CN102250005A - 艾利西平的制备方法 - Google Patents
艾利西平的制备方法 Download PDFInfo
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- CN102250005A CN102250005A CN2010101768960A CN201010176896A CN102250005A CN 102250005 A CN102250005 A CN 102250005A CN 2010101768960 A CN2010101768960 A CN 2010101768960A CN 201010176896 A CN201010176896 A CN 201010176896A CN 102250005 A CN102250005 A CN 102250005A
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- hydrogen
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- 0 *N(c1c(C2)cccc1)c1ccccc1C2O Chemical compound *N(c1c(C2)cccc1)c1ccccc1C2O 0.000 description 4
- ZNKKYYNWFKHNHZ-UHFFFAOYSA-N CC1C=CC=CC1 Chemical compound CC1C=CC=CC1 ZNKKYYNWFKHNHZ-UHFFFAOYSA-N 0.000 description 1
- URTPUNNVRLBSTJ-UHFFFAOYSA-N COC(C1=CCCC=C1C(O)=O)=O Chemical compound COC(C1=CCCC=C1C(O)=O)=O URTPUNNVRLBSTJ-UHFFFAOYSA-N 0.000 description 1
- UWWYMQJYESUJNI-UHFFFAOYSA-N Cc1cc(N(c2ccccc2C(C2)OC(c3ccccc3C(O)=O)=O)C#N)c2cc1 Chemical compound Cc1cc(N(c2ccccc2C(C2)OC(c3ccccc3C(O)=O)=O)C#N)c2cc1 UWWYMQJYESUJNI-UHFFFAOYSA-N 0.000 description 1
- QQSMCHOABQHASF-HNNXBMFYSA-N N#CN(c1c(C2)cccc1)c1ccccc1[C@H]2O Chemical compound N#CN(c1c(C2)cccc1)c1ccccc1[C@H]2O QQSMCHOABQHASF-HNNXBMFYSA-N 0.000 description 1
- JLXXLCJERIYMQG-UHFFFAOYSA-N N#CNc1ccccc1 Chemical compound N#CNc1ccccc1 JLXXLCJERIYMQG-UHFFFAOYSA-N 0.000 description 1
- CTRLABGOLIVAIY-UHFFFAOYSA-N NC(N(c1ccccc1C1)c(cccc2)c2C1=O)=O Chemical compound NC(N(c1ccccc1C1)c(cccc2)c2C1=O)=O CTRLABGOLIVAIY-UHFFFAOYSA-N 0.000 description 1
- BMPDWHIDQYTSHX-AWEZNQCLSA-N NC(N(c1ccccc1C[C@@H]1O)c2c1cccc2)=O Chemical compound NC(N(c1ccccc1C[C@@H]1O)c2c1cccc2)=O BMPDWHIDQYTSHX-AWEZNQCLSA-N 0.000 description 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-O [NH3+]c1ccccc1 Chemical compound [NH3+]c1ccccc1 PAYRUJLWNCNPSJ-UHFFFAOYSA-O 0.000 description 1
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- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
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CN201010176896.0A CN102250005B (zh) | 2010-05-19 | 2010-05-19 | 艾利西平的制备方法 |
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CN201010176896.0A CN102250005B (zh) | 2010-05-19 | 2010-05-19 | 艾利西平的制备方法 |
Publications (2)
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CN102250005A true CN102250005A (zh) | 2011-11-23 |
CN102250005B CN102250005B (zh) | 2015-04-08 |
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CN201010176896.0A Active CN102250005B (zh) | 2010-05-19 | 2010-05-19 | 艾利西平的制备方法 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108752276A (zh) * | 2018-07-24 | 2018-11-06 | 天津安浩生物科技有限公司 | 不对称催化氢化反应的前体反应物的层析纯化工艺 |
CN112679433A (zh) * | 2019-10-18 | 2021-04-20 | 浙江九洲药业股份有限公司 | 一种艾利西平的制备方法 |
CN110790708B (zh) * | 2018-08-02 | 2022-10-11 | 浙江九洲药业股份有限公司 | 一种艾利西平中间体的制备方法 |
CN112679433B (zh) * | 2019-10-18 | 2024-05-24 | 浙江九洲药业股份有限公司 | 一种艾利西平的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1439643A (zh) * | 2003-02-21 | 2003-09-03 | 南开大学 | 螺环双膦配体 |
