CN104490661A - O/W type nano emulsion containing lemon essential oil and preparation method thereof - Google Patents
O/W type nano emulsion containing lemon essential oil and preparation method thereof Download PDFInfo
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- CN104490661A CN104490661A CN201410726130.3A CN201410726130A CN104490661A CN 104490661 A CN104490661 A CN 104490661A CN 201410726130 A CN201410726130 A CN 201410726130A CN 104490661 A CN104490661 A CN 104490661A
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Abstract
The invention discloses O/W type nano emulsion containing lemon essential oil and a preparation method thereof. The O/W type nano emulsion containing lemon essential oil comprises the following components in percentage by weight: 1-30% of lemon essential oil, 2-20% of grease, 5-30% of an emulsifier, 1-10% of an organic additive, 0.05-2.0% of an inorganic additive and the balance of water. the preparation method comprises the following steps: firstly, mixing grease with the emulsifier to obtain an oil phase component; then, mixing the organic additive and the inorganic additive to obtain a water phase component; homogenizing the water phase component at a stirring speed of 5000-13000rpm, adding the oil phase component to the homogenized water phase component, then homogenizing for 2-4min, stirring at a stirring speed of 300-800rpm till the temperature reaches 45-50 DEG C, adding the lemon essential oil and further stirring to obtain macroemulsion; and circulating the macroemulsion for 1-5 times under the intensity of pressure of 40-200MPa, thus obtaining the O/W type nano emulsion containing lemon essential oil, wherein the particle size distribution of the obtained O/W type nano emulsion is uniform.
Description
Technical field
The invention belongs to cosmetic technical field, relate to a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil and preparation method thereof.
Background technology
Fructus Citri Limoniae quintessence oil belongs to citrus quintessence oil, pass through vapor distillation, the technology such as cold rolling or cold grinding extract from the fruit or peel of Fructus Citri Limoniae, the mixture be made up of 30 many kinds of substances, wherein alkene terpenoid occupies mainly, these compounds have certain antibacterial, antioxidation and spot-removal function.Scientific research now for Fructus Citri Limoniae quintessence oil mainly focuses on its inhibitory action to microorganism and the suppression to antibacterial, and it is applied in natural antiseptic agent by the antibacterial and bacteriostasis according to it, carries out anticorrosion to some food.Containing a large amount of alkene class materials in Fructus Citri Limoniae quintessence oil, wherein the content of limonene is a lot of, and alkene class material has certain non-oxidizability, so the non-oxidizability of Fructus Citri Limoniae quintessence oil is also the focus of research.Mainly be partial to faintly acid due to the composition in Fructus Citri Limoniae quintessence oil and contain the 'alpha '-hydroxy acids of minute quantity, if Fructus Citri Limoniae quintessence oil directly contacts human skin, a kind of offending sensation of pricking can be brought to skin when the too high levels added, so Fructus Citri Limoniae oil needs to act on human skin by a lipid system, thus avoid it to contact with the direct of skin, also be conducive to the infiltration of Fructus Citri Limoniae quintessence oil at epidermal area simultaneously, make effect that the effective ingredient contained by it reaches certain.Fructus Citri Limoniae quintessence oil function is many, except antibacterial and non-oxidizability, it can play effect of whitening in cosmetics, current Fructus Citri Limoniae quintessence oil is confined to it and the composite formation compound essential Oil of other quintessence oil the use people of skin-protection product, Fructus Citri Limoniae quintessence oil is added in other skin protection system very few, Fructus Citri Limoniae quintessence oil is directly used on skin can produce certain zest, so to need it to add in other system thus to reduce zest.
In the skin-protection product that consumer buys on Cosmetic Market, emulsion system is occupied an leading position, and these emulsions belong to ordinary emulsion substantially, its formula forms and preparation technology can produce emulsified particle size heterogeneity and particle diameter is greater than 1 μm substantially, and particle is greatly along with namely the impact brought is that stability of emulsion is poor.If the poor permeability adding active ingredient so this composition in ordinary emulsion can only rest on the stage of declaring, what can not reach desired by consumer is both effectiveness.Along with the extensive use of ordinary emulsion, its limitation makes research worker research and develop a kind of sub-micron emulsion, its emulsifying size is at 200 ~ 500nm, there is certain stability and promote that active substance permeates, absorb, and the size of nanoemulsions is at 100 ~ 400nm, stronger compared to its uniform particle diameter of sub-micron emulsion, stability and short permeability.
