CN102366495B - Self-heated traditional Chinese medicine (TCM) emplastrum for lowering lipid and losing weight - Google Patents
Self-heated traditional Chinese medicine (TCM) emplastrum for lowering lipid and losing weight Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine (TCM) compound preparation, in particular to a self-heated TCM emplastrum for lowering lipid and losing weight. The self-heated TCM emplastrum comprises a sealing bag, a plaster and a self-heated bag, wherein the plaster and the self-heated bag are wrapped in the sealing bag and are bonded together up and down; the self-heated bag comprises an air-permeable bag and chemical heating materials which are wrapped in the air-permeable bag and are used for iron oxidation-reduction reactions; and the plaster comprises a backing layer, a medicine storage layer and an anti-adhesion layer. The emplastrum is characterized in that the medicine storage layer comprises a pharmaceutically acceptable matrix and active ingredients of raw medicines; the active ingredients account for 40% of the matrix by weight and comprise 1.5-3% of menthol and aqueous extracts of the following raw medicines according to the weight percent of the raw medicines: 10-40% of dried orange peel, 10-50% of semen cassiae, 10-30% of semen raphani, 10-30% of hawthorn and 10-30% of rhizoma alismatis. The self-heated TCM emplastrum provided by the invention has the advantages of high effect taking speed, good percutaneous absorption and definite curative effect.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
Obesity refers to that obvious overweight and fat deposit to a certain degree is blocked up, is body fat, and especially triglyceride gathers a kind of state that too much causes.Owing to food intake too much or the change of organism metabolism cause body fat to gather too much causing excess weight to increase and cause human pathology, physiological change or hide.The traditional Chinese medical science is early on the books for the understanding of obesity, and occurrence cause is how relevant with " wet, expectorant, void ".The traditional Chinese medical science thinks that obesity mostly is the disease of deficiency in origin and excess in superficiality.Deficiency in origin if hold concurrently imbalance of YIN and YANG, can have yang deficiency or the gas deficiency of YIN take the deficiency of vital energy as main, the disease being located in the spleen, kidney, liver, gallbladder and the heart, lung, and clinical take the spleen deficiency of kidney-QI as main, also as seen suffocating of liver and gall lacks of proper care.The mark reality is turbid as main take cream fat, expectorant, and it is wet often to have water concurrently, and blood stasis, stagnation of QI person also do not hold concurrently.Motherland's medical science has unique advantage aspect the treatment of obesity.Therefore, seek a kind of can bring into play tcm characteristic again the popular insomnia method of preventing and treating be desirability.
Because the fat factor of impact is many and complicated, therefore for various factors and the too many levels of developing, multi-level compound Chinese medicinal preparation are more common in the disclosed patent application of Patent Office of the People's Republic of China, wherein,
The Patent Application Publication of publication number CN101167906A a kind of pharmaceutical composition of lowering blood-fat and reducing weight, the oral agents of this medicine for being made by the 12 flavor Chinese medicines such as Fructus Crataegi, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Et Rhizoma Rhei, Radix Stephaniae Tetrandrae, the Rhizoma Atractylodis Macrocephalae, the Radix Polygoni Multiflori, Semen Cassiae, Rhizoma Chuanxiong, Folium Nelumbinis, Pericarpium Citri Reticulatae, but its replenishing QI to invigorate the spleen, blood circulation promoting and blood stasis dispelling, the chest stuffiness relieving go to amass, make light of one's life by commiting suicide blood fat reducing, be used for the Simple Obesity successful, but there is first pass effect unavoidably in its a kind of oral formulations.
The Patent Application Publication of the patent application of publication number CN101485865A a kind of " Chinese medicine fat-reducing plaster ", this medicine is to make patch by the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Bupleuri, Rhizoma Curcumae Longae, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae, Fructus Crataegi, Radix Et Rhizoma Rhei, Sargassum, Rhizoma Alismatis, Folium Nelumbinis, Semen Cassiae, Poria, Radix Notoginseng, Stigma Maydis, the Radix Polygoni Multiflori, Herba Artemisiae Scopariae and Moschus, it has the effect of depressed liver-energy dispersing and QI regulating, invigorating blood circulation what, meridians dredging, lowering blood-fat and reducing weight, but this patch not only flavour of a drug is many and complicated, and only rely on the human body temperature effect, remain in onset slow, the dissatisfactory deficiency of Transdermal absorption.
Summary of the invention
Technical problem to be solved by this invention provides a kind of fat Self-heating traditional Chinese medicine plaster for the treatment of, and this patch is rapid-action, and Transdermal absorption is good, and flavour of a drug are few and simple, determined curative effect.
The technical scheme that the present invention addresses the above problem is as described below:
A kind of Self-heating traditional Chinese medicine plaster of lowering blood-fat and reducing weight, this Self-heating traditional Chinese medicine plaster is comprised of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is comprised of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is comprised of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is comprised of acceptable substrate pharmaceutically and the effective ingredient that is equivalent to the crude drug of substrate weight 40%, wherein said effective ingredient is that the percentage by weight by crude drug is comprised of the water extract that menthol 1.5%-3% adds following crude drug: Pericarpium Citri Reticulatae 10%～40%, Semen Cassiae 10%～50%, Semen Raphani 10%～30%, Fructus Crataegi 10%～30%, Rhizoma Alismatis 10%～30%.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said active ingredient preferably forms by the percentage by weight of the crude drug water extract by menthol 2% and following crude drug: Pericarpium Citri Reticulatae 15%, Semen Cassiae 23%, Semen Raphani 20%, Fructus Crataegi 20%, Rhizoma Alismatis 20%.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said water extract can adopt this area water extracting method commonly used to prepare, the method that the inventor recommends is as described below: get Pericarpium Citri Reticulatae, Semen Cassiae, Semen Raphani, Fructus Crataegi, Rhizoma Alismatis by proportioning, add first 6-10 times of water gaging, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder to get final product.Menthol is sprayed in the prepared extract powder, mixes thoroughly, namely get described effective ingredient.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said substrate can be the substrate of conventional patch, as, 2005 editions First appendix of Chinese Pharmacopoeia I rules of preparations is about the substrate of cataplasma described in the emplastrum, i.e. sodium polyacrylate, sodium carboxymethyl cellulose, gelatin, glycerol and micropowder silica gel etc.The substrate that the inventor recommends is comprised of the raw material of following percentage by weight: sticker 6.1%-26.5%, and wetting agent 20%-80%, filler 0.5%-1.5%, cross-linking agent 1.9%-6.5%, all the other are water; Wherein, described sticker be in gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, pressure sensitive adhesive and the carbomer more than three kinds or three kinds; Described wetting agent is glycerol and propylene glycol, perhaps is one or both the mixture in glycerol, propylene glycol and Polyethylene Glycol and the butanediol; Described filler is one or more in Kaolin, zinc oxide and the micropowder silica gel; Described cross-linking agent is two or more in citric acid, triethanolamine, sodium citrate and the aluminum chloride.
Self-heating traditional Chinese medicine plaster of the present invention, the desirable preparation method of wherein said medicine storing layer is: described effective ingredient is soluble in water, add described wetting agent mixing, get mixed liquor; Then, in the described sticker composition any is dissolved in 1/2 mixed liquor, fully swelling gets component one; To be dissolved in 1/6 mixed liquor by the 1-6 kind sticker composition the used sticker composition in component one, fully swelling gets component two; Described filler is dissolved in 1/6 mixed liquor, adds any sticker composition the used sticker composition in component one and component two, mixing gets component three; Described cross-linking agent is dissolved in 1/6 mixed liquor, and mixing gets component four; After adding component one mixing behind component two and component three mixings, get final product with component four mix homogeneously; Wherein,
When contained sticker composition is carbomer in the described component one, just adds triethanolamine, sodium bicarbonate or sodium hydrogen phosphate and transfer PH to 8;
Used sticker composition weight sum equals the content of sticker in the above-mentioned substrate in described component one, component two and the component three.
Self-heating traditional Chinese medicine plaster of the present invention, wherein, described backing layer is non-woven fabrics commonly used; Adherent layer (isolating membrane on mastic surface) is masking foil or cellophane commonly used; Described venting bags is made by non-woven fabrics; Described sealing bag is made by polyethylene film.
