CN101810640A - Composite nanometer emulsion containing borneol and alum and preparation method thereof - Google Patents
Composite nanometer emulsion containing borneol and alum and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a composite containing borneol and alum. The composite can be prepared into an external traditional Chinese medicine preparation for diseases such as empyrosis, allergic skin diseases, surgical wound infection, chemical drug-induced phlebitis, radiodermatitis, and the like. Each 100 ml of emulsion of the composite nanometer emulsion containing borneol and alum comprises 0.125 g to 2.5 g of borneol, 0.69 g to 6.9 g of alum, 0.3 g to 3 g of oil for injection, 0.8 g to 8 g of emulsifier, 0.1 g to 1.5 g of sodium chloride and the balance of distilled water or water for injection, and the particle size range is from 1 to 100 nanometers.
Description
Technical field
The present invention relates to a kind of compositions that contains Borneolum Syntheticum and Alumen.It can be prepared into a kind of Chinese medicine for outer use that is used for burning diseases such as (scalding) wound, allergic dermatosis, surgical wound infection, phlebitis induced by chemical drugs, radiodermatitis.
Background technology
Vitriol ice liquid is that (with reference to documents Liu Li virtue " Chinese tcm emergency " 2002 vol11 (6), p448), formulated by Alumen and Borneolum Syntheticum two flavor Chinese prescriptions, medicine consists of Alumen 14g to preparation in the attached institute of hospital of Hunan University of Traditional Chinese Medicine, Borneolum Syntheticum 2.8g.Get Alumen earlier and be ground into fine powder, it is an amount of to add water, and heating makes it dissolving, adds sodium chloride 9g and dissolves the back filtration; Other gets Borneolum Syntheticum and is ground into fine powder, and one 80 liquid 7ml mix with Polysorbate, add in the above-mentioned filtrate, add water to 1000ml, stir, and fill, it is standby to sterilize.It has the effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, promoting tissue regeneration and ulcer healing.Be used for the treatment of diseases such as I degree, II degree burning (scalding) wound, allergic skin disease, herpes zoster, diabetic foot, surgical infection wound surface, chemotherapeutics induced phlebitis, radiodermatitis over more than 30 year, determined curative effect always.But need during clinical use to continue soak with gauze, because of easily dry, drug treating time is of short duration, need frequent spray medicine, burn (scalding) and hinder that area is big, the extensive person's medication of skin lesion is restricted, and wherein contained Borneolum Syntheticum is separated out because of water solublity hangs down very easily crystallization, be difficult to be uniformly dispersed, need before using medicine bottle is rocked, wound surface also has slight sense of discomfort, thereby makes troubles for clinical use.
In recent years nanoemulsions more and more comes into one's own at the applied research of field of medicaments.Nano-emulsion (nanoemulsion) is that particle diameter is that the emulsion droplet of 10～100nm is dispersed in the dispersion system of colloid that forms in the another kind of liquid, it is spherical that its emulsion droplet mostly is, and size is more even, and is transparent or semitransparent, through pressure sterilizing or centrifugally can not make it layering, belong to the thermodynamically metastable fixed system usually.As a kind of newtype drug transmission system, it has a wide range of applications at aspects such as improving drug solubility, increase medicine stability, reduction drug side effect, slow controlled release drug administration and gene transmission.It has the characteristics of ultralow interfacial tension, superpower solubilization, can increase dissolubility, the raising facile hydrolysis stability of drug of the medicine that is insoluble in water, thereby can improve the infiltration rate and the degree of effective ingredient, improves drug effect, reduces using dosage.Also can be used as targeting drug delivery system, but also can be made into stability height, the good percutaneous of bioavailability, the oral or nano-emulsion injected.
Summary of the invention
Deficiency and defective at the existence of existing vitriol ice liquid, especially the problem separated out of the easy crystallization of Borneolum Syntheticum, the object of the present invention is to provide a kind of composite nano-emulsion that contains Borneolum Syntheticum, Alumen and preparation method thereof, be uniformly dispersed to make, the vitriol ice nano-emulsion of transparent (or translucent), good stability.
The technical scheme that realizes the foregoing invention purpose is: the composite nano-emulsion that contains Borneolum Syntheticum and Alumen, its one-tenth is grouped into proportioning: contain Borneolum Syntheticum 0.125g～1.25g, Alumen 0.69g～6.9g, oil for injection 0.3g～3g, emulsifying agent 0.8g～8g, sodium chloride 0.1～1.5g in every 100ml emulsion, surplusly be distilled water or water for injection, its particle size range is between 1～100nm.
Wherein, described oil is any in soybean oil, Oleum Sesami, olive oil, the ethyl oleate; Described emulsifying agent is any in castor oil polyoxyethylene ether 40, NONIN HS 240, polyoxyethylene castor oil, lecithin, Planck Buddhist nun F-68, the tween 80, perhaps arbitrary combination (blended emulsifier) between them; Also can add co-emulsifier n-octyl alcohol, glycerol, polyglycerin ester, 1 in the described emulsifying agent, any in 2-propylene glycol, the ethanol, co-emulsifier account for 0.1%～40% (t) of both summations.
Preferred composition proportion is: contain Borneolum Syntheticum 0.25g, Alumen 1.38g in every 100ml emulsion, oil for injection selects for use ethyl oleate 0.6g, emulsifying agent to select NONIN HS 240 (OP-10) 1.6g, sodium chloride 0.9g for use.
The above-mentioned preparation method that contains the composite nano-emulsion of Borneolum Syntheticum, Alumen can be the preparation method of the nano-emulsion of routine, but particularly preferred method comprises that the following step poly-: (1) gets the Borneolum Syntheticum porphyrize, by adding oil, stirring makes dissolving, again to wherein adding emulsifying agent, stir or grind and make its abundant mixing, or further under stirring fast, slowly add an amount of distilled water or water for injection is made colostrum; (2) get Alumen, sodium chloride is dissolved in an amount of distilled water or the water for injection, filters, and is standby; (3) aqueous solution that will contain Alumen, sodium chloride is slowly joining the mixture or the first Ruzhong of above-mentioned oil phase and emulsifying agent under stirring fast, and adds water to full dose, and mixing promptly gets composite nano-emulsion; The ratio of each component meets the qualification of one of claim 1-3.
Sterilization can be adopted 115.5 ℃ of sterilization 30min or 121 ℃ of 20min.
According to embodiments of the invention, the result shows that the composite nano-emulsion that contains Borneolum Syntheticum, Alumen provided by the invention is being better than vitriol ice liquid aspect the treatment burn and scald comprehensive therapeutic effect, but both comparing differences do not have the significance meaning, but than difference significance meaning (P＜0.01 are being arranged with vitriol ice liquor ratio aspect the local redness of improvement, the pain relieving; P＜0.05), is better than vitriol ice liquid (P＜0.01) at (dynamic healing rate of wound surface and complete healing time) aspect the promotion wound healing.Show that thus vitriol ice nano-emulsion treatment burn and scald curative effect is better than Chinese medicine vitriol ice liquid.Trace it to its cause, be that contained Borneolum Syntheticum is separated out because of the low very easily crystallization of water solublity in the vitriol ice liquid, be difficult to be uniformly dispersed, bioavailability is lower, and during clinical use because of easily dry, drug treating time is of short duration, need frequent drug administration, and be carrier with the nano-emulsion it is prepared into dissolubility and the dispersion that has improved Borneolum Syntheticum behind the vitriol ice nano-emulsion, has increased the percutaneous absorption rate of medicine, thereby clinical efficacy was further enhanced after Alumen, Borneolum Syntheticum be prepared into nano-emulsion.
The present invention has the following advantages:
1. the preparation method of the composite nano-emulsion that contains Borneolum Syntheticum, Alumen of the present invention is simple, and energy consumption is low.
2. the composite nano-emulsion that contains Borneolum Syntheticum, Alumen of the present invention is uniformly dispersed, transparent (or translucent), good stability, its particle size range is between 1～100nm, can improve the dissolubility (reaching 2% approximately) of Borneolum Syntheticum greatly, thereby overcome the Borneolum Syntheticum problem that easily crystallization is separated out from preparation.
3. the composite nano-emulsion that contains Borneolum Syntheticum, Alumen of the present invention, owing to improved the concentration of Borneolum Syntheticum in medicinal liquid, can produce higher Concentraton gradient in that administration is local, and the emulsifying agent that uses has the surface of good active function, can promote medicine to see through skin and give full play to therapeutical effect.
Description of drawings
Fig. 1 vitriol ice nano-emulsion particle shape figure;
Fig. 2 vitriol ice nano-emulsion particle size distribution figure.
The specific embodiment
Get Borneolum Syntheticum 2.5g, porphyrize adds ethyl oleate 6g, stirring makes dissolving, again to wherein adding NONIN HS 240 (OP-10) 16g, stirring and evenly mixing, then to wherein slowly adding distilled water, the limit edged stirs, and increases with the water yield during beginning, and the system thickness that becomes is gel, when continuation adding distilled water is extremely a certain amount of, solution is thinning, be transparent～translucent, and be with light blue opalescence.Other gets Alumen 13.8g, and sodium chloride 9g is dissolved in an amount of distilled water, filters, filtrate slowly joins in the above-mentioned solution that contains Borneolum Syntheticum etc., and adding distil water is to 1000ml, and stirring and evenly mixing filters, embedding is encapsulated in the 100ml infusion bottle, in 115.5 ℃ of sterilization 30min, promptly.
Get Borneolum Syntheticum 1.25g, porphyrize adds ethyl oleate 3g, stirring makes dissolving, again to wherein adding NONIN HS 240 (OP-10) 8g, stirring and evenly mixing, then to wherein slowly adding distilled water, the limit edged stirs, and increases with the water yield during beginning, and the system thickness that becomes is gel, continue to add distilled water when a certain amount of, solution is thinning, be transparent～translucent, and be with light blue opalescence.Other gets Alumen 6.9g, and sodium chloride 9g is dissolved in an amount of distilled water, filters, filtrate slowly joins in the above-mentioned solution that contains Borneolum Syntheticum etc., and adding distil water is to 1000ml, and stirring and evenly mixing filters, embedding is encapsulated in the 100ml infusion bottle, in 115.5 ℃ of sterilization 30min, promptly.
Get Borneolum Syntheticum 12.5g, porphyrize adds ethyl oleate 30g, stirring makes dissolving, again to wherein adding NONIN HS 240 (OP-10) 80g, stirring and evenly mixing, then to wherein slowly adding distilled water, the limit edged stirs, and increases with the water yield during beginning, and the system thickness that becomes is gel, continue to add distilled water when a certain amount of, solution is thinning, be transparent～translucent, and be with light blue opalescence.Other gets Alumen 69g, and sodium chloride 9g is dissolved in an amount of distilled water, filters, filtrate slowly joins in the above-mentioned solution that contains Borneolum Syntheticum etc., and adding distil water is to 1000ml, and stirring and evenly mixing filters, embedding is encapsulated in the 100ml infusion bottle, in 115.5 ℃ of sterilization 30min, promptly.
Embodiment 4
Get Borneolum Syntheticum 2.5g, porphyrize adds ethyl oleate 6g, stirring makes dissolving, again to wherein adding castor oil polyoxyethylene ether 40 (RH-40) 16g, stirring and evenly mixing, then to wherein slowly adding distilled water, the limit edged stirs, and increases with the water yield during beginning, and the system thickness that becomes is gel, when continuation adding distilled water is extremely a certain amount of, solution is thinning, be transparent～translucent, and be with light blue opalescence.Other gets Alumen 13.8g, and sodium chloride 9g is dissolved in an amount of distilled water, filters, filtrate slowly joins in the above-mentioned solution that contains Borneolum Syntheticum etc., and adding distil water is to 1000ml, and stirring and evenly mixing filters, embedding is encapsulated in the 100ml infusion bottle, in 115.5 ℃ of sterilization 30min, promptly.
Get Borneolum Syntheticum 2.5g, porphyrize adds ethyl oleate 6g, stirring makes dissolving, again to wherein adding polyoxyethylene castor oil (EL) 16g, stirring and evenly mixing, then to wherein slowly adding distilled water, the limit edged stirs, and increases with the water yield during beginning, and the system thickness that becomes is gel, when continuation adding distilled water is extremely a certain amount of, solution is thinning, be transparent～translucent, and be with light blue opalescence.Other gets Alumen 13.8g, and sodium chloride 9g is dissolved in an amount of distilled water, filters, filtrate slowly joins in the above-mentioned solution that contains Borneolum Syntheticum etc., and adding distil water is to 1000ml, and stirring and evenly mixing filters, embedding is encapsulated in the 100ml infusion bottle, in 115.5 ℃ of sterilization 30min, promptly.
