CN102166175B - Anti-aging folia perillae acutae oil nano-emulsion cosmetic - Google Patents
Anti-aging folia perillae acutae oil nano-emulsion cosmetic Download PDFInfo
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Abstract
The invention discloses an anti-aging folia perillae acutae oil nano-emulsion cosmetic. The grain diameter of the cosmetic is 6-100nm. The anti-aging cosmetic comprises the following raw materials: 15.00-31.00wt% of surfactant, 4.00-7.00wt% of oil, 0.10-10.00wt% of folia perillae acutae oil, 1.00-2.00wt% of vitamin E acetic ester, 0.10-0.20wt% of essence and the balance of distilled water, wherein the total amount is equal to 100%. The cosmetic has better skin permeability, can enhance the solubility of the folia perillae acutae oil, improves the anti-aging effect of the folia perillae acutae oil, improves the ductility of the cosmetic on the skin, and brings clear and moisture good feeling for users. The anti-aging cosmetic has wide market prospect in the field of the anti-aging cosmetics.
Description
Technical field
The invention belongs to cosmetic field, relate to a kind of novel form of anti-aging cosmetics, particularly a kind of oil-in-water type Folium perillae acutae oil nano-emulsion of transparent and stable cosmetic article.
Background technology
From at present domestic and international cosmetics industry development trend, general cosmetics are in slow state of development basically, have only the cosmetics of special effects; Still in rising trend like defying age, natural cosmetics, novel cosmetic such as sun-proof; Wherein popular the widest be anti-aging cosmetics, currently account for 50% in the U.S.'s its sales quota of cosmetics market, account for 55% in France; Account for 56% in China, Japan and Southeast Asian countries have also formed the fast-selling situation of anti-aging cosmetics.Along with Chinese society is stepped into aging gradually, the anti-aging beauty-care skin protection more and more receives people's attention.The data of China essence scenting cosmetics TIA issue show that at present, the women is concerned about the defying age problem most.According to conservative statistics, China's anti-aging cosmetics annual sales amount reaches 4,500,000,000 yuan at least at present, and annual speed increment with 2 bit digital.Therefore, by the old and feeble research direction that also becomes each Cosmetic Manufacture producer of cosmetics slow down aging and opposing.
One of main factor of skin aging is that the skin photosensitiveness that caused by ultraviolet radiation is aging; The skin photosensitiveness is aging to be because the increase of free-radical contents in the skin; Free radical can damage biomembrane, impels elastic fiber generation cross-linked polymeric, quickens skin aging.The damaging action of antagonism and elimination free radical control free radical is often realized through antioxidant.Present antioxidant has two types of enzyme and non-enzymes, and because of its poor stability, and molecular weight is bigger, infiltrates skin and is restricted, and has limited its application in cosmetics.Recent study finds that the micromolecule antioxidant that from plant, Chinese herbal medicine, extracts has very strong antioxidation, and more is prone to infiltrate skin, and is more stable.Folium perillae acutae oil is the volatile oil that extracts in the dry stem and leaf of plant Folium Perillae, have eliminate free radical preferably, prevent lipid peroxidation, the synthetic effect of blocking-up nitrous base class material,, health care anti-aging for the mankind has very unique significance because.
At present, the anti-aging cosmetics existing product all be emulsion mostly, its particle diameter is generally all greater than 400nm, skin is difficult for absorbing.Nano-emulsion is as a kind of specific form of emulsion; Compared following characteristics with general emulsion: (1) particle diameter is little, and the nanoemulsions particle diameter sees through skin easily below 100nm; Have higher diffusibility and percutaneous permeability than general emulsion, the product result of use improves.(2) thermodynamic stability is high.Operation is fairly simple during preparation, not phase-splitting, do not precipitate, and bin stability improves; (3) light transmission is good, and sensible quality improves; (4) antiseptic property improves, because decentralized photo liquid is smaller, can prevent the intrusion of antibacterial, increases the dissolubility of some active ingredients simultaneously.(5) nano-emulsion can improve the dissolubility of Folium perillae acutae oil greatly.
Summary of the invention
To problem and the defective that above-mentioned prior art exists, the object of the present invention is to provide a kind of little to the human body zest, have the Folium perillae acutae oil nano-emulsion of removing free radical, antagonism slow down aging article of making up safely and efficiently.
The technical scheme of goal of the invention is a kind of Folium perillae acutae oil nano-emulsion cosmetic article in the realization, and the particle diameter of this nano-emulsion is between 6～100nm, and its raw material and mass percent thereof are:
15.00%～31.00 surface-active agent, 4.00%～7.00% oil, 0.10%～10.00% Folium perillae acutae oil, 1.00%～2.00% Vitamin E acetate, 0.10%～0.20% essence, surplus are distilled water, and total weight percent is 100%.
The weight proportion of each raw material of optimization formula of Folium perillae acutae oil nano-emulsion cosmetic article of the present invention is:
16.00%～29.00% surfactant, 4.50%～6.50% oil, 1.00%～8.00% Folium perillae acutae oil, 1.20%～1.80% Vitamin E acetate, 0.12%～0.18% essence, surplus are distilled water, and total weight percent is 100%.
The weight proportion of further each raw material of optimization formula of Folium perillae acutae oil nano-emulsion cosmetic article of the present invention is:
18.00%～25.00% surfactant, 4.90%～6.00% oil, 2.00%～6.00% Folium perillae acutae oil, 1.25%～1.70% Vitamin E acetate, 0.14%～0.17% essence, surplus are distilled water, and total weight percent is 100%.
Cosmetics of the present invention are on surfactant selection; Select nonionic surfactant for use, its toxicity is less relatively, and is more stable in solution; Be not subject to the influence of strong electrolyte, inorganic salts; Be not subject to the influence of soda acid yet, and good with the compatibility of other surfactants, and haemolysis is less.In theory; The HLB value that the preparation of O/W type nanometer emulsion needs surfactant is between 8～18; Consider preparation technology's simplicity; Be the easy formation property of nano-emulsion and the stability of the nano-emulsion for preparing, the present invention selects the liquid nonionic surfactant of HLB between 10～15 for use, and is perhaps composite with the non-ionic surface active agent of a kind of HLB＜10.Available surfactant has: the lauric acid polyoxyethylene ether; Castor oil polyoxyethylene ether (like EL-40); Castor oil hydrogenated polyoxyethylene ether (like RH-40), TX10 (like TX-8,10 etc.), fatty alcohol polyoxypropylene polyoxyethylene blocks polymer, isostearic acid, tween 80.More than several kinds of surfactants can use separately, also can be respectively during with the 80 composite uses of class of department.
The present invention is according to when the HLB of the required surfactant of emulsifying oil phase is close with surfactant; The principle that formed emulsion is stable, the oils and fats of selecting for use have one or more mixture in isopropyl myristate, isopropyl palmitate, Jojoba oil, white mineral oil, liquid paraffin, vitamin E oil, olive oil, Oleum Ricini, Petiolus Trachycarpi oil, Oleum Cocois, Camellia oil, almond oil, the Semen Tritici aestivi germ oil.These oils and fatss are little to skin irritation, be in a liquid state, do not have bad abnormal smells from the patient under the room temperature, have good wetting property, and infiltration is made skin lubrication glossy by skin absorbs easily.
Vitamin E acetate is as nutritional supplement and antioxidant; Can not only obtain the oxygen atom of excited state, prevent that cell is because of oxidation damaged, stabilizing cell membrane; And the lipid and the lipoprotein of cell membrane have protective effect, also can promote the moisture-retaining capacity of skin simultaneously.
The Folium perillae acutae oil nano-emulsion of the present invention article of making up are filled a prescription and are confirmed according to following method:
1) preparation of surfactant phase takes by weighing surfactant by formula proportion, use separately or with help surface activity composite in proportion, calculate the HLB value of this system, stir.
The HLB value of common emulsifying agent can be found in some chemical industry handbooks, like " the chemical products handbook of chemical industry publishing house.Because hydrophile-lipophile balance (HLB) value of surfactant has additive properties, the available quality averaging method is obtained the HLB value of surfactant.For example, after two kinds of surfactant A, B mixed, the hydrophile-lipophile balance HLBAB value of its mixed surfactant was:
HLBAB＝(WAHLBA+WBHLBB)/(WA+WB)
WA in the formula, WB---the quality of blend surfactants A, B;
HLBA, the HLB value of HLBB---surfactant A, B.
2) preparation of oil phase is selected one or more oil according to the HLB value of surfactant phase, transfers its ratio, makes the required HLB value of its emulsifying close with surfactant HLB mutually.
3) with confirming optimal proportion with surfactant according to 9: 1～1: 9 rule drafting pseudo-ternary phase diagram through calculating the selected oil phase of HLB value; Then oil phase is fully stirred at 20 ℃～25 ℃ with surfactant and make its mix homogeneously; Add Folium perillae acutae oil; Fully stir, slowly add distilled water again and stir, until forming clear, viscosity is little and has mobile faint yellow or colourless O/W type nanometer emulsion.
The present invention detects through transmission electron microscope, and droplet diameter distribution is between 6～100nm, and outward appearance is transparent faint yellow or colourless liquid, has good stability:
1, ageing stability
Ageing stability is meant when nanoemulsions is preserved under room temperature nature change condition, and the nanoemulsions outward appearance prolongs and the degree that changes in time.These Folium perillae acutae oil nano-emulsion cosmetic article are transparent lastingly, find muddy or deposition, explain that then ageing stability is good.This is an important indicator estimating nanoemulsions.
2, heat storage stability
This Folium perillae acutae oil nano-emulsion article of making up are placed test tube, and sealing places 37 ℃ of constant water bath box to store 14 days, this liquid heat storage back appearance transparent.
3, anti-freeze-stable property
This Folium perillae acutae oil nano-emulsion is made up article in refrigerator after-4 ℃ of one weeks of preservation.Return to room temperature.If nanoemulsions becomes solids at-4 ℃, return to room temperature, return to transparently, and it is transparent to place all continued, thinks that then freezing-resistance is good.
4, accelerated stability
This Folium perillae acutae oil nano-emulsion article of making up are placed test tube, seal, under the rotating speed of 15000r/min centrifugal 20 minutes, do not have layering, still clear.
The Folium perillae acutae oil nano-emulsion of the present invention article of making up have better percutaneous permeability; Can strengthen the dissolubility of Folium perillae acutae oil; Improve Folium perillae acutae oil and remove the effect of free radical, antagonism slow down aging; Improve the ductility of cosmetics on skin, can also solubilising have other active ingredient of anti-senescence function.
Be applicable to that skin is slack and undisciplined, mottle, wrinkle and the dark yellow tarnish of face etc., the back of washing one's face sooner or later every day is dipped in to get with cotton swab and evenly is applied in face and cervical region in right amount.For anti-ultraviolet is shot wounded, also can after washing one's face, get and evenly spread upon face in right amount.
The prepared Folium perillae acutae oil nano-emulsion of the present invention makes up that article technology is simple, good stability, available water infinite dilution, and the cosmetic field that can be widely used in and remove free radical, resists slow down aging is a kind of invention that is widely used, has a extensive future.
Below come further to set forth the beneficial effect of cosmetics according to the invention through Test Example, these Test Example have comprised that medicine of the present invention is to animal irritation test, effect observation test and contrast test.
Test Example 1 Folium perillae acutae oil nano-emulsion cosmetic article animal irritation test
8 of New Zealand tower rabbits are divided 2 groups, and one group is carried out the skin irritation test; Adopting 0.5%, 1%, 5%, 10% Folium perillae acutae oil nano-emulsion each 0.3ml of article that makes up respectively observes one of which group eye dripping; Do not occur tangible zest behind the 24h, eyelid is not rubescent, and eyeball does not have the abnormal secretion thing; Adopt each 3ml of Folium perillae acutae oil nano-emulsion cosmetic article of 0.5%, 1%, 5%, 10% that another group is carried out the skin irritation test more respectively, tangible zest does not all appear in observation behind the 24h.
The test of Test Example 2 Folium perillae acutae oil nano-emulsions cosmetic article defying age effect observation
Subjects is young and middle-aged schoolmarm's 20 examples of my institute, and wherein 10 routine faces are dark yellow, and skin lacks gloss, and there is crows-feet at 5 routine canthus, and the 5 routine corners of the mouths have wrinkle, and the cervical region wrinkle also clearly.Sooner or later coat the Folium perillae acutae oil nano-emulsion cosmetic article that experiment makes at face after washing one's face every day, used continuously 1 month, experimental result is found; 10 routine faces are dark yellow, and skin lacks has 8 examples to be produce effects among the gloss person, and obvious effective rate is 80%; 2 examples are that effectively effective percentage is 20%; There is the crows-feet at 5 routine canthus, and the person all has remarkable result, and obvious effective rate is 100%; The 5 routine corners of the mouths have wrinkle, and cervical region wrinkle person also has remarkable result, and obvious effective rate is 60%.Show that the Folium perillae acutae oil nano-emulsion article of making up have good defying age effect.
