CN102178656A - Hm-3多肽冻干粉制剂及其制备方法 - Google Patents
Hm-3多肽冻干粉制剂及其制备方法 Download PDFInfo
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- CN102178656A CN102178656A CN 201110122070 CN201110122070A CN102178656A CN 102178656 A CN102178656 A CN 102178656A CN 201110122070 CN201110122070 CN 201110122070 CN 201110122070 A CN201110122070 A CN 201110122070A CN 102178656 A CN102178656 A CN 102178656A
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稳定性(4℃) | HM-3(0月) | HM-3(3个月) | 实施例2(3个月) | 实施例3(3个月) |
含量: | 99.1% | 90.04% | 98.63% | 96.83% |
抑制HUVEC迁移率 | 85% | 50.78% | 83.28% | 78.77% |
抑制肝癌效果 | 78% | 50.90% | 75.29% | 68.62% |
稳定性(4℃) | HM-3(0月) | HM-3(12个月) | 实施例2(12个月) | 实施例3(12个月) |
含量: | 99.1% | 85.57% | 96.54% | 95.37% |
抑制HUVEC迁移率 | 85% | 40.43% | 80.60% | 82.42% |
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CN2011101220700A CN102178656B (zh) | 2011-05-12 | 2011-05-12 | Hm-3多肽冻干粉制剂及其制备方法 |
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CN2011101220700A CN102178656B (zh) | 2011-05-12 | 2011-05-12 | Hm-3多肽冻干粉制剂及其制备方法 |
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CN102178656A true CN102178656A (zh) | 2011-09-14 |
CN102178656B CN102178656B (zh) | 2012-08-22 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103720667A (zh) * | 2014-01-09 | 2014-04-16 | 中国药科大学 | Ap-25多肽冻干粉针制剂及其制备方法和用途 |
CN103736078A (zh) * | 2014-01-09 | 2014-04-23 | 南京安吉生物科技有限公司 | mPEG-HM-3多肽冻干粉针制剂及其制备方法和用途 |
CN106619543A (zh) * | 2016-12-15 | 2017-05-10 | 首都医科大学 | 抗肿瘤海鞘多肽cs5931冻干粉针制剂及其制备方法 |
CN109553686A (zh) * | 2017-09-26 | 2019-04-02 | 南京安吉生物科技有限公司 | 一种新型可调控的双嵌合抗原受体t细胞及其构建方法和应用 |
EP2784093B1 (en) * | 2011-11-21 | 2019-10-09 | Hanmei Xu | Polyethylene glycol-modified integrin blocker hm-3 and use thereof |
CN111375052A (zh) * | 2020-03-13 | 2020-07-07 | 北京赛升药业股份有限公司 | 一种注射用安替安吉肽冻干制剂的冻干方法 |
CN111419804A (zh) * | 2020-04-17 | 2020-07-17 | 北京赛升药业股份有限公司 | 一种注射用血管生成抑肽冻干制剂及其冻干方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1699408A (zh) * | 2005-06-03 | 2005-11-23 | 中国药科大学 | 高效抑制血管生成多肽及其制备方法和应用 |
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2011
- 2011-05-12 CN CN2011101220700A patent/CN102178656B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1699408A (zh) * | 2005-06-03 | 2005-11-23 | 中国药科大学 | 高效抑制血管生成多肽及其制备方法和应用 |
Non-Patent Citations (2)
Title |
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《中国药科大学学报》 20101231 殷润婷等 抗肿瘤多肽HM-3的中和抗体活性研究 171-174 1-3 第41卷, 第2期 2 * |
《中外医疗》 20091231 孙晓东等 蛋白质多肽类药物给药途径及剂型的研究进展 160-162 1-3 第2009年卷, 第21期 2 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2784093B1 (en) * | 2011-11-21 | 2019-10-09 | Hanmei Xu | Polyethylene glycol-modified integrin blocker hm-3 and use thereof |
CN103720667A (zh) * | 2014-01-09 | 2014-04-16 | 中国药科大学 | Ap-25多肽冻干粉针制剂及其制备方法和用途 |
CN103736078A (zh) * | 2014-01-09 | 2014-04-23 | 南京安吉生物科技有限公司 | mPEG-HM-3多肽冻干粉针制剂及其制备方法和用途 |
CN103720667B (zh) * | 2014-01-09 | 2016-04-13 | 中国药科大学 | Ap-25多肽冻干粉针制剂及其制备方法和用途 |
CN106619543A (zh) * | 2016-12-15 | 2017-05-10 | 首都医科大学 | 抗肿瘤海鞘多肽cs5931冻干粉针制剂及其制备方法 |
CN109553686A (zh) * | 2017-09-26 | 2019-04-02 | 南京安吉生物科技有限公司 | 一种新型可调控的双嵌合抗原受体t细胞及其构建方法和应用 |
CN111375052A (zh) * | 2020-03-13 | 2020-07-07 | 北京赛升药业股份有限公司 | 一种注射用安替安吉肽冻干制剂的冻干方法 |
CN111419804A (zh) * | 2020-04-17 | 2020-07-17 | 北京赛升药业股份有限公司 | 一种注射用血管生成抑肽冻干制剂及其冻干方法 |
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CN102178656B (zh) | 2012-08-22 |
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Address after: The town of Hongmiao Hongshan District, West Water Village 024000 the Inner Mongolia Autonomous Region Chifeng City Patentee after: INNER MONGOLIA TIANQI PHARMACEUTICAL INVESTMENT (Group) Co.,Ltd. Patentee after: Xu Hanmei Address before: The town of Hongmiao Hongshan District, West Water Village 024000 the Inner Mongolia Autonomous Region Chifeng City Patentee before: Inner Mongolia wonder investment (Group) Co.,Ltd. Patentee before: Xu Hanmei Address after: The town of Hongmiao Hongshan District, West Water Village 024000 the Inner Mongolia Autonomous Region Chifeng City Patentee after: Inner Mongolia wonder investment (Group) Co.,Ltd. Patentee after: Xu Hanmei Address before: The town of Hongmiao Hongshan District, West Water Village 024000 the Inner Mongolia Autonomous Region Chifeng City Patentee before: Inner Mongolia Strange Biological High Technology (Group) Co.,Ltd. Patentee before: Xu Hanmei Address after: The town of Hongmiao Hongshan District, West Water Village 024000 the Inner Mongolia Autonomous Region Chifeng City Patentee after: Inner Mongolia Strange Biological High Technology (Group) Co.,Ltd. Patentee after: Xu Hanmei Address before: The town of Hongmiao Hongshan District, West Water Village 024000 the Inner Mongolia Autonomous Region Chifeng City Patentee before: INNER MONGOLIA QITE BIOLOG HIGH TECH GROUP Co.,Ltd. Patentee before: Xu Hanmei |
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Effective date of registration: 20151211 Address after: 100176 No. 8 prosperous street, Beijing economic and Technological Development Zone, Beijing Patentee after: Beijing Saisheng Pharmaceutical Co.,Ltd. Address before: The town of Hongmiao Hongshan District, West Water Village 024000 the Inner Mongolia Autonomous Region Chifeng City Patentee before: INNER MONGOLIA TIANQI PHARMACEUTICAL INVESTMENT (Group) Co.,Ltd. Patentee before: Xu Hanmei |