CN102245633A - 新的胰岛素类似物 - Google Patents

新的胰岛素类似物 Download PDF

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Publication number
CN102245633A
CN102245633A CN2009801494190A CN200980149419A CN102245633A CN 102245633 A CN102245633 A CN 102245633A CN 2009801494190 A CN2009801494190 A CN 2009801494190A CN 200980149419 A CN200980149419 A CN 200980149419A CN 102245633 A CN102245633 A CN 102245633A
Authority
CN
China
Prior art keywords
desb30
insulin
insulin human
human
human insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN2009801494190A
Other languages
English (en)
Chinese (zh)
Inventor
C.E.施蒂德森
T.格伦多夫
T.B.克尔德森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2009/053017 external-priority patent/WO2009115469A1/en
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of CN102245633A publication Critical patent/CN102245633A/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2009801494190A 2008-12-09 2009-12-03 新的胰岛素类似物 Withdrawn CN102245633A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP08171086 2008-12-09
EP08171086.5 2008-12-09
EPPCT/EP2009/053017 2009-03-13
PCT/EP2009/053017 WO2009115469A1 (en) 2008-03-18 2009-03-13 Protease stabilized, acylated insulin analogues
EP09161014.7 2009-05-25
EP09161014 2009-05-25
EP09161232 2009-05-27
EP09161232.5 2009-05-27
PCT/EP2009/066335 WO2010066636A1 (en) 2008-12-09 2009-12-03 Novel insulin analogues

Publications (1)

Publication Number Publication Date
CN102245633A true CN102245633A (zh) 2011-11-16

Family

ID=41651437

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801494190A Withdrawn CN102245633A (zh) 2008-12-09 2009-12-03 新的胰岛素类似物

Country Status (5)

Country Link
US (1) US20110294729A1 (https=)
EP (1) EP2376531A1 (https=)
JP (1) JP2012511506A (https=)
CN (1) CN102245633A (https=)
WO (1) WO2010066636A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110072884A (zh) * 2016-07-22 2019-07-30 犹他大学研究基金会 胰岛素类似物

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102037008B (zh) 2008-03-18 2016-08-31 诺沃-诺迪斯克有限公司 蛋白酶稳定化的、酰化胰岛素类似物
CN102933599A (zh) 2010-06-23 2013-02-13 诺沃—诺迪斯克有限公司 包含额外的二硫键的人胰岛素
EP2585484A1 (en) * 2010-06-23 2013-05-01 Novo Nordisk A/S Insulin analogues containing additional disulfide bonds
RU2598273C2 (ru) 2010-06-23 2016-09-20 Ново Нордиск А/С Производные инсулина, содержащие дополнительные дисульфидные связи
US9481721B2 (en) 2012-04-11 2016-11-01 Novo Nordisk A/S Insulin formulations
US20150198619A1 (en) * 2012-09-25 2015-07-16 The Walter And Eliza Hall Institute Of Medical Research Structure of insulin in complex with n- and c-terminal regions of the insulin receptor alpha-chain
US20140269611A1 (en) * 2013-03-14 2014-09-18 T-Mobile Usa, Inc. Communication Handovers from Networks Using Unlicensed Spectrum to Circuit-Switched Networks
TWI700091B (zh) 2016-12-16 2020-08-01 丹麥商諾佛 儂迪克股份有限公司 含胰島素醫藥組成物
SG11202106167XA (en) 2018-12-11 2021-07-29 Sanofi Sa Insulin conjugates

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012814A1 (en) * 1989-04-20 1990-11-01 Mount Sinai School Of Medicine Of The City University Of New York Hepatospecific insulin analogues
US6746853B1 (en) * 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
WO2008034881A1 (en) * 2006-09-22 2008-03-27 Novo Nordisk A/S Protease resistant insulin analogues

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR900701842A (ko) * 1988-07-20 1990-12-04 헨리 브뢰늄 인간 인슐린 동족체와 그를 포함하는 제제
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
US5268453A (en) * 1991-08-08 1993-12-07 Scios Inc. Tissue-selective insulin analogs
WO2000069901A2 (en) * 1999-05-19 2000-11-23 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
WO2009112583A2 (en) * 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
CN102037008B (zh) * 2008-03-18 2016-08-31 诺沃-诺迪斯克有限公司 蛋白酶稳定化的、酰化胰岛素类似物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012814A1 (en) * 1989-04-20 1990-11-01 Mount Sinai School Of Medicine Of The City University Of New York Hepatospecific insulin analogues
US6746853B1 (en) * 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
WO2008034881A1 (en) * 2006-09-22 2008-03-27 Novo Nordisk A/S Protease resistant insulin analogues

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110072884A (zh) * 2016-07-22 2019-07-30 犹他大学研究基金会 胰岛素类似物
CN110072884B (zh) * 2016-07-22 2023-07-28 犹他大学研究基金会 胰岛素类似物

Also Published As

Publication number Publication date
US20110294729A1 (en) 2011-12-01
WO2010066636A1 (en) 2010-06-17
EP2376531A1 (en) 2011-10-19
JP2012511506A (ja) 2012-05-24

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C04 Withdrawal of patent application after publication (patent law 2001)
WW01 Invention patent application withdrawn after publication

Application publication date: 20111116