The technology of preparing of nanoemulsions is divided into high energy emulsion process and low-energy emulsification method, and what be most widely used is high energy emulsion process, and low-energy emulsification method only rests in theoretical research.In practical study, high energy emulsion process is divided into high pressure homogenization method and supersound method, larger compared to the former using value of the latter.Namely so-called high pressure homogenization method gives by mechanical forces such as high speed shear, high frequency oscillation, cavitation and convection current impacts the energy that thick emulsion is certain, makes thick emulsion become more tiny nanoemulsions.The homogenizing pressure of general high pressure homogenize is between 50-100MPa, and up-to-the-minute pressure can reach the high pressure of 350MPa.
Summary of the invention
An object of the present invention directly acts on human skin produce certain zest to solve above-mentioned Fructus Citri Limoniae quintessence oil, ordinary emulsion emulsified particle size heterogeneity, particle diameter is comparatively large thus stable poor, not easily permeate, a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil is provided etc. problem, Fructus Citri Limoniae quintessence oil and direct skin contact should be avoided by O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil, thus minimizing zest, the particle size of nanoemulsions is homogeneous and particle diameter is less than sub-micron emulsion, and the nanoemulsions stability that should contain the O/W type of Fructus Citri Limoniae quintessence oil is better, more easily permeate.
Two of object of the present invention is to provide the preparation method of above-mentioned a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil.
Know-why of the present invention
Fructus Citri Limoniae quintessence oil is volatile, heat is adopted to join legal system for nanoemulsions, first a volatilization temperature lower than Fructus Citri Limoniae quintessence oil (45 DEG C ~ 50 DEG C) is selected to be added by Fructus Citri Limoniae quintessence oil again by after emulsifying agent and nonvolatile oils and fats heating mixing and aqueous phase homogenizing, general O/W type emulsifying agent easily forms w/o type emulsion under the high temperature conditions, but the reduction along with temperature changes O/W type emulsion into, so add System forming O/W type emulsion in this temperature, and the freezing point that this temperature does not reach solid state emulsifying agent is emulsified in drop by Fructus Citri Limoniae quintessence oil, be more tiny drop by high pressure homogenization method by the large drop homogenizing in thick emulsion.
Technical scheme of the present invention
Containing the O/W type nanoemulsions of Fructus Citri Limoniae quintessence oil, count by weight percentage, its raw material composition and content as follows:
Fructus Citri Limoniae quintessence oil 1 ~ 30%
Oils and fats 2 ~ 20%
Emulsifying agent 5 ~ 30%
Organic additive 1 ~ 10%
Inorganic additive 0.01 ~ 2%
Surplus is water;
Described oils and fats is Vegetable oil lipoprotein, mineral grease or synthetic ester oil;
Wherein Vegetable oil lipoprotein is one or more the mixture in shea butter, American Avocado Tree oil, Oleum Vitis viniferae, Jojoba oil, macadimia nut oil, olive oil, Semen pruni armeniacae oil, Oleum Cocois, Oleum Ricini, the young oil of Helianthi and Semen Tritici aestivi germ oil;
Mineral grease is white oil;
Artificial oil is one or more the mixture in isomery hexadecane hydrocarbon, iso-octyl palmitate, isopropyl palmitate, caprylic/capric triglyceride, dimethicone, squalane, ethyl oleate, stearic acid 13 ester and the different monooctyl ester of isostearic acid;
Described emulsifying agent is solid state emulsifying agent or liquid milk agent;
Wherein solid state emulsifying agent is one or more the mixture in ceteareth-25, ceteareth-6, ceteareth-12, ceteareth-20, ceteareth-30, stereth-2, stereth-21, polyglycereol-6 pairs of stearates, three cetearyl alcohol ether-4 phosphate esters, PEG-20 tri-Glyceryl Behenate, PEG-8 Cera Flava, PEG-stearate and PEG-32 stearate;
Liquid milk agent is one or more the mixture in sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, laureth, Polyethylene Glycol-7-castor oil hydrogenated, caprylic/capric polyethyleneglycol glyceride, lauryl glycol ether, polysorbate and polyglycereol-3-diisopstearate;
Described organic additive is sorbitol, ethylene glycol, 1,2-PD, 1,3-PD, 1, one or more mixed alcohols formed in 3 butanediols and glycerol;
Described inorganic additive is sodium chloride, one or more mixture formed in potassium chloride, magnesium sulfate, sodium sulfate.
