CN102245758A - 增强造血干细胞植入过程的材料和方法 - Google Patents

增强造血干细胞植入过程的材料和方法 Download PDF

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CN102245758A
CN102245758A CN2009801495225A CN200980149522A CN102245758A CN 102245758 A CN102245758 A CN 102245758A CN 2009801495225 A CN2009801495225 A CN 2009801495225A CN 200980149522 A CN200980149522 A CN 200980149522A CN 102245758 A CN102245758 A CN 102245758A
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cells
pge2
hematopoietic stem
compound
activity
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路易斯·M·佩卢斯
乔纳森·霍格特
普拉蒂夫哈·辛格
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Indiana University Research and Technology Corp
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Indiana University Research and Technology Corp
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Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp
Priority to CN201810232658.3A priority Critical patent/CN108379292A/zh
Priority to CN201710777354.0A priority patent/CN107630001A/zh
Priority to CN201710777353.6A priority patent/CN107523587A/zh
Publication of CN102245758A publication Critical patent/CN102245758A/zh
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CN2009801495225A 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法 Pending CN102245758A (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201810232658.3A CN108379292A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法
CN201710777354.0A CN107630001A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法
CN201710777353.6A CN107523587A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法

Applications Claiming Priority (3)

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US11201808P 2008-11-06 2008-11-06
US61/112,018 2008-11-06
PCT/US2009/063654 WO2010054271A1 (en) 2008-11-06 2009-11-06 Materials and methds to enhance hematopoietic stem cells engraftment procedures

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CN201710777353.6A Division CN107523587A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法
CN201710777354.0A Division CN107630001A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法
CN201810232658.3A Division CN108379292A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法

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CN2009801495225A Pending CN102245758A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法
CN201710777353.6A Pending CN107523587A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法
CN201710777354.0A Pending CN107630001A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法
CN201810232658.3A Pending CN108379292A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法

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CN201710777353.6A Pending CN107523587A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法
CN201710777354.0A Pending CN107630001A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法
CN201810232658.3A Pending CN108379292A (zh) 2008-11-06 2009-11-06 增强造血干细胞植入过程的材料和方法

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US (5) US9107909B2 (OSRAM)
EP (3) EP3031907B1 (OSRAM)
JP (5) JP5846915B2 (OSRAM)
CN (4) CN102245758A (OSRAM)
AU (4) AU2009313290B2 (OSRAM)
CA (3) CA3203374A1 (OSRAM)
ES (1) ES2845641T3 (OSRAM)
PT (1) PT3031907T (OSRAM)
WO (1) WO2010054271A1 (OSRAM)
ZA (1) ZA201804932B (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104066837A (zh) * 2011-12-02 2014-09-24 菲特治疗公司 增强的干细胞组合物
CN108220246A (zh) * 2011-09-30 2018-06-29 蓝鸟生物公司 用于改善病毒转导的化合物
CN114040967A (zh) * 2018-10-31 2022-02-11 能源环境与技术研究中心(Ciemat) 造血干细胞移植后恢复及促进恢复的改进

