CN100581537C - Nano emu oil condensed emulsion liquid - Google Patents
Nano emu oil condensed emulsion liquid Download PDFInfo
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- CN100581537C CN100581537C CN200710063485A CN200710063485A CN100581537C CN 100581537 C CN100581537 C CN 100581537C CN 200710063485 A CN200710063485 A CN 200710063485A CN 200710063485 A CN200710063485 A CN 200710063485A CN 100581537 C CN100581537 C CN 100581537C
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Abstract
The invention provides a condensed milk liquid which is prepared from emu oil 100 parts, phospholipids 65-150 parts, stabilizer 35-100 parts, glycerine 85-500 parts and balancing deionized water through steps of mixing homogeneously and heavy pressure homogeneous circulating.
Description
Technical field
The invention belongs to the cosmetics technical field, be specifically related to a kind of nano emu oil condensed milk-like liquid.
Background technology
The Dromaius novaehollandiae bird comes from Europe, fat of Oromaius norvaehollandeae is by extracting with subcutaneous fatty tissue behind the Dromaius novaehollandiae peritoneum, having to the oils and fats of human skin has very similar fatty acid to form, unsaturated fatty acid accounts for 70% in the fat of Oromaius norvaehollandeae, wherein contains two kinds of essential fatty acid linoleic acids and and alpha-linolenic acid.It is reported, fat of Oromaius norvaehollandeae can have anti-inflammatory analgesic, calm down wrinkle, remove dead bark, effects such as moisture retention, antioxidation, defying age, anti-ultraviolet.
Because the fat of Oromaius norvaehollandeae unsaturated fatty acid content is very high, is easy to the oxidative rancidity instability in the storage process, so that lose the effect of fat of Oromaius norvaehollandeae.Along with the extensive use of nanotechnology at cosmetic field, adopt the cosmetics of nanotechnology development, unique distinction is that the composition of tool effect in the cosmetics is carried out special handling becomes nano level micro-structure, deep layer smoothly penetrates to the skin, better bring into play effects such as skin protection, especially adopt the nano-carrier technology, active matter is wrapped up, can guarantee the activity of active matter like this, increase the stability of active matter, active matter can be transported to the effect that deep skin discharges active matter the performance active matter again.
Patent CN1726926A has announced a kind of fat of Oromaius norvaehollandeae injection medicine that is used for anti-inflammatory analgesic and preparation method thereof, it is used for field of medicaments, about 1 micron, the fat of Oromaius norvaehollandeae concentration ratio is lower more greatly for size ratio, and the preparation that is not suitable for cosmetics is unfavorable for that also dermal osmosis absorbs.Patent US6103246A1 has announced fat of Oromaius norvaehollandeae emulsifiable paste and lotion, directly fat of Oromaius norvaehollandeae is prepared into common O/W or w/o type emulsifiable paste and lotion, and fat of Oromaius norvaehollandeae drop granule is unfavorable for that more greatly dermal osmosis absorbs.
Summary of the invention
The object of the invention provides a kind of nano emu oil condensed milk-like liquid, improves on the one hand the stability of fat of Oromaius norvaehollandeae in cosmetics, strengthens fat of Oromaius norvaehollandeae to percutaneous permeability, gives full play to the effect of fat of Oromaius norvaehollandeae; Make on the other hand emu oil condensed milk-like liquid when cosmetic formulations more easily with other water-soluble components uniform mixing, prepare needed opaque products.
The technical solution adopted in the present invention is:
A kind of nano emu oil condensed milk-like liquid is characterized in that: it is by following component:
Fat of Oromaius norvaehollandeae 100 weight portions
Phosphatidase 16 5～150 weight portions
Stabilizing agent 35～100 weight portions
Glycerol 85～500 weight portions
Deionized water 170～650 weight portions
Said components obtains mean diameter is transparent or semitransparent shape less than 100nm, outward appearance nano emu oil condensed milk-like liquid through Over emulsfication, high pressure homogenize.
The phospholipid that the present invention adopts is the soybean lecithin of PC content 〉=72% or the Ovum Gallus domesticus Flavus lecithin of PC content 〉=72%.
The non-ionic surface active agent of HLB value between 13～20 of stabilizing agent of the present invention for example selected polyoxyl 40 hydrogenated castor oil, polyoxyethylene 20 sorbitan mono-oleic acid esters or Polyethylene Glycol caprylic/capric glyceride for use; Adopt this hydrophilic non-ionic surfactant, the hydrophobic end can be embedded on the immobilized artificial membrane, forms the hydrophilic protective layer around immobilized artificial membrane, thereby has increased the physical stability of product.
Can also add 8～30 weight portion vitamin Es as required in the emu oil condensed milk-like liquid provided by the invention, so both can increase the product oxidation resistance, can prevent the oxidation of fat of Oromaius norvaehollandeae and phospholipid again, increase the chemical stability of product.
Emu oil condensed milk-like liquid provided by the invention, its concrete preparation method step is as follows:
1) 100 weight portion fat of Oromaius norvaehollandeaes, 65～150 weight portion phospholipid, 8～30 weight portion vitamin Es and 35～100 weight portion stabilizing agents are mixed to formation homogeneous mixed liquor under 25 ℃～60 ℃ temperature and stirring condition;
2) above-mentioned mixed liquor is mixed with the glycerol of 85～500 weight portions and the deionized water of 170～650 weight portions under 25 ℃～60 ℃ temperature and stirring condition, be prepared into the fat of Oromaius norvaehollandeae colostrum;
3) with step 2) in the fat of Oromaius norvaehollandeae colostric fluid that obtains by sophisticated high pressure homogenizer technical finesse, high pressure homogenize pressure is 500bar～1500bar, cycle-index is 3～18 times; Can obtain nano emu oil condensed milk-like liquid according to claim 1.
Above-mentioned steps 1) in, can add the vitamin E of 8～30 weight portions as required.
The present invention compared with prior art, prepared nano emu oil condensed milk-like liquid has the following advantages: the lipoid phospholipid that employing of the present invention and sebum film are close wraps up fat of Oromaius norvaehollandeae, and adopt the macromolecule non-ionic surface active agent as stabilizing agent, prepared nano emu oil condensed milk-like liquid appearance transparent, particle diameter are less than 100nm, constant product quality, have good water solublity, make that the preparation of the cosmetics contain fat of Oromaius norvaehollandeae is convenient, simple, can with any interworking of required skin care item preparation.Because the lapping that this nano emu oil condensed milk-like liquid adopted is lipoids such as phospholipid, make fat of Oromaius norvaehollandeae isoreactivity composition be easier to infiltrate into deep skin, both improve the stability of fat of Oromaius norvaehollandeae, helped the fat of Oromaius norvaehollandeae deep layer that penetrates to the skin again, given full play to the effect of fat of Oromaius norvaehollandeae; Also has the effect that increases moisture retention, slow release fat of Oromaius norvaehollandeae isoreactivity composition in addition, to reach the effect of long-time cosmetology.
Description of drawings
Fig. 1 is the freeze-etching transmission electron microscope picture of transparent nano emu oil condensed milk-like liquid provided by the invention.
The specific embodiment
Nano emu oil condensed milk-like liquid provided by the invention, by following component:
Fat of Oromaius norvaehollandeae 100 weight portions
Phosphatidase 16 5～150 weight portions
Stabilizing agent 35～100 weight portions
Glycerol 85～500 weight portions
Deionized water 170～650 weight portions,
Be prepared from through Over emulsfication, high pressure homogenize, its mean diameter is the nano emu oil condensed milk-like liquid of transparent or semitransparent shape less than 100nm, outward appearance.
This nano emu oil condensed milk-like liquid mean diameter is less than 100nm, and outward appearance is transparent or semitransparent shape.
Phospholipid of the present invention is the soybean lecithin or PC content 〉=72% Ovum Gallus domesticus Flavus lecithin of PC content 〉=72%.
The non-ionic surface active agent of HLB value between 13～20 of stabilizing agent of the present invention, as select polyoxyl 40 hydrogenated castor oil, polyoxyethylene 20 sorbitan mono-oleic acid esters or Polyethylene Glycol caprylic/capric glyceride for use.
Can add 8～30 weight portion vitamin Es as required in the emu oil condensed milk-like liquid of the present invention.
Preparation method of the present invention is as follows:
1) 100 weight portion fat of Oromaius norvaehollandeaes, 65～150 weight portion phospholipid and 35～100 weight portion stabilizing agents are mixed to formation homogeneous mixed liquor under 25 ℃～60 ℃ temperature and stirring condition;
2) above-mentioned mixed liquor is mixed with the glycerol of 85～500 weight portions and the deionized water of 170～650 weight portions under 25 ℃～60 ℃ temperature and stirring condition, be prepared into the fat of Oromaius norvaehollandeae colostrum.
3) with step 2) in the fat of Oromaius norvaehollandeae colostric fluid that obtains by sophisticated high pressure homogenizer technical finesse, high pressure homogenize pressure is 500bar～1500bar, cycle-index is 3～18 times, can obtain described nano emu oil condensed milk-like liquid.
7. according to the method for the described nano emu oil condensed milk-like liquid of claim 6, it is characterized in that: the vitamin E that in described step 1), adds 8～30 weight portions.
The method of described nano emu oil condensed milk-like liquid is characterized in that: the phospholipid that is adopted is the soybean lecithin of PC content 〉=72% or the Ovum Gallus domesticus Flavus lecithin of PC content 〉=72%.
The non-ionic surface active agent of HLB value between 13～20 of stabilizing agent of the present invention, preferably adopting has polyoxyl 40 hydrogenated castor oil, polyoxyethylene 20 sorbitan mono-oleic acid esters or Polyethylene Glycol caprylic/capric glyceride.
In the said method, can also add 8～30 weight portion vitamin Es as required.
Below enumerating embodiment is described further concrete enforcement of the present invention.
Embodiment 1
1, take by weighing 65g phospholipid (PC content ≈ 72%) and under 60 ℃ and 200rpm speed conditions, stir and form the homogeneous mixed liquor with 100g fat of Oromaius norvaehollandeae and 50g polyoxyl 40 hydrogenated castor oil,
2, under 60 ℃ and 1800rpm speed conditions, above-mentioned mixed solution is mixed with 200g glycerol and 450g deionized water, and continues to be stirred to the formation homogenous emulsion,
3, at last above-mentioned emulsion is promptly obtained the transparent nano emu oil condensed milk-like liquid through 5 processing of high pressure homogenizer circulation under the 800bar pressure condition.
Embodiment 2
1, take by weighing 100g phospholipid (PC content ≈ 72%) and under 55 ℃ and 400rpm speed conditions, stir and form the homogeneous mixed liquor with 100g fat of Oromaius norvaehollandeae and 35g polyoxyethylene 20 sorbitan mono-oleic acid esters,
2, under 50 ℃ and 1800rpm speed conditions, above-mentioned mixed liquor is mixed with 500g glycerol and 650g deionized water, and continues to be stirred to the formation homogenous emulsion,
3, at last above-mentioned emulsion is promptly obtained the transparent nano emu oil condensed milk-like liquid through 4 processing of high pressure homogenizer circulation under the 1000bar pressure condition.
Embodiment 3
1, take by weighing 150g phospholipid (PC content ≈ 92%) and under 45 ℃ and 600rpm speed conditions with in 100g fat of Oromaius norvaehollandeae, 70g polyoxyl 40 hydrogenated castor oil and the 30g vitamin E, form the homogeneous mixed liquor,
2, under 50 ℃ and 2500rpm speed conditions, above-mentioned mixed solution is mixed with 200g glycerol and 550g deionized water, and continues to be stirred to the formation homogenous emulsion,
3, at last above-mentioned emulsion is promptly obtained translucent nano emu oil condensed milk-like liquid through 8 processing of high pressure homogenizer circulation under the 800bar pressure condition.
Embodiment 4
1, take by weighing 100g phospholipid (PC content ≈ 72%) and under 40 ℃ and 500rpm speed conditions, stir and form the homogeneous mixed liquor with 100g fat of Oromaius norvaehollandeae and 80g polyoxyethylene 20 sorbitan mono-oleic acid esters,
2, under 40 ℃ and 1800rpm speed conditions, above-mentioned mixed liquor is mixed with 85g glycerol and 400g deionized water, and continues to be stirred to the formation homogenous emulsion,
3, at last above-mentioned emulsion is promptly obtained the transparent nano emu oil condensed milk-like liquid through 5 processing of high pressure homogenizer circulation under the 1000bar pressure condition.
Embodiment 5
1, take by weighing 70g phospholipid (PC content ≈ 72%) and under 35 ℃ and 200rpm speed conditions, stir and form the homogeneous mixed liquor with 100g fat of Oromaius norvaehollandeae and 100g Polyethylene Glycol caprylic/capric glyceride,
2, under 35 ℃ and 1800rpm speed conditions, above-mentioned mixed liquor is mixed with 200g glycerol and 170g deionized water, and continues to be stirred to the formation homogenous emulsion,
3, at last above-mentioned emulsion is promptly obtained translucent nano emu oil condensed milk-like liquid through 3 processing of high pressure homogenizer circulation under the 1500bar pressure condition.
Embodiment 6
1, take by weighing 80g phospholipid (PC content ≈ 72%) and under 25 ℃ and 800rpm speed conditions with in 100g fat of Oromaius norvaehollandeae, 85g polyoxyethylene 20 sorbitan mono-oleic acid esters and the 8g vitamin E, stir and form the homogeneous mixed liquor,
2, under 25 ℃ and 3500rpm speed conditions, above-mentioned mixed liquor is mixed with 160g glycerol and 330g deionized water, and continues to be stirred to the formation homogenous emulsion,
3, at last above-mentioned emulsion is promptly obtained the transparent nano emu oil condensed milk-like liquid through 18 processing of high pressure homogenizer circulation under the 500bar pressure condition.
Embodiment 7
1, take by weighing 90g phospholipid (PC content ≈ 72%) and under 45 ℃ and 200rpm speed conditions, stir and form the homogeneous mixed liquor with 100g fat of Oromaius norvaehollandeae and 70g polyoxyethylene 20 sorbitan mono-oleic acid esters,
2, under 45 ℃ and 1800rpm speed conditions, above-mentioned mixed liquor is mixed with 250g glycerol and 415g deionized water, and continues to be stirred to the formation homogenous emulsion,
3, at last above-mentioned emulsion is promptly obtained the transparent nano emu oil condensed milk-like liquid through 10 processing of high pressure homogenizer circulation under the 800bar pressure condition.
Embodiment 8
1, take by weighing 135g phospholipid (PC content ≈ 92%) and under 50 ℃ and 800rpm speed conditions with in 100g fat of Oromaius norvaehollandeae, 60g Polyethylene Glycol caprylic/capric glyceride and the 15g vitamin E, stir and form the homogeneous mixed liquor,
2, under 50 ℃ and 800rpm speed conditions, above-mentioned mixed liquor is mixed with 200g glycerol and 250g deionized water, and continues to be stirred to the formation homogenous emulsion,
3, at last above-mentioned emulsion is promptly obtained the transparent nano emu oil condensed milk-like liquid through 6 processing of high pressure homogenizer circulation under the 1000bar pressure condition.
Embodiment 9
1, take by weighing 115g phospholipid (PC content ≈ 92%) and under 40 ℃ and 1000rpm speed conditions with in 100g fat of Oromaius norvaehollandeae, 75g polyoxyl 40 hydrogenated castor oil and the 10g vitamin E, stir and form the homogeneous mixed liquor,
2, under 40 ℃ and 2800rpm speed conditions, above-mentioned mixed liquor is mixed with 208g glycerol and 372g deionized water, and continues to be stirred to the formation homogenous emulsion,
3, at last above-mentioned emulsion is promptly obtained the transparent nano emu oil condensed milk-like liquid through 5 processing of high pressure homogenizer circulation under the 1200bar pressure condition.
Claims (6)
1. nano emu oil condensed milk-like liquid is characterized in that: this nano emu oil condensed milk-like liquid is by following component:
Fat of Oromaius norvaehollandeae 100 weight portions
Phosphatidase 16 5～150 weight portions
Stabilizing agent 35～100 weight portions
Glycerol 85～500 weight portions
Deionized water 170～650 weight portions,
Be prepared from through Over emulsfication, high pressure homogenize, mean diameter is transparent or semitransparent shape less than 100nm, outward appearance;
Described stabilizing agent adopts polyoxyl 40 hydrogenated castor oil, polyoxyethylene 20 sorbitan mono-oleic acid esters or Polyethylene Glycol caprylic/capric glyceride.
2. according to the described nano emu oil condensed milk-like liquid of claim 1, it is characterized in that: the phospholipid that is adopted is the soybean lecithin of PC content 〉=72% or the Ovum Gallus domesticus Flavus lecithin of PC content 〉=72%.
3. a nano emu oil condensed milk-like liquid is characterized in that: the vitamin E that also contains 8～30 weight portions on the basis of claim 1 or 2.
4. method for preparing nano emu oil condensed milk-like liquid as claimed in claim 1 is characterized in that this method carries out as follows:
1) 100 weight portion fat of Oromaius norvaehollandeaes, 65～150 weight portion phospholipid and 35～100 weight portion stabilizing agents are mixed under 25 ℃～60 ℃ temperature and stirring condition, form the homogeneous mixed liquor;
2) above-mentioned mixed liquor is mixed with the glycerol of 85～500 weight portions and the deionized water of 170～650 weight portions under 25 ℃～60 ℃ temperature and stirring condition, be prepared into the fat of Oromaius norvaehollandeae colostrum;
3) with step 2) in the fat of Oromaius norvaehollandeae colostric fluid that obtains handle by high pressure homogenizer, high pressure homogenize pressure is 500bar～1500bar, cycle-index is 3～18 times, promptly obtains described nano emu oil condensed milk-like liquid.
5. according to the described method for preparing nano emu oil condensed milk-like liquid of claim 4, it is characterized in that: the phospholipid that is adopted is the soybean lecithin of PC content 〉=72% or the Ovum Gallus domesticus Flavus lecithin of PC content 〉=72%.
6. method for preparing nano emu oil condensed milk-like liquid as claimed in claim 3 is characterized in that this method carries out as follows:
1) 100 weight portion fat of Oromaius norvaehollandeaes, 65～150 weight portion phospholipid, 8～30 weight portion vitamin Es and 35～100 weight portion stabilizing agents are mixed under 25 ℃～60 ℃ temperature and stirring condition, form the homogeneous mixed liquor;
2) above-mentioned mixed liquor is mixed with the glycerol of 85～500 weight portions and the deionized water of 170～650 weight portions under 25 ℃～60 ℃ temperature and stirring condition, be prepared into the fat of Oromaius norvaehollandeae colostrum;
3) with step 2) in the fat of Oromaius norvaehollandeae colostric fluid that obtains by sophisticated high pressure homogenizer technical finesse, high pressure homogenize pressure is 500bar～1500bar, cycle-index is 3～18 times; Promptly obtain described nano emu oil condensed milk-like liquid.
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| CN200710063485A CN100581537C (en) | 2007-02-02 | 2007-02-02 | Nano emu oil condensed emulsion liquid |
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| CN200710063485A CN100581537C (en) | 2007-02-02 | 2007-02-02 | Nano emu oil condensed emulsion liquid |
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| CN100581537C true CN100581537C (en) | 2010-01-20 |
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Families Citing this family (3)
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| CN105769734A (en) * | 2016-03-28 | 2016-07-20 | 四川力久知识产权服务有限公司 | Anti-aging cosmetic composition |
| CN110841567A (en) * | 2019-11-18 | 2020-02-28 | 杭州诗昀生物科技有限公司 | Large-scale production method of cosmetic nanoparticles |
| CN114680180A (en) * | 2020-12-29 | 2022-07-01 | 丰益(上海)生物技术研发中心有限公司 | A concentrated emulsion containing low concentration plant phospholipid with high lipid digestibility |
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