CN102177427B - 颗粒分析中的检测和处理同步 - Google Patents

颗粒分析中的检测和处理同步 Download PDF

Info

Publication number
CN102177427B
CN102177427B CN200980140598.1A CN200980140598A CN102177427B CN 102177427 B CN102177427 B CN 102177427B CN 200980140598 A CN200980140598 A CN 200980140598A CN 102177427 B CN102177427 B CN 102177427B
Authority
CN
China
Prior art keywords
signal
particle
measurement
points
peak
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200980140598.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN102177427A (zh
Inventor
特德·W·布里顿
陆久留
杰弗里·L·罗斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Publication of CN102177427A publication Critical patent/CN102177427A/zh
Application granted granted Critical
Publication of CN102177427B publication Critical patent/CN102177427B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N2015/1461—Coincidence detecting; Circuits therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Optical Measuring Cells (AREA)
CN200980140598.1A 2008-10-10 2009-10-02 颗粒分析中的检测和处理同步 Active CN102177427B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/249,473 2008-10-10
US12/249,473 US8154273B2 (en) 2008-10-10 2008-10-10 Detecting and handling coincidence in particle analysis
PCT/US2009/059363 WO2010042401A1 (en) 2008-10-10 2009-10-02 Detecting and handling coincidence in particle analysis

Publications (2)

Publication Number Publication Date
CN102177427A CN102177427A (zh) 2011-09-07
CN102177427B true CN102177427B (zh) 2014-06-18

Family

ID=42098277

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980140598.1A Active CN102177427B (zh) 2008-10-10 2009-10-02 颗粒分析中的检测和处理同步

Country Status (7)

Country Link
US (1) US8154273B2 (enExample)
EP (1) EP2350611B1 (enExample)
JP (1) JP5557842B2 (enExample)
CN (1) CN102177427B (enExample)
ES (1) ES2717843T3 (enExample)
TR (1) TR201904506T4 (enExample)
WO (1) WO2010042401A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8395398B2 (en) * 2009-04-24 2013-03-12 Beckman Coulter, Inc. Method of characterizing particles
SMT201700421T1 (it) * 2009-06-10 2017-11-15 Cynvenio Biosystems Inc Dispositivi e metodi a flusso di guaina
EP2499591A2 (en) 2009-11-13 2012-09-19 Beckman Coulter, Inc. Systems and methods for detecting the presence of a biological status using clustering
WO2013096137A1 (en) * 2011-12-20 2013-06-27 Becton, Dickinson And Company System and method to improve yield of sorted particles
EP2955512B1 (en) * 2013-02-08 2018-10-24 Sony Corporation Microparticle analyzing device and microparticle analyzing system
ES2880609T3 (es) 2013-03-14 2021-11-25 Abbott Lab Métodos para detectar eventos de muestras coincidentes
WO2015154288A1 (zh) * 2014-04-10 2015-10-15 深圳迈瑞生物医疗电子股份有限公司 一种进行自动补偿的方法、装置及相应的流式细胞分析仪
US20170227447A1 (en) * 2014-08-06 2017-08-10 Beckman Coulter, Inc. Evaluation of multi-peak events using a flow cytometer
JP2016080563A (ja) * 2014-10-20 2016-05-16 日本光電工業株式会社 分析システム、分析装置
US11029241B2 (en) 2015-02-13 2021-06-08 Artium Technologies, Inc. Enhanced detection through parsing records into signal components
FR3034520B1 (fr) 2015-04-02 2020-02-14 Horiba Abx Sas Dispositif de comptage de particules
CN107367453A (zh) * 2016-05-13 2017-11-21 上海纳衍生物科技有限公司 一种基于直流电阻抗测量的细胞粒子检测方法
US10725061B2 (en) * 2017-02-03 2020-07-28 Pentagon Technologies Group, Inc. Modulated air surface particle detector
US10648909B2 (en) 2017-05-25 2020-05-12 Abbott Laboratories Methods and systems for assessing flow cell cleanliness
EP3415608B1 (en) 2017-06-14 2022-05-11 Ricoh Company, Ltd. Method for producing cell containing base
JP7124438B2 (ja) * 2017-06-14 2022-08-24 株式会社リコー 細胞保持基材の生成方法、及び装置評価方法
CN108037060B (zh) * 2018-01-26 2019-11-08 中国人民解放军总医院 粒子计数方法、实现所述方法的粒子计数装置和粒子分析仪
EP3785012A4 (en) * 2018-04-26 2022-02-09 Becton, Dickinson and Company CHARACTERIZATION AND SORTING FOR PARTICLE ANALYZERS
KR102094373B1 (ko) * 2018-09-05 2020-03-27 주식회사 마하테크 미세플라스틱 검출장치
JP7437393B2 (ja) 2018-10-17 2024-02-22 ベクトン・ディキンソン・アンド・カンパニー 粒子分析器のための適応ソーティング
CN109323975B (zh) * 2018-11-07 2021-05-25 中国科学院合肥物质科学研究院 一种基于回波阈值比较的opc计数校正方法
EP3942278B1 (en) * 2019-03-22 2023-07-19 Precision Planting LLC Particle counting apparatus, systems and methods
MA55471A (fr) 2019-12-27 2022-02-09 Beckman Coulter Inc Instrument de préparation d'échantillons
CN111751864B (zh) * 2020-06-30 2022-07-05 北京卫星环境工程研究所 粒子探测器指令处理方法和系统
CN112730408B (zh) * 2020-12-24 2024-07-09 贝克曼库尔特生物科技（苏州）有限公司 液流检测系统和液流检测方法以及分选装置
WO2023163813A1 (en) * 2022-02-24 2023-08-31 Becton, Dickinson And Company Methods and systems for evaluating flow cytometer data for the presence of a coincident event

