CN102258047B - Germicide composition - Google Patents
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Abstract
The invention relates to a germicide composition with synergistic effect, in particular to a germicide composition containing iminoctadine tris(albesilate) (bellkute) and polyoxin. The composition contains A) iminoctadine tris(albesilate) (bellkute) and B) polyoxin, wherein the chemical name of A) is 1,1'-iminobis(1,8-octadienyl) iminoctadine tris; the chemical name of B) is 5-{[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylosyl]amino}-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidyl]-beta-D-sec-D-glucuronic acid; and the mass ratio of the compound A to the compound B is (500:1)-(1:1). The invention provides application of the germicide composition to control of crop diseases. The germicide composition is used for controlling crop powdery mildew and gray mold.
Description
Technical field
What microbicide compositions of the present invention related to is a kind of microbicide compositions with synergistic effect, especially a kind of microbicide compositions that contains biguanides three octyl benzene sulfonates (hundred can get) and polyoxin.
Background technology
Agriculture and garden crop (cereal class, melon and fruit, vegetables, flowers) goes up, and multiple fungal disease often takes place, as black spot, powdery mildew, damping off, fusarium wilt, gray mold, scab, anthracnose, leaf spot, early blight etc.
Biguanides three octyl benzene sulfonates (hundred can get), the iminoctadine class, mainly biosynthesis and the cell membrane function to the lipids of fungi works, and suppresses the formation of spore germination, germ tube elongation, appresorium and mycelia, is that a class is tagged and preventative bactericide.To tomato, grape grey mould, the apple tree spot defoliation, powdery mildew of cucumber, the climing rot of watermelon all have good preventive effect.But such disease of single control, the variation frequency of pathogen self is big in addition, causes pathogen that these medicaments have been produced pesticide resistance in various degree, and its anti-medicine heredity is very stable.
Polyoxin (polyoxin) is the metabolite that streptomyces aureus produces, and belongs to the broad-spectrum antibiotics class, inhale conduction in having preferably, its mechanism of action is to disturb the chitinous biosynthesis of germ cell wall, and germ tube is with after mycelium contacts medicament, and expand the part, break, overflow cell inclusion, and can not normal development cause death, suppress germ in addition and produce spore and scab expansion effect, this medicine does not have toxicity to animal, and plant is not had poisoning.Can be used for preventing and treating multiple fungal diseases such as paddy rice, wheat, vegetables, fruit tree.
Composite about biguanides three octyl benzene sulfonates and polyoxin do not see relevant report at present both at home and abroad.
Summary of the invention
The present invention has carried out various further investigations for solving above-mentioned problem, found that: the composition that contains biguanides three octyl benzene sulfonates (hundred can get) and polyoxin, not only for common phytopathogen, and it is also very effective that those have been produced chemical sproof pathogen (comprising fungi and bacterium), recur in disease and also to have good control efficiency under the condition, thereby finished the present invention.
Experiment shows, contains the bacteriocide compositions for agricultural and horticultural use that following composition is made the novelty of active ingredient, has very good sterilizing power:
A) biguanides three octyl benzene sulfonates (hundred can get), chemical name 1 ' 1-imino group (octyl group methylene) biguanides 3(alkyl benzene sulfonate)
B) polyoxin, chemical name 5-[[2-amino-5-O-(amino carbonyl)-2-deoxidation-L-xylosyl] amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1 (2H)-pyrimidine radicals]-β-D-furanose aldehydic acid in addition
Surprisingly, the bactericidal effect of active compound of the present invention, more much bigger than single reactive compound effect sum.Thereby have expection less than, pure synergy, this effect is not simple addition.
