistance.Main controlling object is various crop, fruit tree and the fruit storage phase disease that Botrytis, clump stalk spore genus, Penicillium, Sclerotinia, Alternaria, Helminthosporium etc. cause.
Own azoles alcohol, chemical name: 2-(2,4-dichlorophenyl)-1-[1; 2,4] triazol-1-yl-own-2-alcohol belongs to azoles fungicide; the sterol demethylation inhibitor, the disease that fungi especially Basidiomycotina and Ascomycotina are caused has the protection and the therapeutic action of broad spectrum activity.Destroy and stop the biosynthesis of the cell membrane important composition composition ergosterol of germ, cause cell membrane not form, make germ death.Have interior suction, protection and therapeutic activity.Can prevent banded sclerotial blight, powdery mildew, black viral disease, spot defoliation, scab, false smut etc.Suitable crop and fruit tree such as apple, grape, banana, pear tree, vegetables (melon and fruit, capsicum etc.), peanut, coffee, cereal crop and ornamental plants etc.The fungicidal spectrum of own azoles alcohol is wide, active high, and has the plant resistance of enhancing and function in delaying senility.
Composite about iprodione and own azoles alcohol do not see relevant report at present at home and abroad.Iprodione is a special agent of preventing and treating gray mold, because use year for a long time, germ has produced pesticide resistance and poor effect.Own azoles alcohol all has good preventing and result of treatment to gray mold and multiple fungal disease, and the plant of enhancing disease resistance, function in delaying senility are arranged.
Summary of the invention
The present invention seeks to provides a kind of microbicide compositions with synergistic effect at above-mentioned weak point, microbicide compositions of the present invention satisfies the needs of agricultural production, make full use of two kinds of synergistic effects that active component is mixed and is produced, improve preventive effect and delay the drug-fast generation of germ, the present invention is a kind of efficient, environmental protection, safety and the bactericidal composition that contains iprodione and own azoles alcohol that helps the germ resistance management.
The present invention has carried out various further investigations for solving above-mentioned problem, found that: the composition that contains iprodione and own azoles alcohol, not only for phytopathogen, effective to phytopathogens such as ash arrhizus bacterias especially, and it is also very effective to these medicament drug resistance bacterium, recur in disease and also to have good control efficiency under the condition, thereby finished the present invention.In addition, large-scale plant disease is effective to composition of the present invention under the condition to recurring.
The discovery that the present invention is surprised, iprodione and own azoles alcohol are composite, control vegetables, flowers gray mold and other fungal diseases are had obvious synergistic effect, and do not have cross resistance between iprodione and the own azoles alcohol.
Surprisingly, the bactericidal effect after the active compound combination of the present invention, more much bigger than single reactive compound effect sum.Thereby have expection less than, pure trade-off effect, this effect is not a simple addition.
A kind of microbicide compositions with synergistic effect of the present invention is to take following technical scheme to realize:
A kind of microbicide compositions with synergistic effect is characterized in that described composition contains:
A) 1-isopropylamine base formoxyl-3-(3, the 5-dichlorophenyl) hydantoins, following formula (I):
(iprodione)
And
B) 2-(2, the 4-dichlorophenyl)-1-[1,2,4] triazol-1-yl-oneself-2-alcohol, following formula (II):
(own azoles alcohol)
Wherein the mass ratio of compd A and B is 50:1-1:20, and ratio is 20:1-1:10 preferably, and all the other are to allow in the agricultural chemicals to use and the acceptable auxiliary element.
The content of present composition active component depends on the dosage when bactericide uses separately, also depends on the mixed ratio and the synergistic effect degree of a kind of bactericide and another kind of bactericide.In the described microbicide compositions with synergistic effect, the quality percentage composition that compd A and compd B account in the bactericidal composition is 5%-80%, and the quality percentage composition that compd A and compd B account in the bactericidal composition is preferably 10%-60%.
Bactericidal composition of the present invention can be prepared into known method and be fit to any one formulation that agricultural is used, and reasonable formulation is wetting powder, missible oil, suspending agent, microemulsion, aqueous emulsion, water dispersible granules.