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014DN06624A (OSRAM) 2005-10-18 2015-07-10 Univ Colorado
US8986702B2 (en) 2008-05-16 2015-03-24 Taiga Biotechnologies, Inc. Antibodies and processes for preparing the same
DK2966084T3 (en) 2008-08-28 2018-08-06 Taiga Biotechnologies Inc MODULATORS OF MYC, PROCEDURES FOR USING SAME AND PROCEDURES FOR IDENTIFYING SUBSTANCES MODULATING MYC
EP3031907B1 (en) 2008-11-06 2021-01-06 Indiana University Research and Technology Corporation Materials and methods to enhance hematopoietic stem cells engraftment procedures
US10813917B2 (en) 2009-12-11 2020-10-27 Medregen, Llc Treatment methods utilizing stem cell mobilizers and immunosuppressive agents
EP2603227B1 (en) * 2010-08-12 2017-10-04 Fate Therapeutics, Inc. Improved hematopoietic stem and progenitor cell therapy
ES2693622T3 (es) 2011-01-13 2018-12-13 SciPharm S.à r.l. Método para mejorar el injerto de células madre hematopoyéticas
US10111907B2 (en) * 2011-12-02 2018-10-30 Fate Therapeutics, Inc. Methods of treating ischemia
WO2013130499A1 (en) * 2012-02-29 2013-09-06 University Of Virginia Patent Foundation Compositions and methods for cxcr4 signaling and umbilical cord blood stem cell engraftment
WO2014015318A1 (en) * 2012-07-19 2014-01-23 Bluebird Bio, Inc. Soluble compounds for improved gene therapy methods
AU2013292330B2 (en) * 2012-07-20 2018-07-12 Htyr Acquisition Llc Enhanced reconstitution and autoreconstitution of the hematopoietic compartment
WO2014026110A2 (en) * 2012-08-10 2014-02-13 Bluebird Bio, Inc. Compounds for improved viral transduction
KR20160023638A (ko) 2013-02-28 2016-03-03 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 줄기세포를 이동하기 위한 방법 및 조성물
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
WO2014150602A1 (en) 2013-03-15 2014-09-25 Fate Therapeutics, Inc. Cell potency assay for therapeutic potential
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
EP3030232B1 (en) 2013-04-29 2022-07-06 Medregen, LLC Wound healing via autologous stem cell mobilization
KR101489861B1 (ko) * 2013-05-07 2015-02-05 경북대학교 산학협력단 Amd3100을 포함하는 골질환 예방 또는 치료용 조성물
EP3250682A4 (en) 2015-01-26 2018-08-01 Fate Therapeutics, Inc. Cells with increased immuno-regulatory properties and methods for their use and manufacture
CN104774806B (zh) * 2015-04-09 2019-02-15 广州赛莱拉干细胞科技股份有限公司 一种胎盘造血干细胞的制备方法
KR20180033537A (ko) 2015-07-21 2018-04-03 더 칠드런스 메디칼 센터 코포레이션 Pd-l1 발현 조혈 줄기 세포 및 용도
EP3413896B1 (en) 2016-02-12 2021-03-17 Bluebird Bio, Inc. Vcn enhancer compositions and methods of using the same
RU2021103425A (ru) 2016-02-12 2021-02-25 Блубёрд Био, Инк. Композиции, повышающие число копий вектора (чкв), и способы их применения
WO2017147610A1 (en) * 2016-02-26 2017-08-31 President And Fellows Of Harvard College Highly engraftable hematopoietic stem cells
WO2018017341A1 (en) * 2016-07-22 2018-01-25 Senlin Li Methods and compositions for rejuvenation
CN113786476A (zh) 2016-12-02 2021-12-14 泰加生物工艺学公司 纳米颗粒调配物
AU2018212854B2 (en) * 2017-01-27 2024-06-20 Children's Hospital Medical Center Methods of enhancing engraftment activity of hematopoietic stem cells
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
US11213546B2 (en) 2017-09-07 2022-01-04 Emory University Methods to mobilize tissue resident cells for adoptive t cell therapy
US11879137B2 (en) 2017-09-22 2024-01-23 The Children's Medical Center Corporation Treatment of type 1 diabetes and autoimmune diseases or disorders
FR3074189A1 (fr) * 2017-11-30 2019-05-31 Assistance Publique - Hopitaux De Paris Methode de generation de greffons de cellules souches hematopoietiques
CN108404112B (zh) * 2018-04-01 2020-05-12 北京诺赛启研再生医学研究院有限公司 提高造血干细胞归巢及植入率的方法及其试剂
CN113874033A (zh) 2019-04-08 2021-12-31 泰加生物工艺学公司 用于冷冻保存免疫细胞的组合物和方法
JP2022532608A (ja) 2019-05-14 2022-07-15 タイガ バイオテクノロジーズ,インク. T細胞疲弊を処置するための組成物および方法
KR20220160018A (ko) 2020-03-31 2022-12-05 덴카 주식회사 알루미나 분말, 수지 조성물, 및 방열 부품
CN116509834B (zh) * 2023-01-20 2025-05-13 东北师范大学 化合物在制备造血干/祖细胞增殖和损伤修复药物中的应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215452A1 (en) * 2002-02-04 2003-11-20 Millennium Pharmaceuticals, Inc. Methods and compositions for treating hematological disorders using 131, 148, 199, 12303, 13906, 15513, 17822, 302, 5677, 194, 14393, 28059, 7366, 12212, 1981, 261, 12416, 270, 1410, 137, 1871, 13051, 1847, 1849, 15402, 340, 10217, 837, 1761, 8990 or 13249 molecules
US20050163760A1 (en) * 2001-12-06 2005-07-28 Nathalie Cartier-Lacave Use of cd34+ hematopoietic progenitor cells for the treatment of cns disorders
US20070087988A1 (en) * 2005-09-30 2007-04-19 New York University Hematopoietic progenitor kinase 1 for modulation of an immune response
WO2008073748A1 (en) * 2006-12-08 2008-06-19 University Of Rochester Expansion of hematopoietic stem cells
US20080207584A1 (en) * 2004-06-23 2008-08-28 Ono Pharmaceutical Co., Ltd. Compound Having S1P Receptor Binding Potency and Use Thereof
US20080261922A1 (en) * 2005-10-14 2008-10-23 Carley David W Pharmacological Treatments for Sleep Disorders (Apnoe) With Prostanoid Receptor Antagonists