The preparation method of the above-mentioned O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil, specifically comprises the steps:
(1), emulsifying agent and oils and fats mixing post-heating to 80 ~ 85 DEG C are obtained finely dispersed oil phase component;
(2), organic additive, inorganic additive and water mixing post-heating to 80 ~ 85 DEG C are obtained finely dispersed water phase components;
(3), take speed as the water phase components of 5000 ~ 13000rpm homogenizing step (2) gained, the oil phase component of step (1) gained is added wherein simultaneously, emulsion is obtained after homogenizing 2 ~ 4min, then controlling rotating speed is that to be stirred to emulsion temperature be after 45 ~ 50 DEG C to 300 ~ 800rpm, Fructus Citri Limoniae quintessence oil is added wherein to continue to control rotating speed be the thick emulsion of 0/W type that 300 ~ 800rpm stirs 30min and obtains containing Fructus Citri Limoniae quintessence oil;
(4) is 40 ~ 200MPa containing the thick emulsion of 0/W type of Fructus Citri Limoniae quintessence oil at pressure, by step (3) gained, circulates 1 ~ 5 time, obtains the 0/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil.
Beneficial effect of the present invention
A kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil of the present invention, method and high pressure homogenization method is joined owing to have employed heat in preparation process, the nanoemulsions particle diameter of gained is at about 140nm, compared with simple emulsion, system is more homogeneous, good stability, simultaneously, emulsified emulsified Fructus Citri Limoniae quintessence oil is easier to infiltration, and then plays both effectiveness effect.
Further, a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil of the present invention, avoid Fructus Citri Limoniae quintessence oil and contact with the direct of skin thus reduce zest, comfortable during use, tiny drop impels Fructus Citri Limoniae quintessence oil in use more easily to permeate, obviously both effectiveness.
Further, the preparation method of a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil of the present invention, it is compared relative to the cold method of joining of emulsifying Fructus Citri Limoniae quintessence oil in emulsification system, this heat join emulsifying agent that method uses and fat type more extensive, cold joining in method can only use liquid oils and fats and liquid emulsifying agent, and heat of the present invention joins oils and fats solid-state and liquid in method, solid-state and liquid emulsifying agent can both use.
Accompanying drawing explanation
Fig. 1, embodiment 1 gained are containing the grain size distribution of the O/W type nanoemulsions of Fructus Citri Limoniae quintessence oil.
Detailed description of the invention
Below by specific embodiment, the present invention is set forth further, but do not limit the present invention.
Raw material used in various embodiments of the present invention, except specified otherwise in embodiment, other are commercially available.
embodiment 1
Containing the O/W type nanoemulsions of Fructus Citri Limoniae quintessence oil, by the total of 100g, its composition and content as follows:
Fructus Citri Limoniae quintessence oil 1g (1%)
Oils and fats 2g (2%)
Emulsifying agent 5g(5%)
Organic additive 1g (1%)
Inorganic additive 0.01g (0.01%)
Surplus is water;
Described Fructus Citri Limoniae quintessence oil, the food grade products of Shanghai IKEA spices and essence company limited;
Described oils and fats is Vegetable oil lipoprotein, and described Vegetable oil lipoprotein is shea butter, the cosmetics-stage product of Lai Baokang daily use chemicals (Shanghai) Co., Ltd.;
Described emulsifying agent is solid state emulsifying agent, and described solid state emulsifying agent is stereth-2, stereth-21 is the mixture of 2:3 composition in mass ratio, the product of the cosmetics-stage of BASF China;
Described organic additive is 1,3-PD, the chemical pure product of Chemical Reagent Co., Ltd., Sinopharm Group;
Described inorganic additive is potassium chloride, the chemical pure product of Chemical Reagent Co., Ltd., Sinopharm Group.
The preparation method of above-mentioned a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil, specifically comprises the steps:
(1), emulsifying agent and oils and fats mixing post-heating to 80 DEG C are obtained finely dispersed oil phase component;
(2), organic additive, inorganic additive and water mixing post-heating to 80 DEG C are obtained finely dispersed water phase components;
(3), take speed as the water phase components of 5000rpm homogenizing step (2) gained, the oil phase component of step (1) gained is added wherein simultaneously, emulsion is obtained after homogenizing 4min, then controlling rotating speed is that to be stirred to emulsion temperature be after 45 DEG C to 300 ~ 800rpm, Fructus Citri Limoniae quintessence oil is added wherein to continue to control rotating speed be the thick emulsion of 0/W type that 300 ~ 800rpm rpm stirs 30min and obtains containing Fructus Citri Limoniae quintessence oil;
(4) is 40 ~ 200 MPas containing the thick emulsion of 0/W type of Fructus Citri Limoniae quintessence oil at pressure, by step (3) gained, circulates 1 ~ 5 time, obtains the 0/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil.
Use Nano-ZS(Malvern) particle instrument measure above-mentioned gained containing the O/W type nanoemulsions particle diameter of Fructus Citri Limoniae quintessence oil, the grain size distribution of gained as shown in Figure 1, as can be seen from Figure 1, particle size distribution is homogeneous, most particle diameter is at about 140nm, illustrate that Fructus Citri Limoniae quintessence oil better can penetrate into skin, play effect.
embodiment 2
Containing the O/W type nanoemulsions of Fructus Citri Limoniae quintessence oil, by the total of 100g, its composition and content as follows:
Fructus Citri Limoniae quintessence oil 5g (5%)
Oils and fats 8g (8%)
Emulsifying agent 10g (10%)
Organic additive 3g (3%)
Inorganic additive 0.03g (0.03%)
Surplus is deionized water;
Described Fructus Citri Limoniae quintessence oil, the food grade products of Shanghai IKEA spices and essence company limited;
Described oils and fats is synthetic ester oil, and described artificial oil is caprylic/capric triglyceride, the cosmetics-stage product of He great chemicals (Shanghai) Co., Ltd.;
Described emulsifying agent is liquid milk agent, and described liquid milk agent is sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester is the mixture of 1:4 composition in mass ratio, the technical grade product that Chemical Reagent Co., Ltd., Sinopharm Group provides;
Described organic additive is sorbitol, the technical grade product that Chemical Reagent Co., Ltd., Sinopharm Group provides;
Described inorganic additive is sodium chloride, the technical grade product that Chemical Reagent Co., Ltd., Sinopharm Group provides.
The preparation method of the above-mentioned O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil, with embodiment 1.
embodiment 3
Containing the O/W type nanoemulsions of Fructus Citri Limoniae quintessence oil, by the total of 100g, its composition and content as follows:
Fructus Citri Limoniae quintessence oil 12g (12%)
Oils and fats 10g(10%)
Emulsifying agent 13g (13%)
Organic additive 5g(5%)
Inorganic additive 0.05g (0.05%)
Surplus is deionized water
Described Fructus Citri Limoniae quintessence oil, the food grade products of Shanghai IKEA spices and essence company limited;
Described oils and fats is Vegetable oil lipoprotein, and described Vegetable oil lipoprotein is Jojoba oil, the cosmetics-stage product of Lai Baokang daily use chemicals (Shanghai) Co., Ltd.;
Described emulsifying agent is described emulsifying agent is solid state emulsifying agent, and described solid state emulsifying agent is ceteareth-20 is the mixture that 3:2 forms with PEG-8 Cera Flava in mass ratio, the cosmetics-stage product of good method lion (Shanghai) trade Co., Ltd;
Described organic additive is 1,2-butanediol, the chemical pure product of Chemical Reagent Co., Ltd., Sinopharm Group;
Described inorganic additive is magnesium sulfate, the chemical pure product of Chemical Reagent Co., Ltd., Sinopharm Group.