The auxiliary agent that uses in the bactericidal composition of the present invention comprises that solvent, dispersant, emulsifier, stabilizing agent, antifreezing agent, thickener etc. and other are of value to the known substance that active ingredient is stablized and drug effect is brought into play in preparation, all be the various compositions of using or allow use in the agricultural chemicals always, be not particularly limited, concrete composition and consumption require to determine by simple experiment according to prescription.
The liquid-carrier that is fit to preparation microbicide compositions of the present invention comprises aromatic hydrocarbons, aliphatic hydrocarbon.Particularly suitable be polar solvent, as alcohols and their ether and ester.Also have vegetable oil and the molten fiber of methyl in addition.Simultaneously, mixtures of different liquids also is suitable for.
The solid carrier that is fit to preparation microbicide compositions of the present invention is any carrier that is generally used for preparing bactericide.For example diatomite, Magnesiumaluminumsilicate, atlapulgite, kaolin, clay, gypsum, bentonite, white carbon, precipitated calcium carbonate, lime stone, wood chip, corn starch, soluble starch etc.
The emulsifier that is fit to preparation microbicide compositions of the present invention can be anion and/or non-example type emulsifier, for example alkylphenol polyoxyethylene, alkylphenol-polyethenoxy polyethenoxy ether, benzylphenol APEO, polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether, polyoxyethylene fatty amine, alkyl phenol polyglycol ether etc.
The dispersant that is fit to preparation microbicide compositions of the present invention can be alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, the alkylphenol-polyethenoxy based phosphates, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, the alkylphenol polyoxyethylene phosphate, alkylphenol polyoxyethylene, the castor oil ethylene oxide adduct, ethylene oxide-propylene oxide block copolymer, the dirt of alkylphenol polyoxyethylene formaldehyde condensation, octylphenol polyethylene oxyethylene group ether sulfate and methylcellulose.For example sodium lignin sulfonate, calcium lignosulfonate, methyl naphthalene sulfonate formaldehyde condensate, the dirt of sodium naphthalene sulfonate formaldehyde condensation, methanonaphthalene sodium sulfonate etc.
Other additive can be enumerated the carboxymethyl cellulose that uses with the auxiliary agent form usually, ethylene glycol and propane diols etc. when preparation.
Composition of the present invention can also contain colouring agent, for example inorganic pigment iron oxide, titanium oxide or Prussia orchid; Organic dyestuff alizarin, azo dyes, metal phthalocyanine orchid or kiton colors etc.
The described a kind of application of microbicide compositions bactericidal composition on control of crop disease with synergistic effect.
Described crop in a kind of application of microbicide compositions bactericidal composition on control of crop disease with synergistic effect is vegetables, fruit tree, flowers, cereal.
Described a kind of microbicide compositions with synergistic effect is used for the control of gray mold.
Composition of the present invention can also have the medicament of weeding, desinsection or bactericidal property with other, particularly mixes use with protective fungicide, also can mix use with nematocide, protective agent, growth regulator, nutrient for plants or soil conditioner.
Composition of the present invention can be used by common method, and amount of application is with weather or crop state variation, use optimum period and be crop susceptible before or the susceptible initial stage.Its lasting period is relevant with the content in the composition, also relevant with extraneous factor usually.
A kind of bactericidal composition with synergistic effect of the present invention has very good sterilization idiocratic, can be used to prevent and treat the pathogen on the various crop.This composition can good control causes the pathogen and the medicament drug-fast bacteria of following disease: the gray mold of tomato, leaf rust, spot disease, anthracnose and phytophthora root rot early; The powdery mildew of cucumber, gray mold, anthracnose, climing rot, black spot and brown spot; Anthracnose of strawberry and gray mold; The powdery mildew of pumpkin, anthracnose and climing rot; Hickie leaf blight, black spot, gray mold and the Mild Powder of onion; The powdery mildew of eggplant, gray mold and bacterial blight; The black spot of shallot; Leucoplakia of Chinese cabbage and black spot; The stalk break of green pepper and gray mold; The powdery mildew of muskmelon, anthracnose and climing rot; The gray mold of lettuce; Black spot of red bayberry and gray mold; The powdery mildew of persimmon, anthracnose, gray mold and defoliation; The scab of pears, black spot and phytophthora root rot early; The gray mold of grape, anthracnose, brown spot, black rattan disease, withered rattan disease, sticking rot and the swollen disease of branch; The scab of peach, graywall, anthracnose; The spot defoliation of apple, anthracnose, scab, zonate spot, brown spot, diplostomiasis and brown rot; The stem wilt of mung bean, anthracnose, gray mold and stalk break; The anthracnose of Kidney bean, gray mold and stalk break; The ring spot of broad bean; Soybean purple speck; The powdery mildew of tobacco, the brown spot of beet and spot disease; Withered disease of the anthracnose of tea, zonate spot and sprouting and gray mold; The plant diseases such as scab, anthracnose, gray mold and powdery mildew of flower class.Phytopathogen and medicament drug-fast bacterias such as ash arrhizus bacteria on crops such as control fruit tree that particularly can be good, vegetables and the flowers.
Product described in the invention can the finished product preparation form provide, and promptly each material mixes in the composition, and the composition of composition also can provide with single agent form, directly directly mixes in bucket or in the jar before the use, is diluted to required concentration then.The frequency of administration of the present composition and amount of application change with weather condition and crop state, can reach the purpose of control by using suitable formulation.
The present invention also comprises on-the-spot method of administering fungi: handle this place with microbicide compositions of the present invention, wherein the place comprises and is subjected to fungal infection or the plant of not infecting, the seed of these plants or the medium of plant growing.
Composition of the present invention has the following advantages:
1. said composition can show obvious synergistic effect in certain ratio range, and its bactericidal effect obviously improves;
2. said composition can reduce the using dosage of medicament in application, thereby has reduced cost and the pollution that has alleviated environment;
3. in the said composition, iprodione is mainly used in the gray mold of control crop, and own azoles alcohol also has good activity to gray mold, thus its composition to the crop gray mold have more synergy, preventive and therapeutic effect targetedly.
Embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to these examples absolutely not.The following stated only is the present invention embodiment preferably, only in order to explain the present invention, can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that all any modifications of being made within the spirit and principles in the present invention, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
The combination of active principles of different agricultural chemicals is made agricultural chemicals, is a kind of mode effectively and efficiently that exploitation at present and development novel pesticide and control agricultural go up the resistance germ.The agricultural chemicals of different cultivars shows three kinds of type of action: summation action, synergistic effect and antagonism after mixing usually.But be specially which kind of effect, unpredictable, have only by a large amount of experiments and just can know.Compound synergic is well filled a prescription, owing to obviously improved actual control efficiency, reduced the usage amount of agricultural chemicals, thereby delayed the drug-fast generation speed of germ widely, and be the important means of integrated control disease.
The inventor is by a large amount of screening tests, iprodione is carried out the synergistic effect analysis of different proportionings with own azoles alcohol microbicide compositions, discovery is in certain ratio range, iprodione and own azoles alcohol microbicide compositions antagonism phytopathogen have obvious role in synergism, and be not only the simple addition of two kinds of medicaments, specifically be illustrated with following biologicall test example.
Biologicall test embodiment 1:
Iprodione and own azoles alcohol are to the Toxicity Determination and the proportioning screening of botrytis cinerea pers
Adopt potted plant spray-on process, measure the iprodione and the composite indoor virulence of own azoles alcohol of different proportion botrytis cinerea pers.