Embodiment 6
Get Borneolum Syntheticum 2.5g, porphyrize adds ethyl oleate 6g, stirring makes dissolving, again to wherein adding NONIN HS 240 (OP-10) 18g, glycerol 2g, stirring and evenly mixing, then to wherein slowly adding distilled water, the limit edged stirs, and increases with the water yield during beginning, and the system thickness that becomes is gel, when continuation adding distilled water is extremely a certain amount of, solution is thinning, be transparent～translucent, and be with light blue opalescence.Other gets Alumen 13.8g, and sodium chloride 9g is dissolved in an amount of distilled water, filters, filtrate slowly joins in the above-mentioned solution that contains Borneolum Syntheticum etc., and adding distil water is to 1000ml, and stirring and evenly mixing filters, embedding is encapsulated in the 100ml infusion bottle, in 115.5 ℃ of sterilization 30min, promptly.
Embodiment 7
Mensuration by the prepared composite nano-emulsion that contains Borneolum Syntheticum and Alumen of embodiment 1 (being called for short vitriol ice nano-emulsion) particle shape and particle diameter
Vitriol ice nano-emulsion of the present invention detects through atomic force microscope CSPM-3400, and as shown in Figure 1, emulsion droplet is the uniform class sphere of size, and good dispersion does not have adhesion each other.The employing laser particle size analyzer is measured, and as shown in Figure 2, the emulsion droplet mean diameter is about 13～16nm, and particle size range is about 7～35nm.
Embodiment 8
Stability test by the prepared composite nano-emulsion that contains Borneolum Syntheticum and Alumen of embodiment 1
1. pressure sterilizing test
Get in right amount, embedding is rolled aluminium lid in infusion bottle, 116 ℃ of pressure sterilizing 40min.After being cooled to room temperature, vitriol ice nano-emulsion still can recover transparent, does not see muddiness, lamination.
2. centrifugal test
The vitriol ice nano-emulsion of getting after the above-mentioned sterilization is an amount of, puts into centrifuge tube, and sealing orifice is put in the centrifuge, centrifugal (3000r/min) 30min, and vitriol ice nano-emulsion still can keep transparent, does not see muddiness, lamination.
Embodiment 9
Treat shallow II degree burn clinical observation on the therapeutic effect by the embodiment 2 prepared composite nano-emulsions that contain Borneolum Syntheticum and Alumen
1. data and method
1.1 case is included in and exclusion standard
Case is included standard in: meet shallow II degree burn and scald standard in " the clinical research guideline tcm diagnosis standard of new Chinese medicine treatment burn and scald " [1]; Burn surface area≤29%.Case exclusion standard: I degree, shallow II degree area＞29%, III degree wound surface; Merge that privileged sites such as respiratory tract are burnt, severe complication and systemic infection person; Other reasons is as bright the wounded such as chemistry, electricity, lonizing radiation; Gestation and women breast-feeding their children; Be associated with serious primary disease such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, the psychotic.
1.2 case data
120 routine patient's examples all meet the standard of including in, and burn surface area is by Chinese rule of Nine and palm test estimation.With table of random number the patient is divided into treatment group and matched group at random.60 examples are organized in treatment, male's 32 examples, women's 28 examples; 10～65 years old age, 36.8 years old mean age; Burn surface area 1%～5%23 example, 6%～10%27 example, 11%～15%5 example, 16%～20%3 example, 21%～29%2 example.Matched group 60 examples, male's 34 examples, women's 26 examples; 8～65 years old age, 37.5 years old mean age; Burn surface area 1%～5%25 example, 6%～10%23 example, 11%～15%7 example, 16%～20%2 example, 21%～29%2 example.Data comparing differences such as two groups of ages, sex, burn surface area, burn position do not have significance (P＞0.5) and have comparability.
1.3 Therapeutic Method
(1) treatment group is iced nano-emulsion with vitriol provided by the invention.Using method: conventional debridement, disinfection, the little person of area directly is applied to wound surface with medicine, every day 4 times, the big person of area uses 4～8 layers of tiling of the sterile gauze wound surface that is soaked with medicine, every day 1 time, it is moistening with it that gauze is done back reuse medicine, keeps gauze and wound surface to be moisture state in the therapeutic process.(2) matched group is iced liquid (document that preparation method is passed away and quoted in the scape technology) with vitriol.Using method: conventional debridement, disinfection, with 4～8 layers of tiling of the sterile gauze that is soaked with medicine wound surface, every day 1 time, it is moistening with it to spray vitriol ice liquid after gauze is done again, keeps gauze and wound surface to be moisture state in the therapeutic process.Two groups was 1 course of treatment with 10d all.Two groups of patient's wound surface are if there is pyesis, and cultivating has bacterial growth, or the systemic infection symptom is arranged, and then selects to use antibiotic according to antibacterial culturing and drug sensitive test result.There are water, electrolyte balance disorder person to adopt fluid infusion and the disorderly treatment measures of correction electrolyte balance.
1.4 observation index
(1) parameters for observation on effect: 1. related symptoms: degree, onset time (h), the extinction time (d) of mainly observing local pain, redness, exudate, incrustation etc.Local symptom pain, redness, the score of sepage degree by heavy, in, light, no four- stage grading 6,4,2,0 minutes.Incrustation meter 1 minute, no person counted 0 fen.Respectively at before the medication and finish in back 1 day record and scoring the course of treatment, per 2 days observed and recordeds, scoring 1 time in the therapeutic process simultaneously.2. dynamic healing rate of wound surface and healing time fully: observe wound surface area, the degree of depth and variation, healing state.The dynamic healing rate of wound surface was estimated record in 5,7,10 days with wound healing rate (%) expression in the identical time respectively at medication, write down the complete healing time of wound surface simultaneously.
(2) criterion of therapeutical effect: with reference to " new Chinese medicine clinical research guideline new Chinese medicine treatment burn and scald clinical research guideline "
[1]Draft: clinical recovery: the healing of skin ulcer face, General Symptoms disappears.Produce effects: the skin ulcer face heals more than 90%, and General Symptoms disappears.Effectively: the skin ulcer face heals more than 50%, and General Symptoms disappears.Invalid: do not reach effective standard, the skin ulcer face infects fails to control.
(3) safety observation index: 1. general physical examination project.2. three is big conventional.3. liver, kidney function test, Electrocardioscopy.
1.5 statistical procedures
The measurement data data are represented with mean ± SD, relatively adopt t check in groups between group, and enumeration data adopts x
2Check.Total data is handled through the SPSS10.0 statistical software, and P＜0.05 expression difference has statistical significance.
2. result
2.1 comprehensive therapeutic effect: estimate the burn and scald comprehensive therapeutic effect when finish 1 course of treatment, total obvious effective rate is organized in treatment and total effective rate is better than matched group, but two groups of comparing differences do not have significance (P＞0.05), the results are shown in Table 1.
Therapeutic evaluation after combining after table 1 a liang group patient treats (n, %)
Compare between group: X
2=3.73, P＞0.05.
2.2 primary symptom onset time: primary symptom onset time observed result shows, the treatment group is better than matched group (P＜0.05) aspect local red and swollen, the pain alleviating, minimizing ooze out aspect the curative effect indifference opposite sex relatively, the results are shown in Table 2.
Table 2 liang group patient primary symptom onset time observed result
Compare t with matched group
Red and swollen=2.03, t
Pain=2.35, t
Ooze out=0.33, * P＜0.05.
2.3 primary symptom extinction time: primary symptom complete obiteration time observed result shows that treatment group and matched group comparison have significance (P＜0.01, P＜0.05) in difference aspect elimination redness, the pain, the results are shown in Table 3.
Table 3 liang group patient primary symptom extinction time observed result
Compare t with matched group
Red and swollen=3.18, t
Pain=2.34, t
Ooze out=0.31, * P＜0.05, * * P＜0.01.
2.4 pain palliation efficacy at once: the pain situation is observed by local application after 30 minutes, estimate pain palliation efficacy at once, and treatment group and matched group comparing difference have significance meaning (P＜0.05) to the results are shown in Table 4.
Table 4 liang group patient pain palliation efficacy evaluation at once (n, %)
Compare between group: X
2=6.65, P＜0.05.
2.5 the dynamic healing rate of wound surface: respectively at 5,7,10 days records of medication wound healing area, estimate the wound healing rate, show that treatment group and matched group more all have significant difference (P＜0.01), the results are shown in Table 5.
The table 5 liang dynamic healing rate of group patient's wound surface
Compare medication the 5th day: t=2.73, medication the 7th day: t=4.39 with matched group; Finish the course of treatment: t=3.53.**P＜0.01。
2.6 the complete healing time of wound surface: record wound healing time when finish the course of treatment the results are shown in Table 6.
The table 6 liang complete healing time of group patient wound surface is observed
Compare t=4.57, * * P＜0.01 with matched group.