The said medicine bin-storing layer is coated on the backing layer, and drying is added a cover adherent layer and is namely got described plaster.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said chemical exothermic material is a kind of common chance oxygen generation oxidation reaction and the reduced iron powder oxidation exothermic material that generates heat, usually formed by reduced iron powder, water and catalyst, as, the inner packing (namely removing the outer package of sealing) of the self-heating bag that Qingdao ADO industry and trade company limited is produced is that the disclosed scheme of application for a patent for invention of CN1172143A, CN1181482A, CN1191294A or CN1760310A is produced voluntarily by publication number perhaps.The chemical exothermic material that the inventor recommends is comprised of following raw material by weight percentage: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25%, Kaolin 5-30%.Preferably formed by by weight percentage following raw material: reduced iron powder 57%, active carbon 12.5%, 15% sodium chloride solution 10.5%, Kaolin 15%.The consumption of above-mentioned chemical exothermic material and proportioning can be adjusted according to needed heating temp and fever time, and suitable heating temp is advisable with 35-50 ℃, and desirable fever time is suitable with 7-11 hour.
The traditional Chinese medical science thinks that obesity mostly is the disease of deficiency in origin and excess in superficiality.Deficiency in origin if hold concurrently imbalance of YIN and YANG, can have yang deficiency or the gas deficiency of YIN take the deficiency of vital energy as main, the disease being located in the spleen, kidney, liver, gallbladder and the heart, lung, and clinical take the spleen deficiency of kidney-QI as main, also as seen suffocating of liver and gall lacks of proper care.The mark reality is turbid as main take cream fat, expectorant, and it is wet often to have water concurrently, and blood stasis, stagnation of QI person also do not hold concurrently.Between the specimen deficiency and excess, can have stress, mixed.Clinical should concentrating on crucial points, identification of etiology according to differenciation of symptoms and signs is sent medicine meticulously, can obtain satisfactory effect.
Active ingredient of the present invention is made by Pericarpium Citri Reticulatae, Semen Cassiae, Semen Raphani, Fructus Crataegi, Rhizoma Alismatis, menthol, and its monarch drug is Semen Cassiae, the tool purging liver-heat, and the merit of loosening bowel to relieve constipation cures mainly the suffocating of liver and gall imbalance; Ministerial drug is Semen Raphani, Fructus Crataegi, Pericarpium Citri Reticulatae, Rhizoma Alismatis, auxiliary monarch drug dissipation food stagnation, strong activating the spleen gas; Adjuvant drug is menthol, cooperates monarch-minister drug mind tranquilizing and the heart calming, YIN nourishing and the production of body fluid promoting.Full side's Six-element compatibility, combined effect reaches strong activating the spleen gas, and the soothing the liver fire of letting out waits effect.
During use, the sealing bag of Self-heating traditional Chinese medicine plaster of the present invention is taken apart, be pasted on overweight people's abdominal part, oxidation reaction just occurs and generates heat in the chemical exothermic material chance oxygen of venting bags, heat energy makes the unimpeded and quickening of skin blood circulation, further promotes the effective ingredient Transdermal absorption, the holographic echo area of effective stimulus whole body, regulate function, and then reach the purpose of lowering blood-fat and reducing weight.
In order to understand better the present invention, the below illustrates its effect with the fat clinical trial of Self-heating traditional Chinese medicine plaster treatment of the present invention.
Clinical experiment
One, physical data
Selection meets 129 routine patients of diagnostic criteria, treatment group 86 examples, male 37 examples, women 49 examples; Minimum 35 years old of age, maximum 60 years old, average 51.37 ± 10.81 years old; The course of disease is the shortest 1 year, and is the longest 20 years, average 8.74 ± 3.47 years.And eliminating is associated with myocardial infarction, cerebrovascular accident, diabetes, the nephrotic syndrome, thyroid disease and other relevant diseases.
The Western medicine diagnose standard is in the normal diet situation, and 2 weeks are interior through 2 survey TC 〉=6.0mmol/L, or TG 〉=1.54mmoll/L, or HDL-c man≤1.04mmol/L, woman≤1.17mmol/L person.
Standards of Chinese Medical Syndrome Differentiation is phlegm stagnation syndrome type: dizzy, headache, nose heave, uncomfortable in chest, cardiopalmus, shortness of breath and fatigue, or phlegm dyspnea, limb fiber crops are heavy, abdominal distention, indigestion and loss of appetite, mouthful glutinous or vomiting and nausea, and tongue fur is satiny, stringy and rolling pulse.
Two. inclusive criteria
Age 18-65 meets Western medicine diagnose and Standards of Chinese Medical Syndrome Differentiation person between year.