Calculate the toxicity index of each medicament and the co-toxicity coefficient of mixture (CTC value) according to the abundant method of Sun Yun, when CTC≤80, then compositions table reveals antagonism, when 80＜CTC＜120, then compositions table reveals summation action, and when CTC 〉=120, then compositions table reveals synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) X100
The percentage composition of B in percentage composition+B medicament toxicity index X mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index X mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] X100
Table 1 iprodione and own azoles alcohol are to the Toxicity Determination and the proportioning screening of botrytis cinerea pers
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Iprodione | 35.2 | 100 | ? | ? |
| Own azoles alcohol | 14.6 | 241.1 | ? | ? |
| Iprodione 50: own azoles alcohol 1 | 28.1 | 125.3 | 102.8 | 121.9 |
| Iprodione 30: own azoles alcohol 1 | 23.8 | 147.9 | 104.6 | 141.5 |
| Iprodione 20: own azoles alcohol 1 | 21.3 | 165.3 | 106.7 | 154.9 |
| Iprodione 10: own azoles alcohol 1 | 18.7 | 188.2 | 112.8 | 166.8 |
| Iprodione 7: own azoles alcohol 1 | 16.5 | 213.3 | 117.6 | 181.3 |
| Iprodione 3: own azoles alcohol 1 | 12.9 | 272.9 | 135.3 | 201.7 |
| Iprodione 1: own azoles alcohol 1 | 10.7 | 329.0 | 170.5 | 192.9 |
| Iprodione 1: own azoles alcohol 5 | 9.2 | 382.6 | 217.6 | 175.8 |
| Iprodione 1: own azoles alcohol 10 | 10.1 | 348.5 | 228.3 | 152.7 |
| Iprodione 1: own azoles alcohol 15 | 11.2 | 314.3 | 232.3 | 135.3 |
| Iprodione 1: own azoles alcohol 20 | 11.9 | 295.8 | 234.4 | 126.2 |
The result shows that iprodione and own azoles alcohol have obvious synergistic effect to botrytis cinerea pers between proportioning 50:1-1:20, and especially between 20:1-1:10, co-toxicity coefficient is more than 150.
Biologicall test example 2:
Iprodione and the composite Toxicity Determination of own azoles alcohol to early blight of tomato
Adopt potted plant spray-on process, measure the iprodione and the composite indoor virulence of own azoles alcohol of different proportion tomato early blight bacterium.
Table 2 iprodione and own azoles alcohol are to the Toxicity Determination and the proportioning screening of tomato early blight bacterium
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Iprodione | 32.2 | 100 | ? | ? |
| Own azoles alcohol | 12.5 | 257.6 | ? | ? |
| Iprodione 50: own azoles alcohol 1 | 25.3 | 127.3 | 103.1 | 123.5 |
| Iprodione 30: own azoles alcohol 1 | 22.1 | 145.7 | 105.1 | 138.7 |
| Iprodione 20: own azoles alcohol 1 | 20.1 | 160.2 | 107.5 | 149.0 |
| Iprodione 10: own azoles alcohol 1 | 16.6 | 194.0 | 114.3 | 169.7 |
| Iprodione 7: own azoles alcohol 1 | 14.6 | 220.5 | 119.7 | 184.3 |
| Iprodione 3: own azoles alcohol 1 | 11.9 | 270.6 | 139.4 | 194.1 |
| Iprodione 1: own azoles alcohol 1 | 9.2 | 350.0 | 178.8 | 195.7 |
| Iprodione 1: own azoles alcohol 5 | 8.2 | 392.7 | 231.3 | 169.7 |
| Iprodione 1: own azoles alcohol 10 | 9.1 | 353.8 | 243.3 | 145.5 |
| Iprodione 1: own azoles alcohol 15 | 10.0 | 322.0 | 247.8 | 130.0 |
| Iprodione 1: own azoles alcohol 20 | 10.7 | 300.9 | 250.1 | 120.3 |
The result shows that iprodione and own azoles alcohol have obvious synergistic effect between proportioning 50:1-1:20, and co-toxicity coefficient is more than 120.
Biologicall test example 3:
Iprodione and the composite Toxicity Determination of own azoles alcohol to apple tree spot defoliation bacterium
Adopt potted plant spray-on process, measure the iprodione and the composite indoor virulence of own azoles alcohol of different proportion apple tree spot defoliation bacterium.