WO2004031155A1 (en) * | 2002-10-07 | 2004-04-15 | Novartis Ag | ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF BOTH ENANTIOMERS OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ [b,f]AZEPINE-5-CARBOXAMIDE AND NEW CRYSTAL FORMS THEREOF |
CN101277937A (zh) * | 2005-07-29 | 2008-10-01 | 坡特拉有限公司 | 奥卡西平的不对称催化还原 |
-
2010
- 2010-05-19 CN CN201010176896.0A patent/CN102250005B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004031155A1 (en) * | 2002-10-07 | 2004-04-15 | Novartis Ag | ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF BOTH ENANTIOMERS OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ [b,f]AZEPINE-5-CARBOXAMIDE AND NEW CRYSTAL FORMS THEREOF |
CN1439643A (zh) * | 2003-02-21 | 2003-09-03 | 南开大学 | 螺环双膦配体 |
CN101277937A (zh) * | 2005-07-29 | 2008-10-01 | 坡特拉有限公司 | 奥卡西平的不对称催化还原 |
Non-Patent Citations (2)
Title |
---|
JIAN-HUA XIE,等: "Synthesis of Spiro Diphosphines and Their Application in AsymmetricHydrogenation of Ketones", 《J. AM. CHEM. SOC.》 * |
SHENG LIU,等: "Dynamic Kinetic Resolution Allows a Highly Enantioselective Synthesis of cis-a-Aminocycloalkanols by Ruthenium-Catalyzed Asymmetric Hydrogenation", 《ANGEW. CHEM.》 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108752276A (zh) * | 2018-07-24 | 2018-11-06 | 天津安浩生物科技有限公司 | 不对称催化氢化反应的前体反应物的层析纯化工艺 |
CN110790708B (zh) * | 2018-08-02 | 2022-10-11 | 浙江九洲药业股份有限公司 | 一种艾利西平中间体的制备方法 |
CN112679433A (zh) * | 2019-10-18 | 2021-04-20 | 浙江九洲药业股份有限公司 | 一种艾利西平的制备方法 |
WO2021073231A1 (zh) * | 2019-10-18 | 2021-04-22 | 浙江九洲药业股份有限公司 | 一种艾利西平的制备方法 |
CN112679433B (zh) * | 2019-10-18 | 2024-05-24 | 浙江九洲药业股份有限公司 | 一种艾利西平的制备方法 |
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CN102250005B (zh) | 2015-04-08 |
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Address after: 310018 room 103, first floor, building 2, Heke science and technology center, No. 500 QiaoXin Road, Xiasha street, Hangzhou Economic and Technological Development Zone, Zhejiang Province Patentee after: Zhejiang Jiuzhou biomedical Co.,Ltd. Address before: 310051 fifth floor, building 4, No. 88, Jiangling Road, Binjiang District, Hangzhou, Zhejiang Patentee before: ZHEJIANG JIUZHOU PHARMA SCIENCE & TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20211104 Address after: 318000 No. 58 Binhai Road, Jiaojiang District, Taizhou City, Zhejiang Province Patentee after: Zhejiang Siwei Pharmaceutical Technology Co.,Ltd. Address before: 310018 room 103, first floor, building 2, Heke science and technology center, No. 500 QiaoXin Road, Xiasha street, Hangzhou Economic and Technological Development Zone, Zhejiang Province Patentee before: Zhejiang Jiuzhou biomedical Co.,Ltd. |
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Effective date of registration: 20230515 Address after: 317016 No. 18 Nanyang Third Road, Linhai Park, Zhejiang Chemical Raw Material Drug Base, Linhai City, Taizhou City, Zhejiang Province Patentee after: ZHEJIANG RAYBOW PHARMACEUTICAL CO.,LTD. Address before: 318000 No. 58 Binhai Road, Jiaojiang District, Taizhou City, Zhejiang Province Patentee before: Zhejiang Siwei Pharmaceutical Technology Co.,Ltd. |