CN102218024B - 一种祛痘的组合物及其在化妆品中的应用 - Google Patents
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Abstract
一种祛痘的组合物,提供一种含有穿心莲提取物、丹参提取物和硫辛酸的组合物,本组合物组分合理,是一种能产生协同作用,效果显著的安全稳定的皮肤祛痘组合物,以及该组合物在化妆品及皮肤科领域的应用。
Description
技术领域
本发明涉及一种祛痘护肤组合物,具体来说涉及一种含有穿心莲提取物、丹参提取物和硫辛酸的组合物及其在化妆品的应用,属于化妆品领域。
背景技术
痤疮又叫青春痘、粉刺、毛囊炎,是发生于毛囊皮脂腺的一种慢性炎症性疾病,临床上主要表现在面部、胸部及背部出现粉刺、丘疹、脓疱、囊肿和结节,有的可形成瘢痕,严重影响人们的容貌,对正常人的就业、社交和婚育等产生重要影响。目前认为痤疮的发病与雄激素水平、皮脂分泌增加、毛囊导管角化过度、痤疮丙酸杆菌感染有关。
痤疮的形成过程:油光满面,油脂过多→毛孔粗大/堵塞→皮脂腺分泌油脂→角质层增厚,油脂渐往皮层表面隆起→角质层隆起,油脂堵塞毛孔,隆起的顶点氧化变成黑色→细菌在毛孔里和油脂搅和在一起→痤疮丙酸杆菌在缺氧情况下大量繁殖→导致炎症细菌侵入,变成脓疱、结节→整个毛囊变红、发炎→细菌扩散到附近的皮肤组织,变得更大,进而形成痤疮。
丹参提取物具有活血调经、祛瘀生新、镇静安神、凉血消痈、消肿止痛等功能。丹参中活性成分丹参酮有抗菌作用,对痤疮杆菌高度敏感,且是一种缓和的雌激素样物质,起着抗雄性素作用,同时还具有类似氢化可的松的抗炎作用,对革兰阳性细菌抗菌作用强,可明显降低痤疮丙酸杆菌计数,并能抑制急性与亚急性炎症反应,有抗炎作用。尚有温和的雌激素样活性和抗内酸睾丸酮作用,抗雄激素作用和抗皮脂腺分泌作用确切。性激素尤其是雄性激素同痤疮的发生、发展、持续状态有密切的关系。丹参酮避免了通常应用雌激素治疗痤疮,干扰病人体内代谢的缺点,从多方面改善了痤疮的临床症状.适应范围更广。此外,丹参酮具有的活血化瘀功能尚町改善面部的血液循环,促进病变皮肤的新陈代谢。
穿心莲Andrographis paniclata(Burm.f.)Nees的地上部分,又名一见喜、斩蛇剑、印度草等,为爵科植物。味苦、寒,人心、肺、胃大肠经。穿心莲具有清热解毒、凉血消肿之功,对多种感染性疾病有效;穿心莲提取物对金色葡萄球菌、枯草杆菌、大肠杆菌、黑曲霉、青霉都有明显的抑菌效果,其中对大肠杆菌的抑菌效果最强。穿心莲提取物在pH 4~7时保持较强的抑菌效果,当pH=8时,对供试菌的抑菌活性减弱,pH=9时,对黑曲霉、青霉的抑菌活性消失,对金色葡萄球菌、枯草杆菌、大肠杆菌仍然有抑制活性。
硫辛酸英文名为thioctic acid或a-lipoic acid,具有脂溶性和水溶性双重特性,是已知天然抗氧化剂中效果最强的一种,被誉为万能氧化剂,其特点为高效、低毒,由于它具有脂溶性水溶性的双重特性,可以快速渗入到皮肤,分散到细胞的所有部分,对皮肤疤痕、色斑有很好的美白作用。
本品组合物主要是通过抑制痤疮杆菌等痤疮致病菌的活性和抗氧化作用,从而达到祛痘祛斑的功效。
发明内容
本发明的目的在于提供一种组分合理,能产生协同作用,效果显著的安全稳定的皮肤祛痘组合物,以及该组合物在化妆品及皮肤科领域的应用。
