CN111870673A - A topical Chinese medicinal composition for the treatment of hyperplasia of mammary glands and breast cancer - Google Patents

A topical Chinese medicinal composition for the treatment of hyperplasia of mammary glands and breast cancer Download PDF

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Publication number
CN111870673A
CN111870673A CN202010813694.6A CN202010813694A CN111870673A CN 111870673 A CN111870673 A CN 111870673A CN 202010813694 A CN202010813694 A CN 202010813694A CN 111870673 A CN111870673 A CN 111870673A
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China
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parts
chinese medicine
traditional chinese
hyperplasia
breast cancer
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王振强
王凤汕
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HEBEI PROVINCE CANGZHOU HOSPITAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
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HEBEI PROVINCE CANGZHOU HOSPITAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
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Priority to CN202010813694.6A priority Critical patent/CN111870673A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/902—Sparganiaceae (Bur-reed family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/648—Myriapods, e.g. centipedes or millipedes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention discloses an externally applied traditional Chinese medicine composition for treating hyperplasia of mammary glands and breast cancer, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises: 25-35 parts of rhizoma sparganii, 25-35 parts of curcuma zedoary, 15-25 parts of frankincense, 4-8 parts of stir-fried white mustard seed, 15-25 parts of spina gleditsiae, 15-25 parts of myrrh, 10-20 parts of rhizoma corydalis, 25-35 parts of tangerine seed, 10-20 parts of centipede, 25-35 parts of fructus forsythiae, 10-20 parts of asarum and 10-20 parts of borneol. The traditional Chinese medicine composition has the effects of soothing liver, promoting qi circulation, removing blood stasis, detoxifying, resolving masses and relieving pain, and is suitable for conservative treatment of hyperplasia of mammary glands, mammary gland fibroma and breast cancer.

Description

A topical Chinese medicinal composition for the treatment of hyperplasia of mammary glands and breast cancer
Technical Field
The invention relates to an externally applied traditional Chinese medicine composition for treating hyperplasia of mammary glands and breast cancer, belonging to the technical field of traditional Chinese medicine compositions.
Background
Hyperplasia of mammary glands refers to hyperplasia of mammary epithelium and fibrous tissue, degenerative changes of mammary tissue ducts and mammary lobules in structure and growth of progressive connective tissue, and the pathogenesis is mainly due to endocrine hormone imbalance. The symptoms of the breast distending pain are usually unilateral or bilateral breast distending pain or tenderness, the disease course is different from 2 months to several years, most patients have the characteristic of periodic pain, the premenstrual period is increased, and the postmenstrual period is reduced or disappeared, it is necessary to pay attention to that the periodicity of the breast pain is the typical expression of the disease, but the existence of the disease cannot be denied by the patients without the characteristic. Breast lumps: it is usually multiple, unilateral or bilateral, with multiple external and upper quadrants; the sizes and the textures of the medicinal materials also change periodically along with menstruation, the mass in the early period of the menstruation is enlarged, the texture is hard, the mass after the menstruation is reduced, the medicinal materials are tough but not hard, the medicinal materials can be touched during palpation, are in a node structure, are different in sizes, are not clear with surrounding tissues, are mostly tender, are not adhered to skin and deep tissues, can be pushed, and axillary lymph nodes are not enlarged.
About 70% to 80% of women are investigated to have different degrees of hyperplasia of mammary glands, most commonly found in women 25-45 years of age. Mammary gland hyperplasia is a chronic disease, and the disease is painful when being developed, but the normal learning work is not affected generally, so the disease is easy to ignore, but if the long-time mastitis is developed, mastitis can be caused in the lactation period of women, and the risk of breast cancer is increased. Therefore, a traditional Chinese medicine composition capable of treating hyperplasia of mammary glands is urgently needed to be found.
Disclosure of Invention
The invention aims to provide an externally applied traditional Chinese medicine composition for treating hyperplasia of mammary glands and breast cancer, which comprises the following components in part by weight: 25-35 parts of rhizoma sparganii, 25-35 parts of curcuma zedoary, 15-25 parts of frankincense, 4-8 parts of stir-fried white mustard seed, 15-25 parts of spina gleditsiae, 15-25 parts of myrrh, 25-35 parts of rhizoma corydalis, 25-35 parts of tangerine seed, 10-20 parts of centipede, 25-35 parts of fructus forsythiae, 10-20 parts of asarum and 10-20 parts of borneol.
Preferably, the traditional Chinese medicine composition comprises: 30 parts of rhizoma sparganii, 30 parts of curcuma zedoary, 20 parts of prepared frankincense, 6 parts of stir-fried white mustard seed, 20 parts of spina gleditsiae, 20 parts of prepared myrrh, 30 parts of rhizoma corydalis, 30 parts of tangerine seed, 15 parts of centipede, 30 parts of fructus forsythiae, 15 parts of asarum and 15 parts of borneol.
The traditional Chinese medicine composition is prepared into a plaster by adopting a conventional method, and the specific process comprises the following steps:
(1) decocting rhizoma sparganii, curcuma zedoary, prepared frankincense, stir-fried semen brassicae, spina gleditsiae, prepared myrrh, rhizoma corydalis, tangerine seed, centipede, fructus forsythiae, asarum and borneol for 1-2 hours with small fire.
(2) Filtering the decoction with gauze, adding 60-70 wt% ethanol into the filtrate while stirring until the precipitate is not increased, filtering, and concentrating the filtrate to obtain medicinal extract.
(3) Adding the medicine extract obtained in the step (2) into the matrix according to the mass ratio of 1:4, and uniformly stirring;
(4) coating the mixed plaster obtained in the step (3) on a back lining layer, solidifying and drying, covering a protective film, slicing, sterilizing, bagging and storing.
The matrix of the invention can be prepared by a conventional method.
The invention has the beneficial effects that: the traditional Chinese medicine composition has the effects of soothing liver, promoting qi circulation, removing blood stasis, detoxifying, resolving masses and relieving pain, and is suitable for conservative treatment of hyperplasia of mammary glands, mammary gland fibroma and breast cancer.
Detailed Description
The present invention is further described in detail with reference to the following specific examples, but the scope of the present invention is not limited to the above description.
Example 1
An externally applied traditional Chinese medicine composition for treating hyperplasia of mammary glands and breast cancer, the traditional Chinese medicine composition is as follows: 30g of rhizoma sparganii, 30g of curcuma zedoary, 20g of prepared frankincense, 6g of fried white mustard seed, 20g of spina gleditsiae, 20g of prepared myrrh, 30g of rhizoma corydalis, 30g of tangerine seed, 15g of centipede, 30g of fructus forsythiae, 15g of asarum and 15g of borneol.
Example 2
An externally applied traditional Chinese medicine composition for treating hyperplasia of mammary glands and breast cancer, the traditional Chinese medicine composition is as follows: 35g of rhizoma sparganii, 35g of curcuma zedoary, 15g of prepared frankincense, 4g of fried white mustard seed, 15g of spina gleditsiae, 25g of prepared myrrh, 35g of rhizoma corydalis, 35g of tangerine seed, 10g of centipede, 30g of fructus forsythiae, 15g of asarum and 15g of borneol.
Example 3
An externally applied traditional Chinese medicine composition for treating hyperplasia of mammary glands and breast cancer, the traditional Chinese medicine composition is as follows: 25g of rhizoma sparganii, 25g of curcuma zedoary, 25g of prepared frankincense, 8g of fried white mustard seed, 25g of spina gleditsiae, 15g of prepared myrrh, 25g of rhizoma corydalis, 25g of tangerine seed, 20g of centipede, 30g of fructus forsythiae, 15g of asarum and 15g of borneol.
The traditional Chinese medicine composition of embodiments 1-3 of the invention is prepared into a plaster by the following method.
(1) Decocting rhizoma sparganii, curcuma zedoary, prepared frankincense, stir-fried semen brassicae, spina gleditsiae, prepared myrrh, rhizoma corydalis, tangerine seed, centipede, fructus forsythiae, asarum and borneol for 1-2 hours with small fire.
(2) Filtering the decoction with gauze, adding 60-70 wt% ethanol into the filtrate while stirring until the precipitate is not increased, filtering, and concentrating the filtrate to obtain medicinal extract.
(3) Adding the medicine extract obtained in the step (2) into the matrix according to the mass ratio of 1:4, and uniformly stirring.
(4) Coating the mixed plaster obtained in the step (3) on a back lining layer, solidifying and drying, covering a protective film, slicing, sterilizing, bagging and storing.
The application method of the plaster comprises the following steps: the patch is applied to the affected part, and the dressing change is carried out once every two days, and the patch is continuously applied for seven times, which is a treatment course.
Diagnosis standard of hyperplasia of mammary glands:
the diagnostic criteria for a patient are classified into three classes based on clinical experience: first-stage: the breast is tenderness, the distribution range of the lumps is limited to 1-2 breast quadrants, and the maximum diameter is 1-2 cm; and (2) second stage: spontaneous pain of breasts, mainly premenstrual, 3-4 breast quadrants with mass distribution and 2-4 cm of maximum diameter; third-stage: spontaneous pain of breasts is continuous, and the diameter of a lump is 5-6 cm, so that normal work and life are influenced, menstrual disorder is accompanied, and the mood is irritated.
The curative effect standard of the hyperplasia of mammary glands is as follows:
the method has the following advantages: the lump disappears, and other symptoms still exist;
and (3) curing: pain disappeared, mass disappeared, with symptom disappeared;
and (4) invalidation: pain and lumps were not significantly improved.
Opening a certain sheet: female, 30 years old, bilateral breast lumps, 3-4 cm in diameter, severe pain in days before menstruation and diagnosis of hyperplasia of mammary glands, the plaster disclosed in the invention, in the embodiment 1, is continuously used for 7 days, the patient feels obviously relieved of pain, the breast lumps detected by B ultrasonic are reduced to 1-2 cm, the plaster is continuously used for 3 courses, the breast lumps disappear, the pain in menstrual period disappears, and the disease does not recur within one year, and the patient is considered to be cured.
Plum, a certain female, 42 years old unilateral breast lump, hard and irregular edge, unobvious pain, occasional stabbing pain, and due to heavy work and pressure, the patient suffers from hyperplasia of mammary glands for many years, the pain is related to the menstrual cycle, generally aggravated before menstruation, slightly relieved after menstruation, accompanied by uncomfortable emotion, irritability, and fullness in chest and hypochondrium. After the plaster disclosed by the embodiment 2 of the invention is continuously used for 7 days, the breast distending pain of a patient is obviously relieved, the patient feels refreshing, the sleep, the mood and the chest and hypochondrium fullness are obviously improved, the pain is obviously relieved, the breast lumps disappear after the plaster is continuously used for 3 treatment courses, the pain in the menstrual period disappears, and the patient is treated as recovery without relapse within one year.
Somebody in grandson, a woman, age 36. The patient has hyperplasia of mammary glands, flat feeling of unilateral breast stabbing pain, palpable breast lumps, tough texture, slight tenderness, and breast pain related to menstrual cycle and mood. Often, the mood is very vexation, and the anxiety is accompanied by insomnia. After the plaster disclosed by the embodiment 2 of the invention is pasted for 7 days, the breast stabbing pain is obviously relieved, the lumps are reduced, the mood is smooth, and the diet and the sleep are better. After 3 treatment courses of continuous use, the breast lumps disappear, the pain in the menstrual period disappears, and no recurrence occurs within one year, so the patients are considered to be cured.

Claims (3)

1. An externally applied traditional Chinese medicine composition for treating hyperplasia of mammary glands and breast cancer is characterized in that: the traditional Chinese medicine composition comprises: 25-35 parts of rhizoma sparganii, 25-35 parts of curcuma zedoary, 15-25 parts of frankincense, 4-8 parts of stir-fried white mustard seed, 15-25 parts of spina gleditsiae, 15-25 parts of myrrh, 25-35 parts of rhizoma corydalis, 25-35 parts of tangerine seed, 10-20 parts of centipede, 25-35 parts of fructus forsythiae, 10-20 parts of asarum and 10-20 parts of borneol.
2. An externally applied traditional Chinese medicine composition for treating hyperplasia of mammary glands and breast cancer according to claim 1, wherein: the traditional Chinese medicine composition comprises: 30 parts of rhizoma sparganii, 30 parts of curcuma zedoary, 20 parts of prepared frankincense, 6 parts of stir-fried white mustard seed, 20 parts of spina gleditsiae, 20 parts of prepared myrrh, 30 parts of rhizoma corydalis, 30 parts of tangerine seed, 15 parts of centipede, 30 parts of fructus forsythiae, 15 parts of asarum and 15 parts of borneol.
3. A topical Chinese medicinal composition for the treatment of mammary gland hyperplasia and breast cancer according to claim 1 or 2, wherein: the Chinese medicinal composition is prepared into plaster.
CN202010813694.6A 2020-08-13 2020-08-13 A topical Chinese medicinal composition for the treatment of hyperplasia of mammary glands and breast cancer Pending CN111870673A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101361950A (en) * 2008-07-31 2009-02-11 西安三八妇乐健康产业有限公司 Gynaecologic traditional Chinese medicine capable of dispelling coldness, promoting blood and alleviating pain and preparation method thereof
CN102416140A (en) * 2011-10-16 2012-04-18 广东养美医药投资有限公司 Self-heating type Chinese medicinal emplastrum for treating proliferation of mammary gland
CN110755574A (en) * 2019-05-08 2020-02-07 薛华金 External plaster for treating hyperplasia of mammary glands

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101361950A (en) * 2008-07-31 2009-02-11 西安三八妇乐健康产业有限公司 Gynaecologic traditional Chinese medicine capable of dispelling coldness, promoting blood and alleviating pain and preparation method thereof
CN102416140A (en) * 2011-10-16 2012-04-18 广东养美医药投资有限公司 Self-heating type Chinese medicinal emplastrum for treating proliferation of mammary gland
CN110755574A (en) * 2019-05-08 2020-02-07 薛华金 External plaster for treating hyperplasia of mammary glands

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
周文涛等: "补肾理气活血法联合消癖热熨袋治疗乳腺增生病的疗效观察", 《湖北中医杂志》 *
田彦华: "中医外治法治疗乳腺增生病的临床研究", 《辽宁中医药大学学报》 *

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Application publication date: 20201103