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981580A (en) * 1989-05-01 1991-01-01 Coulter Corporation Coincidence arbitration in a flow cytomery sorting system
US5996212A (en) * 1997-05-23 1999-12-07 U.S. Philips Corporation Method of manufacturing a body having a structure of layers
US20030235919A1 (en) * 1998-05-14 2003-12-25 Chandler Van S. Multi-analyte diagnostic system and computer implemented process for same
US20060203226A1 (en) * 2000-06-02 2006-09-14 Idexx Laboratories, Inc. Flow-cytometry-based hematology system
US20070047674A1 (en) * 2005-08-24 2007-03-01 Beckman Coulter, Inc. Method and apparatus for finding center amplitude of particle size-representative pulses produced by aperture based sizing system
US20080015291A1 (en) * 2006-07-12 2008-01-17 General Electric Company Flame retardant and scratch resistant thermoplastic polycarbonate compositions
US20080158561A1 (en) * 2006-12-29 2008-07-03 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US20080215297A1 (en) * 2006-12-22 2008-09-04 Clement James Goebel Detection system and user interface for a flow cytometer system
US20080221812A1 (en) * 2006-09-29 2008-09-11 Richard Pittaro Differentiation of flow cytometry pulses and applications
US20080248966A1 (en) * 1997-05-05 2008-10-09 Chemometec A/S Method and a system for determination of particles in a liquid sample

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949198A (en) 1972-03-27 1976-04-06 Coulter Electronics, Inc. Methods and apparatuses for correcting coincidence count inaccuracies in a coulter type of particle analyzer
US4021117A (en) * 1975-08-07 1977-05-03 Hildegard Gohde Process for automatic counting and measurement of particles
HU173092B (hu) 1976-02-24 1979-02-28 Medicor Muevek Ehlektroskhema dlja opredelenija chisla eritrocito, srednego ob"joma tel'ca, velichini gematokrita i drugikh parametrov krovi
US4263508A (en) 1979-04-20 1981-04-21 Research Corporation Pulse edge measurement for determining particle dimensional characteristics
US5199576A (en) * 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
US5286452A (en) * 1991-05-20 1994-02-15 Sienna Biotech, Inc. Simultaneous multiple assays
WO1994027146A1 (en) 1993-05-14 1994-11-24 Coulter Corporation Reticulocyte analyzing method and apparatus utilizing light scatter techniques
US5633945A (en) * 1994-10-05 1997-05-27 Compucyte Corporation Accuracy in cell mitosis analysis
JP3946444B2 (ja) * 1998-05-14 2007-07-18 ルミネックス コーポレイション フローサイトメータのデッドタイムをゼロにする構成および方法
US6408679B1 (en) * 2000-02-04 2002-06-25 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Bubble measuring instrument and method
US6518747B2 (en) * 2001-02-16 2003-02-11 Quantum Design, Inc. Method and apparatus for quantitative determination of accumulations of magnetic particles
US6744245B2 (en) * 2001-07-27 2004-06-01 Coulter International Corp. Particle count correction method and apparatus
US20060015291A1 (en) 2002-10-18 2006-01-19 Leland Stanford Junior University Methods and systems for data analysis
JP4654070B2 (ja) * 2004-06-17 2011-03-16 シチズンホールディングス株式会社 液晶表示装置及びメモリ性液晶パネルの駆動回路
US7352461B2 (en) 2004-11-30 2008-04-01 Tokyo Electron Limited Particle detecting method and storage medium storing program for implementing the method
US20080204716A1 (en) * 2005-03-07 2008-08-28 Michael Trainer Methods and apparatus for determining characteristics of particles
US7417418B1 (en) * 2005-06-14 2008-08-26 Ayliffe Harold E Thin film sensor
JP2007024844A (ja) * 2005-07-21 2007-02-01 Sysmex Corp 血液分析方法及び血液分析装置
US7457709B2 (en) * 2005-12-20 2008-11-25 Beckman Coulter, Inc. Systems and methods for particle counting
JP4994920B2 (ja) * 2007-02-01 2012-08-08 シスメックス株式会社 検体分析装置

