CN102204916A - 一种含头孢美唑钠化合物的药物组合物及其制备方法 - Google Patents
一种含头孢美唑钠化合物的药物组合物及其制备方法 Download PDFInfo
- Publication number
- CN102204916A CN102204916A CN 201110089578 CN201110089578A CN102204916A CN 102204916 A CN102204916 A CN 102204916A CN 201110089578 CN201110089578 CN 201110089578 CN 201110089578 A CN201110089578 A CN 201110089578A CN 102204916 A CN102204916 A CN 102204916A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- cefmetazole
- mannitol
- sodium carbonate
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SNBUBQHDYVFSQF-HIFRSBDPSA-N cefmetazole Chemical compound S([C@@H]1[C@@](C(N1C=1C(O)=O)=O)(NC(=O)CSCC#N)OC)CC=1CSC1=NN=NN1C SNBUBQHDYVFSQF-HIFRSBDPSA-N 0.000 title claims abstract description 37
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 20
- 229960002676 cefmetazole sodium Drugs 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title abstract description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 44
- 229960003585 cefmetazole Drugs 0.000 claims abstract description 25
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 24
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 22
- 229930195725 Mannitol Natural products 0.000 claims abstract description 22
- 239000000594 mannitol Substances 0.000 claims abstract description 22
- 235000010355 mannitol Nutrition 0.000 claims abstract description 22
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract description 22
- 239000002253 acid Substances 0.000 claims abstract description 21
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000003756 stirring Methods 0.000 claims abstract description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000012528 membrane Substances 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000008215 water for injection Substances 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 16
- 238000010792 warming Methods 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 230000005496 eutectics Effects 0.000 claims description 7
- 238000007710 freezing Methods 0.000 claims description 7
- 230000008014 freezing Effects 0.000 claims description 7
- 238000001291 vacuum drying Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000008176 lyophilized powder Substances 0.000 abstract description 12
- 239000006184 cosolvent Substances 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 230000007774 longterm Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000004904 shortening Methods 0.000 abstract 1
- BITQGIOJQWZUPL-PBCQUBLHSA-M cefmetazole sodium Chemical compound [Na+].S([C@@H]1[C@@](C(N1C=1C([O-])=O)=O)(NC(=O)CSCC#N)OC)CC=1CSC1=NN=NN1C BITQGIOJQWZUPL-PBCQUBLHSA-M 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 3
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010061695 Biliary tract infection Diseases 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 108090000204 Dipeptidase 1 Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010028116 Mucosal inflammation Diseases 0.000 description 1
- 201000010927 Mucositis Diseases 0.000 description 1
- AYDQIZKZTQHYIY-UHFFFAOYSA-N OC(=O)C1(C)CC(C(O)=O)=CC=C1 Chemical compound OC(=O)C1(C)CC(C(O)=O)=CC=C1 AYDQIZKZTQHYIY-UHFFFAOYSA-N 0.000 description 1
- 241000588770 Proteus mirabilis Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 206010062255 Soft tissue infection Diseases 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 102000006635 beta-lactamase Human genes 0.000 description 1
- -1 cefmetazole acid Chemical class 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 208000003167 cholangitis Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- JMANVNJQNLATNU-UHFFFAOYSA-N glycolonitrile Natural products N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011100895785A CN102204916B (zh) | 2011-04-07 | 2011-04-07 | 一种含头孢美唑钠化合物的药物组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011100895785A CN102204916B (zh) | 2011-04-07 | 2011-04-07 | 一种含头孢美唑钠化合物的药物组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102204916A true CN102204916A (zh) | 2011-10-05 |
CN102204916B CN102204916B (zh) | 2012-11-21 |
Family
ID=44694161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011100895785A Active CN102204916B (zh) | 2011-04-07 | 2011-04-07 | 一种含头孢美唑钠化合物的药物组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102204916B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102727451A (zh) * | 2012-07-03 | 2012-10-17 | 哈药集团制药总厂 | 一种含有头孢美唑钠的药物组合物 |
CN102920671A (zh) * | 2012-11-11 | 2013-02-13 | 苏州二叶制药有限公司 | 注射用头孢美唑钠 |
CN103044459A (zh) * | 2012-12-28 | 2013-04-17 | 吴秋萍 | 一种新型头孢美唑钠化合物及其药物组合物 |
CN110314163A (zh) * | 2018-03-30 | 2019-10-11 | 杭州森泽医药科技有限公司 | 一种拉氧头孢钠药物组合物及应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101574351A (zh) * | 2009-05-12 | 2009-11-11 | 张轶伦 | 一种注射用头孢美唑制剂及其制备方法 |
-
2011
- 2011-04-07 CN CN2011100895785A patent/CN102204916B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101574351A (zh) * | 2009-05-12 | 2009-11-11 | 张轶伦 | 一种注射用头孢美唑制剂及其制备方法 |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102727451A (zh) * | 2012-07-03 | 2012-10-17 | 哈药集团制药总厂 | 一种含有头孢美唑钠的药物组合物 |
CN102727451B (zh) * | 2012-07-03 | 2013-07-03 | 哈药集团制药总厂 | 一种含有头孢美唑钠的药物组合物 |
CN102920671A (zh) * | 2012-11-11 | 2013-02-13 | 苏州二叶制药有限公司 | 注射用头孢美唑钠 |
CN103044459A (zh) * | 2012-12-28 | 2013-04-17 | 吴秋萍 | 一种新型头孢美唑钠化合物及其药物组合物 |
CN110314163A (zh) * | 2018-03-30 | 2019-10-11 | 杭州森泽医药科技有限公司 | 一种拉氧头孢钠药物组合物及应用 |
Also Published As
Publication number | Publication date |
---|---|
CN102204916B (zh) | 2012-11-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2062582B1 (en) | Antibiotic composition comprising beta-lactam antibiotics, aminoglycosides and buffers | |
CN102204916B (zh) | 一种含头孢美唑钠化合物的药物组合物及其制备方法 | |
RU2510659C2 (ru) | Гидраты солей эритромицина, их получение и применение | |
CN102180890B (zh) | 头孢硫脒结晶物及其用途 | |
WO2016095660A1 (zh) | 头孢孟多酯钠化合物新晶型及其制剂和制备方法 | |
WO2016166653A1 (en) | Stable liquid pharmaceutical compositions of bortezomib | |
CN102766148A (zh) | 一种头孢孟多酯钠化合物及其组合物 | |
JP3835815B2 (ja) | エンロフロキサシンの注射用もしくは注入用溶液 | |
JP5750680B2 (ja) | 5α−アンドロスタン−3β,5,6β−トリオール注射剤及びその調製方法 | |
HU200558B (en) | Process for producing nongelable vancomycin hydrochloride solutions and lyophilizates | |
CN104758976A (zh) | 负载了温敏性微粒蛋白类药物的双网络水凝胶及制备方法 | |
CN101297809B (zh) | 头孢哌酮钠与舒巴坦钠混粉的制备方法 | |
TW565565B (en) | Crystalline amrubicin hydrochloride | |
WO2014045296A2 (en) | Improved daptomycin injectable formulation | |
CN102988286A (zh) | 一种恩诺沙星注射液 | |
CN102617643B (zh) | 一种核黄素磷酸钠化合物 | |
JPH03502793A (ja) | 亜鉛セフチオフル複合体 | |
US5972912A (en) | Method for lyophilizing ifosfamide | |
JPS6119605B2 (zh) | ||
CN108653197B (zh) | 一种羧甲基壳聚糖季铵盐温敏凝胶及其制备方法 | |
CN102000036A (zh) | 畜禽注射用盐酸林可霉素冻干粉针剂及其制备方法 | |
CN102145001B (zh) | 稳定的氨曲南组合物及其制备方法 | |
JPS58146504A (ja) | α―インターフェロン製剤およびその製造方法 | |
TW201737920A (zh) | 磷酸鉑(phosphaplatin)液態調配物 | |
CN102727451A (zh) | 一种含有头孢美唑钠的药物组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20111005 Assignee: Hainan Tianhuang Pharmaceutical Co., Ltd. Assignor: Luo Cheng Contract record no.: 2012990000824 Denomination of invention: Pharmaceutical composition containing cefmetazole sodium compound, and preparation method thereof License type: Common License Record date: 20121109 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Hainan Tianhuang Pharmaceutical Co., Ltd. Assignor: Luo Cheng Contract record no.: 2012990000824 Date of cancellation: 20140402 |
|
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20111005 Assignee: Hainan Tianhuang Pharmaceutical Co., Ltd. Assignor: Luo Cheng Contract record no.: 2014990000169 Denomination of invention: Pharmaceutical composition containing cefmetazole sodium compound, and preparation method thereof Granted publication date: 20121121 License type: Common License Record date: 20140402 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20111005 Assignee: Fujian Kang Cheng Pharmaceutical Co., Ltd. Assignor: Luo Cheng Contract record no.: 2018990000074 Denomination of invention: Pharmaceutical composition containing cefmetazole sodium compound, and preparation method thereof Granted publication date: 20121121 License type: Common License Record date: 20180329 |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210402 Address after: 350108 haixiyuan medical science and technology building, high tech Zone, Fuzhou City, Fujian Province Patentee after: Fujian Yiyi Xinghua Biotechnology Development Co.,Ltd. Address before: Room 601, building a, shengshijiayuan, Renmin Road, Longyan City, Fujian Province, 364000 Patentee before: Luo Cheng |