Microbicide compositions of the present invention is to take following technical scheme to realize:
A kind of microbicide compositions is characterized in that described composition contains:
A) following formula (Ia):
1 of expression, 1 '-imino group two (the inferior octyl group of 1,8-), two guanidine trialkyl benzene sulfonates, and
B) following formula (II):
5-[[2-amino-5-O-(the amino carbonyl)-2-deoxidation-L-xylosyl of expression] amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1 (2H)-pyrimidine radicals]-β-D-furanose aldehydic acid in addition;
Wherein the mass ratio of compd A and B is 500:1-1:1.
The mass ratio of described compd A and B is 200:1-1:1.
The mass percent that described compd A and B account in the microbicide compositions is 5%-80%.
The quality percentage composition that described compd A and B account in the microbicide compositions is 10%-80%.
Described compd A and B and liquid-carrier or solid carrier and/or surfactant mix.
The formulation of described microbicide compositions is wetting powder, water dispersible granules, suspending agent, coated granule.
The application of described a kind of microbicide compositions on control of crop disease.
Described a kind of microbicide compositions is used for the control of crop powdery mildew, gray mold.
1,1 '-imino group two (the inferior octyl group of 1,8-), two guanidines are known to the specific expression of formula (I), generally iminoctadine by name.
The acid-addition salts of Iminoctadine can be enumerated for example carboxylate, sulfonate, hydrochloride, carbonate, lauryl sulfate, sulphate, phosphate etc.Said carboxylate can be enumerated acetate, oxalate, laruate, oleate, citrate etc.Said sulfonate can be enumerated alkylsulfonate and alkylbenzenesulfonate etc.Said alkylsulfonate can be enumerated bay acidic group sulfonate, dodecane sulfonate etc.
Said alkylbenzenesulfonate can be enumerated dodecyl benzene sulfonate, tosilate etc.Sulfonate such as optimization acid's salt and alkylbenzenesulfonate.Wherein have 1-18 carbon atom in the preferred alkyl, more preferably have the alkylbenzenesulfonate of 10-13 carbon atom.
Can enumerate 1,1 '-imino group two (the inferior octyl group of 1,8-), two guanidines. trialkyl benzene sulfonate (two eight guanidinesalts), hundred can get, as the acid-addition salts example of Iminoctadine.This compound is represented with following structural formula:
Formula (I)Iminoctadine and acid-addition salts thereof are known material (opening clear 62-209003 communique referring to the spy).
Polyoxin, chemical name 5-[[2-amino-5-O-(amino carbonyl)-2-deoxidation-L-xylosyl] amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1 (2H)-pyrimidine radicals]-β-D-furanose aldehydic acid in addition, structural formula is as follows:
Contain following composition and make the bacteriocide compositions for agricultural and horticultural use of the novelty of active ingredient, have very good sterilizing power:
A)1,1 '-imino group two (the inferior octyl group of 1,8-), two guanidines. the trialkyl benzene sulfonate
B)5-[[2-amino-5-O-(amino carbonyl)-2-deoxidation-L-xylosyl] amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1 (2H)-pyrimidine radicals]-β-D-furanose aldehydic acid in addition
The synergy of compd A and B, obvious especially when reactive compound is present in the composition of the present invention with the specified weight ratio.But the weight ratio of reactive compound can be selected in bigger scope.Generally speaking, the weight ratio of compd A and compd B is the preferred 200:1-1:1. of 500:1-1:1.
The content of present composition active component depends on the dosage when bactericide uses separately, also depends on mixed ratio and the synergistic effect degree of a kind of bactericide and another kind of bactericide.In the described microbicide compositions with synergistic effect, the quality percentage composition that compd A and compd B account in the bactericidal composition is 5%-80%, and the quality percentage composition that compd A and compd B account in the bactericidal composition is preferably 10%-80%.
Above-mentioned composition of the present invention can only comprise active ingredient, also can be mixed together use with additive, and therefore composition of the present invention can be prepared into various formulations, liquor for example, wetting powder, emulsion, water dispersion granule, suspending agent, pulvis, microcapsules, foaming agent, paste, coated granule, tablet, aerosol etc.According to the character of these compositions and use purpose and the ambient conditions that composition will reach, can select composition is used with spraying, immersion, atomizing, the method for bumping powder, broadcast sowing or pouring etc. and so on.
