CN102202655B - 基因工程抗IL-23p19抗体的冻干制剂 - Google Patents

基因工程抗IL-23p19抗体的冻干制剂 Download PDF

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CN102202655B
CN102202655B CN2009801428023A CN200980142802A CN102202655B CN 102202655 B CN102202655 B CN 102202655B CN 2009801428023 A CN2009801428023 A CN 2009801428023A CN 200980142802 A CN200980142802 A CN 200980142802A CN 102202655 B CN102202655 B CN 102202655B
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CN102202655A (zh
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李旭红
R·S·卡施
A·巴卡
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Merck Sharp and Dohme BV
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Schering Corp
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Proteomics, Peptides & Aminoacids (AREA)
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CN2009801428023A 2008-08-27 2009-08-25 基因工程抗IL-23p19抗体的冻干制剂 Active CN102202655B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9232608P 2008-08-27 2008-08-27
US61/092326 2008-08-27
US61/092,326 2008-08-27
PCT/US2009/054842 WO2010027766A1 (en) 2008-08-27 2009-08-25 Lyophilized formulatons of engineered anti-il-23p19 antibodies

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CN102202655A CN102202655A (zh) 2011-09-28
CN102202655B true CN102202655B (zh) 2013-06-19

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US (1) US8263748B2 (https=)
EP (1) EP2331078B1 (https=)
JP (2) JP5931442B2 (https=)
CN (1) CN102202655B (https=)
AU (1) AU2009288419B2 (https=)
CA (1) CA2734919C (https=)
MX (1) MX2011002159A (https=)
WO (1) WO2010027766A1 (https=)

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UA117466C2 (uk) * 2012-12-13 2018-08-10 Мерк Шарп Енд Доме Корп. СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19
KR20150128859A (ko) 2013-03-15 2015-11-18 암젠 인크 항-il23 항체를 사용하여 크론병을 치료하는 방법
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CA3105598A1 (en) 2018-07-13 2020-01-16 Carl GOMMOLL Treating ulcerative colitis with brazikumab
KR102885113B1 (ko) 2018-10-18 2025-11-13 머크 샤프 앤드 돔 엘엘씨 항-rsv 항체의 제제 및 그의 사용 방법
CN120842406A (zh) 2018-10-31 2025-10-28 默沙东有限责任公司 抗人pd-1抗体晶体及其使用方法
CN113316458B (zh) 2018-11-07 2024-08-02 默沙东有限责任公司 抗lag3抗体和抗pd-1抗体的共制剂
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AU2009288419A1 (en) 2010-03-11
WO2010027766A1 (en) 2010-03-11
JP2016028086A (ja) 2016-02-25
EP2331078A1 (en) 2011-06-15
JP5931442B2 (ja) 2016-06-08
US20110229490A1 (en) 2011-09-22
EP2331078B1 (en) 2012-09-19
CA2734919A1 (en) 2010-03-11
JP2012501332A (ja) 2012-01-19
CA2734919C (en) 2016-08-16
US8263748B2 (en) 2012-09-11
MX2011002159A (es) 2011-03-29
AU2009288419B2 (en) 2015-08-06
CN102202655A (zh) 2011-09-28

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