CN102232073B - Ssao活性抑制剂 - Google Patents
Ssao活性抑制剂 Download PDFInfo
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- CN102232073B CN102232073B CN200980136970.1A CN200980136970A CN102232073B CN 102232073 B CN102232073 B CN 102232073B CN 200980136970 A CN200980136970 A CN 200980136970A CN 102232073 B CN102232073 B CN 102232073B
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- Prior art keywords
- propyl
- imidazo
- sec
- tetrahydrochysene
- pyridine
- Prior art date
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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| SE0801979 | 2008-09-16 | ||
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| US10673408P | 2008-10-20 | 2008-10-20 | |
| US61/106,734 | 2008-10-20 | ||
| PCT/EP2009/062011 WO2010031789A1 (en) | 2008-09-16 | 2009-09-16 | New compounds i |
Publications (2)
| Publication Number | Publication Date |
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| CN102232073A CN102232073A (zh) | 2011-11-02 |
| CN102232073B true CN102232073B (zh) | 2014-10-29 |
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| DK2334672T3 (da) | 2008-09-16 | 2013-12-02 | Proximagen Ltd | 4,5,6,7-tetrahydroimidazo[4,5-c]pyridinforbindelser som inhibitorer af SSAO |
| UA112154C2 (uk) | 2009-09-08 | 2016-08-10 | Біоті Терапіс Корп. | Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів |
| GB201004311D0 (en) | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
| CN102311396B (zh) * | 2010-07-05 | 2015-01-07 | 暨南大学 | 一种吡嗪类衍生物和其制备方法及在制药中的应用 |
| FI20115234A0 (fi) | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
| CN103889983B (zh) | 2011-09-14 | 2015-12-09 | 普罗克西梅根有限公司 | 酶抑制剂化合物 |
| GB201304527D0 (en) | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
| GB201304526D0 (en) | 2013-03-13 | 2013-04-24 | Proximagen Ltd | New compounds |
| WO2014199171A1 (en) | 2013-06-12 | 2014-12-18 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
| WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
| GB201416444D0 (en) * | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New compounds |
| GB201416446D0 (en) * | 2014-09-17 | 2014-10-29 | Proximagen Ltd | New enzyme inhibitor compounds |
| KR102041761B1 (ko) | 2015-03-02 | 2019-11-06 | 닛본 덴끼 가부시끼가이샤 | 디코딩 장치, 수신기기, 송신기기, 송수신 시스템, 디코딩 방법, 및 디코딩 프로그램이 저장된 저장매체 |
| GB201507048D0 (en) | 2015-04-24 | 2015-06-10 | Proximagen Ltd | Treatment of pain |
| GB201507036D0 (en) * | 2015-04-24 | 2015-06-10 | Proximagen Ltd | Crystalline enzyme inhibitor compound |
| GB201507031D0 (en) | 2015-04-24 | 2015-06-10 | Proximagen Ltd | New pharmaceutical salt forms |
| GB201513115D0 (en) | 2015-07-24 | 2015-09-09 | Proximagen Ltd | New therapeutic compound and use in therapy |
| IL300788A (en) | 2015-11-20 | 2023-04-01 | Forma Therapeutics Inc | Furinones as ubiquitin-specific protease 1 inhibitors |
| JP2019502672A (ja) * | 2015-12-07 | 2019-01-31 | ベネボレンタイ ケンブリッジ リミティド | 疼痛の治療のためのｖａｐ−１阻害剤 |
| GB201618029D0 (en) * | 2016-10-25 | 2016-12-07 | Proximagen Ltd | New process |
| EP3902802A4 (en) * | 2018-12-28 | 2022-09-07 | Forma Therapeutics, Inc. | COMPOSITIONS FOR INHIBITING UBIQUITIN-SPECIFIC PROTEASE 1 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5285191A (en) * | 1976-01-07 | 1977-07-15 | Farmaceutici Italia | Novel 4*5*6*77tetrahydroimidazoo *4*55c*pyridine derivative process for preparing same and medicine having antiiulcer antiisecretion and antiicolline activities containing same |
| US4141899A (en) * | 1976-01-07 | 1979-02-27 | Societa' Farmaceutici Italia S.P.A. | 4,5,6,7-Tetrahydroimidazo-[4,5-c]-pyridine derivatives |
| IT1098015B (it) * | 1978-08-07 | 1985-08-31 | Farmaceutici Italia | Nuovi 4,5,6,7,-tetraidroimidazo-aperta par.quadrata 4,5-c chiusa par.quadrata-piridin-derivati |
| US6908926B1 (en) | 1999-04-16 | 2005-06-21 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
| SE0004101D0 (sv) * | 2000-11-09 | 2000-11-09 | Pharmacia Ab | New use |
| AU2002214505A1 (en) * | 2000-11-09 | 2002-05-21 | Biovitrum Ab | New use of 4, 5, 6, 7-tetrahydroimidazo-(4,5-c)pyridine derivatives |
| US6576249B1 (en) * | 2000-11-13 | 2003-06-10 | El Gendler | Bone putty and method |
| DK2334672T3 (da) | 2008-09-16 | 2013-12-02 | Proximagen Ltd | 4,5,6,7-tetrahydroimidazo[4,5-c]pyridinforbindelser som inhibitorer af SSAO |
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- 2009-09-16 AU AU2009294660A patent/AU2009294660B2/en not_active Ceased
- 2009-09-16 CN CN200980136970.1A patent/CN102232073B/zh not_active Expired - Fee Related
- 2009-09-16 EA EA201100391A patent/EA019167B1/ru not_active IP Right Cessation
- 2009-09-16 BR BRPI0918602A patent/BRPI0918602B8/pt not_active IP Right Cessation
- 2009-09-16 NZ NZ592238A patent/NZ592238A/xx not_active IP Right Cessation
- 2009-09-16 PT PT97830855T patent/PT2334672E/pt unknown
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- 2009-09-16 PL PL09783085T patent/PL2334672T3/pl unknown
- 2009-09-16 EP EP09783085.5A patent/EP2334672B1/en not_active Not-in-force
- 2009-09-16 MX MX2011002581A patent/MX2011002581A/es active IP Right Grant
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2012
- 2012-08-06 US US13/567,146 patent/US8569338B2/en not_active Expired - Fee Related
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2013
- 2013-10-25 US US14/062,969 patent/US9035066B2/en active Active
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2015
- 2015-04-13 US US14/684,813 patent/US9493457B2/en not_active Expired - Fee Related
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2016
- 2016-10-27 US US15/335,751 patent/US9890160B2/en active Active
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2017
- 2017-12-29 US US15/858,407 patent/US10399973B2/en active Active
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2019
- 2019-07-17 US US16/514,413 patent/US11040969B2/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| Anti-ulcer and Antisecretory Activity of Selected Imidazopiperidines;G.Arcari,et al.;《Arzneimittel-Forschung》;19841231;第34卷(第11期);1467-1471 * |
| G.Arcari,et al..Anti-ulcer and Antisecretory Activity of Selected Imidazopiperidines.《Arzneimittel-Forschung》.1984,第34卷(第11期),1467-1471. |
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