Can produce these preparations by known method, for example, under the situation of selectively using surfactant, by being mixed with filler, reactive compound prepares preparation, said filler is the diluent or carrier of liquid or liquid gas or solid, said surfactant is emulsifier, dispersant, and/or foam agent.Under the situation of water as filler, also can with an organic solvent for example, organic solvent be used as cosolvent.
Liquid diluent or the carrier that can address are generally: aromatic compound is dimethylbenzene, toluene or Fluhyzon for example, chlorination aromatic compound or chlorinated aliphatic be chlorobenzene, vinyl chloride or carrene for example, aliphatic hydrocarbon is cyclohexane or paraffin petroleum distillate for example for example, mineral and vegetable oil, alcohol is butanols or ethylene glycol and ether and ester for example, ketone is acetone, MEK, methyl iso-butyl ketone (MIBK) or cyclohexanone for example, and intensive polar solvent is dimethyl formamide and dimethyl sulfoxide (DMSO) for example, or water.
But as being used for pulvis and dispersible granule, the solid carrier that is fit to is: the natural minerals of ammonium salt and pulverizing for example, for example kaolin, clay, talcum powder, chalk, quartz, attapulgite, montmorillonite or silicate, and the synthetic mineral of pulverizing for example high dispersive silica, aluminium oxide and silicate.
Spendable solid carrier is the particle of natural minerals, as kaolin, and clay, talcum, chalk, quartz, Attagel, imvite or diatomite and synthetic mineral particle, as the silicic acid of high dispersive, aluminium oxide and silicate.
The solid carrier that can be used for granule is to pulverize and the natural rock of classification for example calcite, marble, float stone, sepiolite and dolomite, and inorganic synthetic particle and organic dust, with the particle of organic product, for example sawmilling, coconut husk, corncob and tobacco stem.
The emulsifier that is fit to is: for example nonionic and anion emulsifier, for example polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether, alkylaryl polyglycol ether for example, alkylsulfonate, alkyl sulfate, arylsulphonate, or protein hydrolysate.The dispersant that is fit to is: for example lignin sulfite waste liquor and methylcellulose.
Can use for example carboxymethyl cellulose of tackifier in the preparation, and the natural and synthetic polymer of powder, particle or latex form, for example gum Arabic, polyvinyl alcohol and polyvinyl acetate or natural phospholipid, for example cephalin and lecithin, and synthetic phospholipid.Other additive is mineral oil and vegetable oil.
The colouring agent that may use such as inorganic pigment, for example, iron oxide, titanium oxide and Prussia orchid, and organic dyestuff, as alizarin dyes, azo dyes or metal phthalein mountain valley with clumps of trees and bamboo dyestuff and trace nutrient, as iron, manganese, boron, ketone, cobalt, molybdenum and zinc salt.
Active compounds of the present invention, they can its dosage forms or use with its type of service, and its type of service prepares by further dilution, as stock solution, emulsion suspension, powder is stuck with paste particle and tablet.Can use these formulations in a usual manner, for example, by pouring, dipping sprays cloth, and spraying is stifling, and immersion liquid suspends, and dressing dusts, and broadcasts sowing, dried dressing, moist dressing, wet type dressing, slurries dressing or involucrum mode.
Composition of the present invention can also have the medicament of weeding, desinsection or bactericidal property with other, particularly mixes use with protective fungicide, also can mix use with insecticide, protective agent, growth regulator, nutrient for plants or soil conditioner.
Composition of the present invention can be used by common method, and amount of application is with weather or crop state variation, use optimum period and be crop susceptible before or the susceptible initial stage.Its lasting period is relevant with the content in the composition, also relevant with extraneous factor usually.
