CN108685771A - A kind of borneol essence oil nanometer breast and preparation method thereof - Google Patents
A kind of borneol essence oil nanometer breast and preparation method thereof Download PDFInfo
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- CN108685771A CN108685771A CN201810938356.8A CN201810938356A CN108685771A CN 108685771 A CN108685771 A CN 108685771A CN 201810938356 A CN201810938356 A CN 201810938356A CN 108685771 A CN108685771 A CN 108685771A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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Abstract
This application involves a kind of borneol essence oil nanometer breast and preparation method thereof, belong to the preparation technical field characterized by component.It is compounded by the organic phase and the water phase that include borneol essential oil, the mass ratio of the organic phase and water phase is(0.5-4):(9.5-6), and borneol essential oil mass content is not less than 5%.The application is applied to the fields such as cosmetics, skin care item, has many advantages, such as that property is stable, absorbs rapid, modest viscosity.
Description
Technical field
This application involves a kind of borneol essence oil nanometer breast and preparation method thereof, belong to the preparation technology characterized by component
Field.
Background technology
Borneol essential oil fragrance is pleasant, and inducing resuscitation is had one's ideas straightened out.Through nasal inhalation borneol oil active constituent, smell is fled in meridian point,
Poison gas can be also dispersed in vitro, you can reach effect promoting blood circulation and removing obstruction in channels.Prevent breathing problem in addition, also having, adjusts gastrointestinal function.It is special
It is not especially effective in stuffy unknown city.Borneol oil is coated in affected part, energy Repercusion analgesia, myogenic are antipruritic, externally
The analgesia at all nerve endings positions is particularly evident.Borneol oil is coated in temple or people, can inspire enthusiasm, refresh the mind, it can
Improve study, working efficiency.If borneol oil is applied to skin surface, the old dead cell of skin can be removed, promotes collagen
It generates, softens causes scar tissue, desalinate melanin, prevent wrinkle of skin from generating, increase gloss, desalinate freckle.Borneol oil is coated in
Collar etc. has the elegant effect of delicate fragrance.
Nano-emulsion is a kind of spherical nanoparticles hydrophilic outside the interior oleophylic being made of surfactant, crosslinking agent, can be wrapped
Wrap up in oily matter.Nano-emulsion appearance transparent, macroscopic property are stablized, isotropism.Nano-emulsion has many other preparations can not
The advantages of analogy:1. being isotropic transparency liquid, belong to Thermodynamically stable system, can not be allowed to through pressure sterilizing or centrifugation
Layering;2. simple for process, preparation process is not required to special installation, can spontaneously form, nano-emulsion particle diameter is generally 1~100nm;3. sticking
It spends low, pain when injection can be reduced;4. with sustained release and targeting;5. improving the solubility of drug, drug is reduced in body
Interior enzymolysis can form the protective effect to drug and improve absorption of the gastrointestinal tract to drug, improve the bioavilability of drug.
Therefore nano-emulsion is widely paid close attention to as a kind of pharmaceutical carrier.
However, since borneol essential oil is oily matter, it is coated on skin surface, easy tos produce oil stain sense, and cause
Clogging of pores;It is dissolved in other surfaces activating agent, then due to its poorly water-soluble, cannot achieve the loading of essential oil and aqueous painting
It covers;Meanwhile based on nano-emulsion there is hydrophilic and oleophilic double grading to be wrapped in borneol essential oil by amphoteric surfactant and receive
Inside rice milk, it can be very good to solve the above problems.Occur or report there has been no the nano-emulsion of borneol essential oil in existing document.
Based on this, the application is made.
Invention content
For the drawbacks described above in the presence of the prior art, the application provides a kind of borneol essential oil oil-in-water nanometer breast, institute
The nano-emulsion of offer can use 0.5mM phosphate buffer infinite dilutions.
To achieve the above object, the technical solution that the application takes is as follows:
A kind of borneol essence oil nanometer breast, is compounded, the organic phase by the organic phase and the water phase that include borneol essential oil
Mass ratio with water phase is (0.5-4):(9.5-6), and borneol essential oil mass content is not less than 5%.
