CN102366463B - Self-heating traditional Chinese medicinal emplastrum for treating chronic gastritis - Google Patents
Self-heating traditional Chinese medicinal emplastrum for treating chronic gastritis Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal compound preparation, and concretely relates to a self-heating traditional Chinese medicinal emplastrum for treating chronic gastritis. The self-heating traditional Chinese medicinal emplastrum comprises a sealing bag, and a plaster and a self-heating bag which are wrapped in the sealing bag and are up-down bonded, wherein the self-heating bag comprises a ventilating bag and chemical heating materials of an iron oxidation reduction reaction, and the chemical heating materials are wrapped in the ventilating bag; the plaster comprises a backing layer, a medicine storage layer and an anti-bonding layer, the medicine storage layer comprises a pharmaceutically acceptable matrix and effective components of bulk medicines, the weight of the bulk medicines accounts for 40% the weight of the matrix, and the effective components are aqueous extracts of the following bulk medicines: 10-30 wt% of dried orange peel, 10-20 wt% of wrinkled giant hyssop, 10-20 wt% of immature bitter orange, 10-30 wt% of radish seed and 20-40 wt% of haw. The self-heating traditional Chinese medicinal emplastrum of the invention has the advantages of fast action, good transdermal absorption, and definite therapeutic effect.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
Chronic gastritis has been current common gastroenteropathy, how by eating and drinking without temperance, or emptiness of spleen and stomach, due to transformation failure of spleen.At present, not yet fully clear and definite for the mechanism of chronic gastritis, modern medicine to it also without treating preferably way.Yet motherland's medical science has obvious advantage aspect the treatment of chronic gastritis.Because the incidence rate of chronic gastritis is very high, this just requires must be popular to its means of prevention and method, to satisfy numerous chronic gastritis crowd demand.Therefore, seek a kind of can bring into play tcm characteristic again the popular chronic gastritis method of preventing and treating be desirability.
Because the factor that affects hypertension is many and complicated, therefore for various factors and the too many levels of developing, multi-level compound Chinese medicinal preparation are more common in the disclosed patent application of Patent Office of the People's Republic of China, wherein,
publication number be CN101766782A Patent Application Publication a kind of Chinese medicine composition for the treatment of chronic gastritis, described compositions is by Massa Medicata Fermentata, Fructus Hordei Germinatus, Semen Raphani, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Rhizoma Dioscoreae, Fructus Aurantii Immaturus, Semen Coicis, Lignum Dalbergiae Odoriferae, Rhizoma Acori Graminei, Cortex Magnoliae Officinalis, Styrax, Poria, Fructus Amomi, Radix Et Rhizoma Rhei, Semen Pruni, Radix Trichosanthis, Rhizoma Coptidis, Flos Lonicerae, Herba Taraxaci, Radix Scrophulariae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Massa Medicata Fermentata, Radix Angelicae Sinensis and rhizoma corydalis 26 flavors are made, this medicine can improve completely pain of gastral cavilty, loss of appetite, glutted after the meal, acid regurgitation, the painful abdominal mass plug, heartburn, dysphoria with smothery sensation is noisy, fatigue and weak, dryness of the mouth and throat, and stomachache of starvation satiety appears, the health symptom such as become thin,
Publication number be CN1302645A Patent Application Publication a kind of medical capsule for invigorating function of spleen, described capsule is made by Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Semen Nelumbinis, Semen Coicis, Seem Lablab Album, Fructus Hordei Germinatus, Fructus Setariae Germinatus, Radix Platycodonis, the Radix Paeoniae Alba, CORTEX MAGNOLIAE OFFICINALIS from Sichuan of China, the Radix Astragali, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata, Fructus Jujubae, Hu Huang, Fructus Forsythiae, Fructus Crataegi, Radix Raphani, Rhizoma Zingiberis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparatum, Radix Aucklandiae (Radix Vladimiriae), Fructus Amomi, Semen Arecae and Cordyceps 28 flavors, this medical instrument has the spleen reinforcing stomach invigorating, relieving distension and in effect.
But the prescription taste of Chinese medicine number of above two publication numbers is numerous, prescription is not optimized and screens, and is difficult to outstanding TCM Features.
Summary of the invention
Technical problem solved by the invention is to provide a kind of Self-heating traditional Chinese medicine plaster for the treatment of chronic gastritis, and this emplastrum is rapid-action, and Transdermal absorption is effective, determined curative effect.
The technical scheme that the present invention addresses the above problem is as described below:
A kind of Self-heating traditional Chinese medicine plaster for the treatment of chronic gastritis, a kind of Self-heating traditional Chinese medicine plaster that improves apoplexy sequela, this Self-heating traditional Chinese medicine plaster is comprised of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is comprised of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is comprised of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is comprised of acceptable substrate pharmaceutically and the effective ingredient that is equivalent to the crude drug of substrate weight 40%, and wherein said effective ingredient is the water extract of the crude drug of following percentage by weight: Pericarpium Citri Reticulatae 10%-30%, Herba Pogostemonis 10%-20%, Fructus Aurantii Immaturus 10%-20%, Semen Raphani 10%-30%, Fructus Crataegi 20%-40%.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said effective ingredient is the water extract of the crude drug of following percentage by weight preferably: Pericarpium Citri Reticulatae 20%, Herba Pogostemonis 15%, Fructus Aurantii Immaturus 15%, Semen Raphani 20%, Fructus Crataegi 30%.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said effective ingredient can adopt this area water extracting method commonly used to prepare, the method that the inventor recommends is as described below: get Pericarpium Citri Reticulatae, Herba Pogostemonis, Fructus Aurantii Immaturus, Semen Raphani, Fructus Crataegi by proportioning, first add 6-10 times of water gaging, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder, namely gets effective ingredient.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said substrate can be the substrate of conventional patch, as, 2005 editions First appendix I ruless of preparations of Chinese Pharmacopoeia are about the substrate of cataplasma described in emplastrum, i.e. sodium polyacrylate, sodium carboxymethyl cellulose, gelatin, glycerol and micropowder silica gel etc.The substrate that the inventor recommends is comprised of the raw material of following percentage by weight: sticker 6.1%-26.5%, and wetting agent 20%-80%, filler 0.5%-1.5%, cross-linking agent 1.9%-6.5%, all the other are water; Wherein, described sticker be in gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, pressure sensitive adhesive and carbomer more than three kinds or three kinds; Described wetting agent is glycerol (glycerol) and propylene glycol, is perhaps one or both the mixture in glycerol (glycerol), propylene glycol and Polyethylene Glycol and butanediol; Described filler is one or more in Kaolin, zinc oxide and micropowder silica gel; Described cross-linking agent is two or three in citric acid, sodium citrate and aluminum chloride.
Self-heating traditional Chinese medicine plaster of the present invention, the desirable preparation method of wherein said medicine storing layer is: described effective ingredient is soluble in water, add described wetting agent mixing, get mixed liquor; Then, any in described sticker composition is dissolved in 1/2 mixed liquor, fully swelling, transfer PH to 8, gets component one; To be dissolved in 1/6 mixed liquor by the 1-6 kind sticker composition sticker composition used in component one, fully swelling, get component two; Described filler is dissolved in 1/6 mixed liquor, adds any sticker composition sticker composition used in component one and component two, mixing gets component three; Described cross-linking agent is dissolved in 1/6 mixed liquor, and mixing gets component four; Get final product with component four mix homogeneously after adding component one mixing after component two and component three mixings; Wherein,
When in described component one, contained sticker composition is carbomer, just add triethanolamine, sodium bicarbonate or sodium hydrogen phosphate to transfer PH to 8;
In described component one, component two and component three, sticker composition weight sum used equals the content of sticker in above-mentioned substrate.
Self-heating traditional Chinese medicine plaster of the present invention, wherein, described backing layer is non-woven fabrics commonly used; The adherent layer isolating membrane of surface (mastic) is masking foil or cellophane commonly used; Described venting bags is made by non-woven fabrics; Described sealing bag is made by polyethylene film.
The said medicine bin-storing layer is coated on backing layer, and drying is added a cover adherent layer and is namely got described plaster.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said chemical exothermic material is a kind of common chance oxygen generation oxidation reaction and the reduced iron powder oxidation exothermic material that generates heat, usually formed by reduced iron powder, water and catalyst, as, the inner packing (namely removing the outer package of sealing) of the self-heating bag that Qingdao ADO industry and trade company limited is produced, the disclosed scheme of application for a patent for invention that is perhaps CN1172143A, CN1181482A, CN1191294A or CN1760310A by publication number is produced voluntarily.The chemical exothermic material that the inventor recommends is comprised of following raw material by weight percentage: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25%, Kaolin 5-30%; Preferably formed by by weight percentage following raw material: reduced iron powder 57%, active carbon 12.5%, 15% sodium chloride solution 10.5%, Kaolin 15%.The consumption of above-mentioned chemical exothermic material and proportioning can be adjusted according to needed heating temp and fever time, and suitable heating temp is advisable with 35-50 ℃, and desirable fever time is suitable with 7-11 hour.
Chronic gastritis refers to common gastrointestinal chronic disease, main clinical manifestation: epigastric distending pain, and anorexia, belching and acid regurgitation or vomiting food are told rear distending pain and are alleviated, or vow the gas loose stool.The traditional Chinese medical science thinks that they are many by eating and drinking without temperance, or emptiness of spleen and stomach, due to transformation failure of spleen.Active ingredient of the present invention is made by Pericarpium Citri Reticulatae, Herba Pogostemonis, Fructus Aurantii Immaturus, Semen Raphani and Fructus Crataegi, and wherein, monarch drug is Fructus Aurantii Immaturus, Semen Raphani, has the loose painful abdominal mass of removing food stagnancy, the merit of the de-swelling that helps digestion; Ministerial drug is Pericarpium Citri Reticulatae, Fructus Crataegi, energy regulating qi-flowing for strengthening spleen, promoting digestion and invigorating the stomach; Adjuvant drug is Herba Pogostemonis, has the merit of removing dampness to restore normal function of the stomach.Above-mentioned five tastes compatibility reaches the effect for the treatment of chronic gastritis.
During use, the sealing bag of Self-heating traditional Chinese medicine plaster of the present invention is taken apart, be pasted on chronic gastritis person's abdominal part, the chemical exothermic material of venting bags is met oxygen and just oxidation reaction is occured and generate heat, heat energy makes the skin blood circulation unimpeded and accelerate, and further promotes the effective ingredient Transdermal absorption, the holographic echo area of effective stimulus whole body, regulate function, and then reach the purpose for the treatment of chronic gastritis.
In order to understand better the present invention, the below illustrates its effect with the clinical trial of Self-heating traditional Chinese medicine plaster treatment chronic gastritis of the present invention.
Clinical experiment
One, physical data
All cases are the patient that chronic gastritis is arranged, male's 30 examples, age 30-50 year; Women's 30 examples, 25～45 years old age.Be divided at random Self-heating traditional Chinese medicine plaster group 30 examples (male 15 examples, female's 15 examples); Blank group 30 examples (male 15 examples, female's 15 examples).Treat front two groups of patients' sex, age, symptom integral there are no significant difference (P＞0.05), have comparability.
Two, inclusive criteria
Show effect lastingly or repeatedly, and the case of repeatedly showing effect continuously.Meet the case of inclusive criteria, as suffer from various organic diseases and do not list this therapeutic domain in.
Three, method
The Self-heating traditional Chinese medicine plaster group: the Self-heating traditional Chinese medicine plaster (specification is 10cm*10cm) of embodiment one is affixed on abdominal part, once a day, each 6h, continuous 1 week.
Blank group: the blank substrate subsides (specification is 10cm*10cm) that do not contain effective composition are affixed on abdominal part, once a day, and each 6h, continuous 1 week.
Four, observation of curative effect
Symptom scores standard: mark take feeling of oppression and fullness in the chest and epigastrium, abdominal distention and pain, belching and acid regurgitation, vomiting and nausea anorexia four aspects as leading indicator, each index is divided into 4 grades by degrees of symptoms, is respectively non-evident sympton, mild, the moderate symptom, the severe symptom.Scoring rule is, non-evident sympton 0 minute, mild 1 minute, moderate symptom 2 minutes, severe symptom 3 minutes.Evaluation time is respectively before the treatment beginning and after the treatment end.
Concrete standards of grading are as follows:
Feeling of oppression and fullness in the chest and epigastrium: count 0 minute without feeling of oppression and fullness in the chest and epigastrium, occasionally have feeling of oppression and fullness in the chest and epigastrium to count 1 minute, the time have feeling of oppression and fullness in the chest and epigastrium to count 2 minutes, often have feeling of oppression and fullness in the chest and epigastrium to count 3 minutes;
Abdominal distention and pain: count 0 minute without abdominal distention and pain, occasionally have abdominal distention and pain to count 1 minute, the time have abdominal distention and pain to count 2 minutes, often have abdominal distention and pain to count 3 minutes;
Belching and acid regurgitation: count 0 minute without belching and acid regurgitation, occasionally have belching and acid regurgitation to count 1 minute, the time have belching and acid regurgitation to count 2 minutes, often have belching and acid regurgitation to count 3 minutes;
The vomiting and nausea anorexia: count 0 minute without the vomiting and nausea anorexia, occasionally have the vomiting and nausea anorexia to count 1 minute, the time have the vomiting and nausea anorexia to count 2 minutes, often have the vomiting and nausea anorexia to count 3 minutes;
Efficacy assessment standard: this standard reference " new Chinese medicine guideline of clinical investigations " is formulated, score value * 100% before clinical symptoms integrated value improvement rate=(symptom integral value after symptom integral value before treatment-treatment)/treatment.
Efficacy assessment standard:
Produce effects: symptom integral value improvement rate 〉=70%;
Effectively: symptom integral value improvement rate 〉=50%;
Invalid: symptom has no obvious improvement or instead sees deterioration, symptom integral value improvement rate＜50%.
Statistical procedures: total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, the (x ± s) expression of measurement data mean ± standard deviation.Before and after two groups of experimenters treat, symptom score more all adopts the t check, and two groups of experimenter's Clinical efficacy comparisons adopt X
2Check.
Result of the test:
Before and after Self-heating traditional Chinese medicine plaster group and blank group, the clinical symptoms integral contrast sees Table 1; Curative effect relatively sees Table 2.The improvement of cardinal symptom sign relatively sees Table 3.As known from Table 2, Self-heating traditional Chinese medicine plaster group produce effects 21 examples, effective 3 examples, invalid 6 examples, total effective rate is 80%, blank group: produce effects 0 example, effective 3 examples, invalid 27 examples, total effective rate is 10%.Self-heating traditional Chinese medicine plaster group successful is organized higher than blank.N in table 1 and table 2 represents number.
Before and after table 1 a liang group sticks, symptom scores compares (x ± s divides)
| Group | n | Before sticking | After sticking |
| Self-heating traditional Chinese medicine plaster | 30 | 9.19±2.15 | 4.78±1.9a b |
| Blank group | 30 | 9.21±1.93 | 8.49±1.85 |
With stick front comparison: Pa＜0.05, with the blank group relatively: Pb＜0.05
Table 2 liang group curative effect relatively
Table 3 Self-heating traditional Chinese medicine plaster group and blank group cardinal symptom sign are improved relatively
Stick front comparison: Pa＜0.05 with this group, stick rear comparison: Pb＜0.05 with the blank group
The specific embodiment
Embodiment one
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 80g, Herba Pogostemonis 60g, Fructus Aurantii Immaturus 60g, Semen Raphani 80g, Fructus Crataegi 120g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, polyvinyl alcohol 8g, pressure sensitive adhesive 88g, carbomer 24g, glycerol 250g, propylene glycol 250g, Kaolin 5g, zinc oxide 5g, citric acid 9g, sodium citrate 33g, water 285g.
The preparation of effective ingredient: above five tastes crude drug decocts with water secondary, add for the first time 6 times of water gagings, add for the second time 6 times of water gagings, each 1.5 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve to such an extent that traditional Chinese medicinal extract powder gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add propylene glycol, glycerol mixing to get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, transfer PH to 8 with triethanolamine, gets component one; Gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol are dissolved in 1/6 above-mentioned mixed liquor, fully swelling, get component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid and sodium citrate are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment two
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 40g, Herba Pogostemonis 49g, Fructus Aurantii Immaturus 58g, Semen Raphani 97g, Fructus Crataegi 156g.
Matrix formulations: gelatin 37g, sodium carboxymethyl cellulose 14g, polyvinyl alcohol 10g, glycerol 307g, propylene glycol 306g, Polyethylene Glycol 50g, butanediol 50g, zinc oxide 6g, micropowder silica gel 6g, sodium citrate 29g, aluminum chloride 8g, water 177g.
The preparation of effective ingredient: identical with embodiment one.
The preparation plaster: prepared effective ingredient is soluble in water, add propylene glycol, glycerol, Polyethylene Glycol and butanediol mixing to get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, get component one; Sodium carboxymethyl cellulose is dissolved in 1/6 above-mentioned mixed liquor, fully swelling, get component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add gelatin, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment three
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 111g, Herba Pogostemonis 40g, Fructus Aurantii Immaturus 46g, Semen Raphani 74g, Fructus Crataegi 129g.
Matrix formulations: gelatin 40g, sodium carboxymethyl cellulose 17g, methylcellulose 17g, sodium polyacrylate 11g, polyvinyl alcohol 11g, polyvinylpyrrolidone 11g, pressure sensitive adhesive 125g, carbomer 33g, glycerol 156g, propylene glycol 156g, micropowder silica gel 8g, citric acid 15g, sodium citrate 27g, water 373g.
The preparation of effective ingredient: identical with embodiment one.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing to get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, get component one; Gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, fully swelling, get component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add carbomer, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 432g, active carbon 227g, 15% sodium chloride solution 182g, Kaolin 159g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment four
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 100g, Herba Pogostemonis 80g, Fructus Aurantii Immaturus 40g, Semen Raphani 60g, Fructus Crataegi 120g.
Matrix formulations: gelatin 32g, sodium carboxymethyl cellulose 13g, methylcellulose 12g, sodium polyacrylate 8g, pressure sensitive adhesive 91g, glycerol 266g, propylene glycol 267g, Polyethylene Glycol 44g, butanediol 44g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 4g, sodium citrate 10g, aluminum chloride 9g, water 190g.
The preparation of effective ingredient: identical with embodiment one.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing to get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, get component one; Sodium carboxymethyl cellulose, methylcellulose and sodium polyacrylate are dissolved in 1/6 above-mentioned mixed liquor, fully swelling, get component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 602g, active carbon 172g, 15% sodium chloride solution 129g, Kaolin 97g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment five
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 80g, Herba Pogostemonis 70g, Fructus Aurantii Immaturus 80g, Semen Raphani 70g, Fructus Crataegi 100g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, pressure sensitive adhesive 86g, polyvinylpyrrolidone 8g, carbomer 23g, glycerol 256, propylene glycol 256, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, aluminum chloride 13g, citric acid 10g, water 214g.
The preparation of effective ingredient: identical with embodiment one.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing to get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, get component one; Carbomer, sodium carboxymethyl cellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, fully swelling, get component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds polyvinylpyrrolidone, mixing gets component three; Aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 422g, active carbon 133g, 15% sodium chloride solution 178g, Kaolin 267g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment six
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 60g, Herba Pogostemonis 60g, Fructus Aurantii Immaturus 70g, Semen Raphani 120g, Fructus Crataegi 90g.
Matrix formulations: gelatin 24g, sodium carboxymethyl cellulose 9g, methylcellulose 9g, pressure sensitive adhesive 68g, glycerol 246g, propylene glycol 246g, Polyethylene Glycol 42g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 5g, sodium citrate 32g, aluminum chloride 11g, citric acid 11g, water 285g.
The preparation of effective ingredient: identical with embodiment one.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol and Polyethylene Glycol mixing to get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, get component one; Sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling, get component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate, aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 589g, active carbon 85g, 15% sodium chloride solution 126g, Kaolin 200g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment seven
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 54g, Herba Pogostemonis 53g, Fructus Aurantii Immaturus 62g, Semen Raphani 107g, Fructus Crataegi 124g.
Matrix formulations: carbomer 27g, sodium carboxymethyl cellulose 14g, methylcellulose 13g, pressure sensitive adhesive 100g, polyvinyl alcohol 9g, glycerol 197g, propylene glycol 197g, micropowder silica gel 5g, citric acid 18g, sodium citrate 35g, aluminum chloride 12g, water 373g.
The preparation of effective ingredient: identical with embodiment one.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing to get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, transfer PH to 8 with triethanolamine, gets component one; Polyvinyl alcohol, sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, fully swelling, get component two; Micropowder silica gel is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid, sodium citrate, aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 532g, active carbon 128g, 15% sodium chloride solution 85g, Kaolin 255g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment eight
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 68g, Herba Pogostemonis 51g, Fructus Aurantii Immaturus 60g, Semen Raphani 102g, Fructus Crataegi 119g.
Matrix formulations: sodium carboxymethyl cellulose 15g, methylcellulose 15g, sodium polyacrylate 10g, polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 108g, carbomer 30g, glycerol 224g, propylene glycol 224g, butanediol 38g, zinc oxide 6g, citric acid 16g, aluminum chloride 15g, water 279g.
The preparation of effective ingredient: identical with embodiment one.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing to get mixed liquor; Sodium carboxymethyl cellulose is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, get component one; Methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, fully swelling, get component two; The zinc oxide peptization in 1/6 above-mentioned mixed liquor, is added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 494g, active carbon 180g, 15% sodium chloride solution 224g, Kaolin 102g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment nine
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 84g, Herba Pogostemonis 50g, Fructus Aurantii Immaturus 50g, Semen Raphani 83g, Fructus Crataegi 133g.
Matrix formulations: polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 109g, carbomer 30g, glycerol 255g, propylene glycol 255g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 5g, citric acid 11g, aluminum chloride 12g, water 212g.
The preparation of effective ingredient: identical with embodiment one.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing to get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, get component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling, get component two; Kaolin and zinc oxide peptization in 1/6 above-mentioned mixed liquor, are added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 444g, active carbon 162g, 15% sodium chloride solution 202g, Kaolin 192g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment ten
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 60g, Herba Pogostemonis 40g, Fructus Aurantii Immaturus 80g, Semen Raphani 100g, Fructus Crataegi 120g.
Matrix formulations: methylcellulose 16g, sodium polyacrylate 15g, pressure sensitive adhesive 110g, polyvinylpyrrolidone 10g, glycerol 258g, propylene glycol 258g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 4g, micropowder silica gel 5g, sodium citrate 35g, aluminum chloride 15g, water 183g.
The preparation of effective ingredient: identical with embodiment one.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing to get mixed liquor; Methylcellulose is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, get component one; Sodium polyacrylate and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling, get component two; Micropowder silica gel, Kaolin and zinc oxide are dissolved in 1/6 above-mentioned mixed liquor, add polyvinylpyrrolidone, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 490g, active carbon 118g, 15% sodium chloride solution 157g, Kaolin 235g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment 11
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 74g, Herba Pogostemonis 46g, Fructus Aurantii Immaturus 40g, Semen Raphani 111g, Fructus Crataegi 129g.
Matrix formulations: carbomer 31g, pressure sensitive adhesive 89g, methylcellulose 12g, sodium polyacrylate 8g, glycerol 257g, propylene glycol 257g, butanediol 43g, Kaolin 7g, micropowder silica gel 6g, citric acid 10g, sodium citrate 36g, water 244g.
The preparation of effective ingredient: identical with embodiment one.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing to get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, transfer PH to 8 with sodium hydrogen phosphate, gets component one; Methylcellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling, get component two; Micropowder silica gel and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add sodium polyacrylate, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 544g, active carbon 155g, 15% sodium chloride solution 116g, Kaolin 185g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment 12
1, the preparation of plaster:
Crude drug prescription: Pericarpium Citri Reticulatae 97g, Herba Pogostemonis 58g, Fructus Aurantii Immaturus 49g, Semen Raphani 40g, Fructus Crataegi 156g.
Matrix formulations: methylcellulose 13g, polyvinylpyrrolidone 9g, pressure sensitive adhesive 97g, carbomer 27g, glycerol 207g, propylene glycol 207g, butanediol 35g, Kaolin 6g, zinc oxide 6g, citric acid 10g, sodium citrate 38g, aluminum chloride 10g, water 335g.
The preparation of effective ingredient: identical with embodiment one.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing to get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, fully swelling, transfer PH to 8 with sodium bicarbonate, gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling, get component two; Zinc oxide and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add methylcellulose, mixing gets component three; Aluminum chloride, sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, mixing gets component four; With adding after component two and component three mixings after component one mixing and component four mix homogeneously, to coat on non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 500g, active carbon 200g, 15% sodium chloride solution 160g, Kaolin 140g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution to remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Claims (4)
1. Self-heating traditional Chinese medicine plaster for the treatment of chronic gastritis, this Self-heating traditional Chinese medicine plaster is comprised of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is comprised of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is comprised of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is comprised of acceptable substrate pharmaceutically and the effective ingredient that is equivalent to the crude drug of substrate weight 40%, and wherein said effective ingredient is the water extract of the crude drug of following percentage by weight: Pericarpium Citri Reticulatae 10%-30%, Herba Pogostemonis 10%-20%, Fructus Aurantii Immaturus 10%-20%, Semen Raphani 10%-30%, Fructus Crataegi 20%-40%.
2. a kind of Self-heating traditional Chinese medicine plaster for the treatment of chronic gastritis according to claim 1, it is characterized in that, described active ingredient is the water extract of the crude drug of following percentage by weight: Pericarpium Citri Reticulatae 20%, Herba Pogostemonis 15%, Fructus Aurantii Immaturus 15%, Semen Raphani 20%, Fructus Crataegi 30%.
3. a kind of Self-heating traditional Chinese medicine plaster for the treatment of chronic gastritis according to claim 1 and 2, it is characterized in that, described effective ingredient is prepared by following methods: get Pericarpium Citri Reticulatae, Herba Pogostemonis, Fructus Aurantii Immaturus, Semen Raphani, Fructus Crataegi by proportioning, first add 6-10 times of water gaging, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder, namely gets effective ingredient.
4. a kind of Self-heating traditional Chinese medicine plaster for the treatment of chronic gastritis according to claim 1 and 2, it is characterized in that, the raw material of the following percentage by weight of described chemical exothermic material forms: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25% and Kaolin 5-30%.
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| CN201110313336.XA CN102366463B (en) | 2011-10-16 | 2011-10-16 | Self-heating traditional Chinese medicinal emplastrum for treating chronic gastritis |
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| CN201110313336.XA CN102366463B (en) | 2011-10-16 | 2011-10-16 | Self-heating traditional Chinese medicinal emplastrum for treating chronic gastritis |
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| CN116115697A (en) * | 2022-12-26 | 2023-05-16 | 北京中医药大学深圳医院(龙岗) | Self-heating type flavored five-seed powder traditional Chinese medicine application suitable for gastrointestinal dysfunction and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1191294A (en) * | 1998-03-19 | 1998-08-26 | 李连生 | Heat-generating agent and its use |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1191294A (en) * | 1998-03-19 | 1998-08-26 | 李连生 | Heat-generating agent and its use |
Non-Patent Citations (2)
| Title |
|---|
| 陈健一.陈德润辨治慢性胃炎经验.《江西中医药》.2010,第41卷(第325期),27-28. |
| 陈德润辨治慢性胃炎经验;陈健一;《江西中医药》;20100131;第41卷(第325期);27-28 * |
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