Table 3 iprodione and own azoles alcohol are to Toxicity Determination and the proportioning screening of apple tree spot defoliation bacterium
| Handle | EC 50（μg/ml） | ATI | TTI | CTC |
| Iprodione | 24.8 | 100 | ? | ? |
| Own azoles alcohol | 10.2 | 243.1 | ? | ? |
| Iprodione 50: own azoles alcohol 1 | 20.1 | 123.4 | 102.8 | 120.0 |
| Iprodione 30: own azoles alcohol 1 | 17.8 | 139.3 | 104.6 | 133.2 |
| Iprodione 20: own azoles alcohol 1 | 16.2 | 153.1 | 106.8 | 143.3 |
| Iprodione 10: own azoles alcohol 1 | 14.8 | 167.6 | 113.0 | 148.3 |
| Iprodione 7: own azoles alcohol 1 | 13.1 | 189.3 | 117.9 | 160.6 |
| Iprodione 3: own azoles alcohol 1 | 9.8 | 253.1 | 135.8 | 186.4 |
| Iprodione 1: own azoles alcohol 1 | 8.5 | 291.8 | 171.6 | 170.1 |
| Iprodione 1: own azoles alcohol 5 | 7.5 | 330.7 | 219.3 | 150.8 |
| Iprodione 1: own azoles alcohol 10 | 7.7 | 322.1 | 230.1 | 140.0 |
| Iprodione 1: own azoles alcohol 15 | 8.3 | 298.8 | 234.2 | 127.6 |
| Iprodione 1: own azoles alcohol 20 | 8.6 | 288.4 | 236.3 | 122.0 |
The result shows that iprodione and own azoles alcohol have obvious synergistic effect between proportioning 50:1-1:20, and co-toxicity coefficient is more than 120.
Embodiment
Embodiment 1:40% iprodione+own azoles alcohol wetting powder
Iprodione 30%
Own azoles alcohol 10%
Lauryl sodium sulfate 2%
Sodium lignin sulfonate 5%
White carbon 10%
Kaolin complements to 100%
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get 40% iprodione+own azoles alcohol wetting powder.
This embodiment is used to prevent and treat the grape grey mould germ.40% iprodione+own azoles alcohol wetting powder is pressed 1000 extraordinarily water dilution sprayings, and 7 days control efficiency is 91.4% behind the medicine.1000 times of 50% iprodione wettable powder dilutions are used with quadrat method and are used, 7 days preventive effect 79.4% behind the medicine.Synergistic effect is obvious behind the pure and mild iprodione of own azoles, to the preventive effect of grape grey mould significantly better than single agent; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
Embodiment 2:20% iprodione+hexaconazole suspending agent
Iprodione 10%
Own azoles alcohol 10%
Methyl naphthalene sulfonate formaldehyde condensate 10%
Xanthans 1%
Bentonite 1%
Glycerine 5%
Water complements to 100%
The ratio of each component such as active component, dispersant, wetting agent and water in prescription mixed, through grind and/obtain 20% iprodione+hexaconazole suspending agent after the high speed shear.
This embodiment is used to prevent and treat the apple tree spot defoliation.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 93% behind the medicine with 20% own azoles alcohol+iprodione suspending agent.20% iprodione+15% carbendazim suspending agent is used with quadrat method and is used by 1000 times of dilutions, and 7 days preventive effect is 87.4% behind the medicine.Synergistic effect is obvious behind own azoles alcohol and the iprodione, to the preventive effect of apple tree spot defoliation significantly better than existing iprodione preparation.
Embodiment 3:22% iprodione+hexaconazole aqueous emulsion
Iprodione 20%
Own azoles alcohol 2%
N-Methyl pyrrolidone 10%
Calcium dodecyl benzene sulfonate 5%
The newborn 600# 5% of farming
Water complements to 100%.