本发明的技术方案如下:本化妆品按重量计它含有0.001%~20%穿心莲提取物、0.001%~30%丹参提取物和0.001%~10%硫辛酸。优选0.002%~4%穿心莲提取物、0.01%~12%丹参酮提取物和0.005%~3%硫辛酸。
另外,常用化妆品助剂、载体或这些物质的混合物组成了其他部分,使总量达到100%。
本发明化妆品组合物可用作制备防晒霜、防晒露、晒后产品、日霜、晚霜、面膜、润肤露、洗面奶、爽肤粉、眼状、发膜、护发素、精油以及在彩妆产品中,如除臭棒、香料棒、啫喱等,上述的产品由本行业熟知的技术制造。特别适用于制备霜剂、乳剂、凝胶、面膜膏剂。
同时该组合物可以作为祛痘美白化妆品的添加剂。
具体实施方式
本发明将通过实施例来进一步详述。所有的成分除特别指明的以外,均以百分重量表示。
组分 | 实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 |
丹参提取物 | 0.001 | 0.02 | 12 | 0.02 | 0.05 |
穿心莲提取物 | 0.001 | 0.2 | 4 | 0.05 | 0.2 |
硫辛酸 | 0.001 | 0.005 | 1 | 0.5 | 0.2 |
甘油 | 5.0 | 5.0 | 6.0 | ||
琼蜡硬脂醇聚醚 | 4.0 | 4.0 | |||
维生素E | 0.5 | 1.0 | |||
维生素A | 0.2 | 0.5 | |||
肉豆蔻酸异丙酯 | 4.0 | 5.0 | |||
橄榄油 | 5.0 | ||||
甘油硬脂酸酯 | 4.0 | 4.0 | |||
聚山梨醇酯80 | 4.0 | 4.0 | 8.0 | 8.0 | 8.0 |
防腐剂 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 |
卡波姆 | 0.2 | 0.2 | 1.0 | 0.3 | |
三乙醇胺 | 0.2 | 0.2 | 1.0 | 0.3 |
聚乙烯醇 | 10.0 | ||||
乙醇 | 8.0 | ||||
香精 | 0.1 | 0.1 | 0.05 | 0.05 | 0.1 |
水 | 77.60 | 70.58 | 68.75 | 85.18 | 65.65 |
丙二醇 | 10.0 | 6.0 |
实施例1祛痘乳液
将0.2公斤防腐剂、5公斤甘油、0.2公斤卡波姆、77.60公斤去离子水,搅拌均匀,加热至85摄氏度备用;将0.001公斤丹参提取物、0.001公斤穿心莲提取物、0.001公斤硫辛酸、4公斤甘油硬脂酸酯、4公斤琼蜡硬脂醇聚醚、0.5公斤维生素E、0.2公斤维生素A、4公斤肉豆蔻酸异丙酯、4公斤聚山梨醇酯80,加热至85摄氏度,慢慢加入水相,均质3000转/分钟,冷却至50摄氏度,加入0.1公斤香精,搅拌均匀,35摄氏度出料。
实施例2祛痘霜
将0.2公斤防腐剂、5公斤甘油、0.2公斤卡波姆、70.58公斤去离子水、10公斤聚甲基丙烯酸甘油酯,搅拌均匀,加热至85摄氏度备用;将0.02公斤丹参提取物、0.2公斤穿心莲提取物、0.005公斤硫辛酸、4公斤甘油硬脂酸酯、4公斤琼蜡硬脂醇聚醚、1公斤维生素E、0.5公斤维生素A、5公斤橄榄油、5公斤肉豆蔻酸异丙酯、4公斤聚山梨醇酯80,加热至85摄氏度,慢慢加入水相,均质3000转/分钟,冷却至50摄氏度,加入0.1公斤香精,搅拌均匀,35摄氏度出料。
实施例3祛痘凝胶