The preparation method of the above-mentioned O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil, with embodiment 1.
embodiment 4
Containing the O/W type nanoemulsions of Fructus Citri Limoniae quintessence oil, by the total of 100g, its composition and content as follows:
Fructus Citri Limoniae quintessence oil 15g (15%)
Oils and fats 13g(13%)
Emulsifying agent 16g (16%)
Organic additive 8g(8%)
Inorganic additive 1g (1%)
Surplus is deionized water;
Described Fructus Citri Limoniae quintessence oil, the food grade products of Shanghai IKEA spices and essence company limited;
Described oils and fats is artificial oil, and described artificial oil is squalane, the cosmetics-stage product of He great chemicals (Shanghai) Co., Ltd.;
Described emulsifying agent is liquid milk agent, and described liquid milk agent is the cosmetics-stage product of Polyethylene Glycol-7-castor oil hydrogenated, He great chemicals (Shanghai) Co., Ltd.;
Described organic additive is glycerol, the technical grade product that Chemical Reagent Co., Ltd., Sinopharm Group provides;
Described inorganic additive is potassium chloride, the technical grade product that Chemical Reagent Co., Ltd., Sinopharm Group provides.
The preparation method of the above-mentioned O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil, with embodiment 1.
embodiment 5
Containing the O/W type nanoemulsions of Fructus Citri Limoniae quintessence oil, by the total of 100g, its composition and content as follows:
Fructus Citri Limoniae quintessence oil 23g (23%)
Oils and fats 18g(18%)
Emulsifying agent 25g (25%)
Organic additive 10g(10%)
Inorganic additive 1.5g (1.5%)
Surplus is deionized water;
Described Fructus Citri Limoniae quintessence oil, the food grade products of Shanghai IKEA spices and essence company limited;
Described oils and fats is mineral grease, and described mineral grease is white oil, the cosmetics-stage product of BASF chemicals (China) company limited;
Described emulsifying agent is solid state emulsifying agent, and described solid state emulsifying agent is ceteareth-20, the cosmetics-stage product of BASF chemicals (China) company limited;
Described organic additive is glycerol and 1, and 3 butanediols are the mixture of 1:1 composition by volume, the technical grade product that Chemical Reagent Co., Ltd., Sinopharm Group provides;
Described inorganic additive is potassium chloride, the technical grade product that Chemical Reagent Co., Ltd., Sinopharm Group provides.
The preparation method of the above-mentioned O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil, with embodiment 1.
embodiment 6
Containing the O/W type nanoemulsions of Fructus Citri Limoniae quintessence oil, by the total of 100g, its composition and content as follows:
Fructus Citri Limoniae quintessence oil 30g (30%)
Oils and fats 20g(20%)
Emulsifying agent 30g (30%)
Organic additive 10g(10%)
Inorganic additive 2g (2%)
Surplus is deionized water;
Described Fructus Citri Limoniae quintessence oil, the food grade products of Shanghai IKEA spices and essence company limited;
Described oils and fats is Vegetable oil lipoprotein, and described Vegetable oil lipoprotein is Jojoba oil and macadimia nut oil is the mixture of 1:1 composition in mass ratio, the cosmetics-stage product of Lai Baokang daily use chemicals (Shanghai) Co., Ltd.;
Described emulsifying agent is the mixture of solid state emulsifying agent ceteareth-30 and liquid milk agent caprylic/capric polyethyleneglycol glyceride composition, in mixture, solid emulsifier ceteareth-30 and liquid milk agent caprylic/capric polyethyleneglycol glyceride are the cosmetics-stage product of 1:2, BASF chemicals (China) company limited in mass ratio;
Described organic additive is glycerol and 1, and 3 butanediols are the mixture of 1:1 composition by volume, the technical grade product that Chemical Reagent Co., Ltd., Sinopharm Group provides;
Described inorganic additive is sodium chloride, the technical grade product that Chemical Reagent Co., Ltd., Sinopharm Group provides.
The preparation method of the above-mentioned O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil, with embodiment 1.
Foregoing be only the present invention conceive under basic explanation, and according to any equivalent transformation that technical scheme of the present invention is done, all should protection scope of the present invention be belonged to.
