CN101596300A - Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent and preparation method thereof - Google Patents
Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent and preparation method thereof Download PDFInfo
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- CN101596300A CN101596300A CNA2009100407816A CN200910040781A CN101596300A CN 101596300 A CN101596300 A CN 101596300A CN A2009100407816 A CNA2009100407816 A CN A2009100407816A CN 200910040781 A CN200910040781 A CN 200910040781A CN 101596300 A CN101596300 A CN 101596300A
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Abstract
The present invention relates to a kind of Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent and preparation method thereof, the present invention is by artificial Moschus 10-20 part, Borneolum Syntheticum 2-8 part, Radix Curcumae 30-40 part, Fructus Gardeniae 40-50 part, polyoxyethylene-9-Laurel ether 10-20 part, sulfo-lauryl alcohol 5-8 part, egg yolk lecithin 1-6 part, lecithin 1-4 part, fabaceous lecithin 2-10 part, vitamin E 2-4 part, refined soybean oil 10-30 part, 1, and 2-propylene glycol 10-20 part, glycerol 10-15 part, cholic acid 2-4 part, ethanol is an amount of, purified water is an amount of, essence is an amount of and propellant is formed in right amount; Has heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, the function of inducing resuscitation, Nantural non-toxic, safe, efficient, biodegradable, be used for various cerebrovascular disease clinically, effective for central coma diseases such as disturbance of consciousness, serious symptom craniocerebral injury, cerebral hemorrhage, cerebral infarction and drug intoxication especially; This medicine is realized the brain target administration by the nose approach, can break through blood brain barrier, can play rapidly playing a role, simultaneously convenient drug administration.
Description
Technical field
The present invention relates to a kind of Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent, be specifically related to a kind of Chinese medicine microemulsion nasal cavity spraying agent, belong to technical field of pharmaceuticals with heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, inducing resuscitation.
Background technology
There is following shortcoming in traditional pill in the cerebrovascular disease first aid: 1. medicine is subjected to the destruction and the liver first-pass effect of enzyme in the gastrointestinal tract; 2. be difficult to break through blood brain barrier, be difficult to treat quickly and effectively cerebral disease.
Nasal drug delivery system (nasal drug deliveery system NDDS) is meant at nasal cavity and uses, and brings into play the preparation of part or general action through Nasal Mucosa Absorption.Total measurement (volume) in the human nasal is 15ml, and the nasal mucosa area is 150cm
2, numerous ciliums is arranged on the nasal mucosa, can increase the effective area of drug absorption.After medicine via intranasal application capillary tube absorbs, directly enter the body circulation, and, avoided the first pass effect of liver without the liver system, thereby, be the good position of drug absorption.
Nasal cavity is as medicine-feeding part, its drug absorption is compared with other positions has following characteristics: numerous trickle fine hair is arranged on (1) nasal mucosa, but the surface area that significantly increasing medicament absorbs has many abundant blood capillaries under the epithelial cell membrane, simultaneously so medicine can absorb rapidly.(2) directly enter the body circulation after the drug absorption, no liver first-pass effect, hydrolase of proteolysis is low in the nasal mucosa, to easily peptide class and protein drug metabolic or that first pass effect is very big are effective route of administration in gastro-intestinal Fluid and gastrointestinal wall film.(3) nasal mucosa is higher than the permeability of the human body mucosa at other positions such as gastrointestinal tract, oral cavity and vagina etc., and medicine can absorb well.(4) convenient drug administration, to spray into the mode administration, the patient can finish voluntarily.
Patent No. 01101993.X " quiet preparation of nano consciousness restoring and preparation method thereof " is the preparation that makes with Moschus, Radix Curcumae, Borneolum Syntheticum, the direct nanorize of Fructus Gardeniae four flavor Chinese crude drugs, this method lacks the guidance of theory of Chinese medical science, do not consider the particularity of heterogeneity in the Chinese crude drug of respectively distinguishing the flavor of, practical value is little.
The patent No. 200410097167.0 " a kind of XINGNAOJING DIWAN for the treatment of encephalitis, hepatic coma and preparation method thereof " is to be principal agent with Moschus, Radix Curcumae, Borneolum Syntheticum, Fructus Gardeniae etc. four flavor Chinese medicines, is equipped with the drop pill that multiple adjuvant is made; The patent No. 200610072942.6 " medicine composition of refreshing solid dispersion and preparation thereof and preparation method " is to be principal agent with Moschus, Radix Curcumae volatile oil, Radix Curcumae total curcumines, Borneolum Syntheticum, Fructus Gardeniae total glycosides etc., be equipped with the dispersion formulations that multiple adjuvant is made, as: drop pill, capsule, tablet etc.; Above-mentioned dosage form is oral drug preparation, and oral formulations, problem such as all exist when dissolving limit for length after especially oral preparation of Chinese traditional medicinal is taken, dissolution is low, absorption is relatively poor, liver sausage first pass effect and bioavailability are lower, thus the performance of drug effect influenced, also directly influenced therapeutic effect; While oral formulations complex process in preparation process, the production cost height, thus cause drug cost to improve thereupon, be unfavorable for improving the ability of seeking medical advice of extensive patients, also be unfavorable for improving Community health's level.
The patent No. 200510077199.9 " a kind of nano ' Xing Nao Jing ' injection and preparation method thereof " is the Chinese medicine based on Moschus, Radix Curcumae, Borneolum Syntheticum, Fructus Gardeniae four Chinese medicine material; But the Chinese medicine less stable stores and can occur that pH value changes, appearance luster deepens behind the certain hour even muddiness to occur and phenomenon such as precipitation, has a strong impact on the safety of medicine; Simultaneously, Chinese medicine is because of containing materials such as albumen, polysaccharide, polypeptide, and dna purity is not enough, and interaction between component contains the easy anaphylactic generations of factor such as cosolvent, bulking agent; And injection reduces patient's compliance, uses to be subjected to certain restriction.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of heat-clearing and toxic substances removing that has is provided, removing heat from blood and promoting blood circulation, the function of inducing resuscitation, Nantural non-toxic, safe, efficient, biodegradable, be used for various cerebrovascular disease clinically, for central coma diseases such as disturbance of consciousness, serious symptom craniocerebral injury, cerebral hemorrhage, cerebral infarction and drug intoxication, also can be used for robbing the Chinese medicine inducing resuscitation medicine that passes through nasal mucosa brain target administration-Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent of emergency danger disease patient especially.
Another object of the present invention provides the preparation method of Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent.
Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent is the nasal mucosa release preparation by nose approach brain target administration; The present invention adopts modernization of Chinese medicine microemulsion technology to make with extra care by Chinese medicines such as Moschus, Borneolum Syntheticum, Radix Curcumae, Fructus Gardeniaes and forms, have heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, the function of inducing resuscitation.The present invention is guidance with the theory of Chinese medical science, muskiness fragrance, property is apt to away scurry, have stronger have one's ideas straightened out logically close effect, be refreshment analepsia key medicine.Borneolum Syntheticum is arduous to be slightly cold, and logical all keys and the stagnated fire of loosing also is the short penetrating agent of good nasal mucosa 5 are used for consciousness and resuscitation restoring mutually with Moschus; Fructus Gardeniae lets out the fire of three warmers, clearing away heat and cooling blood, eliminating damp, detoxifying; Radix Curcumae is arduous cold in nature, promoting blood circulation and stopping pain, and promoting QI circulation for relieving depression, removing heat from blood clears away heart-fire.Four medicines share, and have effects such as causing resuscitation with aromatic drugs, refreshment pain relieving, heat-clearing and toxic substances removing.
The present invention is guidance with the theory of Chinese medical science, and through the prescription of repeatedly groping repeatedly to sum up, it is prepared from by the component of following weight proportion:
Artificial Moschus 10-20 part, Borneolum Syntheticum 2-8 part, Radix Curcumae 30-40 part, Fructus Gardeniae 40-50 part, polyoxyethylene-9-Laurel ether 10-20 part, sulfo-lauryl alcohol 5-8 part, egg yolk lecithin 1-6 part, lecithin 1-4 part, fabaceous lecithin 2-10 part, vitamin E 2-4 part, refined soybean oil 10-30 part, 1,2-propylene glycol 10-20 part, glycerol 10-15 part, cholic acid 2-4 part, ethanol is an amount of, purified water is an amount of, essence is an amount of and propellant is an amount of.
Described essence is medicinal essence.
Described propellant is the medicinal propellant that country allows use.
Described spray dosage form is aerosol or spray.
A kind of preparation method of Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent may further comprise the steps:
(1) gets Radix Curcumae 30-40 part, the grinding of Fructus Gardeniae 40-50 part, add purified water 1500ml distillation, collect distillate 1000ml;
(2) with artificial Moschus 10-20 part pulverization, stand-by; With Borneolum Syntheticum 2-8 part pulverization, stand-by;
(3) measure extracting solution, add 1,2-propylene glycol 10-20 part, glycerol 10-15 part, heating makes clarification, continues heating, stirs and make temperature reach 62 ℃ and keep constant;
(4) get Borneolum Syntheticum smalls, egg yolk lecithin 1-6 part, lecithin 1-4 part, fabaceous lecithin 2-10 part, add an amount of dehydrated alcohol and make its dissolving, add refined soybean oil 10-30 part, vitamin E 2-4 part, cholic acid 2-4 part then, heated and stirred makes temperature reach 60 ℃ and keep constant;
(5) under the constant temperature step (3) gained solution slowly is added drop-wise in step (4) the gained solution, evenly stir simultaneously, dropwise adding polyoxyethylene-9-Laurel ether 10-20 part, sulfo-lauryl alcohol 5-8 part, add the purified water standardize solution of equality of temperature then, continue stir about 15min and get colostrum;
(6) after colostrum is crossed 0.80 μ m filter membrane, cross the nanometer machine, cross 0.22 μ m filter membrane, get breast eventually;
(7) fill, seal, add propellant, pack Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent or aerosol.
The present invention with respect to the beneficial effect of prior art is:
(1) the XINGNAOJING microemulsion nasal cavity spraying agent is realized the brain target administration by the nose approach, avoids the destruction of enzyme in the gastrointestinal tract and has avoided the first-pass effect of liver to medicine; Simultaneously can break through blood brain barrier, can play rapidly playing a role, and convenient drug administration, the very first time realizes rescuing purpose.
(2) use Emulsion that microemulsion nanoparticle innovative technology makes as pharmaceutical carrier, have the effect that selectivity distributes and can relatively play slow release long-acting in vivo, improve the curative effect of medicine, reduce toxicity, have practical value.
(3) adopt nasal mucosa penetration enhancer new technique, can improve the absorption of nasal mucosa effectively, improve bioavailability Chinese medicine main component in the prescription.
The specific embodiment
Below the invention will be further described by specific embodiment, it should be understood that these embodiment only are used to illustrate the present invention, do not limit the scope of the invention.
Embodiment 1
(1) gets 30 parts of Radix Curcumaes, 40 parts of grindings of Fructus Gardeniae, add purified water 1500ml distillation, collect distillate 1000ml;
(2) with 10 parts of pulverizations of artificial Moschus, stand-by; With 2 parts of pulverizations of Borneolum Syntheticum, stand-by;
(3) measure extracting solution, add 1,10 parts of 2-propylene glycol, 10 parts of glycerol, heating makes clarification, continues heating, stirs and make temperature reach 62 ℃ and keep constant;
(4) get Borneolum Syntheticum smalls, 1 part of egg yolk lecithin, 1 part in lecithin, 2 parts of fabaceous lecithins, add an amount of dehydrated alcohol and make dissolving, add 10 parts of refined soybean oils, 2 parts of vitamin Es, 2 parts of cholic acid then, heated and stirred makes temperature reach 60 ℃ and keep constant;
(5) under the constant temperature the 3rd step gained solution slowly is added drop-wise in the 4th step gained solution, evenly stirs simultaneously, dropwise adding polyoxyethylene-10 parts in 9-Laurel ether, 5 parts of sulfo-lauryl alcohols, add the purified water standardize solution of equality of temperature then, continue stir about 15min and get colostrum;
(6) after colostrum is crossed 0.80 μ m filter membrane, cross the nanometer machine, cross 0.22 μ m filter membrane, get breast eventually;
(7) fill, seal, add propellant, pack Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent.
Embodiment 2
(1) gets 35 parts of Radix Curcumaes, 45 parts of grindings of Fructus Gardeniae, add purified water 1500ml distillation, collect distillate 1000ml;
(2) with 15 parts of pulverizations of artificial Moschus, stand-by; With 4 parts of pulverizations of Borneolum Syntheticum, stand-by;
(3), measure extracting solution, add 1,15 parts of 2-propylene glycol, 15 parts of glycerol, heating makes clarification, continues heating, stirs and make temperature reach 62 ℃ and keep constant;
(4) get Borneolum Syntheticum smalls, 3 parts of egg yolk lecithin, 1 part in lecithin, 3 parts of fabaceous lecithins, add an amount of dehydrated alcohol and make dissolving, add 15 parts of refined soybean oils, 2 parts of vitamin Es, 2 parts of cholic acid then, heated and stirred makes temperature reach 60 ℃ and keep constant;
(5) under the constant temperature the 3rd step gained solution slowly is added drop-wise in the 4th step gained solution, evenly stirs simultaneously, dropwise adding polyoxyethylene-15 parts in 9-Laurel ether, 5 parts of sulfo-lauryl alcohols, add the purified water standardize solution of equality of temperature then, continue stir about 15min and get colostrum;
(6) after colostrum is crossed 0.80 μ m filter membrane, cross the nanometer machine, cross 0.22 μ m filter membrane, get breast eventually;
(7) fill, seal, add propellant, pack Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent.
Embodiment 3
(1) gets 40 parts of Radix Curcumaes, 50 parts of grindings of Fructus Gardeniae, add purified water 1500ml distillation, collect distillate 1000ml;
(2) with 20 parts of pulverizations of artificial Moschus, stand-by; With 8 parts of pulverizations of Borneolum Syntheticum, stand-by;
(3) measure extracting solution, add 1,20 parts of 2-propylene glycol, 15 parts of glycerol, heating makes clarification, continues heating, stirs and make temperature reach 62 ℃ and keep constant;
(4) get Borneolum Syntheticum smalls, 6 parts of egg yolk lecithin, 4 parts in lecithin, 10 parts of fabaceous lecithins, add an amount of dehydrated alcohol and make dissolving, add 30 parts of refined soybean oils, 4 parts of vitamin Es, 4 parts of cholic acid then, heated and stirred makes temperature reach 60 ℃ and keep constant;
(5) under the constant temperature the 3rd step gained solution slowly is added drop-wise in the 4th step gained solution, evenly stirs simultaneously, dropwise adding polyoxyethylene-20 parts in 9-Laurel ether, 8 parts of sulfo-lauryl alcohols, add the purified water standardize solution of equality of temperature then, continue stir about 15min and get colostrum;
(6) after colostrum is crossed 0.80 μ m filter membrane, cross the nanometer machine, cross 0.22 μ m filter membrane, get breast eventually;
(7) fill, seal, add propellant, pack Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent.
Embodiment 4
(1) gets 40 parts of Radix Curcumaes, 45 parts of grindings of Fructus Gardeniae, add purified water 1500ml distillation, collect distillate 1000ml;
(2) with 15 parts of pulverizations of artificial Moschus, stand-by; With 6 parts of pulverizations of Borneolum Syntheticum, stand-by;
(3) measure extracting solution, add 1,10 parts of 2-propylene glycol, 15 parts of glycerol, heating makes clarification, continues heating, stirs and make temperature reach 62 ℃ and keep constant;
(4) get Borneolum Syntheticum smalls, 1 part of egg yolk lecithin, 4 parts in lecithin, 8 parts of fabaceous lecithins, add an amount of dehydrated alcohol and make dissolving, add 30 parts of refined soybean oils, 3 parts of vitamin Es, 4 parts of cholic acid then, heated and stirred makes temperature reach 60 ℃ and keep constant;
(5) under the constant temperature the 3rd step gained solution slowly is added drop-wise in the 4th step gained solution, evenly stirs simultaneously, dropwise adding polyoxyethylene-10 parts in 9-Laurel ether, 8 parts of sulfo-lauryl alcohols, add the purified water standardize solution of equality of temperature then, continue stir about 15min and get colostrum;
(6) after colostrum is crossed 0.80 μ m filter membrane, cross the nanometer machine, cross 0.22 μ m filter membrane, get breast eventually;
(7) fill, seal, add propellant, pack Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent.
Embodiment 5
(1) gets 40 parts of Radix Curcumaes, 50 parts of grindings of Fructus Gardeniae, add purified water 1500ml distillation, collect distillate 1000ml;
(2) with 10 parts of pulverizations of artificial Moschus, stand-by; With 2 parts of pulverizations of Borneolum Syntheticum, stand-by;
(3) measure extracting solution, add 1,10 parts of 2-propylene glycol, 10 parts of glycerol, heating makes clarification, continues heating, stirs and make temperature reach 62 ℃ and keep constant;
(4) get Borneolum Syntheticum smalls, 6 parts of egg yolk lecithin, 1 part in lecithin, 2 parts of fabaceous lecithins, add an amount of dehydrated alcohol and make dissolving, add 30 parts of refined soybean oils, 2 parts of vitamin Es, 2 parts of cholic acid then, heated and stirred makes temperature reach 60 ℃ and keep constant;
(5) under the constant temperature the 3rd step gained solution slowly is added drop-wise in the 4th step gained solution, evenly stirs simultaneously, dropwise adding polyoxyethylene-20 parts in 9-Laurel ether, 5 parts of sulfo-lauryl alcohols, add the purified water standardize solution of equality of temperature then, continue stir about 15min and get colostrum;
(6) after colostrum is crossed 0.80 μ m filter membrane, cross the nanometer machine, cross 0.22 μ m filter membrane, get breast eventually;
(7) fill, seal, add propellant, pack Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent.
Claims (5)
1. Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent, it is characterized in that: it is prepared from by the component of following weight proportion:
Artificial Moschus 10-20 part, Borneolum Syntheticum 2-8 part, Radix Curcumae 30-40 part, Fructus Gardeniae 40-50 part, polyoxyethylene-9-Laurel ether 10-20 part, sulfo-lauryl alcohol 5-8 part, egg yolk lecithin 1-6 part, lecithin 1-4 part, fabaceous lecithin 2-10 part, vitamin E 2-4 part, refined soybean oil 10-30 part, 1,2-propylene glycol 10-20 part, glycerol 10-15 part, cholic acid 2-4 part, ethanol is an amount of, purified water is an amount of, essence is an amount of and propellant is an amount of.
2. a kind of Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent according to claim 1, it is characterized in that: described essence is medicinal essence.
3. Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent according to claim 1 is characterized in that: described propellant allows the medicinal propellant of use for country.
4. Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent according to claim 1 is characterized in that: described spray dosage form is aerosol or spray.
5. method that is used to prepare the described Chinese medicine inducing resuscitation of claim 1 microemulsion nasal cavity spraying agent is characterized in that: may further comprise the steps:
(1) gets Radix Curcumae 30-40 part, the grinding of Fructus Gardeniae 40-50 part, add purified water 1500ml distillation, collect distillate 1000ml;
(2) with artificial Moschus 10-20 part pulverization, stand-by; With Borneolum Syntheticum 2-8 part pulverization, stand-by;
(3) measure extracting solution, add 1,2-propylene glycol 10-20 part, glycerol 10-15 part, heating makes clarification, continues heating, stirs and make temperature reach 62 ℃ and keep constant;
(4) get Borneolum Syntheticum smalls, egg yolk lecithin 1-6 part, lecithin 1-4 part, fabaceous lecithin 2-10 part, add an amount of dehydrated alcohol and make its dissolving, add refined soybean oil 10-30 part, vitamin E 2-4 part, cholic acid 2-4 part then, heated and stirred makes temperature reach 60 ℃ and keep constant;
(5) under the constant temperature step (3) gained solution slowly is added drop-wise in step (4) the gained solution, evenly stir simultaneously, dropwise adding polyoxyethylene-9-Laurel ether 10-20 part, sulfo-lauryl alcohol 5-8 part, add the purified water standardize solution of equality of temperature then, continue stir about 15min and get colostrum;
(6) after colostrum is crossed 0.80 μ m filter membrane, cross the nanometer machine, cross 0.22 μ m filter membrane, get breast eventually;
(7) fill, seal, add propellant, pack Chinese medicine inducing resuscitation microemulsion nasal cavity spraying agent or aerosol.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526602A (en) * | 2010-12-08 | 2012-07-04 | 无锡济民可信山禾药业股份有限公司 | Xingnaojing self-emulsifying soft capsule and preparation method thereof |
| CN102526619A (en) * | 2012-01-20 | 2012-07-04 | 赵联华 | Xingnaojing nasal spray and preparation method and application thereof |
| CN102886030A (en) * | 2012-11-05 | 2013-01-23 | 广东同德药业有限公司 | Traditional Chinese medicine refreshment intravenous injection nasal delivery preparation used for resuscitation and refreshment and preparation method of nasal delivery preparation |
| CN102886015A (en) * | 2011-07-20 | 2013-01-23 | 北京中医药大学 | Preparation for restoring consciousness and calming nasal mucosa and preparation method thereof |
| CN103690608A (en) * | 2013-12-12 | 2014-04-02 | 南京中医药大学 | Spicy nasal spraying nanoemulsion and preparation method thereof |
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2009
- 2009-07-03 CN CNA2009100407816A patent/CN101596300A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526602A (en) * | 2010-12-08 | 2012-07-04 | 无锡济民可信山禾药业股份有限公司 | Xingnaojing self-emulsifying soft capsule and preparation method thereof |
| CN102526602B (en) * | 2010-12-08 | 2015-07-22 | 无锡济民可信山禾药业股份有限公司 | Xingnaojing self-emulsifying soft capsule and preparation method thereof |
| CN102886015A (en) * | 2011-07-20 | 2013-01-23 | 北京中医药大学 | Preparation for restoring consciousness and calming nasal mucosa and preparation method thereof |
| CN102886015B (en) * | 2011-07-20 | 2014-07-16 | 北京中医药大学 | Preparation for restoring consciousness and calming nasal mucosa and preparation method thereof |
| CN102526619A (en) * | 2012-01-20 | 2012-07-04 | 赵联华 | Xingnaojing nasal spray and preparation method and application thereof |
| CN102886030A (en) * | 2012-11-05 | 2013-01-23 | 广东同德药业有限公司 | Traditional Chinese medicine refreshment intravenous injection nasal delivery preparation used for resuscitation and refreshment and preparation method of nasal delivery preparation |
| CN102886030B (en) * | 2012-11-05 | 2014-10-29 | 广东同德药业有限公司 | Traditional Chinese medicine refreshment intravenous injection nasal delivery preparation used for resuscitation and refreshment and preparation method of nasal delivery preparation |
| CN103690608A (en) * | 2013-12-12 | 2014-04-02 | 南京中医药大学 | Spicy nasal spraying nanoemulsion and preparation method thereof |
| CN103690608B (en) * | 2013-12-12 | 2016-08-17 | 南京中医药大学 | A kind of pungent sweet-smelling nose nano-emulsion and preparation method thereof |
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Open date: 20091209 |