2.7 safety evaluatio
Three big routines, hepatic and renal function, the every index difference of electrocardiogram do not have significance (P＞0.5) before and after treatment group, the treatment of control group.
Claims (5)
1. the composite nano-emulsion that contains Borneolum Syntheticum and Alumen, its one-tenth is grouped into proportioning: contain Borneolum Syntheticum 0.125g～1.25g, Alumen 0.69g～6.9g, oil for injection 0.3g～3g, emulsifying agent 0.8g～8g, sodium chloride 0.1～1.5g in every 100ml nano-emulsion, surplusly be distilled water or water for injection, its particle size range is between 1～100nm; Wherein said oil is any in soybean oil, Oleum Sesami, olive oil, the ethyl oleate; Described emulsifying agent is any in castor oil polyoxyethylene ether 40, NONIN HS 240, polyoxyethylene castor oil, lecithin, Planck Buddhist nun F-68, the tween 80, perhaps arbitrary combined hybrid emulsifying agent between them.
2. the composite nano-emulsion that contains Borneolum Syntheticum and Alumen according to claim 1 is characterized in that Borneolum Syntheticum 0.125g, Alumen 0.69g, oil for injection select for use ethyl oleate 0.3g, emulsifying agent to select NONIN HS 240 0.8g, sodium chloride 0.9g for use in every 100ml emulsion.
3. the composite nano-emulsion that contains Borneolum Syntheticum and Alumen according to claim 1, it is characterized in that also adding in every 100ml emulsion co-emulsifier n-octyl alcohol, glycerol, polyglycerin ester, 1, in 2-propylene glycol, the ethanol any, co-emulsifier account for 0.1%～40% (wt) of emulsifying agent and co-emulsifier summation.
4. the composite nano-emulsion that contains Borneolum Syntheticum and Alumen according to claim 3, it is characterized in that Borneolum Syntheticum 0.25g, Alumen 1.38g, oil for injection select for use ethyl oleate 0.6g, emulsifying agent to select NONIN HS 240 1.6g for use in every 100ml emulsion, glycerol 0.2g, sodium chloride 0.9g.
5. the preparation method for preparing the described composite nano-emulsion of claim 1-4, comprise the steps: that (1) get the Borneolum Syntheticum porphyrize, by adding oil, stirring makes dissolving, again to wherein adding emulsifying agent/and co-emulsifier, stir or grind and make its abundant mixing, or further under stirring fast, slowly add an amount of distilled water or water for injection is made colostrum; (2) get Alumen, sodium chloride is dissolved in an amount of distilled water or the water for injection, filters, and is standby; (3) aqueous solution that will contain Alumen, sodium chloride is slowly joining the mixture or the first Ruzhong of above-mentioned oil phase and emulsifying agent under stirring fast, and adds water to full dose, and mixing promptly gets composite nano-emulsion, and the ratio of each component meets the qualification of one of claim 1-3.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462660A (en) * | 2010-08-16 | 2012-05-23 | 重庆富进生物医药有限公司 | Preparation and application of oil-in-water emulsion of borneol |
| CN108685771A (en) * | 2018-08-17 | 2018-10-23 | 范加家 | A kind of borneol essence oil nanometer breast and preparation method thereof |
| CN111407771A (en) * | 2020-04-02 | 2020-07-14 | 北京化工大学 | Antibacterial alum ice fiber membrane and preparation method thereof |
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| CN1457867A (en) * | 2003-06-03 | 2003-11-26 | 钟筑军 | Medicine powder for clearing away toxic matter and promoting granulation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1457867A (en) * | 2003-06-03 | 2003-11-26 | 钟筑军 | Medicine powder for clearing away toxic matter and promoting granulation |
Non-Patent Citations (1)
| Title |
|---|
| 《河北中医》 20010930 叶玉娣，等 《冰矾涂剂治疗慢性鼻炎疗效观察》 第23卷, 第9期 2 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462660A (en) * | 2010-08-16 | 2012-05-23 | 重庆富进生物医药有限公司 | Preparation and application of oil-in-water emulsion of borneol |
| CN108685771A (en) * | 2018-08-17 | 2018-10-23 | 范加家 | A kind of borneol essence oil nanometer breast and preparation method thereof |
| CN111407771A (en) * | 2020-04-02 | 2020-07-14 | 北京化工大学 | Antibacterial alum ice fiber membrane and preparation method thereof |
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