CN102257388B - 单克隆抗体stro-4 - Google Patents

单克隆抗体stro-4 Download PDF

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Publication number
CN102257388B
CN102257388B CN200980141163.9A CN200980141163A CN102257388B CN 102257388 B CN102257388 B CN 102257388B CN 200980141163 A CN200980141163 A CN 200980141163A CN 102257388 B CN102257388 B CN 102257388B
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CN
China
Prior art keywords
cell
antibody
hsp
stro
cells
Prior art date
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CN200980141163.9A
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English (en)
Chinese (zh)
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CN102257388A (zh
Inventor
S·格龙索斯
A·C·W·赞内蒂诺
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Mesoblast Inc
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Mesoblast Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Mesoblast Inc filed Critical Mesoblast Inc
Priority to CN201610940377.4A priority Critical patent/CN106995797B/zh
Priority to CN201510067688.XA priority patent/CN104678106B/zh
Publication of CN102257388A publication Critical patent/CN102257388A/zh
Application granted granted Critical
Publication of CN102257388B publication Critical patent/CN102257388B/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN200980141163.9A 2008-08-18 2009-08-18 单克隆抗体stro-4 Active CN102257388B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201610940377.4A CN106995797B (zh) 2008-08-18 2009-08-18 单克隆抗体stro-4
CN201510067688.XA CN104678106B (zh) 2008-08-18 2009-08-18 单克隆抗体stro-4

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18934908P 2008-08-18 2008-08-18
US61/189,349 2008-08-18
PCT/AU2009/001060 WO2010019997A1 (en) 2008-08-18 2009-08-18 Monoclonal antibody stro-4

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201610940377.4A Division CN106995797B (zh) 2008-08-18 2009-08-18 单克隆抗体stro-4
CN201510067688.XA Division CN104678106B (zh) 2008-08-18 2009-08-18 单克隆抗体stro-4

Publications (2)

Publication Number Publication Date
CN102257388A CN102257388A (zh) 2011-11-23
CN102257388B true CN102257388B (zh) 2015-03-18

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN200980141163.9A Active CN102257388B (zh) 2008-08-18 2009-08-18 单克隆抗体stro-4
CN201510067688.XA Active CN104678106B (zh) 2008-08-18 2009-08-18 单克隆抗体stro-4
CN201610940377.4A Active CN106995797B (zh) 2008-08-18 2009-08-18 单克隆抗体stro-4

Family Applications After (2)

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CN201510067688.XA Active CN104678106B (zh) 2008-08-18 2009-08-18 单克隆抗体stro-4
CN201610940377.4A Active CN106995797B (zh) 2008-08-18 2009-08-18 单克隆抗体stro-4

Country Status (11)

Country Link
US (2) US9090678B2 (https=)
EP (2) EP3121597A1 (https=)
JP (1) JP5826629B2 (https=)
KR (1) KR101713343B1 (https=)
CN (3) CN102257388B (https=)
AU (2) AU2009284692B2 (https=)
CA (1) CA2734210C (https=)
ES (1) ES2707274T3 (https=)
SG (1) SG10201601279SA (https=)
TR (1) TR201900975T4 (https=)
WO (1) WO2010019997A1 (https=)

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US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
GB201011173D0 (en) 2010-07-02 2010-08-18 Smith & Nephew Provision of wound filler
WO2012048276A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
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GB201020005D0 (en) 2010-11-25 2011-01-12 Smith & Nephew Composition 1-1
AU2012262675B2 (en) * 2011-06-03 2016-05-19 Mesoblast, Inc Methods of treating or preventing neurological diseases
CN104508124B (zh) 2011-07-06 2017-11-17 细胞治疗有限公司 中胚层谱系祖细胞
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US20160120706A1 (en) 2013-03-15 2016-05-05 Smith & Nephew Plc Wound dressing sealant and use thereof
EP2968647B1 (en) 2013-03-15 2022-06-29 Smith & Nephew plc Wound dressing sealant and use thereof
US20150037436A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
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US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
CN110684105B (zh) * 2019-09-11 2021-01-29 江苏莱森生物科技研究院有限公司 一种抗hsp90单克隆抗体及试剂盒
EP4314244B1 (en) 2021-03-23 2025-07-23 Terumo BCT, Inc. Cell capture and expansion
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

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Also Published As

Publication number Publication date
CN102257388A (zh) 2011-11-23
TR201900975T4 (tr) 2019-02-21
US9815896B2 (en) 2017-11-14
SG10201601279SA (en) 2016-03-30
US20110189696A1 (en) 2011-08-04
JP2012500010A (ja) 2012-01-05
EP2324359A1 (en) 2011-05-25
CA2734210A1 (en) 2010-02-25
JP5826629B2 (ja) 2015-12-02
WO2010019997A1 (en) 2010-02-25
CN104678106B (zh) 2016-12-07
ES2707274T3 (es) 2019-04-03
CN104678106A (zh) 2015-06-03
CN106995797B (zh) 2021-04-30
AU2009284692A1 (en) 2010-02-25
CN106995797A (zh) 2017-08-01
US20150307608A1 (en) 2015-10-29
KR20110055605A (ko) 2011-05-25
EP3121597A1 (en) 2017-01-25
US9090678B2 (en) 2015-07-28
EP2324359B1 (en) 2018-10-31
EP2324359A4 (en) 2013-04-17
AU2016203436A1 (en) 2016-06-16
AU2009284692B2 (en) 2016-02-25
KR101713343B1 (ko) 2017-03-22
CA2734210C (en) 2018-03-27

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