Former medicine, solvent, emulsifier are added together, make and be dissolved into even oil phase; With water-msoluble ingredients and the mixed water that gets of water; Under high-speed stirred, oil phase is mixed with water, make 22% own azoles alcohol+iprodione aqueous emulsion.
This embodiment is used to prevent and treat cucumber anthracnose.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 94.2% behind the medicine with 22% iprodione+hexaconazole aqueous emulsion.40% thiophanate-methyl+20% iprodione wettable powder dilutes 2000 times, uses with quadrat method and uses, and 7 days preventive effect is 86.8% behind the medicine.The composite back synergistic effect of iprodione and own azoles alcohol is obvious, to the preventive effect of cucumber anthracnose significantly better than existing iprodione preparation; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
The own azoles alcohol of embodiment 4:50% iprodione+1% wetting powder
Iprodione 50%
Own azoles alcohol 1%
Lauryl sodium sulfate 2%
Sodium lignin sulfonate 5%
White carbon 10%
Kaolin complements to 100%
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get the own azoles alcohol of 50% iprodione+1% wetting powder.
This embodiment is used for early blight of tomato.By 2000 extraordinarily water dilution sprayings, 7 days control efficiency is 95.3% behind the medicine with the own azoles alcohol of 50% iprodione+1% wetting powder.50% iprodione wettable powder is used with quadrat method and is used, 7 days preventive effect 81.6% behind the medicine by 2000 times of dilutions.Composite dose of iprodione and own azoles alcohol to the preventive effect of early blight of tomato significantly better than single agent.
Embodiment 5:20% iprodione+1% hexaconazole suspending agent
Iprodione 20%
Own azoles alcohol 1%
Methyl naphthalene sulfonate formaldehyde condensate 5%
Xanthans 1%
Bentonite 1%
Glycerine 3%
Water complements to 100%
The ratio of each component such as active component, dispersant, wetting agent and water in prescription mixed, through grind and/obtain 20% iprodione+1% hexaconazole suspending agent after the high speed shear.
This embodiment is used to prevent and treat sclerotinia rot of colza.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 95.4% behind the medicine with 20% iprodione+1% hexaconazole suspending agent.The 255g/L iprodione suspending agent is used with quadrat method and is used by 1000 times of dilutions, and 7 days preventive effect is 85.4% behind the medicine.Own azoles alcohol and iprodione to the preventive effect of sclerotinia rot of colza significantly better than single agent.
Embodiment 6:8% iprodione+8% hexaconazole suspending agent
Iprodione 8%
Own azoles alcohol 8%
Methyl naphthalene sulfonate formaldehyde condensate 5%
Xanthans 1%
Bentonite 1%
Glycerine 3%
Water complements to 100%
The ratio of each component such as active component, dispersant, wetting agent and water in prescription mixed, through grind and/obtain 8% iprodione+8% hexaconazole suspending agent after the high speed shear.
This embodiment is used to prevent and treat the banana crown rot.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 97.3% behind the medicine with 8% iprodione+8% hexaconazole suspending agent.With 8% Prochloraz+1000 times of dilutions of 8% iprodione suspending agent, to use with quadrat method and use, 7 days preventive effect is respectively 85% behind the medicine.Synergistic effect is obvious behind own azoles alcohol and the iprodione, to the preventive effect of banana crown rot significantly better than existing iprodione preparation.
The own azoles alcohol of embodiment 7:10% iprodione+1% missible oil
Iprodione 10%
Own azoles alcohol 1%
N-Methyl pyrrolidone 10%
Calcium dodecyl benzene sulfonate 5%
The newborn 600# 5% of farming
Former medicine, solvent, emulsifier are added together, make and be dissolved into even oil phase, obtain the own azoles alcohol of 10% iprodione+1% missible oil
This embodiment is used for the apple tree spot defoliation.By 500 extraordinarily water dilution sprayings, 7 days preventive effect is 95.7% behind the medicine with the own azoles alcohol of 10% iprodione+1% missible oil.10% height oozes 500 times of iprodione missible oil dilutions, and use uses the same method.7 days preventive effect is 85% behind the medicine.The composite back synergistic effect of iprodione and own azoles alcohol is obvious, to the preventive effect of apple tree spot defoliation significantly better than single agent.