Three, exclusion standard:
(1) age under-18s or over-65s, gestation or women breast-feeding their children can not accept the scheme therapist.(2) once suffered from acute myocardial infarction, cerebrovascular accident in half a year, and other serious illness affect this programme implementer.(3) the secondary factor causers such as diabetes, the nephrotic syndrome, thyroid illness, gout and long-term steroid, contraceptive, phenothiazines, beta-blocker.(4) using and affecting lipid metabolism or other lipid lowerers person.(5) not by scheme medication (maybe can not adhere to) or the imperfect person of data.
Four, method
Meet above-mentioned Model Patient, be divided at random Self-heating traditional Chinese medicine plaster 86 examples, matched group 43 examples.
The Self-heating traditional Chinese medicine plaster group: the Self-heating traditional Chinese medicine plaster (specification is 10cm*10cm) of embodiment one is affixed on abdominal part, once a day, each 6h, continuously January.
Matched group: JIANGZHILINGPIAN is oral, and 4 tablets/times, every day 3 times, 30 days courses for the treatment of.
Five, observation of curative effect
Observation index:
T-CHOL, triglyceride, high density lipoprotein, low density lipoprotein, LDL.
Efficacy assessment standard:
Clinic control: clinical symptoms, sign disappear, and the every inspection of laboratory recovers normal.
Produce effects: clinical symptom disappearance, lipids detection can reach following any one person: TC decline 〉=20%, TG decline 〉=40%, HDL-c rising 〉=0.26mmol/L, and LDL=-c/HDL-c descends 〉=20%.Effectively: lipids detection reaches following any one person: TC and descends 〉=10%, less than or equal to 20%; TG descends 〉=20% ,≤40%; HDL-c rising 〉=0.104mmol/L ,≤0.26mmol/L, LDL=-c/HDL-c descends 〉=10% ,≤20%; Invalid: symptom, sign are without improvement after the treatment, and lipids detection is without the positive effect person.
Six, results and analysis
1, among the Self-heating traditional Chinese medicine plaster group 86 routine patients, clinic control 32 examples, produce effects 27 examples, effective 19 examples, invalid 8 examples, total effective rate 90.70%.In matched group 43 examples, clinic control 14 examples, produce effects 9 examples, effective 8 examples, invalid 12 examples, total effective rate 72.09%.Two groups of total effective routine number contrasts, x
2There is significant difference=6.22, P＜0.05, sees Table 1.
Table 1 liang group Clinical efficacy comparison
| Group | n | Clinical recovery | Produce effects | Effectively | Total effective rate | Invalid |
| The Self-heating traditional Chinese medicine plaster group | 86 | 32(37.21％) | 27(31.40％) | 19(22.09％) | 90.70％* | 8 |
| Matched group | 43 | 14(32.36％) | 9(20.93％) | 8(18.60％) | 72.09％ | 12 |
Compare with matched group: * P＞0.05
Show through the t check that 2, treatment group self relatively has significant difference (P＜0.01) before and after treatment, be significantly improved after treatment.Treatment group and matched group are relatively, significant difference (P＜0.01) is being arranged aspect TC, the HDL-c, and significant difference (P＜0.05) is being arranged aspect TG, the LDL-c, treatment group is at the matched group that is better than evident in efficacy that improves aspect the lipid metabolism as can be known, see Table 2,3.
TC, TG comparison before and after the table 2 liang group treatment (x ± s)
Annotate: with * P＜0.05 relatively before the treatment on the same group, * * P＜0.01, with matched group #P＜0.05 relatively, ##P＜0.01
HDL-c, LDL-c comparison before and after the table 3 liang group treatment (x ± s)
Annotate: with * P＜0.05 relatively before the treatment on the same group, * * P＜0.01
The specific embodiment
Embodiment one
1, the preparation of plaster:
Crude drug prescription: menthol 8g, Pericarpium Citri Reticulatae 60g, Semen Cassiae 92g, Semen Raphani 80g, Fructus Crataegi 80g, Rhizoma Alismatis 80g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, polyvinyl alcohol 8g, pressure sensitive adhesive 88g, carbomer 24g, glycerol 250g, propylene glycol 250g, Kaolin 8g, zinc oxide 8g, citric acid 9g, sodium citrate 33g, water 285g.
The preparation of water extract: get Pericarpium Citri Reticulatae, Semen Cassiae, Semen Raphani, Fructus Crataegi and Rhizoma Alismatis and decoct with water secondary, add for the first time 6 times of water gagings, add for the second time 6 times of water gagings, each 1.5 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve and get final product.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, and adding propylene glycol, glycerol mixing get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid and sodium citrate are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment two
1, the preparation of plaster:
Crude drug prescription: menthol 6g, Pericarpium Citri Reticulatae 54g, Semen Cassiae 93g, Semen Raphani 77g, Fructus Crataegi 93g, Rhizoma Alismatis 77g.
Matrix formulations: gelatin 37g, sodium carboxymethyl cellulose 14g, polyvinyl alcohol 10g, glycerol 307g, propylene glycol 306g, Polyethylene Glycol 50g, butanediol 50g, zinc oxide 6g, micropowder silica gel 6g, sodium citrate 29g, aluminum chloride 8g, water 177g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add propylene glycol, glycerol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose is dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add gelatin, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment three
1, the preparation of plaster:
Crude drug prescription: menthol 10g, Pericarpium Citri Reticulatae 40g, Semen Cassiae 74g, Semen Raphani 74g, Fructus Crataegi 92g, Rhizoma Alismatis 110g.
Matrix formulations: gelatin 40g, sodium carboxymethyl cellulose 17g, methylcellulose 17g, sodium polyacrylate 11g, polyvinyl alcohol 11g, polyvinylpyrrolidone 11g, pressure sensitive adhesive 125g, carbomer 33g, glycerol 156g, propylene glycol 156g, micropowder silica gel 8g, citric acid 15g, sodium citrate 27g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add carbomer, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 432g, active carbon 227g, 15% sodium chloride solution 182g, Kaolin 159g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment four
1, the preparation of plaster:
Crude drug prescription: menthol 11g, Pericarpium Citri Reticulatae 123g, Semen Cassiae 40g, Semen Raphani 57g, Fructus Crataegi 75g, Rhizoma Alismatis 94g.
Matrix formulations: gelatin 32g, sodium carboxymethyl cellulose 13g, methylcellulose 12g, sodium polyacrylate 8g, pressure sensitive adhesive 91g, glycerol 266g, propylene glycol 267g, Polyethylene Glycol 44g, butanediol 44g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 4g, sodium citrate 10g, aluminum chloride 9g, water 190g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose, methylcellulose and sodium polyacrylate are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 602g, active carbon 172g, 15% sodium chloride solution 129g, Kaolin 97g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment five
1, the preparation of plaster:
Crude drug prescription: menthol 8g, Pericarpium Citri Reticulatae 122g, Semen Cassiae 122g, Semen Raphani 41g, Fructus Crataegi 46g, Rhizoma Alismatis 61g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, pressure sensitive adhesive 86g, polyvinylpyrrolidone 8g, carbomer 23g, glycerol 256, propylene glycol 256, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, aluminum chloride 13g, citric acid 10g, water 214g,
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose, carbomer and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds polyvinylpyrrolidone, mixing gets component three; Aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 422g, active carbon 133g, 15% sodium chloride solution 178g, Kaolin 267g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment six
1, the preparation of plaster:
Crude drug prescription: menthol 6g, Pericarpium Citri Reticulatae 94g, Semen Cassiae 144g, Semen Raphani 72g, Fructus Crataegi 41g, Rhizoma Alismatis 43g.
Matrix formulations: gelatin 24g, sodium carboxymethyl cellulose 9g, methylcellulose 9g, pressure sensitive adhesive 68g, glycerol 246g, propylene glycol 246g, Polyethylene Glycol 42g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 5g, sodium citrate 32g, aluminum chloride 11g, citric acid 11g, water 285g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol and Polyethylene Glycol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate, aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 589g, active carbon 85g, 15% sodium chloride solution 126g, Kaolin 200g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment seven
1, the preparation of plaster:
Crude drug prescription: menthol 10g, Pericarpium Citri Reticulatae 111g, Semen Cassiae 103g, Semen Raphani 51g, Fructus Crataegi 40g, Rhizoma Alismatis 85g.