The test of Test Example 3 Folium perillae acutae oil nano-emulsions cosmetic article defying age effect comparison
Select my schoolmarm of institute 40 examples; Wherein 10 examples have chloasma; And pachylosis, dimness (be equally divided into two groups of a, b at random, a group is used the Folium perillae acutae oil nano-emulsion cosmetic article of this test invention, and the b group uses the bright red frost of P&G (China) company limited production to do contrast), 10 examples have tangible crows-feet (to be equally divided into two groups of c, d at random; The c group is used the Folium perillae acutae oil nano-emulsion cosmetic article of this test invention; D group uses the eye cream of P&G (China) company limited production to do contrast), the 10 routine corners of the mouths and cervical region wrinkle all very dark (be equally divided into two groups of m, n at random, the m group is used the Folium perillae acutae oil nano-emulsion of this test invention article of making up, and n organizes the Olay anti-wrinkle cream of use P&G (China) company limited production and does contrast), the 10 routine colours of skin are evenly pale (is equally divided into two groups of s, t at random; The s group is used the Folium perillae acutae oil nano-emulsion cosmetic article of this test invention; The t group uses the Olay whitening sun protection emulsion of P&G (China) company limited production to do contrast, does not adopt other sun-proof measures after smearing), through 30 days observing effects.Wherein a group has 2 routine chloasma almost all to disappear, and 1 routine speckle is thin out, and the colour of skin all has clear improvement; B organizes all desalinations to some extent of 5 routine speckles, does not all disappear but there is 1 routine speckle.C organizes 2 routine crows-feet and all disappears, and 3 routine crows-feet shoal, and colour of skin change is even; D organizes 5 routine crows-feet and all shoals.M organizes the 1 routine corners of the mouth and the cervical region wrinkle all disappears, and all the other 4 routine wrinkles shoal, and are glossy and careful; N organizes 5 examples also all has improvement, and wrinkle shoals.S organizes 5 routine skins and does not have too big variation, richer gloss and careful before; T organizes 5 routine skin blackening slightly, and skin lacks brightness and drying.The result shows that obviously the Folium perillae acutae oil nano-emulsion article of making up have good defying age effect.
The specific embodiment
Below the embodiment that provides through the inventor further specify the make up method for preparing of article of Folium perillae acutae oil nano-emulsion of the present invention.
Embodiment 1
TX10 30.00g, Folium perillae acutae oil 1.00g, isopropyl palmitate 4.40g, vitamin E oil 0.70g, Vitamin E acetate 1.00g, essence 0.20g are added together, under 25 ℃ of room temperature conditions, fully stir and make its mix homogeneously; To wherein slowly adding distilled water, the limit adds the waterside stirs then, and the system viscosity is less during beginning; With the increase of rate of water added, it is sticky that system can become, and this moment, liquid crystal state or water-in-oil type nanoemulsion may appear in system; Continue to drip and constantly stir; Thinning suddenly when system, what produced this moment promptly is faint yellow transparent water oil-packaging type Folium perillae acutae oil nano-emulsion cosmetic article, claims that its gross weight is 100.00g.
Embodiment 2
Castor oil polyoxyethylene ether 15.00g, Folium perillae acutae oil 0.70g, isopropyl myristate 4.60g, liquid paraffin 0.70g, Vitamin E acetate 1.00g, essence 0.20g, distilled water 77.80g.
Preparation Method is with embodiment 1.
Embodiment 3
Castor oil polyoxyethylene ether 18.00g, Folium perillae acutae oil 2.00g, isopropyl palmitate 3.00g, olive oil 0.60g, Semen Tritici aestivi germ oil 1.00g, Vitamin E acetate 1.50g, essence 0.15g, distilled water 73.74g.Preparation Method is with embodiment 1.
Embodiment 4
Tween 80 23.00g, Arlacel-80 4.00g, Folium perillae acutae oil 10.00g, isopropyl myristate 2.50g, white mineral oil 1.00g, Camellia oil 0.50g, Vitamin E acetate 1.20g, essence 0.20g, distilled water 57.60g.Preparation Method is with embodiment 1.
Embodiment 5
Lauric acid polyoxyethylene ether 16.00g, Folium perillae acutae oil 5.00g, isopropyl myristate 3.00g, almond oil 1.00g, Oleum Cocois 1.00g, Vitamin E acetate 0.80g, essence 0.14g, distilled water 73.06g.
Preparation Method is with embodiment 1.
Embodiment 6
Castor oil polyoxyethylene ether 25.00g, Folium perillae acutae oil 0.60g, Vitamin E acetate 1.70g, almond oil 4.50g, Semen Tritici aestivi germ oil 1.20g, essence 0.17g, distilled water 66.83g.
Preparation Method is with embodiment 1.
Embodiment 7
Castor oil hydrogenated polyoxyethylene ether 29.00g, olive oil 5.00g, vitamin E oil 0.50g, Vitamin E acetate 1.80g; Essence 0.10 mixture under 24 ℃ of room temperature conditions, fully stirs and makes its mix homogeneously, then to wherein slowly adding distilled water; Stir on adding distil water limit, limit, and the system viscosity is less during beginning, along with the increase of the distillation water yield; It is sticky that system can become, and this moment, liquid crystal state or water-in-oil type nanoemulsion may appear in system, continues to drip and constantly stir; Unexpected when thinning when system, what produced this moment promptly is O/W type nano-emulsion, and the Folium perillae acutae oil of 6.00g is directly added; Stirring is until whole dissolvings, and what produced this moment promptly is water white transparency oil-in-water type Folium perillae acutae oil nano-emulsion cosmetic article, claims that its weight is 100.00g.
Embodiment 8
Castor oil polyoxyethylene ether 31.00g, Folium perillae acutae oil 0.60g, white mineral oil 4.00g, vitamin E oil 0.70g, Vitamin E acetate 1.50g, essence 0.20g, distilled water 62.00g.
Method for preparing is with embodiment 7.
Claims (3)
1. defying age Folium perillae acutae oil nano-emulsion cosmetic article is characterized in that the particle diameter of these cosmetics is between 6～100nm, and its raw material and mass percent thereof are:
15.00%～31.00% surfactant, 4.00%～7.00% oil, 0.10%～10.00% Folium perillae acutae oil, 1.00%～2.00% Vitamin E acetate, 0.10%～0.20% essence, surplus are distilled water, and total weight percent is 100%;
Described surfactant is one or more mixture in lauric acid polyoxyethylene ether, castor oil polyoxyethylene ether, TX10, castor oil hydrogenated polyoxyethylene ether, fatty alcohol polyoxypropylene polyoxyethylene blocks polymer, tween 80 and the Arlacel-80;
Described oil is one or more mixture in isopropyl myristate, isopropyl palmitate, Jojoba oil, liquid paraffin, vitamin E oil, olive oil, Oleum Ricini, Petiolus Trachycarpi oil, Oleum Cocois, Camellia oil, almond oil, the Semen Tritici aestivi germ oil.
2. ask according to right and want 1 described defying age Folium perillae acutae oil nano-emulsion cosmetic article, it is characterized in that wherein the percentage by weight of each raw material is:
16.00%～29.00% surfactant, 4.50%～6.50% oil, 1.00%～8.00% Folium perillae acutae oil, 1.20%～1.80% Vitamin E acetate, 0.12%～0.18% essence, surplus are distilled water, and total weight percent is 100%.
3. ask according to right and want 1 described defying age Folium perillae acutae oil nano-emulsion cosmetic article, it is characterized in that wherein the percentage by weight of each raw material is:
18.00%～25.00% surfactant, 4.90%～6.00% oil, 2.00%～6.00% Folium perillae acutae oil, 1.25%～1.70% Vitamin E acetate, 0.14%～0.17% essence, surplus are distilled water, and total weight percent is 100%.
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| CN107519047B (en) * | 2017-08-24 | 2020-04-14 | 山西医科大学 | Contains TiO2The sun-proof nano-emulsion and the preparation method thereof |
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| CN100577140C (en) * | 2006-09-18 | 2010-01-06 | 西北农林科技大学 | Baicalin nanometer emulsion cosmetics |
| CN1931232B (en) * | 2006-09-21 | 2011-11-09 | 西北农林科技大学 | Oil-in-water nanometer perilla seed oil emulsion oral liquid and its preparation process |
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