8: 1% iprodione+20% hexaconazole suspending agents of embodiment
Iprodione 1%
Own azoles alcohol 20%
Methyl naphthalene sulfonate formaldehyde condensate 5%
Xanthans 1%
Bentonite 1%
Glycerine 3%
Water complements to 100%
The ratio of each component such as active component, dispersant, wetting agent and water in prescription mixed, through grind and/obtain 1% iprodione+20% hexaconazole suspending agent after the high speed shear.
This embodiment is used to prevent and treat pear scab.By 2000 extraordinarily water dilution sprayings, 7 days control efficiency is 94.3% behind the medicine with 1% iprodione+20% hexaconazole suspending agent.30% hexaconazole suspending agent is by 2000 times of dilutions, with using with quadrat method, behind the medicine 7 days preventive effect be 86.4% own azoles alcohol with iprodione after synergistic effect obvious, to the preventive effect of pear scab significantly better than single agent, and the consumption of active ingredient obviously reduces, thereby has alleviated the pollution to environment.
9: 4% own azoles alcohol of iprodione+40% of embodiment wetting powder
Iprodione 4%
Own azoles alcohol 40%
Lauryl sodium sulfate 2%
Sodium lignin sulfonate 5%
White carbon 10%
Kaolin complements to 100%
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get the own azoles alcohol of 4% iprodione+40% wetting powder.
This embodiment is used to prevent and treat rice sheath blight disease.By 2000 extraordinarily water dilution sprayings, 7 days control efficiency is 94.2% behind the medicine with the own azoles alcohol of 4% iprodione+40% wetting powder.50% own azoles alcohol wetting powder is used with quadrat method and is used by 2000 extraordinarily water dilutions, and 7 days preventive effect is 85.2% behind the medicine.The composite back synergistic effect of iprodione+own azoles alcohol is obvious, and significantly better than single agent, and the consumption of active ingredient obviously reduces to the preventive effect of rice sheath blight disease, thereby alleviated the pollution to environment.
10: 1% iprodione+20% hexaconazole suspending agents of embodiment
Iprodione 1%
Own azoles alcohol 20%
Methyl naphthalene sulfonate formaldehyde condensate 5%
Xanthans 1%
Bentonite 1%
Glycerine 3%
Water complements to 100%
The ratio of each component such as active component, dispersant, wetting agent and water in prescription mixed, through grind and/obtain 1% iprodione+20% hexaconazole suspending agent after the high speed shear.
This embodiment is used to prevent and treat powdery mildew of cucumber.By 2000 extraordinarily water dilution sprayings, 7 days control efficiency is 96.1% behind the medicine with 1% iprodione+20% hexaconazole suspending agent.10% hexaconazole suspending agent is used with quadrat method and is used by 1000 times, and 7 days preventive effect is 82.4% behind the medicine.The pure and mild iprodione agent of own azoles to the preventive effect of powdery mildew of cucumber significantly better than single agent.
Embodiment 11 2% iprodiones+3% hexaconazole microemulsion
Iprodione 2%
Own azoles alcohol 3%
Calcium dodecyl benzene sulfonate 10%
The newborn 600# 10% of farming
N-Methyl pyrrolidone complements to 100%
Former medicine, solvent, emulsifier are added together, make and be dissolved into even oil phase and make 3% iprodione+2% hexaconazole aqueous emulsion.
This embodiment is used to prevent and treat the apple tree powdery mildew.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 91.2% behind the medicine with 2% iprodione+3% hexaconazole microemulsion.5% hexaconazole microemulsion is used with quadrat method and is used by 1000 times of dilutions, and 7 days preventive effect is 86.8% behind the medicine.The composite back synergistic effect of iprodione and own azoles alcohol is obvious, to the preventive effect of apple tree powdery mildew significantly better than single agent.
