CN102206204A - 一种苯并咪唑类化合物及其医药用途 - Google Patents
一种苯并咪唑类化合物及其医药用途 Download PDFInfo
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- CN102206204A CN102206204A CN2011100877429A CN201110087742A CN102206204A CN 102206204 A CN102206204 A CN 102206204A CN 2011100877429 A CN2011100877429 A CN 2011100877429A CN 201110087742 A CN201110087742 A CN 201110087742A CN 102206204 A CN102206204 A CN 102206204A
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- 0 CCN(C(c(cccn1)c1Cl)=C)c1cc(C)c(C)cc1* Chemical compound CCN(C(c(cccn1)c1Cl)=C)c1cc(C)c(C)cc1* 0.000 description 1
- FUJDXHWIQOCQCX-UHFFFAOYSA-N CCN(C(c(cccn1)c1Cl)=O)c1cc(C)c(C)cc1 Chemical compound CCN(C(c(cccn1)c1Cl)=O)c1cc(C)c(C)cc1 FUJDXHWIQOCQCX-UHFFFAOYSA-N 0.000 description 1
- ABBZGFAXKITKNT-UHFFFAOYSA-N Cc(c(C)c1)cc2c1nc(-c(cccn1)c1F)[n]2C Chemical compound Cc(c(C)c1)cc2c1nc(-c(cccn1)c1F)[n]2C ABBZGFAXKITKNT-UHFFFAOYSA-N 0.000 description 1
- WNBQKZLVYIDSQI-UHFFFAOYSA-N Cc(c(C)c1)cc2c1nc(-c1cccnc1Br)[n]2C Chemical compound Cc(c(C)c1)cc2c1nc(-c1cccnc1Br)[n]2C WNBQKZLVYIDSQI-UHFFFAOYSA-N 0.000 description 1
- ZYRWYZYFNDGBRT-UHFFFAOYSA-N Cc(cc12)c(C)cc1nc(-c1cccnc1Cl)[n]2O Chemical compound Cc(cc12)c(C)cc1nc(-c1cccnc1Cl)[n]2O ZYRWYZYFNDGBRT-UHFFFAOYSA-N 0.000 description 1
- WNVCCPGFEOKNPN-UHFFFAOYSA-N Cc1c(C)cc2nc(-c3cccnc3Br)[n](CCCO)c2c1 Chemical compound Cc1c(C)cc2nc(-c3cccnc3Br)[n](CCCO)c2c1 WNVCCPGFEOKNPN-UHFFFAOYSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
化合物编号 | 剂量(mg/kg) | 药物起效时间(S) | 恢复知觉时间(MIN) |
1 | 1.0 | 7 | 12 |
2 | 1.0 | 8 | 12 |
3 | 1.0 | 8 | 12 |
4 | 1.0 | 9 | 11 |
5 | 1.0 | 6 | 13 |
6 | 1.0 | 5 | 8 |
7 | 1.0 | 6 | 11 |
8 | 1.0 | 7 | 12 |
9 | 1.0 | 9 | 10 |
10 | 1.0 | 8 | 12 |
11 | 1.0 | 9 | 13 |
12 | 1.0 | 9 | 12 |
13 | 1.0 | 12 | 10 |
14 | 1.0 | 11 | 12 |
15 | 1.0 | 12 | 12 |
16 | 1.0 | 12 | 15 |
17 | 1.0 | 6 | 10 |
18 | 1.0 | 6 | 12 |
19 | 1.0 | 7 | 11 |
20 | 1.0 | 6 | 13 |
21 | 1.0 | 13 | 15 |
22 | 1.0 | 15 | 15 |
23 | 1.0 | 12 | 15 |
24 | 1.0 | 13 | 16 |
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2011100877429A CN102206204B (zh) | 2011-04-08 | 2011-04-08 | 一种苯并咪唑类化合物及其医药用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN2011100877429A CN102206204B (zh) | 2011-04-08 | 2011-04-08 | 一种苯并咪唑类化合物及其医药用途 |
Publications (2)
Publication Number | Publication Date |
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CN102206204A true CN102206204A (zh) | 2011-10-05 |
CN102206204B CN102206204B (zh) | 2012-12-12 |
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CN2011100877429A Active CN102206204B (zh) | 2011-04-08 | 2011-04-08 | 一种苯并咪唑类化合物及其医药用途 |
Country Status (1)
Country | Link |
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CN (1) | CN102206204B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1060558A (en) * | 1965-11-29 | 1967-03-08 | Egyt Gyogyszervegyeszeti Gyar | Benzimidazole derivatives |
CN1356987A (zh) * | 1999-06-22 | 2002-07-03 | 神经研究公司 | 新型苯并咪唑衍生物和包括这些化合物的药物组合物 |
-
2011
- 2011-04-08 CN CN2011100877429A patent/CN102206204B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1060558A (en) * | 1965-11-29 | 1967-03-08 | Egyt Gyogyszervegyeszeti Gyar | Benzimidazole derivatives |
CN1356987A (zh) * | 1999-06-22 | 2002-07-03 | 神经研究公司 | 新型苯并咪唑衍生物和包括这些化合物的药物组合物 |
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Publication number | Publication date |
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CN102206204B (zh) | 2012-12-12 |
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C06 | Publication | ||
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C10 | Entry into substantive examination | ||
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180810 Address after: 510000 13B01, 193 Guangzhou Avenue North Road, Yuexiu District, Guangzhou, Guangdong. Patentee after: Qifang Pharmaceutical Co., Ltd., Guangdong Province Address before: 300457 Tianjin Binhai New Area Dongting Road 220 International Joint Research Institute of biomedicine N1202 Patentee before: Tianjin Qifang Medical Technology Co., Ltd. |
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TR01 | Transfer of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Benzimidazole compound and medicinal application thereof Effective date of registration: 20190725 Granted publication date: 20121212 Pledgee: Bank of China, Limited by Share Ltd, Guangzhou, Panyu branch Pledgor: Qifang Pharmaceutical Co., Ltd., Guangdong Province Registration number: 2019440000276 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220223 Granted publication date: 20121212 Pledgee: Bank of China Limited by Share Ltd. Guangzhou Panyu branch Pledgor: GUANGDONG QIFANG MEDICINES Co.,Ltd. Registration number: 2019440000276 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |