CN111603458B - A composition for treating ovarian cancer - Google Patents

A composition for treating ovarian cancer Download PDF

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CN111603458B
CN111603458B CN202010588394.2A CN202010588394A CN111603458B CN 111603458 B CN111603458 B CN 111603458B CN 202010588394 A CN202010588394 A CN 202010588394A CN 111603458 B CN111603458 B CN 111603458B
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ovarian cancer
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cyclophosphamide
traditional chinese
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CN111603458A (en
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李�荣
许时丽
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Second Hospital University Of South China
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Abstract

The invention discloses a composition for treating ovarian cancer, which belongs to the field of antitumor drugs and comprises the following raw materials of lycopene cis-isomer with the mass ratio of 1-10 to 20-40, cyclophosphamide and traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is any one or a mixture of more of frankincense, saffron, myrrh, black nightshade, turmeric, golden cypress, leech, endothelium corneum gigeriae galli, angelica and charred triplet. The invention combines lycopene and cyclophosphamide, improves the sensitivity of tumor cells to cyclophosphamide, thereby improving the killing effect of cyclophosphamide on ovarian tumor cells, further selects the traditional Chinese medicine components for strengthening body resistance and consolidating the constitution, reducing swelling and clearing heat, and promoting blood circulation and removing blood stasis, and combines the active components, thereby enhancing the effect of lycopene and cyclophosphamide. Has the characteristics of quick response and obvious effect.

Description

A composition for treating ovarian cancer
Technical Field
The invention relates to a pharmaceutical composition, in particular to a composition for treating ovarian cancer, and belongs to the field of antitumor drugs.
Background
Ovarian cancer is a common malignant tumor in women, and the mortality rate of ovarian cancer is the first mortality rate caused by female tumors. Because the early stage of the ovarian cancer lacks obvious external symptoms, the condition of the ovarian cancer is hidden, and missed diagnosis is easily caused. Metastasis already occurs when most ovarian cancer patients are diagnosed, and the tumor focus is difficult to completely remove by simple surgical treatment, so that postoperative recurrence is easy to occur. Over 70% of patients have been diagnosed with advanced stages and about 70% relapse within two years after surgery.
Drug therapy is an auxiliary means for ovarian cancer surgical treatment, and the primary therapeutic drugs mainly use alkylating agents, including cyclophosphamide. With the development of new drugs, platinum, gemcitabine, docetaxel, etoposide, paclitaxel, etc. are also gradually used for the treatment of ovarian cancer. However, clinical practice proves that the curative effect of single chemotherapeutic drugs on ovarian cancer is not ideal, so that the combined administration scheme becomes the main treatment scheme of clinical ovarian cancer. Such as cyclophosphamide, cisplatin combinations, paclitaxel and cisplatin combinations, and the like. The anti-ovarian cancer drugs currently being researched mainly comprise targeted small molecule drugs. In addition, in the use of chemotherapy drugs, the ovarian cancer is easy to have drug resistance, so that the tumor cells lose sensitivity to the chemotherapy drugs and the curative effect of the drugs is reduced.
Ovarian cancer is rather similar to the history of "ovarian cyst" in ancient TCM. Conventionally, the pathogenesis of the disease is related to qi stagnation, blood stasis, phlegm dampness and blood stasis, so the treatment is mostly performed by regulating qi, activating blood and softening hardness to dissipate stagnation. The invention considers that although the clinical symptoms of ovarian cancer are accompanied by pathogenic excess and healthy qi deficiency, pathogenic toxin is accumulated in the heat, and the symptoms are the basis. Although the later stage of the disease shows deficiency of qi and blood, and is also the result of damaging vital qi due to heat toxin, the existing traditional Chinese medicine treatment has some obvious defects: firstly, the treatment effect is not obvious enough; secondly, the effect is relatively slow.
However, no report on the treatment of ovarian cancer by combining traditional Chinese medicines with western medicines is seen at present.
Disclosure of Invention
In view of the above, the invention provides a composition for treating ovarian cancer, which solves the problems of insufficient obvious effect, delayed effect and easy recurrence in the previous ovarian cancer treatment.
In order to achieve the purpose, the invention adopts the following technical scheme:
a composition for treating ovarian cancer comprises raw materials of 1-10 mass ratio of lycopene cis-isomer, cyclophosphamide and traditional Chinese medicine extract, wherein the lycopene cis-isomer comprises the following components;
the Chinese medicinal extract is one or more of Olibanum, stigma croci Sativi, myrrha, herba Solani Nigri, curcuma rhizome, cortex Phellodendri, hirudo, endothelium corneum Gigeriae Galli, radix Angelicae sinensis, charred Hawthorn fruit and charred malt.
Further, raw materials for preparing the composition comprise the cis-isomer of lycopene, cyclophosphamide and traditional Chinese medicine extracts in a mass ratio of 1.
Further, raw materials for preparing the composition comprise the lycopene cis-isomer, cyclophosphamide and traditional Chinese medicine extracts in a mass ratio of 1.
Further, the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 6-38 parts of frankincense, 6-10 parts of saffron, 5-35 parts of myrrh, 5-32 parts of black nightshade, 5-15 parts of turmeric, 5-15 parts of golden cypress, 5-7 parts of leech, 5-10 parts of chicken's gizzard-membrane, 4-30 parts of angelica and 4-9 parts of charred triplet.
Further, the traditional Chinese medicine extract is a mixture of extract fine powder prepared by respectively crushing the raw materials and extracting the raw materials by a conventional water extraction process.
Further, the pharmaceutic adjuvant comprises any one or a mixture of more of an adsorbent, an adhesive, a solvent and a wetting agent, wherein the adsorbent is calcium hydrophosphate or microcrystalline cellulose, the adhesive is medicinal starch, the wetting agent is ethanol, glycerol or tween-80, and the solvent is purified water.
The Lycopene has the beneficial effects that the Lycopene (Lycopene, lyp) has the physiological functions of quenching active oxygen, eliminating free radicals of a human body, preventing heart diseases, relieving atherosclerosis, preventing various cancers, resisting aging, protecting skin and the like. Epidemiological studies have shown that Lyp concentrations in blood are inversely correlated with the incidence of various cancers. Lyp can reduce the activity of breast cancer cell mitogen, inhibit cell cycle from being arrested in the G1 stage to the S stage, enhance the function of intercellular gap junction communication (GJIC), promote the interaction between phagocytes and lymphocytes, activate cells by secreting cell activating factors, finally express the promotion of phagocytic ability and lymphocyte transformation, enhance immune function and further induce tumor cell apoptosis.
Cyclophosphamide (CTX) is a nitrogen mustard derivative which enters a human body and is hydrolyzed by an excessive amount of phosphoramidase or phosphatase present in the liver or tumor to become activated phosphoramide. The antineoplastic spectrum is wide, is the first so-called 'latent' broad-spectrum antineoplastic drug and is effective to leukemia and solid tumors.
The cis-isomer of lycopene is selected through experiments, and the combination of lycopene and cyclophosphamide improves the sensitivity of tumor cells to cyclophosphamide, thereby improving the killing effect of cyclophosphamide on ovarian tumor cells. Has the characteristics of quick response and obvious effect.
The traditional Chinese medicine components related by the invention have the following effects:
frankincense, which is warm in nature, pungent and bitter in flavor, enters heart, liver and spleen meridians, promote blood circulation, move qi and alleviate pain, resolve swelling and promote tissue regeneration.
Saffron, neutral in nature and sweet in taste, enters heart and liver meridians, and has the effects of promoting blood circulation to remove blood stasis, cooling blood and removing toxicity, and relieving depression and tranquilizing mind.
Myrrh, mild in nature, pungent and bitter in flavor, enters heart, liver and spleen channels, removes stasis and relieves pain, and diminishes swelling and promotes granulation.
Solanum nigrum, cold in nature, bitter in taste, non-toxic, heat-clearing, detoxifying, blood circulation-promoting and swelling-reducing.
Turmeric has warm nature and pungent and bitter taste, and has the functions of tonifying spleen and liver meridian, breaking blood and promoting qi circulation, and dredging meridians to stop pain.
Phellodendron bark, cortex Phellodendri, with cold nature and bitter taste, enters kidney and bladder meridians, clears heat and dries dampness, purges fire and removes steam, detoxifies and cures sores.
Leeches, with mild nature, salty and bitter taste, enter liver meridian, break blood and dredge meridians, remove blood stasis and eliminate stasis.
Endothelium corneum Gigeriae Galli, neutral in nature and sweet in taste, enters spleen, stomach, small intestine and bladder channels, and has effects of invigorating stomach, resolving food stagnation, arresting seminal emission, relieving enuresis, and treating stranguria and removing calculus.
Chinese angelica root, radix Angelicae sinensis, warm in nature, sweet and pungent in flavor, enters liver, heart and spleen channels, and has the effects of enriching and activating blood, regulating menstruation, relieving pain, moistening intestines and relaxing bowels.
The charred triplet, namely charred malt, charred hawthorn fruit and charred medicated leaven, has good functions of removing food retention and resolving stagnation, but has different characteristics, and is used together for promoting digestion, removing stagnation and strengthening spleen and stomach.
The invention also provides application of the composition for treating ovarian cancer in preparation of ovarian cancer quality medicines.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
In the following examples, the raw materials and reagents involved meet the criteria set by pharmacopoeia, as well as the safety and formulation requirements.
Example 1
The composition for treating ovarian cancer is prepared by respectively crushing and extracting frankincense 6g, saffron 6g, myrrh 5g, black nightshade 5g, turmeric 5g, golden cypress 5g, leech 5g, chicken's gizzard-membrane 5g, chinese angelica 4g and charred triplet 4g with water to prepare extract fine powder, and mixing the extract powder to obtain a traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is prepared by mixing a lycopene cis-isomer, cyclophosphamide and a traditional Chinese medicine extract according to the mass ratio of 1.
Example 2
The composition for treating ovarian cancer is prepared by respectively crushing 38g of frankincense, 10g of saffron, 35g of myrrh, 32g of black nightshade, 15g of turmeric, 15g of golden cypress, 7g of leech, 10g of chicken's gizzard-membrane, 30g of Chinese angelica and 9g of charred triplet, extracting with water to prepare extract fine powder, and mixing to obtain a traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is prepared by mixing a lycopene cis-isomer, cyclophosphamide and a traditional Chinese medicine extract according to the mass ratio of 1.
Example 3
The composition for treating ovarian cancer is prepared by respectively crushing 30g of frankincense, 10g of saffron, 20g of myrrh, 10g of black nightshade, 10g of turmeric, 10g of golden cypress, 6g of leech, 5g of chicken's gizzard-membrane, 15g of angelica and 5g of charred triplet, extracting with water to prepare extract fine powder, and mixing to obtain a traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is prepared by mixing a lycopene cis-isomer, cyclophosphamide and a traditional Chinese medicine extract according to the mass ratio of 1.
Example 4
The composition for treating ovarian cancer is prepared by respectively crushing and extracting frankincense 20g, saffron 10g, myrrh 20g, black nightshade 20g, turmeric 10g, phellodendron bark 10g, leech 6g, chicken's gizzard-skin 5g, angelica 5g and charred triplet 4g with water to prepare extract fine powder, and mixing the extract powder and the extract powder to obtain a traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is prepared by mixing lycopene cis-isomer, cyclophosphamide and traditional Chinese medicine extract according to the mass ratio of 1.
Example 5
The composition for treating ovarian cancer is prepared by respectively crushing 30g of frankincense, 8g of saffron, 25g of myrrh, 25g of black nightshade, 10g of turmeric, 15g of golden cypress, 5g of leech, 5g of chicken's gizzard-membrane, 20g of Chinese angelica and 5g of charred triplet into fine extract powder, and mixing the fine extract powder with water to obtain a traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is prepared by mixing a lycopene cis-isomer, cyclophosphamide and a traditional Chinese medicine extract according to the mass ratio of 1.
Clinical case statistics
Adding microcrystalline cellulose, medicinal starch, glycerol and purified water into the composition for treating ovarian cancer in the above examples 1-4 respectively to prepare oral tablets, which are respectively marked as tablets 1-4;
the tablets 1-4 are clinical medicines for 20 patients with ovarian cancer respectively, and 20 patients are all patients with middle and advanced stage ovarian cancer, wherein 9 patients are treated by operation and are not cured.
In the above 20 patients, tablets 1-4 of the present examples 1-4 were administered in a targeted manner according to the onset and severity (the sum of the mass ratio of cis-isomer of lycopene and cyclophosphamide was appropriately increased in patients with severe cases), and the following therapeutic effects were counted after 2 courses (60 days) of administration:
item Early stage of life Middle stage Late stage Total of Ratio of
The basic healing is achieved 3 5 1 9 45％
Improvement of life 2 3 2 7 35％
Invalidation 0 3 1 4 20％
Total of 5 11 4 20 100％
The curative effect standard is as follows:
the basic cure is as follows: after the medicine is used, the tumor cells are removed, the symptoms such as pain or bleeding do not exist, and the medicine can automatically and normally move;
improvement: the clinical symptoms are better than those before the administration, and the symptoms are basically controlled;
and (4) invalidation: the symptoms are not obviously different before and after the administration.
The effective rate of the invention reaches 80%, the cure rate reaches 45%, and no toxic or side effect occurs.

Claims (7)

1. A composition for treating ovarian cancer is characterized in that raw materials for preparing the composition comprise a lycopene cis-isomer, cyclophosphamide and a traditional Chinese medicine extract in a mass ratio of 1;
the traditional Chinese medicine extract comprises the following raw material medicines: 6-38 parts of frankincense, 6-10 parts of saffron, 5-35 parts of myrrh, 5-32 parts of black nightshade, 5-15 parts of turmeric, 5-15 parts of golden cypress, 5-7 parts of leech, 5-10 parts of chicken's gizzard-membrane, 4-30 parts of angelica and 4-9 parts of charred triplet.
2. The composition for treating ovarian cancer according to claim 1, wherein raw materials for preparing the composition comprise the cis-isomer of lycopene, cyclophosphamide and traditional Chinese medicine extract in a mass ratio of 1.
3. The composition for treating ovarian cancer according to claim 1, wherein raw materials for preparing the composition comprise the cis-isomer of lycopene, cyclophosphamide and traditional Chinese medicine extract in a mass ratio of 1.
4. The composition for treating ovarian cancer according to claim 1, wherein the traditional Chinese medicine extract is a mixture of extract fine powder prepared by respectively crushing raw materials and extracting the raw materials by a conventional water extraction process.
5. The composition for treating ovarian cancer according to claim 1, further comprising a pharmaceutical adjuvant, wherein the pharmaceutical adjuvant comprises any one or a mixture of several of an adsorbent, a binder, a solvent and a wetting agent.
6. The composition for treating ovarian cancer according to claim 5, wherein the adsorbent is calcium hydrogen phosphate or microcrystalline cellulose, the binder is medicinal starch, the wetting agent is ethanol, glycerol or Tween-80, and the solvent is purified water.
7. Use of a composition according to any one of claims 1 to 6 for the treatment of ovarian cancer in the manufacture of a medicament for the treatment of ovarian cancer.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104474093A (en) * 2014-11-26 2015-04-01 吉林大学 Traditional Chinese medicine for preventing and treating ovarian cancer and preparation method of traditional Chinese medicine
CN107049998A (en) * 2016-09-20 2017-08-18 南华大学附属第二医院 Application of the lycopene cis-isomer in treatment of ovarian cancer medicine is prepared

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104474093A (en) * 2014-11-26 2015-04-01 吉林大学 Traditional Chinese medicine for preventing and treating ovarian cancer and preparation method of traditional Chinese medicine
CN107049998A (en) * 2016-09-20 2017-08-18 南华大学附属第二医院 Application of the lycopene cis-isomer in treatment of ovarian cancer medicine is prepared

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Effect of Lycopene on Cyclophosphamide Induced Hemorrhagic Cystitis in Rats;Akram Jamshidzadeh等;《IJMS》;20090331;第34卷(第1期);第46-52页 *
番茄红素对环磷酰胺治疗小鼠肉瘤Ｈ22的影响;康红钰等;《郑州大学学报（医学版）》;20080731;第43卷(第4期);第751-753页 *
紫杉醇联合顺铂腹腔灌注治疗晚期卵巢癌的临床疗效;兰健;《深圳中西医结合杂志》;20170731;第27卷(第14期);第170-171页 *

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