Matrix formulations: carbomer 27g, sodium carboxymethyl cellulose 14g, methylcellulose 13g, pressure sensitive adhesive 100g, polyvinyl alcohol 9g, glycerol 197g, propylene glycol 197g, micropowder silica gel 5g, citric acid 18g, sodium citrate 35g, aluminum chloride 12g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Sodium carboxymethyl cellulose, polyvinyl alcohol and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid, sodium citrate, aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 532g, active carbon 128g, 15% sodium chloride solution 85g, Kaolin 255g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment eight
1, the preparation of plaster:
Crude drug prescription: menthol 6g, Pericarpium Citri Reticulatae 123g, Semen Cassiae 123g, Semen Raphani 62g, Fructus Crataegi 46g, Rhizoma Alismatis 40g.
Matrix formulations: sodium carboxymethyl cellulose 15g, methylcellulose 15g, sodium polyacrylate 10g, polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 108g, carbomer 30g, glycerol 224g, propylene glycol 224g, butanediol 38g, zinc oxide 6g, citric acid 16g, aluminum chloride 15g, water 279g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Sodium carboxymethyl cellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; The zinc oxide peptization in 1/6 above-mentioned mixed liquor, is added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 494g, active carbon 180g, 15% sodium chloride solution 224g, Kaolin 102g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment nine
1, the preparation of plaster:
Crude drug prescription: menthol 6g, Pericarpium Citri Reticulatae 54g, Semen Cassiae 155g, Semen Raphani 77g, Fructus Crataegi 62g, Rhizoma Alismatis 46g.
Matrix formulations: polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 109g, carbomer 30g, glycerol 255g, propylene glycol 255g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 5g, citric acid 11g, aluminum chloride 12g, water 212g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin and zinc oxide peptization in 1/6 above-mentioned mixed liquor, are added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 444g, active carbon 162g, 15% sodium chloride solution 202g, Kaolin 192g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment ten
1, the preparation of plaster:
Crude drug prescription: menthol 7g, Pericarpium Citri Reticulatae 40g, Semen Cassiae 75g, Semen Raphani 111g, Fructus Crataegi 93g, Rhizoma Alismatis 74g.
Matrix formulations: methylcellulose 16g, sodium polyacrylate 15g, pressure sensitive adhesive 110g, polyvinylpyrrolidone 10g, glycerol 258g, propylene glycol 258g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 4g, micropowder silica gel 5g, sodium citrate 35g, aluminum chloride 15g, water 183g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing and get mixed liquor; Methylcellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium polyacrylate and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel, Kaolin and zinc oxide are dissolved in 1/6 above-mentioned mixed liquor, add polyvinylpyrrolidone, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 490g, active carbon 118g, 15% sodium chloride solution 157g, Kaolin 235g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment 11
1, the preparation of plaster:
Crude drug prescription: menthol 9g, Pericarpium Citri Reticulatae 70g, Semen Cassiae 41g, Semen Raphani 60g, Fructus Crataegi 120g, Rhizoma Alismatis 100g.
Matrix formulations: carbomer 31g, pressure sensitive adhesive 89g, methylcellulose 12g, sodium polyacrylate 8g, glycerol 257g, propylene glycol 257g, butanediol 43g, Kaolin 7g, micropowder silica gel 6g, citric acid 10g, sodium citrate 36g, water 244g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium hydrogen phosphate, gets component one; Methylcellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add sodium polyacrylate, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 544g, active carbon 155g, 15% sodium chloride solution 116g, Kaolin 185g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment 12
1, the preparation of plaster:
Crude drug prescription: menthol 11g, Pericarpium Citri Reticulatae 97g, Semen Cassiae 78g, Semen Raphani 40g, Fructus Crataegi 58g, Rhizoma Alismatis 116g.
Matrix formulations: methylcellulose 13g, polyvinylpyrrolidone 9g, pressure sensitive adhesive 97g, carbomer 27g, glycerol 207g, propylene glycol 207g, butanediol 35g, Kaolin 6g, zinc oxide 6g, citric acid 10g, sodium citrate 38g, aluminum chloride 10g, water 335g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: menthol is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium bicarbonate, gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add methylcellulose, mixing gets component three; Aluminum chloride, sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 500g, active carbon 200g, 15% sodium chloride solution 160g, Kaolin 140g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Claims (6)
1. the Self-heating traditional Chinese medicine plaster of a lowering blood-fat and reducing weight, this Self-heating traditional Chinese medicine plaster is comprised of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is comprised of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is comprised of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is comprised of acceptable substrate pharmaceutically and the effective ingredient that is equivalent to the crude drug of substrate weight 40%, wherein said effective ingredient is that the percentage by weight by crude drug is comprised of the water extract that menthol 1.5%-3% adds following crude drug: Pericarpium Citri Reticulatae 10%～40%, Semen Cassiae 10%～50%, Semen Raphani 10%～30%, Fructus Crataegi 10%～30%, Rhizoma Alismatis 10%～30%.
2. the Self-heating traditional Chinese medicine plaster of a kind of lowering blood-fat and reducing weight according to claim 1, it is characterized in that, described active ingredient is to form by the percentage by weight of the crude drug water extract by menthol 2% and following crude drug: Pericarpium Citri Reticulatae 15%, Semen Cassiae 23%, Semen Raphani 20%, Fructus Crataegi 20%, Rhizoma Alismatis 20%.
3. the Self-heating traditional Chinese medicine plaster of a kind of lowering blood-fat and reducing weight according to claim 1 and 2, it is characterized in that described water extract is prepared by following methods: get Pericarpium Citri Reticulatae, Semen Cassiae, Semen Raphani, Fructus Crataegi, Rhizoma Alismatis by proportioning, add first 6-10 times of water gaging, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder to get final product.
4. the Self-heating traditional Chinese medicine plaster of a kind of lowering blood-fat and reducing weight according to claim 1 and 2 is characterized in that, described substrate is comprised of the raw material of following percentage by weight: sticker 6.1%-26.5%, wetting agent 20%-80%, filler 0.5%-1.5%, cross-linking agent 1.9%-6.5%, all the other are water; Wherein, described sticker be in gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, pressure sensitive adhesive and the carbomer more than three kinds or three kinds; Described wetting agent is glycerol and propylene glycol, perhaps is one or both the mixture in glycerol, propylene glycol, Polyethylene Glycol and the butanediol; Described filler is one or more in Kaolin, zinc oxide and the micropowder silica gel; Described cross-linking agent is two or more in citric acid, triethanolamine, sodium citrate and the aluminum chloride.
5. the Self-heating traditional Chinese medicine plaster of a kind of lowering blood-fat and reducing weight according to claim 4 is characterized in that, described medicine storing layer is prepared by following methods: described effective ingredient is soluble in water, add described wetting agent mixing, and get mixed liquor; Then, in the described sticker composition any is dissolved in 1/2 mixed liquor, fully swelling gets component one; To be dissolved in 1/6 mixed liquor by the 1-6 kind sticker composition the used sticker composition in component one, fully swelling gets component two; Described filler is dissolved in 1/6 mixed liquor, adds any sticker composition the used sticker composition in component one and component two, mixing gets component three; Described cross-linking agent is dissolved in 1/6 mixed liquor, and mixing gets component four; After adding component one mixing behind component two and component three mixings, get final product with component four mix homogeneously; Wherein,
When contained sticker composition is carbomer in the described component one, just adds triethanolamine, sodium bicarbonate or sodium hydrogen phosphate and transfer PH to 8;
Used sticker composition weight sum equals the content of sticker in the substrate claimed in claim 4 in described component one, component two and the component three.
6. the Self-heating traditional Chinese medicine plaster of a kind of lowering blood-fat and reducing weight according to claim 1 and 2, it is characterized in that the raw material of the following percentage by weight of described chemical exothermic material forms: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25% and Kaolin 5-30%.
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| CN106138491B (en) * | 2015-03-27 | 2019-10-29 | 张小飞 | A kind of weight-reducing Chinese medicine compound prescription drug paste |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1191294A (en) * | 1998-03-19 | 1998-08-26 | 李连生 | Heat-generating agent and its use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1191294A (en) * | 1998-03-19 | 1998-08-26 | 李连生 | Heat-generating agent and its use |
Non-Patent Citations (4)
| Title |
|---|
| 中医药防治单纯性肥胖的临床研究进展;孙升云等;《时珍国医国药》;20060328;第17卷(第03期);332页 * |
| 中药泽泻的研究概况;贾良栋;《时珍国医国药》;20050920;第16卷(第09期);924页 * |
| 孙升云等.中医药防治单纯性肥胖的临床研究进展.《时珍国医国药》.2006,第17卷(第03期),332. |
| 贾良栋.中药泽泻的研究概况.《时珍国医国药》.2005,第16卷(第09期),924页. |
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