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399493A (en) * 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
JPH08205860A (ja) * 1994-01-21 1996-08-13 Usa Government 造血細胞の膨大化および移植方法
US5928638A (en) * 1996-06-17 1999-07-27 Systemix, Inc. Methods for gene transfer
CA2462628C (en) 2001-10-02 2019-08-20 Institut Clayton De La Recherche Restricted expression lentiviral vectors
CA2519975C (en) 2003-04-08 2013-07-02 Yeda Research And Development Co. Ltd Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same
IL158868A0 (en) 2003-11-13 2004-05-12 Yeda Res & Dev Methods of generating and using stem cells enriched with immature primitive progenitor
US20080021078A1 (en) * 2006-07-18 2008-01-24 Horizon Therapeutics, Inc. Methods and medicaments for administration of ibuprofen
JP2007099724A (ja) 2005-10-06 2007-04-19 Shizuoka Prefecture スルファチドを標的とした抗ウイルス剤
MX373998B (es) * 2006-03-24 2020-07-22 Childrens Medical Center Uso de un modulador de células madre hematopoyeticas (hsc) para promover el crecimiento de hsc.
EP2049129B1 (en) 2006-06-22 2013-06-12 Yeda Research And Development Co., Ltd. Catecholamine receptor modulation
EP3824885A1 (en) 2006-10-20 2021-05-26 Children's Medical Center Corporation Method to enhance tissue regeneration
US8598328B2 (en) 2006-12-13 2013-12-03 National University Corporation Nagoya University Tol1 factor transposase and DNA introduction system using the same
EP3031907B1 (en) 2008-11-06 2021-01-06 Indiana University Research and Technology Corporation Materials and methods to enhance hematopoietic stem cells engraftment procedures
EP3533445A1 (en) 2009-03-19 2019-09-04 Fate Therapeutics, Inc. Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same
EP3269802B1 (en) 2011-09-30 2019-10-23 Bluebird Bio, Inc. Compounds for improved viral transduction

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050163760A1 (en) * 2001-12-06 2005-07-28 Nathalie Cartier-Lacave Use of cd34+ hematopoietic progenitor cells for the treatment of cns disorders
US20030215452A1 (en) * 2002-02-04 2003-11-20 Millennium Pharmaceuticals, Inc. Methods and compositions for treating hematological disorders using 131, 148, 199, 12303, 13906, 15513, 17822, 302, 5677, 194, 14393, 28059, 7366, 12212, 1981, 261, 12416, 270, 1410, 137, 1871, 13051, 1847, 1849, 15402, 340, 10217, 837, 1761, 8990 or 13249 molecules
US20080207584A1 (en) * 2004-06-23 2008-08-28 Ono Pharmaceutical Co., Ltd. Compound Having S1P Receptor Binding Potency and Use Thereof
US20070087988A1 (en) * 2005-09-30 2007-04-19 New York University Hematopoietic progenitor kinase 1 for modulation of an immune response
US20080261922A1 (en) * 2005-10-14 2008-10-23 Carley David W Pharmacological Treatments for Sleep Disorders (Apnoe) With Prostanoid Receptor Antagonists
WO2008073748A1 (en) * 2006-12-08 2008-06-19 University Of Rochester Expansion of hematopoietic stem cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
高立艳等: "G_CSF和GM_CSF动员小鼠造血干_祖细胞过程中对外周血T淋巴细胞亚群的影响", 《徐州医学院学报》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108220246A (zh) * 2011-09-30 2018-06-29 蓝鸟生物公司 用于改善病毒转导的化合物
CN108220246B (zh) * 2011-09-30 2022-07-12 蓝鸟生物公司 用于改善病毒转导的化合物
CN104066837A (zh) * 2011-12-02 2014-09-24 菲特治疗公司 增强的干细胞组合物
CN104066837B (zh) * 2011-12-02 2020-12-08 菲特治疗公司 增强的干细胞组合物
CN112375734A (zh) * 2011-12-02 2021-02-19 菲特治疗公司 增强的干细胞组合物
CN112410298A (zh) * 2011-12-02 2021-02-26 菲特治疗公司 增强的干细胞组合物
CN114040967A (zh) * 2018-10-31 2022-02-11 能源环境与技术研究中心(Ciemat) 造血干细胞移植后恢复及促进恢复的改进

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