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981580A (en) * 1989-05-01 1991-01-01 Coulter Corporation Coincidence arbitration in a flow cytomery sorting system
US20080248966A1 (en) * 1997-05-05 2008-10-09 Chemometec A/S Method and a system for determination of particles in a liquid sample
US5996212A (en) * 1997-05-23 1999-12-07 U.S. Philips Corporation Method of manufacturing a body having a structure of layers
US20030235919A1 (en) * 1998-05-14 2003-12-25 Chandler Van S. Multi-analyte diagnostic system and computer implemented process for same
US20060203226A1 (en) * 2000-06-02 2006-09-14 Idexx Laboratories, Inc. Flow-cytometry-based hematology system
US20070047674A1 (en) * 2005-08-24 2007-03-01 Beckman Coulter, Inc. Method and apparatus for finding center amplitude of particle size-representative pulses produced by aperture based sizing system
US20080015291A1 (en) * 2006-07-12 2008-01-17 General Electric Company Flame retardant and scratch resistant thermoplastic polycarbonate compositions
US20080221812A1 (en) * 2006-09-29 2008-09-11 Richard Pittaro Differentiation of flow cytometry pulses and applications
US20080215297A1 (en) * 2006-12-22 2008-09-04 Clement James Goebel Detection system and user interface for a flow cytometer system
US20080158561A1 (en) * 2006-12-29 2008-07-03 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream

Also Published As

Publication number Publication date
US20100090677A1 (en) 2010-04-15
JP5557842B2 (ja) 2014-07-23
ES2717843T3 (es) 2019-06-25
WO2010042401A1 (en) 2010-04-15
EP2350611A1 (en) 2011-08-03
EP2350611B1 (en) 2019-02-13
US8154273B2 (en) 2012-04-10
TR201904506T4 (tr) 2019-05-21
CN102177427A (zh) 2011-09-07
EP2350611A4 (en) 2015-08-12
JP2012505406A (ja) 2012-03-01

Similar Documents

Publication Publication Date Title
CN102177427B (zh) 颗粒分析中的检测和处理同步
CN103597349B (zh) 识别和计数早期粒细胞(egc)
US10983042B2 (en) Cell analyzer and sorting method therefor
CN111656161B (zh) 样本分析仪异常的报警方法、系统及存储介质
CN106687810B (zh) 一种非诊断目的的有核红细胞报警方法、装置及流式细胞分析仪
EP0515099B1 (en) Apparatus for analyzing cells in urine
US5325169A (en) Apparatus and method for analyzing cells in urine
CN111684264B (zh) 血液分析方法、血液分析系统及存储介质
CN111801568B (zh) 测定血小板浓度的方法及系统
CN104297135B (zh) 血液样本中粒子的识别方法、系统及血液细胞分析仪
US8512977B2 (en) Analyzing reticulocytes
US5684584A (en) Apparatus for analyzing cells in urine
CN114222907B (zh) 检测和报道中性粒细胞亚群
WO2021207894A1 (zh) 细胞分析方法、细胞分析仪及计算机可读存储介质
CN115201155A (zh) 血液样本的检测方法和样本分析仪
CN115201269A (zh) 应用电阻抗检测血小板的方法和血液分析系统

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant