CN108938565A - A kind of trans-cinnamic aldehyde nano-emulsion and preparation method thereof - Google Patents
A kind of trans-cinnamic aldehyde nano-emulsion and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
This application involves a kind of trans-cinnamic aldehyde nano-emulsion and preparation method thereof, belong to the preparation technical field characterized by component.It is compounded by the organic phase and the water phase that include trans-cinnamic aldehyde, the mass ratio of the organic phase and water phase is (0.5-4): (9.5-6), and trans-cinnamic aldehyde mass content is not less than 5%.The application is applied to the fields such as cosmetics, skin care item, has many advantages, such as that property is stable, absorbs rapid, modest viscosity.
Description
Technical field
This application involves a kind of trans-cinnamic aldehyde nano-emulsion and preparation method thereof, belong to the preparation skill characterized by component
Art field.
Background technique
Trans-cinnamic aldehyde essential oil cinnamic acid is commonly referred to as cinnaldehydrum, cinnamic aldehyde, and it to be aldehyde that its chemical name is triphenyl methacrylaldehyde
Class compound is yellow liquid, and content is more in the plants such as cortex cinnamomi, and natural products is primarily present in cinnamon oil, cassia oil, the leaves of pulse plants
In sesame oil, hyacinth oil, attar of rose etc..Trans-cinnamic aldehyde has the pungent fragrance of cassia oil and cinnamon oil and burns fragranced, fragrant
Gas is lasting.It is insoluble in water, glycerol and petroleum ether, is soluble in alcohol, ether, can volatilize with vapor.Trans-cinnamic aldehyde is in air
Easily it is oxidized, it is unstable in strong acid or strong alkali environment, it is easy to change.But trans-cinnamic aldehyde is a kind of natural antibacterial agent, tool
Play the role of antiviral, trans-cinnamic aldehyde also has expansion blood vessel and antihypertensive effect, and there are also hypoglycemic fat-regulating effects, and animal is promoted to give birth to
Long effect.
Nano-emulsion is a kind of spherical nanoparticles of interior oleophylic external hydrophilicity being made of surfactant, crosslinking agent, can be wrapped
Wrap up in oily matter.Nano-emulsion appearance transparent, macroscopic property are stablized, isotropism.Nano-emulsion has many other preparations can not
The advantages of analogy: being 1. isotropic transparency liquid, belongs to Thermodynamically stable system, can not be allowed to through pressure sterilizing or centrifugation
Layering；2. simple process, preparation process is not required to special installation, can spontaneously form, nano-emulsion particle diameter is generally 1~100nm；3. sticking
It spends low, pain when injection can be reduced；4. having sustained release and targeting；5. improving the solubility of drug, drug is reduced in body
Interior enzymatic hydrolysis can form the protective effect to drug and improve gastrointestinal tract absorption of drugs, improve the bioavilability of drug.
Therefore nano-emulsion is widely paid close attention to as a kind of pharmaceutical carrier.
However, it is coated on skin surface, is easy to produce grease stain sense, and lead since trans-cinnamic aldehyde is oily matter
Cause clogging of pores；It is dissolved in other surfaces activating agent, then due to its poorly water-soluble, cannot achieve the loading of essential oil and aqueous
Coating；Meanwhile based on nano-emulsion there is hydrophilic and oleophilic double grading to be wrapped in borneol essential oil by amphoteric surfactant
Inside nano-emulsion, it can be very good to solve the above problems.In existing document there has been no the nano-emulsion of trans-cinnamic aldehyde occur or
Report.
Based on this, the application is made.
Summary of the invention
For the drawbacks described above in the presence of the prior art, the application provides a kind of trans-cinnamic aldehyde oil-in-water nanometer cream,
Provided nano-emulsion can use the infinite dilution of 0.5mM phosphate buffer.
To achieve the above object, the technical solution that the application takes is as follows:
A kind of trans-cinnamic aldehyde nano-emulsion is compounded by the organic phase and the water phase that include trans-cinnamic aldehyde, described to have
The mass ratio of machine phase and water phase is (0.5-4): (9.5-6), and trans-cinnamic aldehyde mass content is not less than 5%.
Further, as preferred:
It also include grape seed oil in the organic phase, grape seed oil and trans-cinnamic aldehyde form uniform organic phase, instead
The mixing mass ratio of formula cinnamic acid and grape seed oil is (4-9): (6-1).Grape seed oil mainly plays reconciliation in the application formula
Effect, the concentration and viscosity of trans-cinnamic aldehyde are higher, the grape seed oil of addition ensure group while proportion is suitable for, also
Be able to achieve being evenly distributed for component, avoided the occurrence of deposition, realize trans-cinnamic aldehyde give full play to its sterilizing, antiulcer,
Inhibit adrenaline and ACTH to dissociate fatty acid, promote the Fatty synthesis of glucose, has also given full play to its scattered silt blood, promoted
Into blood circulation, skin is made to rise again, Rosemary Extract tissue, and improve moisture retention, improve white blood cell and platelet count.More preferably
, it is formed by the mass content of each component in trans-cinnamic aldehyde nano-emulsion are as follows: trans-cinnamic aldehyde 4-35%, grape seed oil 1-
5%, water phase 60-90%.
Also include emulsifier in the organic phase, the mixing mass ratio of trans-cinnamic aldehyde and emulsifier is 1:(2-4), cream
It is the oil-in-water emulsifiers of 8-15 that agent, which selects HLB,.The addition of oil-in-water emulsifiers improves being uniformly mixed for organic phase
Property, and its good oil-in-water structure is assigned, trans-cinnamic aldehyde is wrapped up in it, it is molten in water phase to realize oily matter
Solution, improves organic phase and well contacts with skin.It is furthermore preferred that the emulsifier is Tween-80, polyethylene glycol, dodecyl
Sodium sulfonate, aliphatic acid polyethenoxy ether, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide, glyceride type, lecithin
Equal cosmetics can use any one of emulsifier.It is furthermore preferred that being formed by the quality of each component in trans-cinnamic aldehyde nano-emulsion
Content are as follows: trans-cinnamic aldehyde 5-15%, emulsifier 5-25%, water phase 60-90%.
It also include grape seed oil and emulsifier in the organic phase, emulsifier selects the oil-in-water type cream that HLB is 8-15
Agent, the mass percentage of each component are as follows: trans-cinnamic aldehyde 5-40%, grape seed oil 1-10%, emulsifier 4-25%, water phase
60-90%.The addition of oil-in-water emulsifiers, improves the mixing uniformity of organic phase, and assigns its good oil-in-water knot
Structure wraps up trans-cinnamic aldehyde, grape seed oil in it, realizes dissolution of the oily matter in water phase, improve organic phase with
Skin well contacts.It is furthermore preferred that the emulsifier is Tween-80, polyethylene glycol, dodecyl sodium sulfate, fatty acid polyoxy
The cosmetics such as vinethene, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide, glyceride type, lecithin can use emulsifier
Any one of.
The water phase is water, phosphate buffer, disodium hydrogen phosphate-citrate buffer solution, citric acid-sodium citrate buffer solution
Any one of.
Meanwhile present invention also provides a kind of preparation methods of trans-cinnamic aldehyde nano-emulsion as characterized above: pressing quality
Than weighing organic phase and water phase, organic phase is taken, is slowly added into water phase, after addition, continues stirring to no gel
Shape substance, overnight stand is to get trans-cinnamic aldehyde nano-emulsion.
Further, as preferred:
Also include grape seed oil in the organic phase, the mixing mass ratio of trans-cinnamic aldehyde and grape seed oil is (4-9):
(6-1), grape seed oil and trans-cinnamic aldehyde first are mixed evenly to form organic phase.Grape seed oil and trans-cinnamic aldehyde belong to
Oily phase first mixes the two when being compounded, and is then added in water phase, can effectively improve its mixing uniformity, and
Ensure the distributing homogeneity of main function ingredient that grape seed oil and trans-cinnamic aldehyde are constituted in finished product nano-emulsion.Wherein,
Grape seed oil mainly plays reconciliation in the application formula, and the concentration and viscosity of trans-cinnamic aldehyde are higher, the Portugal of addition
Grape seed oil is ensuring group while proportion is suitable for, moreover it is possible to realize being evenly distributed for component, avoid the occurrence of deposition, realize trans-
Cinnamic acid gives full play to its sterilizing, antiulcer, inhibits adrenaline and ACTH to the free, promotion glucose of fatty acid
The effect of Fatty synthesis has also given full play to its scattered silt blood, has promoted blood circulation, skin is made to rise again, Rosemary Extract tissue, and changes
Kind moisture retention improves white blood cell and platelet count.
Also include emulsifier in the organic phase, the mixing mass ratio of trans-cinnamic aldehyde and emulsifier is 1:(2-4), cream
It is the oil-in-water emulsifiers of 8-15 that agent, which selects HLB, and trans-cinnamic aldehyde and emulsifier are added to water phase after being mixed evenly
In.The addition of oil-in-water emulsifiers improves the mixing uniformity of organic phase, when being mixed, first by trans-cinnamic aldehyde
Emulsification pretreatment is carried out with emulsifier, trans-cinnamic aldehyde is wrapped up in it, its good oil-in-water structure is assigned, realizes oiliness
Dissolution of the substance in water phase improves organic phase and well contacts with skin.It is furthermore preferred that the emulsifier is Tween-80, gathers
Ethylene glycol, dodecyl sodium sulfate, aliphatic acid polyethenoxy ether, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide,
The cosmetics such as glyceride type, lecithin can use any one of emulsifier.
It also include grape seed oil and emulsifier in the organic phase, emulsifier selects the oil-in-water type cream that HLB is 8-15
Agent, the mass percentage of each component are as follows: trans-cinnamic aldehyde 5-40%, grape seed oil 1-10%, emulsifier 4-25%, water phase
60-90%, grape seed oil are uniformly mixed with emulsifier advance, add emulsifier be stirred uniformly after, be added to water phase
In.Grape seed oil and trans-cinnamic aldehyde belong to oily phase, when being compounded, first mix the two, are then added to water phase
In, it can effectively improve its mixing uniformity, and the main function ingredient for ensuring that grape seed oil and trans-cinnamic aldehyde are constituted exists
Distributing homogeneity in finished product nano-emulsion；Then the oil of mixing is mutually mixed with oil-in-water emulsifiers again, realizes emulsification
Pretreatment, trans-cinnamic aldehyde, grape seed oil are wrapped up in it, its good oil-in-water structure is assigned, realizes oily matter and exist
Dissolution in water phase improves organic phase and well contacts with skin.It is furthermore preferred that the emulsifier is Tween-80, poly- second two
Alcohol, dodecyl sodium sulfate, aliphatic acid polyethenoxy ether, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide, glycerol
The cosmetics such as esters, lecithin can use any one of emulsifier.
The water phase is water, phosphate buffer, disodium hydrogen phosphate-citrate buffer solution, citric acid-sodium citrate buffer solution
Any one of.
It is 500-1000rpm that the organic phase, which is added to the mixing speed in water phase,.
Trans-cinnamic aldehyde oil-in-water nanometer cream provided herein, has pale yellow colored appearance, clear, phosphoric acid
Salt buffer infinite dilution.Present application addresses the problems that oily matter not readily dissolves in water phase, essential oil are wrapped in aqueous
After in nano-emulsion, it can operate in the stronger cosmetics of talent for swimming, obtain better user's sensory experience.The nano-emulsion has property
Stablize, absorb rapidly, modest viscosity the features such as, be with a wide range of applications in cosmetic field.
The application has the following advantages:
(1) oil-in-water nanometer cream clear, modest viscosity, absorb rapidly, property stablize, phosphoric acid salt buffer without
Limit dilution.
(2) the trans-cinnamic aldehyde essential oil of this nano-emulsion package has the old dead cell of removal skin, and collagen is promoted to produce
It is raw, the effect of softening causes scar tissue, desalinate melanin, prevent wrinkle of skin from generating, increase gloss, desalinate freckle.
Specific embodiment
Below in conjunction with example, the present invention will be described in further detail, the application protection range include but is not limited to
The instance method of lower description.
A kind of trans-cinnamic aldehyde nano-emulsion of the present embodiment is mainly compounded by the organic phase and water phase that include trans-cinnamic aldehyde
It forms, the mass ratio of the organic phase and water phase is (1-4): (9-6), and trans-cinnamic aldehyde mass content is not less than 5%.
In preparation process, organic phase and water phase are weighed in mass ratio, takes organic phase, is slowly added into water phase, are added
After adding, continue stirring to no spawn, overnight stand is to get trans-cinnamic aldehyde nano-emulsion.
The trans-cinnamic aldehyde nano-emulsion clear that aforesaid way obtains, modest viscosity absorb rapidly, and property is stablized, can
With phosphate buffer infinite dilution.The trans-cinnamic aldehyde of this nano-emulsion package has sterilizing, antiulcer, inhibits adrenal gland
Element and ACTH dissociate to fatty acid, promote the Fatty synthesis of glucose, and had both scattered silt blood, promoted blood circulation, make skin
Skin rises again, Rosemary Extract tissue, improves moisture retention, improves the effects of white blood cell and platelet count.Trans-cinnamic aldehyde is embedded
In nano-emulsion, solves the reason of trans-cinnamic aldehyde poorly water-soluble, it can be achieved that the load of essential oil and aqueous smearing characteristic.
The influence with regard to factor each in preparation process carries out annotation explanation below.
Embodiment 1: influence of the composition of organic phase to trans-cinnamic aldehyde nano-emulsion function and effect
In the present embodiment, water phase selects 0.5mM phosphate buffer (abbreviation PBS, pH 7.0), and the composition of organic phase has four
Kind mode: only trans-cinnamic aldehyde, trans-cinnamic aldehyde+grape seed oil, trans-cinnamic aldehyde+emulsifier, trans-cinnamic aldehyde+grape seed oil
+ emulsifier, emulsifier select Tween-80, and a certain data selected in adding proportion used carry out differently composed organic phase
Using effect control, ginseng are shown in Table 1.
Influence of the different composition organic phases of table 1 to nano-emulsion (% refers to mass percentage)
In table 1, degeee of stratification is from shallow to deep successively are as follows: slightly be layered < without layering < and has layering < to be layered obvious < layering and shows
< is write to be layered completely.
During the preparation process, organic phase and water phase are weighed in mass ratio, are taken organic phase, are slowly dropped in 15min
In water phase, control revolving speed is 500-1000rpm；After addition, continues to stir 15min, visually observe no spawn, mistake
Night stands to get trans-cinnamic aldehyde nano-emulsion.
Emulsifier-free (is shown in Table the serial number 1 and serial number 2 in 1) in the case where adding, and the composition of organic phase is mainly oily phase, will
It is directly stirred with water phase, although still can satisfy uniformly mixed effect, due to the whole oil base, water base of being rendered as
Therefore the state having is rendered as the phenomenon that color is partially deep, impermeable in appearance；Preparation initial stage can be rendered as uniform state,
With the extension of time of repose, difficulty is compared due to oil and is dissolved in water phase, trans-cinnamic aldehyde or trans-cinnamic aldehyde+grape seed oil are simultaneously
It is not dissolved in water phase actually, thus lamination easily occurs；Solute effect and the group property shown out are macro
Assimilation effect is presented as in sight, since water phase, oil are mutually there is no really dissolution is realized, acquired nano-emulsion is in assimilation effect
On be presented as respective assimilation effect, i.e. the contact angle of water phase and skin is smaller, be very easy to absorb, and oily phase then contact angle compared with
Greatly, it absorbs more slow；Similarly the viscosity as macro manifestations, viscosity can also have irregular phenomenon.
And be added with emulsifier in the case where (be shown in Table serial number 3, the serial number 4 in 1), due to emulsifier can effectively by
Oily phase (trans-cinnamic aldehyde or trans-cinnamic aldehyde+grape seed oil) carries out emulsification treatment, is wrapped up in it, and water base then expression exists
Outside, it when being dissolved in water phase, can be very good oily phased soln in water phase, be formed by nano-emulsion and be integrally presented as apparently
Water phase property, when itself and skin etc. contact, contact angle is smaller, thus stickiness is preferable, is easier to be absorbed, and ought especially have
When the addition of grape seed oil, the grape seed oil of addition has not only reconciled trans-cinnamic aldehyde and has given full play to its sterilizing, anti-bursts
Ulcer inhibits adrenaline and ACTH to dissociate fatty acid, promotes the Fatty synthesis of glucose, has also given full play to its scattered silt
Blood promotes blood circulation, and skin is made to rise again, Rosemary Extract tissue, and improves moisture retention, improves white blood cell and platelet count,
While promoting collagen to generate, the effectiveness of desalination melanin, increase skin gloss plays, Portugal can also have been given full play to
The superpower oxidation resistance of grape seed oil, delaying aging, and skin is protected from deep layer, make skin from repairing from environmental pollution
Cell membrane and cell wall promote cytothesis, restore skin elasticity.
Embodiment 2: influence of the water phase to trans-cinnamic aldehyde nano-emulsion function and effect
In the present embodiment, organic phase uses " trans-cinnamic aldehyde+grape seed oil+Tween-80 ", and water, phosphoric acid can be used in water phase
Buffer, disodium hydrogen phosphate-citrate buffer solution, several schemes of citric acid-sodium citrate buffer solution, to the using effect of finished product
It compares, ginseng is shown in Table 2.
Influence of the different water phases of table 2 to nano-emulsion (% refers to mass percentage)
In table 2, degeee of stratification is from shallow to deep successively are as follows: slightly be layered < without layering < and has layering < to be layered obvious < layering and shows
< is write to be layered completely.
During the preparation process, organic phase and water phase are weighed in mass ratio, are taken organic phase, are slowly dropped in 15min
In water phase, control revolving speed is 500-1000rpm；After addition, continues to stir 15min, visually observe no spawn, mistake
Night stands to get trans-cinnamic aldehyde nano-emulsion.
Water phase selects (pure) water, phosphate buffer, disodium hydrogen phosphate-citrate buffer solution, citric acid-sodium citrate slow
Fliud flushing.
Embodiment 3: influence of the different ratio to trans-cinnamic aldehyde nano-emulsion function and effect
The present embodiment carries out test comparison to the trans-cinnamic aldehyde nano-emulsion of different quality ratio, referring specifically to shown in table 3.
The differently composed trans-cinnamic aldehyde nano-emulsion of table 3 (following % is mass percentage)
In the present embodiment, we respectively test the trans-cinnamic aldehyde nano-emulsion of different content, different compositions, and
The test of using effect is carried out to it, the results showed that, when being tested: we are respectively to only trans-cinnamic aldehyde+water phase, trans-
Cinnamic acid+grape seed oil+water phase, trans-cinnamic aldehyde+emulsifier+water phase, trans-cinnamic aldehyde+grape seed oil+emulsifier+water phase four
Kind situation carries out the experiment of different content, the results showed that
(1) when only with trans-cinnamic aldehyde as organic phase, although trans-cinnamic aldehyde can be realized by being formed by nano-emulsion
The performance of effectiveness realizes sterilizing, antiulcer, scattered silt blood, the effect to promote blood circulation, however, due to trans-cinnamic aldehyde
Solubility property it is bad, can not achieve sufficient assimilation effect, the stability of solution of adsorption effect deviation, formation is poor, be easy
It is layered.
(2) when using trans-cinnamic aldehyde and grape seed oil as organic phase, equally exist that dissolubility is poor, assimilation effect
Defect weak, stability is bad, but in the nano-emulsion trans-cinnamic aldehyde 4-35%, grape seed oil 1-5%, remaining is supplied with water phase
When 100%, is meeting its sterilizing, antiulcer, adrenaline and ACTH is being inhibited to dissociate fatty acid, promoting glucose
Fatty synthesis scattered silt blood, promotes blood circulation, skin is made to rise again, Rosemary Extract tissue, improves moisture retention, improves white blood cell
And while platelet counts, the superpower oxidation resistance of nano-emulsion, and energy delaying aging are also imparted, protects skin from deep layer,
Make skin from from environmental pollution；Accelerate rate of metabolism, dead skin is promoted to fall off, repair cell film and cell wall promote
Cytothesis restores skin elasticity.
(3) when using trans-cinnamic aldehyde, emulsifier as organic phase, dissolubility, absorbability and the solution of nano-emulsion
Stability is improved, especially when trans-cinnamic aldehyde content is 5-15%, emulsifier 5-25%, remaining is supplied with water phase
When 100%, trans-cinnamic aldehyde is emulsified agent and wraps up in it, and dissolubility and uniformity of the organic phase in water phase are preferable, solution
Stability is preferable, stand 3 days layering it is also unobvious, it is preferable in the absorption efficiency and infiltration rate of skin surface.
(4) when using trans-cinnamic aldehyde, emulsifier, grape seed oil as organic phase, finished product nano-emulsion is effectively improved
Dissolubility, stability and absorbability, especially when trans-cinnamic aldehyde 5-10%, grape seed oil 2-5%, emulsifier 15-20%,
When water phase 70-78%, the addition of oil-in-water emulsifiers improves the mixing uniformity of organic phase, and assigns its good water
Oily structure is wrapped, trans-cinnamic aldehyde, grape seed oil are wrapped up in it, dissolution of the oily matter in water phase is realized, has improved
Machine phase is well contacted with skin.
In method (4), as a specific preparation method, it can be described as follows:
1) trans-cinnamic aldehyde essential oil, grape seed oil, Tween 80, phosphate buffer (5mM, pH=7.0)
2) instrument: magnetic stirring apparatus, rotor
3) step: 2.0g trans-cinnamic aldehyde essential oil is mixed with 0.5g grape seed oil, 500rpm, stirs 30min, makes it sufficiently
It mixes, is for oily phase；5.0g Tween 80 is added, 500rpm keeps 30min, mixes well it, be for organic phase.It takes
The above-mentioned organic phase of 7.5g, 15min is interior to be slowly dropped in 17.5ml water phase (phosphate buffer), revolving speed 700rpm.It drips off
Afterwards, continue to stir 15min, visually observe in container without spawn.Overnight stand can obtain the nanoemulsions of clear.
The nanoemulsions phosphoric acid buffer Macrodilution, emulsion state are stablized.
The above method (3), method (4) borneol nano-emulsion obtained, have pale yellow colored appearance, and clear can be used
0.5mM phosphate buffer infinite dilution not only solves the problem that oily matter not readily dissolves in water phase, and essential oil is (anti-
Formula cinnamic acid, grape seed oil) it is wrapped in water nano cream, when applying in the stronger cosmetics of talent for swimming, can get better
User's sensory experience, since dissolubility and absorbability are good, which also has modest viscosity, and property is stable, it is rapid, viscous to absorb
The features such as moderate is spent, is with a wide range of applications in cosmetic field.
The above content is the preferred embodiments of combination the invention to further detailed made by provided technical solution
Describe in detail bright, and it cannot be said that the invention specific implementation is confined to these above-mentioned explanations, technology affiliated for the invention
For the those of ordinary skill in field, without departing from the concept of the premise of the invention, several simple deductions can also be made
Or replacement, it all shall be regarded as belonging to the protection scope of the invention.
Claims (10)
1. a kind of trans-cinnamic aldehyde nano-emulsion, it is characterised in that: by include trans-cinnamic aldehyde organic phase and water phase compounding and
At the mass ratio of the organic phase and water phase is (0.5-4): (9.5-6), and trans-cinnamic aldehyde mass content is not less than 5%.
2. a kind of trans-cinnamic aldehyde nano-emulsion as described in claim 1, it is characterised in that: also include Portugal in the organic phase
Grape seed oil, grape seed oil and trans-cinnamic aldehyde form uniform organic phase, the mixing mass ratio of trans-cinnamic aldehyde and grape seed oil
For (4-9): (6-1).
3. a kind of trans-cinnamic aldehyde nano-emulsion as claimed in claim 1 or 2, which is characterized in that be formed by trans-cinnamic aldehyde
The mass content of each component in nano-emulsion are as follows: trans-cinnamic aldehyde 4-35%, grape seed oil 1-5%, water phase 60-90%.
4. a kind of trans-cinnamic aldehyde nano-emulsion as described in claim 1, it is characterised in that: also include cream in the organic phase
The mixing mass ratio of agent, trans-cinnamic aldehyde and emulsifier is 1:(2-4), emulsifier selects the oil-in-water type cream that HLB is 8-15
Agent.
5. a kind of trans-cinnamic aldehyde nano-emulsion as claimed in claim 4, it is characterised in that: the emulsifier is Tween-80, gathers
Ethylene glycol, dodecyl sodium sulfate, aliphatic acid polyethenoxy ether, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide,
The cosmetics such as glyceride type, lecithin can use any one of emulsifier.
6. a kind of trans-cinnamic aldehyde nano-emulsion as described in claim 1,4 or 5, it is characterised in that: be formed by trans-cinnamate
The mass content of each component in aldehyde nano-emulsion are as follows: trans-cinnamic aldehyde 5-15%, emulsifier 5-25%, water phase 60-90%.
7. a kind of trans-cinnamic aldehyde nano-emulsion as described in claim 1, it is characterised in that: also include Portugal in the organic phase
Grape seed oil and emulsifier, it is the oil-in-water emulsifiers of 8-15, the mass percentage of each component that emulsifier, which selects HLB, are as follows: anti-
Formula cinnamic acid 5-40%, grape seed oil 1-10%, emulsifier 4-25%, water phase 60-90%.
8. a kind of trans-cinnamic aldehyde nano-emulsion as claimed in claim 7, it is characterised in that: the emulsifier is Tween-80, gathers
Ethylene glycol, dodecyl sodium sulfate, aliphatic acid polyethenoxy ether, docosanol, carboxypolymethylene, ceresine, beeswax, coconut monoethanolamide,
The cosmetics such as glyceride type, lecithin can use any one of emulsifier.
9. a kind of trans-cinnamic aldehyde nano-emulsion as described in claim 1, it is characterised in that: the water phase is water, phosphoric acid buffer
Any one of liquid, disodium hydrogen phosphate-citrate buffer solution, citric acid-sodium citrate buffer solution.
10. the preparation method of trans-cinnamic aldehyde nano-emulsion as described in claim 1, it is characterised in that: weigh in mass ratio organic
Phase and water phase, take organic phase, are slowly added into water phase, and mixing speed is 500-1000 rpm；After addition, continue
Stirring is to no spawn, and overnight stand is to get trans-cinnamic aldehyde nano-emulsion.
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| CN112891394A (en) * | 2021-03-02 | 2021-06-04 | 广西壮族自治区中医药研究院 | Application of cinnamon extract in preparation of hypoglycemic drugs |
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