将0.2公斤防腐剂、68.75公斤去离子水,加热使溶解,放冷,加入6公斤甘油、1公斤卡波姆、搅拌均匀,备用,将12公斤丹参提取物、4公斤穿心莲提取物、1公斤硫辛酸、8公斤乙醇、10公斤丙二醇、8公斤聚山梨醇酯80、0.1公斤香精,搅拌使溶解,慢慢加入水相,搅拌均匀。
实施例4祛痘化妆水
将0.02公斤丹参提取物、0.05公斤穿心莲提取物、0.5公斤硫辛酸、0.2公斤防腐剂、6公斤丙二醇、8公斤聚山梨醇酯80,加热使溶解,加入051公斤香精,在搅拌下缓缓加入85.18公斤去离子水中,搅拌至均匀透明。
实施例5祛痘面膜
将0.05公斤丹参提取物、0.2公斤穿心莲提取物、0.2公斤硫辛酸、0.2公斤防腐剂、15公斤乙醇、8公斤聚山梨醇酯80、0.1公斤香精,搅拌使溶解,加入0.3公斤卡波姆,搅匀,加入0.3公斤三乙醇胺调节PH至7.0;将65.65公斤去离子水、10公斤聚乙烯醇,加热搅拌使溶解,慢慢加入油相,搅拌均匀
实施例6光照实验稳定性考察
实验方法:将供试品开口放在装有日光灯的光照箱内,在照度为4500lx±500lx的条件下放置30天,于第5天、第10天、第30天取样,以丹参酮为测定指标,考察样品变化情况;结果显示,加硫辛酸组可以提高丹参提取物的稳定性;未加硫辛酸组丹参提取物丹参酮含量下降50%,而加硫辛酸组丹参提取物丹参酮含量下降8%。
实施例7药效研究
1对家兔耳实验性痤疮模型的治疗作用
实验选用健康白色家兔44只,体重2.0-2.5kg,雌雄兼用,雌性未孕。按文献方法,取38只家兔,于每只家兔右耳内侧耳管开口处2*2cm范围,每日涂煤焦油1次,每次0.5ml,连续两周,另6只作为正常对照组。第14天,取2只家兔于涂煤焦油处取皮肤活检,以确定模型是否形成。然后,随机分5组,设空白组、模型对照组和实验组(组分一:丹参提取物;组分二:穿心莲提取物;组分三:丹参酮提取物+穿心莲提取物)三组。按以上实施1处方制备3份乳剂,作为样品,持续3周。同条件饲养。每日除给药外,应肉眼观察局部给药处皮肤的变化,耳厚薄、硬度、粗糙程度、毛囊口有无黑角栓等。末次给药后24小时,取下涂药处皮肤(全层),10%福尔马林溶液固定后,并按下述标准进行组织学观察、显微照相。参照文献按其表皮增厚及毛囊口扩张程度、角化物质多少将其病理变化分为四级:“0”为无粉刺;“+”为毛囊漏斗部可见少量角化物;“++”为毛囊漏斗部可见中等量角化物质,并向皮脂腺延伸;“+++”为扩张的毛囊内有广泛的角化物质。
对兔耳痤疮模型治疗后的病理学改变
研究表明,本处方对实验性兔耳痤疮模型有较好的治疗作用,有明显减少毛囊角栓,减轻表皮增厚,减少真皮炎细胞浸润;
实施例8祛痘临床研究
组分一:丹参提取物;组分二:穿心莲提取物;组分三:丹参酮提取物+穿心莲提取物。按以上实施1处方制备3份乳剂,作为样品,选择60名15~30岁的作为受试者,采用双盲法每天早晚洗脸后在每位受试者成员的脸部涂用适量制剂。
疗效标准:显效痤疮(包括寻常痤疮和脓胞性痤疮)消退80%以上残留或新生痤疮少于5个,好转痤疮消退70%~80%残留或新生痤疮少于10个无效痤疮消退70%以下残留或新生痤疮多于10个。
Claims (2)
1.一种含有丹参酮提取物和穿心莲提取物的祛痘组合物,其特征在于,所述该组合物按重量计含有0.001%穿心莲提取物、0.001%丹参酮提取物和0.001%硫辛酸,余量为其他可接受的载体。
2.根据权利要求1所述的祛痘组合物,其特征在于,该组合物可作为祛痘化妆品的添加剂。
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