Further, as preferred:
Also include grape seed oil in the organic phase, grape seed oil forms uniform organic phase, borneol with borneol essential oil
Essential oil and the mixing quality of grape seed oil ratio are (4-9):(6-1).Grape seed oil mainly plays the work of reconciliation in the application formula
With the concentration and viscosity of borneol essential oil are higher, and the grape seed oil of addition is ensuring group while proportioning is suitable, moreover it is possible to realize
Being evenly distributed for component avoids the occurrence of deposition, realizes that borneol essential oil gives full play to it and removes old dead cell, promotes collagen
It generates, desalination melanin, softening causes scar tissue, increases skin gloss, aggravates skin surface texture, it is superpower also to have given full play to its
Oxidation resistance, can delaying aging, and from deep layer protect skin, make skin from coming from environmental pollution;Accelerate metabolism
Speed promotes dead skin to fall off, and repair cell film and cell wall promote cytothesis, restore skin elasticity.It is furthermore preferred that institute's shape
At borneol essence oil nanometer breast in the mass content of each component be:Borneol essential oil 4-35%, grape seed oil 1-5%, water phase 60-
90%.
Also include emulsifier in the organic phase, the mixing quality ratio of borneol essential oil and emulsifier is 1:(2-4), emulsification
It is the oil-in-water emulsifiers of 8-15 that HLB is selected in agent.The addition of oil-in-water emulsifiers improves being uniformly mixed for organic phase
Property, and its good oil-in-water structure is assigned, borneol essential oil is wrapped up in it, dissolving of the oily matter in water phase is realized,
Organic phase is improved well to contact with skin.It is furthermore preferred that the emulsifier is Tween-80, polyethylene glycol, dodecyl sodium sulfonate
The changes such as sodium, aliphatic acid polyethenoxy ether, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide, glyceride type, lecithin
Cosmetic can use any one of emulsifier.It is furthermore preferred that the mass content for being formed by each component in borneol essence oil nanometer breast is:
Borneol essential oil 5-15%, emulsifier 5-25%, water phase 60-90%.
Also include grape seed oil and emulsifier in the organic phase, emulsifier selects the oil-in-water type breast that HLB is 8-15
The mass percentage of agent, each component is:Borneol essential oil 5-40%, grape seed oil 1-10%, emulsifier 4-25%, water phase
60-90%.The addition of oil-in-water emulsifiers, improves the mixing uniformity of organic phase, and assigns its good oil-in-water knot
Structure wraps up borneol essential oil, grape seed oil in it, realizes dissolving of the oily matter in water phase, improves organic phase and skin
Skin well contacts.It is furthermore preferred that the emulsifier is Tween-80, polyethylene glycol, dodecyl sodium sulfate, aliphatic acid polyoxy second
The cosmetics such as alkene ether, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide, glyceride type, lecithin can be used in emulsifier
It is any.
The water phase is water, phosphate buffer, disodium hydrogen phosphate-citrate buffer solution, citric acid-sodium citrate buffer solution
Any one of.
Meanwhile present invention also provides a kind of preparation methods of borneol essence oil nanometer breast as characterized above:In mass ratio
Organic phase and water phase are weighed, organic phase is taken, is slowly added into water phase, after addition, continues stirring to no gel
Substance, overnight stand is to get borneol essence oil nanometer breast.
Further, as preferred:
Also include grape seed oil in the organic phase, the mixing quality ratio of borneol essential oil and grape seed oil is (4-9):
(6-1), grape seed oil first are mixed evenly to form organic phase with borneol essential oil.Grape seed oil and borneol essential oil belong to oil
The two is first carried out mixing, is then added in water phase by phase when being compounded, and can effectively improve its mixing uniformity, and really
Distributing homogeneity of the main function ingredient that guarantor grape seed oil and borneol essential oil are constituted in finished product nano-emulsion.Wherein, grape
Seed oil mainly plays reconciliation in the application formula, and the concentration and viscosity of borneol essential oil are higher, the grape seed oil of addition
Ensuring group while proportioning is suitable, moreover it is possible to realize being evenly distributed for component, avoid the occurrence of deposition, realize that borneol essential oil fills
Distribution waves it and removes old dead cell, the generation of promotion collagen, desalination melanin, softening causes scar tissue, increase skin gloss, add
Pipe skin surface tactile sensation has also given full play to its superpower oxidation resistance, energy delaying aging, and has protected skin from deep layer, makes
Skin is from coming from environmental pollution;Accelerate rate of metabolism, dead skin is promoted to fall off, repair cell film and cell wall promote thin
Born of the same parents regenerate, and restore skin elasticity.
