CN102416140B - Self-heating type Chinese medicinal emplastrum for treating proliferation of mammary gland - Google Patents
Self-heating type Chinese medicinal emplastrum for treating proliferation of mammary gland Download PDFInfo
- Publication number
- CN102416140B CN102416140B CN 201110313274 CN201110313274A CN102416140B CN 102416140 B CN102416140 B CN 102416140B CN 201110313274 CN201110313274 CN 201110313274 CN 201110313274 A CN201110313274 A CN 201110313274A CN 102416140 B CN102416140 B CN 102416140B
- Authority
- CN
- China
- Prior art keywords
- self
- plaster
- heating
- bag
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000010438 heat treatment Methods 0.000 title claims abstract description 76
- 210000005075 mammary gland Anatomy 0.000 title abstract description 12
- 230000035755 proliferation Effects 0.000 title abstract description 3
- 239000003814 drug Substances 0.000 claims abstract description 85
- 239000011505 plaster Substances 0.000 claims abstract description 79
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 33
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 32
- 229940079593 drug Drugs 0.000 claims abstract description 30
- 238000007789 sealing Methods 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 10
- 239000000126 substance Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 65
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 54
- 239000012467 final product Substances 0.000 claims description 52
- 239000000843 powder Substances 0.000 claims description 45
- 239000005995 Aluminium silicate Substances 0.000 claims description 44
- 235000012211 aluminium silicate Nutrition 0.000 claims description 44
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 44
- 239000004615 ingredient Substances 0.000 claims description 31
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 27
- 229910052799 carbon Inorganic materials 0.000 claims description 27
- 239000011780 sodium chloride Substances 0.000 claims description 27
- 210000000582 semen Anatomy 0.000 claims description 19
- 238000001035 drying Methods 0.000 claims description 16
- 239000002994 raw material Substances 0.000 claims description 16
- 238000013022 venting Methods 0.000 claims description 16
- 239000000758 substrate Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 7
- 230000001464 adherent effect Effects 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000006479 redox reaction Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 89
- 239000011159 matrix material Substances 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 13
- 238000007254 oxidation reaction Methods 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 230000003647 oxidation Effects 0.000 abstract description 2
- 239000010410 layer Substances 0.000 abstract 3
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 235000014375 Curcuma Nutrition 0.000 abstract 1
- 244000164480 Curcuma aromatica Species 0.000 abstract 1
- 240000009138 Curcuma zedoaria Species 0.000 abstract 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 abstract 1
- 240000004980 Rheum officinale Species 0.000 abstract 1
- 235000008081 Rheum officinale Nutrition 0.000 abstract 1
- 244000178320 Vaccaria pyramidata Species 0.000 abstract 1
- 235000010587 Vaccaria pyramidata Nutrition 0.000 abstract 1
- 239000012790 adhesive layer Substances 0.000 abstract 1
- 230000000181 anti-adherent effect Effects 0.000 abstract 1
- 239000006286 aqueous extract Substances 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 abstract 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 235000019509 white turmeric Nutrition 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 83
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 78
- 238000002156 mixing Methods 0.000 description 77
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 57
- 239000000203 mixture Substances 0.000 description 47
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 38
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 34
- 230000008961 swelling Effects 0.000 description 28
- 239000004745 nonwoven fabric Substances 0.000 description 26
- 238000012856 packing Methods 0.000 description 25
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 23
- 208000002193 Pain Diseases 0.000 description 22
- 239000001509 sodium citrate Substances 0.000 description 19
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 19
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 18
- 229920002125 Sokalan® Polymers 0.000 description 18
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 18
- 229960001631 carbomer Drugs 0.000 description 18
- 239000001768 carboxy methyl cellulose Substances 0.000 description 18
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 18
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 18
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 17
- 229920000609 methyl cellulose Polymers 0.000 description 17
- 239000001923 methylcellulose Substances 0.000 description 17
- 239000011787 zinc oxide Substances 0.000 description 17
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 16
- 239000000741 silica gel Substances 0.000 description 16
- 229910002027 silica gel Inorganic materials 0.000 description 16
- 108010010803 Gelatin Proteins 0.000 description 14
- 239000008273 gelatin Substances 0.000 description 14
- 229920000159 gelatin Polymers 0.000 description 14
- 235000019322 gelatine Nutrition 0.000 description 14
- 235000011852 gelatine desserts Nutrition 0.000 description 14
- -1 polyethylene Polymers 0.000 description 14
- 239000004698 Polyethylene Substances 0.000 description 13
- 239000002202 Polyethylene glycol Substances 0.000 description 13
- 239000004372 Polyvinyl alcohol Substances 0.000 description 13
- 238000009472 formulation Methods 0.000 description 13
- 229920000573 polyethylene Polymers 0.000 description 13
- 229920001223 polyethylene glycol Polymers 0.000 description 13
- 229920002451 polyvinyl alcohol Polymers 0.000 description 13
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 13
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 13
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 13
- 239000000853 adhesive Substances 0.000 description 12
- 230000001070 adhesive effect Effects 0.000 description 12
- 210000000481 breast Anatomy 0.000 description 12
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 12
- 208000024891 symptom Diseases 0.000 description 8
- 229920000298 Cellophane Polymers 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000011888 foil Substances 0.000 description 7
- 230000000873 masking effect Effects 0.000 description 7
- 206010006298 Breast pain Diseases 0.000 description 6
- 208000006662 Mastodynia Diseases 0.000 description 6
- 238000009826 distribution Methods 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 4
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000003431 cross linking reagent Substances 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000002175 menstrual effect Effects 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- 235000019800 disodium phosphate Nutrition 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 238000001935 peptisation Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000283956 Manis Species 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 208000030270 breast disease Diseases 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 230000001314 paroxysmal effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008326 skin blood flow Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Abstract
The invention relates to a Chinese medicinal compound preparation, in particular to a self-heating type Chinese medicinal emplastrum for treating the proliferation of mammary gland. The self-heating type Chinese medicinal emplastrum consists of a sealing bag, and plaster and a self-heating bag which are wrapped in the sealing bag and are bonded together from top to bottom; the self-heating bag consists of a breathable bag and chemical heating materials which are wrapped in the breathable bag and are used for iron oxidation and reduction reaction; and the plaster consists of a back lining layer, a drug storage layer and an anti-adhesive layer. The self-heating type Chinese medicinal emplastrum is characterized in that the drug storage layer consists of pharmaceutically-acceptable matrix and effective components of bulk drugs with the weight being 40% of that of the matrix, wherein the effective components include 1.5%-3% of borneol and aqueous extracts of the following materials according to the weight percentage of the bulk drug: 20%-50% of tangerine seed, 5%-20% of rhizoma sparganii, 5%-20% of curcuma zedoary, 10%-30% of rheum officinale and 10%-30% of cowherb seed. The self-heating type Chinese medicinal emplastrum has the advantages of fast effect, good transdermal absorption and exact curative effect.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of external patch that improves cyclomastopathy.
Technical background
Cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of carrying out property connective tissue, and its pathogenic factor mainly is because the endocrine hormone imbalance.There is approximately according to investigations 70%～85% women that in various degree cyclomastopathy is arranged, show that according to latest survey cyclomastopathy has become the modal mammary gland problem of women, not only sickness rate rises year by year, and the morbidity crowd more and more becomes younger, be more common in 20～45 years old women, or account for the women of child-bearing age's 30%～45%.Modern medicine is thought: the external environment of marriage and childbirth, meals, people living and inherited genetic factors are the main causes of mammary gland morbidity.Cyclomastopathy is the modal cystic hyperplasia of breast of women, should prevent in advance.The pathogenesis more complicated of cyclomastopathy, modern medicine to it also without prevention and treatment method preferably.Yet motherland's medical science has obvious advantage aspect the preventing and treating of cyclomastopathy.
Owing to cause that the factor of cyclomastopathy is many and complicated, therefore the too many levels of developing for various factors, multi-level compound Chinese medicinal preparation is more common in the disclosed patent application of Patent Office of the People's Republic of China, wherein publication number be CN1555816A Patent Application Publication a kind of medicine for the treatment of hyperplasia of mammary glands, this medicine is by Radix Bupleuri, Fructus Trichosanthis, Fructus Aurantii, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Curcumae, Rhizoma Cyperi, Fructus Citri, Fructus Citri tangerinae nuclear, Semen Litchi, Semen Sinapis Albae, Semen Vaccariae, rhizoma sparganic, Rhizoma Curcumae, Radix Glycyrrhizae Preparata, the big gun Squama Manis is prepared from dosage form for oral administration commonly used by certain weight proportion, it has depressed liver-energy dispersing and QI regulating, activating blood circulation to dissipate blood stasis, hard masses softening and resolving, the functions such as reducing swelling and alleviating pain.But this medicine is a kind of oral formulations, has unavoidably first pass effect.
Summary of the invention
Technical problem to be solved by this invention provides a kind of Self-heating traditional Chinese medicine plaster that improves cyclomastopathy, and this patch is rapid-action, and Transdermal absorption is effective, determined curative effect.
The technical scheme that the present invention addresses the above problem is as described below:
A kind of Self-heating traditional Chinese medicine plaster for the treatment of cyclomastopathy, this Self-heating traditional Chinese medicine plaster is comprised of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is comprised of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is comprised of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is comprised of acceptable substrate pharmaceutically and the effective ingredient that is equivalent to the crude drug of substrate weight 40%, wherein said effective ingredient is to form by the percentage by weight of the crude drug water extract by Borneolum Syntheticum 1.5%-3% and following crude drug: Fructus Citri tangerinae nuclear 20%～50%, rhizoma sparganic 5%～20%, Rhizoma Curcumae 5%～20%, Radix Et Rhizoma Rhei 10%～30%, Semen Vaccariae 10%～30%.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said active ingredient preferably are comprised of the water extract that Borneolum Syntheticum 2% adds following crude drug by the percentage by weight of crude drug: Fructus Citri tangerinae nuclear 30%, rhizoma sparganic 14%, Rhizoma Curcumae 14%, Radix Et Rhizoma Rhei 20%, Semen Vaccariae 20%.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said water extract can adopt this area water extracting method commonly used to prepare, the method that the inventor recommends is as described below: get Fructus Citri tangerinae nuclear, rhizoma sparganic, Rhizoma Curcumae, Radix Et Rhizoma Rhei, Semen Vaccariae by proportioning, add first 6-10 times of water gaging, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder to get final product.Borneolum Syntheticum is added in the prepared extract powder, mix thoroughly, namely get described effective ingredient.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said substrate can be the substrate of conventional patch, as, 2005 editions First appendix of Chinese Pharmacopoeia I rules of preparations is about the substrate of cataplasma described in the emplastrum, i.e. sodium polyacrylate, sodium carboxymethyl cellulose, gelatin, glycerol and micropowder silica gel etc.The substrate that the inventor recommends is comprised of the raw material of following percentage by weight: sticker 6.1%-26.5%, and wetting agent 20%-80%, filler 0.5%-1.5%, cross-linking agent 1.9%-6.5%, all the other are water; Wherein, described sticker be in gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, pressure sensitive adhesive and the carbomer more than three kinds or three kinds; Described wetting agent is glycerol and propylene glycol, perhaps is one or both the mixture in glycerol, propylene glycol and Polyethylene Glycol and the butanediol; Described filler is one or more in Kaolin, zinc oxide and the micropowder silica gel; Described cross-linking agent is two or more in citric acid, triethanolamine, sodium citrate and the aluminum chloride.
Self-heating traditional Chinese medicine plaster of the present invention, the desirable preparation method of wherein said medicine storing layer is: described effective ingredient is soluble in water, add described wetting agent mixing, get mixed liquor; Then, in the described sticker composition any is dissolved in 1/2 mixed liquor, fully swelling gets component one; To be dissolved in 1/6 mixed liquor by the 1-6 kind sticker composition the used sticker composition in component one, fully swelling gets component two; Described filler is dissolved in 1/6 mixed liquor, adds any sticker composition the used sticker composition in component one and component two, mixing gets component three; Described cross-linking agent is dissolved in 1/6 mixed liquor, and mixing gets component four; After adding component one mixing behind component two and component three mixings, get final product with component four mix homogeneously; Wherein,
When contained sticker composition is carbomer in the described component one, just adds triethanolamine, sodium bicarbonate or sodium hydrogen phosphate and transfer PH to 8;
Used sticker composition weight sum equals the content of sticker in the above-mentioned substrate in described component one, component two and the component three.
Self-heating traditional Chinese medicine plaster of the present invention, wherein, described backing layer is non-woven fabrics commonly used; Adherent layer (isolating membrane on mastic surface) is masking foil or cellophane commonly used; Described venting bags is made by non-woven fabrics; Described sealing bag is made by polyethylene film.
The said medicine bin-storing layer is coated on the backing layer, and drying is added a cover adherent layer and is namely got described plaster.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said chemical exothermic material is a kind of common chance oxygen generation oxidation reaction and the reduced iron powder oxidation exothermic material that generates heat, usually formed by reduced iron powder, water and catalyst, as, the inner packing (namely removing the outer package of sealing) of the self-heating bag that Qingdao ADO industry and trade company limited is produced is that the disclosed scheme of application for a patent for invention of CN1172143A, CN1181482A, CN1191294A or CN1760310A is produced voluntarily by publication number perhaps.The chemical exothermic material that the inventor recommends is comprised of following raw material by weight percentage: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25%, Kaolin 5-30%.Preferably formed by by weight percentage following raw material: reduced iron powder 57%, active carbon 12.5%, 15% sodium chloride solution 10.5%, Kaolin 15%.The consumption of above-mentioned chemical exothermic material and proportioning can be adjusted according to needed heating temp and fever time, and suitable heating temp is advisable with 35～50 ℃, and desirable fever time is suitable with 7～11 hours.
Clinically, the symptom of disease is mainly take breast periodicity pain as feature.Originally overflow the property distending pain for trip, touch a tender spot for the outer upside of breast and middle and upper part for obviously, the pain increased before the menstruation per month, the rear pain of passing through goes down or disappears.Severe patient through front through after all be rest pain.Sometimes pain is located radiation to armpit, shoulder back, upper limb etc.The patient often has lump in the readme breast, and only touches the corpus mamma that thickens during clinical examination.But the spontaneous recovery about 2 years of the simple cyclomastopathy of only a few adolescence is arranged, and Most patients then need be treated, and Traditional Chinese Medicine thinks that it is because depressed rage impairing the liver, worry impairing spleen, qi stagnation blood stasis, expectorant congeal into due to the nuclear, and Chinese medicine is referred to as " nodules of the breast ".
Active ingredient of the present invention is made by Fructus Citri tangerinae nuclear, rhizoma sparganic, Rhizoma Curcumae, Radix Et Rhizoma Rhei, Semen Vaccariae and Borneolum Syntheticum, and its monarch drug is Fructus Citri tangerinae nuclear, Radix Et Rhizoma Rhei, eliminating stagnation, eliminating carbuncle are arranged, stimulates the menstrual flow, the effect of pain relieving, clinically is commonly used to treat lump in the abdomen, the mammary gland inflammatory disease such as swell and ache; Ministerial drug is rhizoma sparganic, Rhizoma Curcumae, is the key medicine that treatment pain due to blood stasis, note of the ancient Chinese abdominal mass are gathered; Assistant is with Semen Vaccariae, in order to diseases such as carbuncle furunculosiss; Make medicine Borneolum Syntheticum priming descending.Full side's Six-element compatibility, combined effect reaches promoting blood circulation to restore menstrual flow, the effects such as reducing swelling and alleviating pain.
During use, the sealing bag of Self-heating traditional Chinese medicine plaster of the present invention is taken apart, be pasted on pain spot or the lump place of cyclomastopathy person's breast, oxidation reaction just occurs and generates heat in the chemical exothermic material chance oxygen of venting bags, heat energy makes the unimpeded and quickening of skin blood circulation, further promotes the effective ingredient Transdermal absorption, the holographic echo area of effective stimulus whole body, regulate internal organs, and then reach the purpose for the treatment of cyclomastopathy.
In order to understand better the present invention, the below illustrates its effect with the clinical trial of Self-heating traditional Chinese medicine plaster treatment cyclomastopathy of the present invention.
Clinical experiment
One, physical data
The object of observation is all from the medical cyclomastopathy female patient of the court's in March, 2009 to 2010 year December outpatient service.Obtain patient's informed consent, according to medical order, with 1: 1 ratio, the patient is randomized into treatment group and matched group, treatment group 60 examples, blank group 60 examples.Minimum 18 years old of the age in the treatment group, maximum 45 years old, 37 years old mean age; The course of disease is the shortest 6 months, and is the longest 25 years, average course of disease (33.5 ± 0.2) moon.Minimum 18 years old of the age in the matched group, maximum 45 years old, 37 years old mean age; The course of disease is the shortest 7 months, and is the longest 23 years, average course of disease (33.7 ± 0.3) moon.Two groups of patient ages, courses of disease are learned processing by statistics, the equal not statistically significant of difference (P＞0.05).
Two, inclusive criteria
" Diagnosis of Cyclomastopathy, the dialectical and curative effect determinate standard " that the 8th meeting of foundation Chinese surgery of Chinese medicine breast disease Professional Committee of association in 2002 passed through.1. meet above-mentioned Diagnosis of Cyclomastopathy standard; 2. there is the menstrual cycle of comparison rule at the age 18～50 years old women; 3. function normal persons such as the heart, liver, kidney and hemopoietic; 4. voluntary participation clinical research person.
Three, exclusion standard:
1. do not meet above-mentioned Diagnosis of Cyclomastopathy standard; 2. gestation, women breast-feeding their children; 3. good, the malignant tumor of breast; 4. once used hormone medicine in half a year; 5. used the Chinese and western medicine medicine for the treatment of cyclomastopathy in nearly 1 month; 6. allergic constitution patient or to the medicine allergy sufferers; 7. be associated with the serious heart, liver, brain, kidney, disease of hematopoietic system, the mentally disturbed; 8. participating in other drug clinical research person in nearly 1 month.
Four, method
The Self-heating traditional Chinese medicine plaster group: select the Self-heating traditional Chinese medicine plaster (specification is 10cm*10cm) of embodiment one, determine first pain spot and lump during treatment, cleaning skin is then selected the external application method of pain spot or lump, changes 1 time in per 3 days.
Blank group: blank group selects the blank substrate that does not contain far-infrared magnet therapeutic self-heating function to paste (specification is 10cm*10cm), and method is the same.
2 groups all take 3 months as 1 course for the treatment of.
Five, observation of curative effect
The symptom scores standard:
With pain, touch a tender spot, the lump quality, the lump distribution, five aspects of lump size are that leading indicator is marked, each index is divided into 4 grades by degrees of symptoms, is respectively non-evident sympton, mild, moderate symptom, severe symptom.Scoring rule is non-evident sympton 0 minute, mild 1 minute, moderate symptom 2 minutes, severe symptom 3 minutes.Evaluation time is respectively before treatment beginning and after the treatment end, all at menstrual onset inner evaluation the last week, and pain measurement reference standard Cardiff mammary gland pain chart.
1. pain.0 grade (0 minute) is without breast pain; 1 grade (2 minutes) are mild pain, and numbness when not noting does not affect work, life; 2 grades (4 minutes) have pain for often feeling, are paroxysmal, still can stand, and are slightly influential to working, living; 3 grades (6 minutes) are that mastalgia is obvious, and persistence is subjected to more unbearably, and work, life are had considerable influence.
2. touch a tender spot.0 grade (0 minute) is without touching a tender spot; 1 grade (3 minutes) are slight the tenderness, heavily by it pain are arranged; 2 grades (6 minutes) are moderate tenderness, slightly heavily by it pain are arranged; 3 grades (9 minutes) for touching a tender spot obviously, flicking pain namely arranged, the automatic action of dodging is arranged during inspection.
3. lump quality.0 grade (0 minute) is without lump; 1 grade (2 minutes) are the soft as normal body of gland of matter; 2 grades (4 minutes) are matter tough (such as nose); 3 grades (6 minutes) are matter firmly tough (such as volume).
The High frequency color Doppler breast examination
1. lump distribution (bilateral total).0 grade (0 minute) is without lump; 1 grade (2 minutes) are confined to 1～2 breast quadrant for the lump distribution; 2 grades (4 minutes) are 3～4 breast quadrants for the lump distribution; 3 grades (6 minutes) are 5 and 5 above breast quadrants for the lump distribution.
2. lump size (getting the maximum diameter lump).0 grade (0 minute) is without lump; 1 grade (2 minutes) are lump maximum gauge＜2.0cm; 2 grades (4 minutes) are lump maximum gauge 2.0～4.0cm; 3 grades (6 minutes) are lump maximum gauge＞4.0cm.
Efficacy assessment standard:
Recovery from illness: mastalgia and mammary gland tumor disappear, and do not recur in 3 months after the drug withdrawal;
Produce effects: mastalgia disappears or alleviates, and heavy type becomes light-duty, and mammary gland tumor dwindles 〉=and 2/3;
Effectively: mastalgia disappears or alleviates, and medium-sizedly becomes light-dutyly, and heavy type becomes medium-sized, and mammary gland tumor dwindles 〉=and 1/3,＜2/3;
Invalid: mastalgia does not alleviate or increases the weight of on the contrary, and mammary gland tumor is not dwindled or increased on the contrary.
Statistical procedures:
Adopt the SPSS13.0 statistical software, variable data X 2 test between group, measurement data adopts the t check, adopts rank test during heterogeneity of variance.
Result of the test:
2 groups all take 3 months as 1 course for the treatment of.The clinical symptoms integral contrast sees Table 1 before and after Self-heating traditional Chinese medicine plaster group and the blank group, and curative effect relatively sees Table 2.As known from Table 2, Self-heating traditional Chinese medicine plaster: 10 examples of fully recovering, produce effects 25 examples, effective 23 examples, invalid 2 examples, total effective rate is 96.7%; Blank group: 0 example of fully recovering, produce effects 0 example, effective 9 examples, invalid 51 examples, total effective rate is 15.0%.The Self-heating traditional Chinese medicine plaster successful is higher than blank group.N in table 1～table 2 represents number.
Symptom and sign integral contrast before and after the table 1 liang group treatment
Annotate: compare P＜0.05 in organizing with before the treatment; Compare P＜0.05 with the blank group.
Table 2 liang group Clinical efficacy comparison [n (%)]
| Group | n | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate/% |
| The Self-heating traditional Chinese medicine plaster group | 60 | 10(16.6) | 25(41.6) | 23(38.3) | 2(3.3) | 96.7 |
| Blank group | 60 | 0(10.0) | 0(35.0) | 9(38.3) | 51(16.6) | 15.0 |
The specific embodiment
Embodiment one
The Self-heating traditional Chinese medicine plaster group:
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 8g, Fructus Citri tangerinae nuclear 120g, rhizoma sparganic 56g, Rhizoma Curcumae 56g, Radix Et Rhizoma Rhei 80g, Semen Vaccariae 80g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, polyvinyl alcohol 8g, pressure sensitive adhesive 88g, carbomer 24g, glycerol 250g, propylene glycol 250g, Kaolin 5g, zinc oxide 5g, citric acid 9g, sodium citrate 33g, water 285g.
The preparation of water extract: Fructus Citri tangerinae nuclear, rhizoma sparganic, Rhizoma Curcumae, Radix Et Rhizoma Rhei and Semen Vaccariae decoct with water secondary, add for the first time 6 times of water gagings, add for the second time 6 times of water gagings, each 1.5 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve and get final product.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, and adding propylene glycol, glycerol mixing get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid and sodium citrate are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment two
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 6g, Fructus Citri tangerinae nuclear 97g, rhizoma sparganic 44g, Rhizoma Curcumae 58g, Radix Et Rhizoma Rhei 106g, Semen Vaccariae 89g.
Matrix formulations: gelatin 37g, sodium carboxymethyl cellulose 14g, polyvinyl alcohol 10g, glycerol 307g, propylene glycol 306g, Polyethylene Glycol 50g, butanediol 50g, zinc oxide 6g, micropowder silica gel 6g, sodium citrate 29g, aluminum chloride 8g, water 177g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add propylene glycol, glycerol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose is dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add gelatin, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment three
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 11g, Fructus Citri tangerinae nuclear 162g, rhizoma sparganic 20g, Rhizoma Curcumae 34g, Radix Et Rhizoma Rhei 77g, Semen Vaccariae 96g.
Matrix formulations: gelatin 40g, sodium carboxymethyl cellulose 17g, methylcellulose 17g, sodium polyacrylate 11g, polyvinyl alcohol 11g, polyvinylpyrrolidone 11g, pressure sensitive adhesive 125g, carbomer 33g, glycerol 156g, propylene glycol 156g, micropowder silica gel 8g, citric acid 15g, sodium citrate 27g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add carbomer, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 432g, active carbon 227g, 15% sodium chloride solution 182g, Kaolin 159g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment four
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 8g, Fructus Citri tangerinae nuclear 159g, rhizoma sparganic 75g, Rhizoma Curcumae 61g, Radix Et Rhizoma Rhei 41g, Semen Vaccariae 56g.
Matrix formulations: gelatin 32g, sodium carboxymethyl cellulose 13g, methylcellulose 12g, sodium polyacrylate 8g, pressure sensitive adhesive 91g, glycerol 266g, propylene glycol 267g, Polyethylene Glycol 44g, butanediol 44g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 4g, sodium citrate 10g, aluminum chloride 9g, water 190g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose, methylcellulose and sodium polyacrylate are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 602g, active carbon 172g, 15% sodium chloride solution 129g, Kaolin 97g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment five
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 7g, Fructus Citri tangerinae nuclear 128g, rhizoma sparganic 60g, Rhizoma Curcumae 73g, Radix Et Rhizoma Rhei 92g, Semen Vaccariae 40g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, pressure sensitive adhesive 86g, polyvinylpyrrolidone 8g, carbomer 23g, glycerol 256, propylene glycol 256, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, aluminum chloride 13g, citric acid 10g, water 214g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose, carbomer and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds polyvinylpyrrolidone, mixing gets component three; Aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 422g, active carbon 133g, 15% sodium chloride solution 178g, Kaolin 267g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment six
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 8g, Fructus Citri tangerinae nuclear 80g, rhizoma sparganic 62g, Rhizoma Curcumae 77g, Radix Et Rhizoma Rhei 96g, Semen Vaccariae 77g.
Matrix formulations: gelatin 24g, sodium carboxymethyl cellulose 9g, methylcellulose 9g, pressure sensitive adhesive 68g, glycerol 246g, propylene glycol 246g, Polyethylene Glycol 42g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 5g, sodium citrate 32g, aluminum chloride 11g, citric acid 11g, water 285g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol and Polyethylene Glycol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate, aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 589g, active carbon 85g, 15% sodium chloride solution 126g, Kaolin 200g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment seven
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 12g, Fructus Citri tangerinae nuclear 167g, rhizoma sparganic 49g, Rhizoma Curcumae 34g, Radix Et Rhizoma Rhei 40g, Semen Vaccariae 98g.
Matrix formulations: carbomer 27g, sodium carboxymethyl cellulose 14g, methylcellulose 13g, pressure sensitive adhesive 100g, polyvinyl alcohol 9g, glycerol 197g, propylene glycol 197g, micropowder silica gel 5g, citric acid 18g, sodium citrate 35g, aluminum chloride 12g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Sodium carboxymethyl cellulose, polyvinyl alcohol and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid, sodium citrate, aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 532g, active carbon 128g, 15% sodium chloride solution 85g, Kaolin 255g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment eight
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 8g, Fructus Citri tangerinae nuclear 188g, rhizoma sparganic 61g, Rhizoma Curcumae 47g, Radix Et Rhizoma Rhei 56g, Semen Vaccariae 40g.
Matrix formulations: sodium carboxymethyl cellulose 15g, methylcellulose 15g, sodium polyacrylate 10g, polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 108g, carbomer 30g, glycerol 224g, propylene glycol 224g, butanediol 38g, zinc oxide 6g, citric acid 16g, aluminum chloride 15g, water 279g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Sodium carboxymethyl cellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; The zinc oxide peptization in 1/6 above-mentioned mixed liquor, is added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 494g, active carbon 180g, 15% sodium chloride solution 224g, Kaolin 102g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment nine
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 6g, Fructus Citri tangerinae nuclear 110g, rhizoma sparganic 79g, Rhizoma Curcumae 65g, Radix Et Rhizoma Rhei 80g, Semen Vaccariae 60g.
Matrix formulations: polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 109g, carbomer 30g, glycerol 255g, propylene glycol 255g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 5g, citric acid 11g, aluminum chloride 12g, water 212g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin and zinc oxide peptization in 1/6 above-mentioned mixed liquor, are added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 444g, active carbon 162g, 15% sodium chloride solution 202g, Kaolin 192g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment ten
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 8g, Fructus Citri tangerinae nuclear 97g, rhizoma sparganic 35g, Rhizoma Curcumae 80g, Radix Et Rhizoma Rhei 100g, Semen Vaccariae 80g.
Matrix formulations: methylcellulose 16g, sodium polyacrylate 15g, pressure sensitive adhesive 110g, polyvinylpyrrolidone 10g, glycerol 258g, propylene glycol 258g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 4g, micropowder silica gel 5g, sodium citrate 35g, aluminum chloride 15g, water 183g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing and get mixed liquor; Methylcellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium polyacrylate and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel, Kaolin and zinc oxide are dissolved in 1/6 above-mentioned mixed liquor, add polyvinylpyrrolidone, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 490g, active carbon 118g, 15% sodium chloride solution 157g, Kaolin 235g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment 11
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 9g, Fructus Citri tangerinae nuclear 116g, rhizoma sparganic 20g, Rhizoma Curcumae 35g, Radix Et Rhizoma Rhei 120g, Semen Vaccariae 100g.
Matrix formulations: carbomer 31g, pressure sensitive adhesive 89g, methylcellulose 12g, sodium polyacrylate 8g, glycerol 257g, propylene glycol 257g, butanediol 43g, Kaolin 7g, micropowder silica gel 6g, citric acid 10g, sodium citrate 36g, water 244g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium hydrogen phosphate, gets component one; Methylcellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add sodium polyacrylate, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 544g, active carbon 155g, 15% sodium chloride solution 116g, Kaolin 185g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment 12
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 11g, Fructus Citri tangerinae nuclear 154g, rhizoma sparganic 35g, Rhizoma Curcumae 20g, Radix Et Rhizoma Rhei 60g, Semen Vaccariae 120g.
Matrix formulations: methylcellulose 13g, polyvinylpyrrolidone 9g, pressure sensitive adhesive 97g, carbomer 27g, glycerol 207g, propylene glycol 207g, butanediol 35g, Kaolin 6g, zinc oxide 6g, citric acid 10g, sodium citrate 38g, aluminum chloride 10g, water 335g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium bicarbonate, gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add methylcellulose, mixing gets component three; Aluminum chloride, sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 500g, active carbon 200g, 15% sodium chloride solution 160g, Kaolin 140g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Claims (4)
1. Self-heating traditional Chinese medicine plaster for the treatment of cyclomastopathy, this Self-heating traditional Chinese medicine plaster is comprised of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is comprised of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is comprised of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is comprised of acceptable substrate pharmaceutically and the effective ingredient that is equivalent to the crude drug of substrate weight 40%, wherein said effective ingredient is to form by the percentage by weight of the crude drug water extract by Borneolum Syntheticum 1.5%-3% and following crude drug: Fructus Citri tangerinae nuclear 20%～50%, rhizoma sparganic 5%～20%, Rhizoma Curcumae 5%～20%, Radix Et Rhizoma Rhei 10%～30%, Semen Vaccariae 10%～30%.
2. a kind of Self-heating traditional Chinese medicine plaster for the treatment of cyclomastopathy according to claim 1, it is characterized in that, described active ingredient is that the percentage by weight by crude drug is comprised of the water extract that Borneolum Syntheticum 2% adds following crude drug: Fructus Citri tangerinae nuclear 30%, rhizoma sparganic 14%, Rhizoma Curcumae 14%, Radix Et Rhizoma Rhei 20%, Semen Vaccariae 20%.
3. a kind of Self-heating traditional Chinese medicine plaster for the treatment of cyclomastopathy according to claim 1 and 2, it is characterized in that, described water extract is prepared by following methods: get Fructus Citri tangerinae nuclear, rhizoma sparganic, Rhizoma Curcumae, Radix Et Rhizoma Rhei, Semen Vaccariae by proportioning, add first 6-10 times of water gaging, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder to get final product.
4. a kind of Self-heating traditional Chinese medicine plaster for the treatment of cyclomastopathy according to claim 1 and 2, it is characterized in that the raw material of the following percentage by weight of described chemical exothermic material forms: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25% and Kaolin 5-30%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110313274 CN102416140B (en) | 2011-10-16 | 2011-10-16 | Self-heating type Chinese medicinal emplastrum for treating proliferation of mammary gland |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110313274 CN102416140B (en) | 2011-10-16 | 2011-10-16 | Self-heating type Chinese medicinal emplastrum for treating proliferation of mammary gland |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102416140A CN102416140A (en) | 2012-04-18 |
| CN102416140B true CN102416140B (en) | 2013-04-03 |
Family
ID=45940941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110313274 Expired - Fee Related CN102416140B (en) | 2011-10-16 | 2011-10-16 | Self-heating type Chinese medicinal emplastrum for treating proliferation of mammary gland |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102416140B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106139382A (en) * | 2015-04-14 | 2016-11-23 | 上海暖友实业有限公司 | A kind of spontaneous heating breast health promotion patch and its preparation method and application |
| CN104984178A (en) * | 2015-06-19 | 2015-10-21 | 广西信业生物技术有限公司 | Self-heating type mammary gland medical hot compress patch and preparation method thereof |
| CN105944019A (en) * | 2016-06-16 | 2016-09-21 | 周倩 | Self-heating heat-preservation traditional Chinese medicine breast mask and preparation method thereof |
| CN108379523A (en) * | 2018-05-31 | 2018-08-10 | 傅清杰 | A Chinese medicine mammary gland patch |
| CN111870673A (en) * | 2020-08-13 | 2020-11-03 | 河北省沧州中西医结合医院 | A topical Chinese medicinal composition for the treatment of hyperplasia of mammary glands and breast cancer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1191294A (en) * | 1998-03-19 | 1998-08-26 | 李连生 | Heat-generating agent and its use |
| CN1559514A (en) * | 2004-03-05 | 2005-01-05 | 健 张 | Skin penetration and adsorption medicine for treating proliferation of mammary gland |
-
2011
- 2011-10-16 CN CN 201110313274 patent/CN102416140B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1191294A (en) * | 1998-03-19 | 1998-08-26 | 李连生 | Heat-generating agent and its use |
| CN1559514A (en) * | 2004-03-05 | 2005-01-05 | 健 张 | Skin penetration and adsorption medicine for treating proliferation of mammary gland |
Non-Patent Citations (2)
| Title |
|---|
| 刘长征.外治法治疗乳腺增生病概况.《中医杂志》.2006,第47卷(第01期), |
| 外治法治疗乳腺增生病概况;刘长征;《中医杂志》;20060107;第47卷(第01期);68-69 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102416140A (en) | 2012-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102416140B (en) | Self-heating type Chinese medicinal emplastrum for treating proliferation of mammary gland | |
| CN102370730B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for treating osteoarthritis | |
| CN102370740B (en) | Self-heating Chinese medicinal adhesive plaster for treating prostatitis | |
| CN101810826B (en) | Chinese medicament for treating liver cancer | |
| CN102370795B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for treating primary dysmenorrhea | |
| CN100473396C (en) | Combination of medication for treating disease of hyperplasia of mammary glands glands and preparation method thereof | |
| CN102366501B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for improving sleep quality | |
| CN102366495B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for lowering lipid and losing weight | |
| CN102370762B (en) | Self-heating Chinese medicinal adhesive plaster for improving constipation | |
| CN102366471B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for warming deficiency of kidney | |
| CN105148150A (en) | Healthcare tea and making method thereof | |
| CN102366446B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for improving pelvic inflammation | |
| CN102370723B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for improving chest bi | |
| CN102366462B (en) | Self-heating traditional Chinese medicine plaster for improving sub-health | |
| CN102366451B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for improving stroke sequelae | |
| CN110772627B (en) | Tibetan medicine rheumatism eliminating ointment and preparation method and application thereof | |
| CN115105576B (en) | Traditional Chinese medicine composition for treating ovarian cancer, traditional Chinese medicine preparation and application thereof | |
| CN102370809B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for preventing and curing hypertension | |
| CN102205071B (en) | Chinese medicinal composition for treating thyroid cyst | |
| CN100500134C (en) | Preparation for improving bioavailability and effect of golden pheasant and preparation method and purpose thereof | |
| CN103751235A (en) | Traditional Chinese medicine composition for treating dysentery | |
| CN102366441B (en) | Self-heating Chinese medicinal emplastrum for cold prevention | |
| CN103845499B (en) | A kind of Chinese medicine composition for the treatment of chronic prostatitis | |
| CN107890501A (en) | For treating the brave fragrant MEBO of burn wound | |
| CN109674834A (en) | A kind of gynaecology's basin bottom cold compress patch can be used for postpartum vulva Repercusion analgesia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211207 Address after: 265200 No. 101, zhaowangzhuang street, zhaowangzhuang Town, Laiyang City, Yantai City, Shandong Province Patentee after: Yantai Meiding Health Industry Co.,Ltd. Address before: 510665 No. 30, Xinzhuang 2nd Road, Yonghe street, Luogang District, Guangzhou, Guangdong Patentee before: Guangdong Yangmei Medicine Investment Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130403 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |