CN102170881B - 用于肾脏细胞癌的治疗的3,3’,4,4’-四羟基-2,2’-联吡啶-n,n’-二氧化物 - Google Patents

用于肾脏细胞癌的治疗的3,3’,4,4’-四羟基-2,2’-联吡啶-n,n’-二氧化物 Download PDF

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Publication number
CN102170881B
CN102170881B CN200980139366.4A CN200980139366A CN102170881B CN 102170881 B CN102170881 B CN 102170881B CN 200980139366 A CN200980139366 A CN 200980139366A CN 102170881 B CN102170881 B CN 102170881B
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China
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formula
pharmaceutically acceptable
orellanine
acid
treatment
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Chinese (zh)
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CN102170881A (zh
Inventor
燕妮·尼斯特伦
莉萨·布瓦尔
乌尔夫·尼尔松
伯耶·哈拉尔德松
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Oncorena AB
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Oncorena AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200980139366.4A 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3’,4,4’-四羟基-2,2’-联吡啶-n,n’-二氧化物 Active CN102170881B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510353115.3A CN105147683B (zh) 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3＇,4，4＇-四羟基-2,2＇-联吡啶-n,n＇-二氧化物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19531208P 2008-10-06 2008-10-06
US61/195,312 2008-10-06
US12/586,849 US8053430B2 (en) 2008-10-06 2009-09-29 Treatment of renal cell carcinoma
US12/586,849 2009-09-29
PCT/EP2009/062976 WO2010040750A1 (en) 2008-10-06 2009-10-06 3, 3', 4, 4' -tetrahydroxy-2, 2' -bipyridine-n, n' -dioxides for the treatment of renal cell carcinoma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510353115.3A Division CN105147683B (zh) 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3＇,4，4＇-四羟基-2,2＇-联吡啶-n,n＇-二氧化物

Publications (2)

Publication Number Publication Date
CN102170881A CN102170881A (zh) 2011-08-31
CN102170881B true CN102170881B (zh) 2015-07-22

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN200980139366.4A Active CN102170881B (zh) 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3’,4,4’-四羟基-2,2’-联吡啶-n,n’-二氧化物
CN201510353115.3A Active CN105147683B (zh) 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3＇,4，4＇-四羟基-2,2＇-联吡啶-n,n＇-二氧化物

Family Applications After (1)

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CN201510353115.3A Active CN105147683B (zh) 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3＇,4，4＇-四羟基-2,2＇-联吡啶-n,n＇-二氧化物

Country Status (11)

Country Link
US (2) US8053430B2 (cg-RX-API-DMAC7.html)
EP (1) EP2349268B1 (cg-RX-API-DMAC7.html)
JP (1) JP5340393B2 (cg-RX-API-DMAC7.html)
KR (1) KR101678702B1 (cg-RX-API-DMAC7.html)
CN (2) CN102170881B (cg-RX-API-DMAC7.html)
CA (1) CA2736322C (cg-RX-API-DMAC7.html)
DK (1) DK2349268T3 (cg-RX-API-DMAC7.html)
ES (1) ES2401671T3 (cg-RX-API-DMAC7.html)
PL (1) PL2349268T3 (cg-RX-API-DMAC7.html)
PT (1) PT2349268E (cg-RX-API-DMAC7.html)
WO (1) WO2010040750A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2552443B1 (en) * 2010-04-01 2021-07-14 Oncorena Ab Improved treatment of renal cell carcinoma
GB201103578D0 (en) * 2011-03-02 2011-04-13 Sabrepharm Ltd Dipyridinium derivatives
CN105450495B (zh) * 2014-09-18 2018-09-21 中国电信股份有限公司 用于重新建立安全通信通道的方法、装置和系统
WO2024002909A1 (en) 2022-07-01 2024-01-04 Oncorena Ab Orellanine formulation
CN121335885A (zh) 2023-05-03 2026-01-13 奥科瑞纳股份公司 奥来毒素的合成
KR20250083338A (ko) 2023-11-30 2025-06-10 가톨릭대학교 산학협력단 신장암 어셈블로이드 및 이의 제조 방법

Family Cites Families (12)

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US4713352A (en) 1981-08-31 1987-12-15 Sloan-Kettering Institute For Cancer Reseach Monoclonal antibody panel for early diagnosis and therapy of renal carcinoma
US6403373B1 (en) 1997-10-10 2002-06-11 Ludwig Institute For Cancer Research Isolated nucleic acid molecules associated with colon, renal, and stomach cancer and methods of using these
US6440663B1 (en) 1998-10-05 2002-08-27 Ludwig Institute For Cancer Research Renal cancer associated antigens and uses therefor
AR029160A1 (es) 1999-04-08 2003-06-18 Schering Corp El uso del interferon-alfa pegilado para la preparacion de un medicamento para el tratamiento del carcinoma de celula renal, un kit y el uso del mismo
CN1359941A (zh) 2000-12-20 2002-07-24 上海博德基因开发有限公司 一种新的多肽——人肾癌rage4抗原11.44和编码这种多肽的多核苷酸
RU2188026C1 (ru) 2001-01-12 2002-08-27 Ростовский научно-исследовательский онкологический институт Способ лечения рака почки
EP1712234B1 (en) 2001-09-12 2009-01-28 Novartis AG Use of 4-Pyridylmethylphthalazines for Renal Cancer Treatment
ATE537842T1 (de) 2002-07-01 2012-01-15 Wilex Ag Zusammesetzungen von cg250 und il-2 oder von cg250 und ifn-alpha zur krebsbehandlung des nierenzell karzinoms
DE10307928A1 (de) 2003-02-25 2004-09-16 Faustus Forschungs Cie. Translational Cancer Research Gmbh Verwendung von 1-(2-Chlorethyl)-1-nitroso-3-(2-hydroxyethyl)-urea zur Behandlung von Pankreaskarzinomen, Weichteilsarkomen, Hodentumoren, Lymphomen, Thymomen, Wilms Tumoren, Nierenkarzinomen, Melanomen, Lungentumoren, intracerebralen Metastasen, Tumoren im Kopf- und Halsbereich, und Mamma-Karzinomen
WO2006044779A1 (en) 2004-10-14 2006-04-27 Northwestern University Detection and treatment of renal cancer
CA2625741C (en) 2005-10-14 2013-08-06 Government Of The United States Of America, As Represented By The Secret Ary, Department Of Health And Human Services Treating renal cancer using 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-2-methyl-benzaldehyde
EP1957115B8 (en) 2005-11-10 2014-03-05 Celldex Therapeutics, Inc. Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen

Non-Patent Citations (3)

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differential inhibitory action of the fungal toxin orellanine on alkaline phosphatase isoenzymes;Christiane Ruedl, et al.;《biochimica et biophysica acta》;19891231;第991卷;280-283 *
investigations on the mode of action of the fungus toxin orellanine on renal cell cultures;C.Heufler, et al.;《Agents and Actions》;19871231;第21卷(第1/2期);203-208 *
龚庆芳,等.蘑菇毒素及其中毒治疗(II)-奥来毒素.《实用预防医学》.2003,第10卷(第3期),432-434. *

Also Published As

Publication number Publication date
US20100152243A1 (en) 2010-06-17
EP2349268A1 (en) 2011-08-03
CA2736322C (en) 2017-01-10
KR20110073486A (ko) 2011-06-29
PL2349268T3 (pl) 2013-06-28
CA2736322A1 (en) 2010-04-15
CN105147683A (zh) 2015-12-16
WO2010040750A1 (en) 2010-04-15
HK1218857A1 (zh) 2017-03-17
US20120077846A1 (en) 2012-03-29
ES2401671T3 (es) 2013-04-23
KR101678702B1 (ko) 2016-11-22
JP2012504584A (ja) 2012-02-23
DK2349268T3 (da) 2013-04-15
CN105147683B (zh) 2019-01-22
JP5340393B2 (ja) 2013-11-13
CN102170881A (zh) 2011-08-31
PT2349268E (pt) 2013-04-02
EP2349268B1 (en) 2013-01-16
US8349823B2 (en) 2013-01-08
HK1161116A1 (zh) 2012-08-24
US8053430B2 (en) 2011-11-08

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