Also include emulsifier in the organic phase, the mixing quality ratio of borneol essential oil and emulsifier is 1:(2-4), emulsification
It is the oil-in-water emulsifiers of 8-15 that HLB is selected in agent, and borneol essential oil is added to after being mixed evenly with emulsifier in water phase.Water
The addition of oil-in emulsifier improves the mixing uniformity of organic phase, when being mixed, first by borneol essential oil with emulsifier
Emulsification pretreatment is carried out, borneol essential oil is wrapped up in it, its good oil-in-water structure is assigned, realizes oily matter in water phase
In dissolving, improve organic phase and well contacted with skin.It is furthermore preferred that the emulsifier is Tween-80, polyethylene glycol, ten
Dialkyl sulfonates, aliphatic acid polyethenoxy ether, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide, glyceride type,
The cosmetics such as lecithin can use any one of emulsifier.
Also include grape seed oil and emulsifier in the organic phase, emulsifier selects the oil-in-water type breast that HLB is 8-15
The mass percentage of agent, each component is:Borneol essential oil 5-40%, grape seed oil 1-10%, emulsifier 4-25%, water phase
60-90%, grape seed oil are uniformly mixed with emulsifier advance, add emulsifier be stirred uniformly after, be added to water phase
In.Grape seed oil and borneol essential oil belong to oil phase, when being compounded, the two are first carried out mixing, is then added in water phase,
Its mixing uniformity is can effectively improve, and ensures that the main function ingredient that grape seed oil and borneol essential oil are constituted is received in finished product
Distributing homogeneity in rice milk;The oil phase of mixing is mixed again with oil-in-water emulsifiers then, realizes emulsification pretreatment,
Borneol essential oil, grape seed oil are wrapped up in it, its good oil-in-water structure is assigned, it is molten in water phase to realize oily matter
Solution, improves organic phase and is well contacted with skin.It is furthermore preferred that the emulsifier is Tween-80, polyethylene glycol, dodecyl
Sodium sulfonate, aliphatic acid polyethenoxy ether, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide, glyceride type, lecithin
Equal cosmetics can use any one of emulsifier.
The water phase is water, phosphate buffer, disodium hydrogen phosphate-citrate buffer solution, citric acid-sodium citrate buffer solution
Any one of.
It is 500-1000rpm that the organic phase, which is added to the mixing speed in water phase,.
Borneol essential oil oil-in-water nanometer breast provided herein, has pale yellow colored appearance, clear, phosphoric acid salt
Buffer solution infinite dilution.Present application addresses the problems that oily matter not readily dissolves in water phase, and essential oil is wrapped in aqueous receive
After in rice milk, it can operate in the stronger cosmetics of talent for swimming, obtain better user's sensory experience.The nano-emulsion has property steady
It is fixed, absorb the features such as rapid, modest viscosity, be with a wide range of applications in cosmetic field.
The application has the following advantages:
(1) oil-in-water nanometer breast clear, modest viscosity absorbs rapid, and property is stablized, phosphoric acid salt buffer without
Limit dilution.
(2) the borneol essential oil of this nano-emulsion package has the old dead cell of removal skin, and collagen is promoted to generate, softening
The effect of causes scar tissue desalinates melanin, prevents wrinkle of skin from generating, increases gloss, desalinate freckle.
(3) borneol essential oil is embedded in nano-emulsion, solves the reason of borneol essential oil poorly water-soluble, it can be achieved that essential oil
Load and aqueous smearing characteristic.
Specific implementation mode
Below in conjunction with example, the present invention will be described in further detail, the application protection range include but not limited to
The instance method of lower description.
A kind of the present embodiment borneol essence oil nanometer breast, mainly by include borneol essential oil organic phase and water phase compounding and
At the mass ratio of the organic phase and water phase is (1-4):(9-6), and borneol essential oil mass content is not less than 5%.
In preparation process, organic phase and water phase are weighed in mass ratio, takes organic phase, is slowly added into water phase, are added
After adding, continue stirring to no spawn, overnight stand is to get borneol essence oil nanometer breast.
The borneol essence oil nanometer breast clear that aforesaid way obtains, modest viscosity absorb rapidly, and property is stablized, and can use
Phosphate buffer infinite dilution.The borneol essential oil of this nano-emulsion package has the old dead cell of removal skin, promotes collagen egg
It is white to generate, the effect of softening causes scar tissue, desalinate melanin, prevent wrinkle of skin from generating, increase gloss, desalinate freckle.It will be imperial
Brain essential oil is embedded in nano-emulsion, solves the reason of borneol essential oil poorly water-soluble, it can be achieved that the load of essential oil and aqueous smearing
Characteristic.
Annotation explanation is carried out with regard to the influence of each factor in preparation process below.
Embodiment 1:Influence of the composition of organic phase to borneol essence oil nanometer breast function and effect
In the present embodiment, water phase selects 0.5mM phosphate buffers (abbreviation PBS, pH 7.0), and the composition of organic phase has four
Kind mode:Only borneol essential oil, borneol essential oil+grape seed oil, borneol essential oil+emulsifier, borneol essential oil+grape seed oil+emulsifier,
Emulsifier selects Tween-80, a certain data selected in adding proportion used to carry out the using effect of differently composed organic phase
Control, ginseng are shown in Table 1.
Influence of the different composition organic phases of table 1 to nano-emulsion (% refers to mass percentage)
In table 1, degeee of stratification is followed successively by from shallow to deep:Slightly being layered < without layering < has the apparent < layerings of layering < layerings aobvious
< is write to be layered completely.
In preparation process, organic phase and water phase are weighed in mass ratio, are taken organic phase, are slowly dropped in 15min
In water phase, control rotating speed is 500-1000rpm;After addition, continues to stir 15min, visually observe no spawn, mistake
Night stands to get borneol essence oil nanometer breast.
Emulsifier-free (is shown in Table the serial number 1 and serial number 2 in 1) in the case of adding, and the composition of organic phase is mainly oil phase, will
It is directly stirred with water phase, although uniformly mixed effect still can be met, due to the whole oil base, water base of being rendered as
Therefore the state having is rendered as the phenomenon that color is partially deep, impermeable in appearance;Preparation initial stage can be rendered as uniform state,
It with the extension of time of repose, is dissolved in water phase since oil phase is more difficult, borneol essential oil or borneol essential oil+grape seed oil are not
It is actually dissolved in water phase, thus lamination easily occurs;Solute effect and the group property that shows out are macroscopically
It is presented as assimilation effect, since water phase, oil phase are there is no really dissolving is realized, acquired nano-emulsion is in assimilation effect upper body
Be now respective assimilation effect, i.e. the contact angle of water phase and skin is smaller, is very easy to absorb, and then contact angle is larger for oil phase,
It absorbs more slow;Similarly the viscosity as macro manifestations, viscosity can also have irregular phenomenon.
And (be shown in Table serial number 3, the serial number 4 in 1) added with emulsifier, due to emulsifier can effectively by
Oil phase (borneol essential oil or borneol essential oil+grape seed oil) carries out emulsification treatment, is wrapped up in it, and water base, shows out,
When being dissolved in water phase, can be very good oil phase being dissolved in water phase, be formed by nano-emulsion be integrally presented as it is apparent
Water phase property, when itself and skin etc. contact, contact angle is smaller, thus stickiness is preferable, is more easy to be absorbed, and ought especially have Portugal
When the addition of grape seed oil, the grape seed oil of addition not only reconciled borneol essential oil promotion collagen generate, desalination melanin,
The effectiveness for increasing skin gloss plays, and can also give full play to the superpower oxidation resistance of grape seed oil, delaying aging, and from
Deep layer protects skin, makes skin from coming from environmental pollution, repair cell film and cell wall, promotes cytothesis, restore skin
Elasticity.
Embodiment 2:Influence of the water phase to borneol essence oil nanometer breast function and effect
In the present embodiment, organic phase uses " borneol essential oil+grape seed oil+Tween-80 ", and it is slow that water, phosphoric acid can be used in water phase
Fliud flushing, disodium hydrogen phosphate-citrate buffer solution, citric acid-sodium citrate buffer solution, compare the using effect of finished product,
Ginseng is shown in Table 2.
Influence of the different water phases of table 2 to nano-emulsion (% refers to mass percentage)
In table 2, degeee of stratification is followed successively by from shallow to deep:Slightly being layered < without layering < has the apparent < layerings of layering < layerings aobvious
< is write to be layered completely.