The bactericidal composition that agriculture and garden of the present invention is used has very good sterilization idiocratic, can be used for the pathogen of agriculture and garden control plant.This composition can good control causes pathogen and the medicament drug-fast bacteria of following disease: the phytophthora root rot of tomato, gray mold, leaf rust, spot disease, anthracnose and phytophthora root rot early; The downy mildew of cucumber, powdery mildew, gray mold, anthracnose, fusarium wilt, black spot and brown spot; The anthracnose of strawberry and gray mold; The powdery mildew of pumpkin, anthracnose and fusarium wilt; Hickie leaf blight, black spot, gray mold and the Mild Powder of onion; The powdery mildew of eggplant, gray mold and withered (Huang) disease of withering; The black spot of shallot; The Leucoplakia of Chinese cabbage and black spot; The stalk break of green pepper and gray mold; The powdery mildew of cucumber, anthracnose and fusarium wilt, climing rot; The powdery mildew of muskmelon, anthracnose, fusarium wilt and climing rot; The gray mold of lettuce; The black spot of red bayberry and gray mold; The powdery mildew of persimmon, anthracnose and defoliation; The canker of oranges and tangerines, shot hole and anthracnose; The scab of pears, black spot and early blight; The gray mold of grape, anthracnose, brown spot, anthrachose of grape, dead-arm and the swollen disease of branch; The scab of peach, graywall, anthracnose; The scab of apple, zonate spot, early phytophthora root rot, brown spot, coal point disease, coal spot disease, diplostomiasis and brown rot; The stem wilt of mung bean, anthracnose, gray mold and stalk break; The anthracnose of Kidney bean, gray mold and stalk break; The ring spot of broad bean; Soybean purple speck; The powdery mildew of tobacco, the brown spot of beet and spot disease; The withered disease of the anthracnose of tea, zonate spot and sprouting and gray mold; The plant diseases such as scab, anthracnose, gray mold and powdery mildew of flower class; Rice sheath blight disease and false smut etc.
Bacteriocide compositions for agricultural and horticultural use of the present invention can be used for the time of infertility of asparagus, strawberry, pumpkin, wild cabbage, cucumber, asparagus lettuce, watermelon, onion, tomato, eggplant, shallot, Chinese cabbage, green pepper, spinach, muskmelon, muskmelon, lettuce, red bayberry, persimmon, citrus, pears, grape, peach, apple, red bean, Kidney bean, broad bean, soybean, tobacco, beet, tea, flowers class crops such as (rose, chrysanthemum, carnation, ivyleaf cyclamen, felworts etc.).
Product described in the invention can the finished product preparation form provide, and namely each material mixes in the composition, and the composition of composition also can provide with single agent form, directly directly mixes in bucket or in the jar before the use, is diluted to required concentration then.The frequency of administration of the present composition and amount of application change with weather condition and crop state, can reach the purpose of control by using suitable formulation.
The present invention also comprises the method for place mildew-resistant: handle some place with microbicide compositions of the present invention, comprise the medium that is subjected to fungi, bacterial invasion or the plant of not infecting and seed or plant growth.
Composition of the present invention has the following advantages:
1, said composition can show fabulous synergistic effect in certain ratio range, and its bactericidal effect is remarkable;
2, said composition can reduce single every mu of using dosage of planting medicament in application, thereby both can reduce influence degree, can significantly reduce agricultural cost again;
3, microbicide compositions of the present invention selects for use biguanides three octyl benzene sulfonates and polyoxin composite, has obvious synergistic effect, has enlarged fungicidal spectrum simultaneously, and is good to leaf portion and fruit, cereal crop and the ornamental plants disease-controlling effect of fruit tree, vegetables.And biguanides three octyl benzene sulfonates, polyoxin do not have cross resistance.
Embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to these examples absolutely not.The following stated only is the present invention embodiment preferably, only in order to explain the present invention, can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that all any modifications of making within the spirit and principles in the present invention, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
The combination of active principles of different agricultural chemicals is made agricultural chemicals, is a kind of mode effectively and efficiently that exploitation at present and development novel pesticide and control agricultural go up the resistance germ.The agricultural chemicals of different cultivars shows three kinds of type of action: summation action, synergistic effect and antagonism after mixing usually.But be specially which kind of effect, unpredictable, have only by a large amount of experiments and just can know.Compound synergic is well filled a prescription, owing to obviously improved actual control efficiency, reduced the usage amount of agricultural chemicals, thereby delayed the drug-fast generation speed of germ widely, and be the important means of integrated control disease.
The inventor is by a large amount of screening tests, use hundred can carry out the synergistic effect analysis of different proportionings with the polyoxin microbicide compositions, discovery is in certain ratio range, hundred can have obvious role in synergism with polyoxin microbicide compositions antagonism phytopathogen, and be not only the simple addition of two kinds of medicaments, specifically be illustrated with following biologicall test example.
Biologicall test embodiment 1:
Hundred can screen Toxicity Determination and the proportioning of bacterium of downy mildew of cucumber with polyoxin
Adopt spray-on process, measure different proportion hundred can with the composite indoor virulence to cucumber downy mildew of polyoxin.
Calculate the toxicity index of each medicament and the co-toxicity coefficient of mixture (CTC value) according to the abundant method of Sun Yun, when CTC≤80, then compositions table reveals antagonism, when 80＜CTC＜120, then compositions table reveals summation action, and when CTC 〉=120, then compositions table reveals synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) X100
The percentage composition of B in percentage composition+B medicament toxicity index X mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index X mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] X100
Table 1 hundred can screen Toxicity Determination and the proportioning of cucumber downy mildew disease with polyoxin
The result shows, hundred can and polyoxin between proportioning 100:1-1:1, obvious synergistic effect is arranged, co-toxicity coefficient is more than 120.
Biologicall test example 2:
Hundred can with the composite Toxicity Determination to alternaria leaf spot of apple of polyoxin
Adopt spray-on process, measure different proportion hundred can with the composite indoor virulence to alternaria leaf spot of apple of polyoxin.
Table 2 hundred can screen Toxicity Determination and the proportioning of alternaria leaf spot of apple with polyoxin
The result shows, hundred can and polyoxin between proportioning 100:1-1:1, obvious synergistic effect is arranged, co-toxicity coefficient is more than 120.
Biologicall test example 3:
Hundred can with the composite Toxicity Determination to graw mold of tomato of polyoxin
Adopt spray-on process, measure different proportion hundred can with the composite indoor virulence to the graw mold of tomato germ of polyoxin.
Table 3 hundred can screen Toxicity Determination and the proportioning of graw mold of tomato germ with polyoxin
The result shows, hundred can and polyoxin between proportioning 300:1-1:1, obvious synergistic effect is arranged, co-toxicity coefficient is more than 120.
Biologicall test example 4:
Hundred can with the composite Toxicity Determination to the rose gray mold of polyoxin
Adopt spray-on process, measure different proportion hundred can with the composite indoor virulence to the rose gray mold of polyoxin.
Table 2 hundred can screen Toxicity Determination and the proportioning of rose gray mold with polyoxin
The result shows, hundred can and polyoxin between proportioning 100:1-1:1, obvious synergistic effect is arranged, co-toxicity coefficient is more than 120.
Below with specific embodiment the present invention is described.Percentage all is weight percentage in all prescriptions.The processing technology of the various preparations of the present composition is prior art, can change to some extent according to different situations.
Embodiment 1 water dispersion granule (gross weight of preparation is 100 parts)
Hundred can get 40.0 weight portions
Polyoxin 4.0 weight portions
Polyvinyl alcohol 5.0 weight portions
Sodium Laurylsulfate 7.0 weight portions
Lignosulfonates 11.0 weight portions
The kaolin surplus
Above-mentioned substance is evenly mixed, grinds, mixes suitable quantity of water and granulation, namely get said preparation after the drying.
This embodiment is used for control apple tree spot defoliation.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 98.4% behind the medicine with said preparation.3% polyoxin aqueous solution is used with quadrat method and is used by 500 dilutions, and 7 days preventive effect is 85.3% behind the medicine.40,%00 can get pulvis dilutes by 200 times of liquid, uses with quadrat method and uses, and 7 days preventive effect is that 80.3%. hundred can be obvious with the composite back synergistic effect of polyoxin behind the medicine, to the preventive effect of apple tree spot defoliation significantly better than single agent;
Embodiment 2 wetting powders (gross weight of preparation is 100 parts)
Hundred can get 4.0 weight portions
Polyoxin 1.0 weight portions
Alkyl polyoxyethylene ether sulfonate 5.0 weight portions
Sodium lignin sulfonate 4.0 weight portions
NONIN HS 240 (8-9 moles of ethylene oxide) 3.0 weight portions
The kaolin surplus
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, namely get said preparation.
This embodiment is used for preventing and treating powdery mildew of cucumber.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 96.8% behind the medicine with said preparation.1% polyoxin aqueous solution is used with quadrat method and is used by 600 times of dilutions, and 7 days preventive effect is 87.3% behind the medicine.40,%00 can get pulvis dilutes by 800 times of liquid, uses with quadrat method and uses, and 7 days preventive effect is that 83.2%. hundred can be obvious with the composite back synergistic effect of polyoxin behind the medicine, to the preventive effect of powdery mildew of cucumber significantly better than single agent;
Embodiment 3 suspending agents (gross weight of preparation is 100 parts)
Hundred can get 72.0 weight portions
Polyoxin 8.0 weight portions
Propane diols 3.0 weight portions
Lignosulfonates 10.0 weight portions
Sodium Polyacrylate 5.0 weight portions
Octyl phenol polyglycol ether (11-14 moles of ethylene oxide) 5.0 weight portions
Water surplus
The very thin active ingredient of mill is thoroughly mixed with auxiliary agent, and the suspending agent dilutable water that obtains becomes any suspension that needs concentration.
This embodiment is used for the control gray mold of cucumber.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 98.4% behind the medicine with said preparation.10% polyoxin aqueous solution is used with quadrat method and is used by 1000 times of dilutions, and 7 days preventive effect is 84.3% behind the medicine.40,%00 can get pulvis dilutes by 800 times of liquid, uses with quadrat method and uses, and 7 days preventive effect is that 73.2%. hundred can be obvious with the composite back synergistic effect of polyoxin behind the medicine, to the preventive effect of gray mold of cucumber significantly better than single agent.
Embodiment 4 coated granules (gross weight of preparation is 100 parts)
Hundred can get 9.9%
Polyoxin 0.1%
Polyethylene glycol 3%
The silicic acid 1% of high degree of dispersion
Calcium carbonate complements to 100%
In blender, levigate active component evenly is applied to by on the wetting carrier of polyethylene glycol, namely get coated granule.
This embodiment is used for the control wheat powdery mildew.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 98.4% behind the medicine with said preparation.3% polyoxin wetting powder is used with quadrat method and is used by 600 times, and 7 days preventive effect is 90.1% behind the medicine.40,%00 can get pulvis dilutes by 800 times of liquid, uses with quadrat method and uses, and 7 days preventive effect is that 70.2%. hundred can be obvious with the composite back synergistic effect of polyoxin behind the medicine, to the preventive effect of wheat powdery mildew significantly better than single agent.
Embodiment 5 water dispersion granules (gross weight of preparation is 100 parts)
Hundred can get 40.0 weight portions
Polyoxin 0.2 weight portion
Polyvinyl alcohol 2.0 weight portions
Sodium Laurylsulfate 4.0 weight portions
Lignosulfonates 5.0 weight portions
The kaolin surplus
Above-mentioned substance is evenly mixed, grinds, mixes suitable quantity of water and granulation, namely get said preparation after the drying.