Embodiment 12 50% iprodiones+30% diniconazole water dispersible granule
Iprodione 50%
Own azoles alcohol 30%
Negel 5%
Sodium lignin sulfonate 7%
Lauryl sodium sulfate 2%
Sulfuric acid amine 5%
Precipitated calcium carbonate complements to 100%
Active component, dispersant, wetting agent, disintegrant and the filler ratio in prescription is mixed, become wetting powder through comminution by gas stream, add a certain amount of water mixing extruder grain again, obtain 50% iprodione+30% diniconazole water dispersible granule after the drying screening.
This embodiment is used to prevent and treat the apple tree spot defoliation.By 4000 extraordinarily water dilution sprayings, 7 days control efficiency is 98.2% behind the medicine with 50% iprodione+30% diniconazole water dispersible granule.17.5% carbendazim+35% iprodione suspending agent is used with quadrat method and is used by 2000 times of dilutions, and 7 days preventive effect is 87.8% behind the medicine.The composite back synergistic effect of iprodione and own azoles alcohol is obvious, to the preventive effect of apple tree spot defoliation significantly better than existing iprodione preparation.
Claims (9)
1. microbicide compositions with synergistic effect is characterized in that described composition contains:
A) following formula (I):
1-isopropylamine base formoxyl-3-(3, the 5-dichlorophenyl) hydantoins of expression, and
B) following formula (II):
(II)
The 2-(2 of expression, the 4-dichlorophenyl)-1-[1,2,4] triazol-1-yl-oneself-2-alcohol.
2. a kind of microbicide compositions with synergistic effect according to claim 1, the mass ratio that it is characterized in that described compd A and B is 50:1-1:20.
3. a kind of microbicide compositions with synergistic effect according to claim 1, the mass ratio that it is characterized in that described compd A and B is 20:1-1:10.
4. a kind of microbicide compositions with synergistic effect according to claim 1 is characterized in that described compd A and B and liquid-carrier or solid carrier and/or surfactant mix.
5. a kind of microbicide compositions with synergistic effect according to claim 1 is characterized in that the quality percentage composition that compd A and compd B account in the bactericidal composition is 5%-80% in the described microbicide compositions with synergistic effect.
6. a kind of microbicide compositions with synergistic effect according to claim 1, the formulation that it is characterized in that described microbicide compositions is wetting powder, missible oil, suspending agent, microemulsion, aqueous emulsion, water dispersible granules.
7. the described a kind of application of microbicide compositions on control of crop disease of claim 1 with synergistic effect.
8. the described crop in the described a kind of application of microbicide compositions on control of crop disease with synergistic effect of claim 7 is vegetables, fruit tree, flowers, cereal.
9. the described a kind of microbicide compositions with synergistic effect of claim 7 is used for the control of gray mold.
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| CN2011101367160A CN102258046A (en) | 2011-05-25 | 2011-05-25 | Germicide composition with synergistic effect |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565481A (en) * | 1994-01-14 | 1996-10-15 | Rhone-Poulenc Agrochimie | Fungicides comprising iprodione and a triazole |
| CN101524078A (en) * | 2009-01-16 | 2009-09-09 | 陕西韦尔奇作物保护有限公司 | Sterilizing composition compositing Tebuconazole and iprodione |
| CN102150680A (en) * | 2010-12-16 | 2011-08-17 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing iprodione and triazole compound |
-
2011
- 2011-05-25 CN CN2011101367160A patent/CN102258046A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565481A (en) * | 1994-01-14 | 1996-10-15 | Rhone-Poulenc Agrochimie | Fungicides comprising iprodione and a triazole |
| CN101524078A (en) * | 2009-01-16 | 2009-09-09 | 陕西韦尔奇作物保护有限公司 | Sterilizing composition compositing Tebuconazole and iprodione |
| CN102150680A (en) * | 2010-12-16 | 2011-08-17 | 陕西韦尔奇作物保护有限公司 | Bactericidal composition containing iprodione and triazole compound |
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