In preparation process, organic phase and water phase are weighed in mass ratio, are taken organic phase, are slowly dropped in 15min
In water phase, control rotating speed is 500-1000rpm;After addition, continues to stir 15min, visually observe no spawn, mistake
Night stands to get borneol essence oil nanometer breast.
Water phase selects (pure) water, phosphate buffer, disodium hydrogen phosphate-citrate buffer solution, citric acid-sodium citrate slow
Fliud flushing.
Embodiment 3:Influence of the different ratio to borneol essence oil nanometer breast function and effect
The present embodiment to different quality than borneol essence oil nanometer breast carry out test comparison, shown in table 3.
The differently composed borneol essence oil nanometer of table 3 is newborn (following % is mass percentage)
In the present embodiment, we respectively test the borneol essence oil nanometer breast of different content, different compositions, and right
It carries out the test of using effect, the results showed that, when being tested:We are respectively to only borneol essential oil+water phase, borneol essential oil
+ grape seed oil+water phase, borneol essential oil+emulsifier+water phase, borneol essential oil+grape seed oil+four kinds of emulsifier+water phase situation carry out
The experiment of different content, the results showed that:
(1) when only with borneol essential oil as organic phase, although borneol essential oil effectiveness can be realized by being formed by nano-emulsion
Performance, realize and remove old dead cell, promote collagen to generate, desalination melanin, softening causes scar tissue, increase skin light
Pool, the effect for aggravating skin surface texture can not realize sufficient suction however, since the solubility property of borneol essential oil is bad
It produces effects fruit, the stability of solution of adsorption effect deviation, formation is poor, is susceptible to layering.
(2) when using borneol essential oil and grape seed oil as organic phase, equally exist dissolubility is poor, assimilation effect is weak,
The bad defect of stability, but in the nano-emulsion borneol essential oil 4-35%, grape seed oil 1-5%, remaining supply 100% with water phase
When, meet remove old dead cell, promote collagen to generate, desalination melanin, softening causes scar tissue, increase skin gloss,
While aggravating the effect of skin surface texture, the superpower oxidation resistance of nano-emulsion, and energy delaying aging are also imparted, from depth
Layer protection skin, makes skin from coming from environmental pollution;Accelerate rate of metabolism, promote dead skin fall off, repair cell film and
Cell wall promotes cytothesis, restores skin elasticity.
(3) when using borneol essential oil, emulsifier as organic phase, the dissolubility of nano-emulsion, absorbability and solution are steady
It is qualitative to be improved, especially when borneol essential oil content is 5-15%, emulsifier 5-25%, remaining is supplied with water phase
When 100%, borneol essential oil is emulsified agent and wraps up in it, and dissolubility and uniformity of the organic phase in water phase are preferable, solution it is steady
It is qualitative preferably to stand the also unobvious of layering in 3 days, it is preferable in the absorption efficiency and infiltration rate of skin surface.
(4) when using borneol essential oil, emulsifier, grape seed oil as organic phase, finished product nano-emulsion is effectively improved
Dissolubility, stability and absorbability, especially when borneol essential oil 5-10%, grape seed oil 2-5%, emulsifier 15-20%, water phase
When 70-78%, the addition of oil-in-water emulsifiers improves the mixing uniformity of organic phase, and assigns its good oil-in-water
Structure wraps up borneol essential oil, grape seed oil in it, realizes dissolving of the oily matter in water phase, improve organic phase with
Skin well contacts.
In method (4), as a specific preparation method, it can be described as follows:
1) reagent:Borneol essential oil, grape seed oil, Tween 80, phosphate buffer (5mM, pH=7.0)
2) instrument:Magnetic stirring apparatus, rotor
3) step:2.0g borneol essential oil is mixed with 0.5g grape seed oils, 500rpm, stirs 30min, it is made to mix well,
It is for oil phase;5.0g Tween 80s are added, 500rpm keeps 30min, so that it is mixed well, be for organic phase.Take 7.5g above-mentioned
Organic phase, 15min is interior to be slowly dropped in 17.5ml water phases (phosphate buffer), rotating speed 700rpm.After dripping off, continue to stir
15min is mixed, is visually observed in container without spawn.Overnight stand can obtain the nanoemulsions of clear.The nanoemulsions
Phosphoric acid buffer solution Macrodilution, emulsion state are stablized.
There is the borneol nano-emulsion that the above method (3), method (4) are obtained pale yellow colored appearance, clear can use
0.5mM phosphate buffer infinite dilutions not only solve the problem that oily matter not readily dissolves in water phase, by essential oil (dragon
Brain essential oil, grape seed oil) it is wrapped in water nano breast, when applying in the stronger cosmetics of talent for swimming, it can get and preferably use
Family sensory experience, since dissolubility and absorbability are good, which also has modest viscosity, and property is stable, absorbs rapid, viscosity
The features such as moderate, is with a wide range of applications in cosmetic field.
The above content is the preferred embodiments of combination the invention to further detailed made by provided technical solution
Describe in detail bright, and it cannot be said that the invention specific implementation is confined to these above-mentioned explanations, for the affiliated technology of the invention
For the those of ordinary skill in field, without departing from the concept of the premise of the invention, several simple deductions can also be made
Or replace, it all shall be regarded as belonging to the protection domain of the invention.
Claims (10)
1. a kind of borneol essence oil nanometer breast, it is characterised in that:It is compounded by the organic phase and the water phase that include borneol essential oil, institute
The mass ratio for stating organic phase and water phase is(0.5-4):(9.5-6), and borneol essential oil mass content is not less than 5%.
2. a kind of borneol essence oil nanometer breast as described in claim 1, it is characterised in that:It also include grape in the organic phase
Seed oil, grape seed oil and borneol essential oil form uniform organic phase, and the mixing quality ratio of borneol essential oil and grape seed oil is(4-
9):(6-1).
3. a kind of borneol essence oil nanometer breast as claimed in claim 1 or 2, which is characterized in that be formed by borneol essence oil nanometer
The mass content of each component is in breast:Borneol essential oil 4-35%, grape seed oil 1-5%, water phase 60-90%.
4. a kind of borneol essence oil nanometer breast as described in claim 1, it is characterised in that:Also include emulsification in the organic phase
The mixing quality ratio of agent, borneol essential oil and emulsifier is 1:(2-4), it is the oil-in-water emulsifiers of 8-15 that emulsifier, which selects HLB,.
5. a kind of borneol essence oil nanometer breast as claimed in claim 4, it is characterised in that:The emulsifier is Tween-80, poly- second
It is glycol, dodecyl sodium sulfate, aliphatic acid polyethenoxy ether, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide, sweet
The cosmetics such as grease class, lecithin can use any one of emulsifier.
6. a kind of borneol essence oil nanometer breast as described in claim 1,4 or 5, it is characterised in that:Borneol essential oil is formed by receive
The mass content of each component is in rice milk:Borneol essential oil 5-15%, emulsifier 5-25%, water phase 60-90%.
7. a kind of borneol essence oil nanometer breast as described in claim 1, it is characterised in that:It also include grape in the organic phase
Seed oil and emulsifier, it is the oil-in-water emulsifiers of 8-15 that emulsifier, which selects HLB, and the mass percentage of each component is:Borneol
Essential oil 5-40%, grape seed oil 1-10%, emulsifier 4-25%, water phase 60-90%.
8. a kind of borneol essence oil nanometer breast as claimed in claim 7, it is characterised in that:The emulsifier is Tween-80, poly- second
It is glycol, dodecyl sodium sulfate, aliphatic acid polyethenoxy ether, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide, sweet
The cosmetics such as grease class, lecithin can use any one of emulsifier.
9. a kind of borneol essence oil nanometer breast as described in claim 1, it is characterised in that:The water phase be water, phosphate buffer,
Any one of disodium hydrogen phosphate-citrate buffer solution, citric acid-sodium citrate buffer solution.
10. the preparation method of borneol essence oil nanometer breast as described in claim 1, it is characterised in that:Organic phase is weighed in mass ratio
And water phase, organic phase is taken, is slowly added into water phase, mixing speed is 500-1000 rpm;After addition, continue to stir
It mixes to no spawn, overnight stand is to get borneol essence oil nanometer breast.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810938356.8A CN108685771A (en) | 2018-08-17 | 2018-08-17 | A kind of borneol essence oil nanometer breast and preparation method thereof |
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| CN201810938356.8A CN108685771A (en) | 2018-08-17 | 2018-08-17 | A kind of borneol essence oil nanometer breast and preparation method thereof |
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| CN112220824A (en) * | 2020-11-09 | 2021-01-15 | 广东华清园生物科技有限公司 | Antibacterial nano microemulsion system, preparation method, application and application method |
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