This embodiment is used for control rose gray mold.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 99.8% behind the medicine with said preparation.3% polyoxin pulvis is used with quadrat method and is used by 500 times, and 7 days preventive effect is 85.6% behind the medicine.40,%00 can get pulvis dilutes by 800 times of liquid, uses with quadrat method and uses, and 7 days preventive effect is that 76.2%. hundred can be obvious with the composite back synergistic effect of polyoxin behind the medicine, to the preventive effect of rose gray mold significantly better than single agent.
Embodiment 6 wetting powders (gross weight of preparation is 100 parts)
Hundred can get 10.0 weight portions
Polyoxin 10.0 weight portions
Alkyl polyoxyethylene ether sulfonate 5.0 weight portions
Sodium lignin sulfonate 4.0 weight portions
NONIN HS 240
(8-9 moles of ethylene oxide) 3.0 weight portions
The kaolin surplus
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, namely get said preparation.
This embodiment is used for preventing and treating early blight of tomato.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 99.5% behind the medicine with said preparation.0.3% polyoxin aqueous solution is used with quadrat method and is used by 500 times, and 7 days preventive effect is 85.6% behind the medicine.40,%00 can get pulvis dilutes by 800 times of liquid, uses with quadrat method and uses, and 7 days preventive effect is that 77.2%. hundred can be obvious with the composite back synergistic effect of polyoxin behind the medicine, to the preventive effect of early blight of tomato significantly better than single agent.
Embodiment 7 suspending agents (gross weight of preparation is 100 parts)
Hundred can get 40.0 weight portions
Polyoxin 1.0 weight portions
Propane diols 3.0 weight portions
Lignosulfonates 10.0 weight portions
Sodium Polyacrylate 5.0 weight portions
Octyl phenol polyglycol ether (11-14 moles of ethylene oxide) 5.0 weight portions
Water surplus
The very thin active ingredient of mill is thoroughly mixed with auxiliary agent, and the suspending agent dilutable water that obtains becomes any suspension that needs concentration.
This embodiment is used for control leek gray mold.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 97.8% behind the medicine with said preparation.1% polyoxin aqueous solution is used with quadrat method and is used by 500 times, and 7 days preventive effect is 87.6% behind the medicine.40,%00 can get pulvis dilutes by 800 times of liquid, uses with quadrat method and uses, and 7 days preventive effect is that 82.2%. hundred can be obvious with the composite back synergistic effect of polyoxin behind the medicine, to the preventive effect of leek gray mold significantly better than single agent.
Embodiment 8 suspending agents (gross weight of preparation is 100 parts)
Hundred can get 50 weight portions
Polyoxin 0.1 weight portion
Propane diols 3.0 weight portions
Lignosulfonates 10.0 weight portions
Sodium Polyacrylate 5.0 weight portions
Octyl phenol polyglycol ether (11-14 moles of ethylene oxide) 5.0 weight portions
Water surplus
The very thin active ingredient of mill is thoroughly mixed with auxiliary agent, and the suspending agent dilutable water that obtains becomes any suspension that needs concentration.
This embodiment is used for control pear tree black spot.By 1000 extraordinarily water dilution sprayings, 7 days control efficiency is 97.2% behind the medicine with said preparation.3% polyoxin wetting powder is used with quadrat method and is used by 500 times, and 7 days preventive effect is 88.6% behind the medicine.40,%00 can get pulvis dilutes by 800 times of liquid, uses with quadrat method and uses, and 7 days preventive effect is that 72.2%. hundred can be obvious with the composite back synergistic effect of polyoxin behind the medicine, to the preventive effect of pear tree black spot significantly better than single agent.
Claims (8)
1. microbicide compositions is characterized in that the active constituent of described composition is made up of A and B:
A) following formula (Ia):
1 of expression, 1 '-imino group two (the inferior octyl group of 1,8-), two guanidine trialkyl benzene sulfonates, and
B) following formula (II):
5-[[2-amino-5-O-(the amino carbonyl)-2-deoxidation-L-xylosyl of expression] amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1 (2H)-pyrimidine radicals]-β-D-furanose aldehydic acid in addition;
Wherein the mass ratio of compd A and B is 500:1-1:1.
2. microbicide compositions according to claim 1, the mass ratio that it is characterized in that described compd A and B is 200:1-1:1.
3. microbicide compositions according to claim 1 is characterized in that the mass percent that described compd A and B account in the microbicide compositions is 5%-80%.
4. a kind of microbicide compositions according to claim 1 is characterized in that the quality percentage composition that described compd A and B account in the microbicide compositions is 10%-80%.
5. microbicide compositions according to claim 1 is characterized in that described compd A and B and liquid-carrier or solid carrier and/or surfactant mix.
6. microbicide compositions according to claim 1, the formulation that it is characterized in that described microbicide compositions is wetting powder, water dispersible granules, suspending agent, coated granule.
7. the application of the described microbicide compositions of claim 1 on control of crop disease.
8. claim 1 or 5 described microbicide compositions are used for the control of crop powdery mildew, gray mold.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110136693 CN102258047B (en) | 2011-05-25 | 2011-05-25 | Germicide composition |
Applications Claiming Priority (1)
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| CN102715182A (en) * | 2012-06-05 | 2012-10-10 | 江苏龙灯化学有限公司 | Sterilization composition containing active components Bellkute and imazalil |
| CN103098817B (en) * | 2012-12-30 | 2016-01-06 | 湖南农大海特农化有限公司 | The composition pesticide of biguanides three octyl benzene sulfonate and tpn |
| CN103636655A (en) * | 2013-12-20 | 2014-03-19 | 北京燕化永乐生物科技股份有限公司 | Compound bactericide |
| CN104026167A (en) * | 2014-04-16 | 2014-09-10 | 泗阳县农业科学研究所 | Special prevention and treatment pesticide for anthurium anthracnose and application method thereof |
| CN103988843B (en) * | 2014-05-29 | 2016-06-22 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
| CN105851027B (en) * | 2016-04-20 | 2019-04-30 | 山东省烟台市农业科学研究院 | A kind of fruit bag resistant medicament and its application improving Fuji apple exterior quality |
| CN111066806A (en) * | 2020-01-16 | 2020-04-28 | 陕西麦可罗生物科技有限公司 | Pesticide composition containing polyoxin B and iodopropynyl compound and application thereof |
| CN111983059B (en) * | 2020-08-03 | 2023-11-14 | 中化化工科学技术研究总院有限公司 | Analysis method of 40% trioctyl benzene sulfonate wettable powder |
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| US20060189485A1 (en) * | 2003-01-23 | 2006-08-24 | Nippon Soda Co., Ltd., | Water dispersible granules for agricultural and horticultural use |
| WO2010025870A1 (en) * | 2008-09-03 | 2010-03-11 | Bayer Cropscience Ag | Synergistic combinations of thiadiazol carbonic acid derivatives |
| EP2269454A1 (en) * | 2009-06-24 | 2011-01-05 | Bayer CropScience AG | Combinations of fungicidally active yeast and fungicides |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060189485A1 (en) * | 2003-01-23 | 2006-08-24 | Nippon Soda Co., Ltd., | Water dispersible granules for agricultural and horticultural use |
| WO2010025870A1 (en) * | 2008-09-03 | 2010-03-11 | Bayer Cropscience Ag | Synergistic combinations of thiadiazol carbonic acid derivatives |
| EP2269454A1 (en) * | 2009-06-24 | 2011-01-05 | Bayer CropScience AG | Combinations of fungicidally active yeast and fungicides |
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