Claims (9)
1., containing the O/W type nanoemulsions of Fructus Citri Limoniae quintessence oil, it is characterized in that the described O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil counts by weight percentage, its raw material composition and content as follows:
Fructus Citri Limoniae quintessence oil 1 ~ 30%
Oils and fats 2 ~ 20%
Emulsifying agent 5 ~ 30%
Organic additive 1 ~ 10%
Inorganic additive 0.01 ~ 2%
Surplus is water;
Described oils and fats is Vegetable oil lipoprotein, mineral grease or synthetic ester oil;
Wherein Vegetable oil lipoprotein is one or more the mixture in shea butter, American Avocado Tree oil, Oleum Vitis viniferae, Jojoba oil, macadimia nut oil, olive oil, Semen pruni armeniacae oil, Oleum Cocois, Oleum Ricini, the young oil of Helianthi and Semen Tritici aestivi germ oil;
Mineral grease is white oil;
Artificial oil is one or more the mixture in isomery hexadecane hydrocarbon, iso-octyl palmitate, isopropyl palmitate, caprylic/capric triglyceride, dimethicone, squalane, ethyl oleate, stearic acid 13 ester and the different monooctyl ester of isostearic acid;
Described emulsifying agent is solid state emulsifying agent or liquid milk agent;
Wherein solid state emulsifying agent is one or more the mixture in ceteareth-25, ceteareth-6, ceteareth-12, ceteareth-20, ceteareth-30, stereth-2, stereth-21, polyglycereol-6 pairs of stearates, three cetearyl alcohol ether-4 phosphate esters, PEG-20 tri-Glyceryl Behenate, PEG-8 Cera Flava, PEG-stearate and PEG-32 stearate;
Liquid milk agent is one or more the mixture in sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, laureth, Polyethylene Glycol-7-castor oil hydrogenated, caprylic/capric polyethyleneglycol glyceride, lauryl glycol ether, polysorbate and polyglycereol-3-diisopstearate;
Described organic additive is sorbitol, ethylene glycol, 1,2-PD, 1,3-PD, 1, one or more mixed alcohols formed in 3 butanediols and glycerol;
Described inorganic additive is sodium chloride, one or more mixture formed in potassium chloride, magnesium sulfate, sodium sulfate.
2. a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil as claimed in claim 1, is characterized in that described oils and fats is Vegetable oil lipoprotein or synthetic ester oil;
Wherein Vegetable oil lipoprotein is one or more the mixture in shea butter, Jojoba oil or macadimia nut oil;
Artificial oil is caprylic/capric triglyceride or squalane;
The mixture that described emulsifying agent is solid state emulsifying agent, liquid milk agent or solid state emulsifying agent and liquid milk agent form;
Wherein solid state emulsifying agent is one or more the mixture in ceteareth-20, ceteareth-30, stereth-2, stereth-21, PEG-8 Cera Flava;
Liquid milk agent is one or more the mixture in caprylic/capric polyethyleneglycol glyceride, Polyethylene Glycol-7-castor oil hydrogenated, sorbitan fatty acid ester and polyoxyethylene sorbitan fatty acid ester;
In the mixture of solid state emulsifying agent and liquid milk agent composition, solid emulsifier is ceteareth-30, and liquid milk agent is caprylic/capric polyethyleneglycol glyceride;
Described organic additive is sorbitol, 1,2-PD, 1,3-PD, glycerol and 1, one or more mixed alcohols formed in 3 butanediols;
Described inorganic additive is sodium chloride, potassium chloride or magnesium sulfate.
3. a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil as claimed in claim 2, is characterized in that counting by weight percentage, its raw material composition and content as follows:
Fructus Citri Limoniae quintessence oil 1%
Oils and fats 2%
Emulsifying agent 5%
Organic additive 1%
Inorganic additive 0.01%
Surplus is water;
Described oils and fats is Vegetable oil lipoprotein, and described Vegetable oil lipoprotein is shea butter;
Described emulsifying agent is solid state emulsifying agent, and described solid state emulsifying agent is stereth-2 with stereth-21 is mixture that 2:3 forms in mass ratio;
Described organic additive is 1,3-PD;
Described inorganic additive is potassium chloride.
4. a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil as claimed in claim 2, is characterized in that counting by weight percentage, its raw material composition and content as follows:
Fructus Citri Limoniae quintessence oil 5%
Oils and fats 8%
Emulsifying agent 10%
Organic additive 3%
Inorganic additive 0.03%
Surplus is deionized water;
Described Fructus Citri Limoniae quintessence oil;
Described oils and fats is synthetic ester oil, and described artificial oil is caprylic/capric triglyceride;
Described emulsifying agent is liquid milk agent, and described liquid milk agent is sorbitan fatty acid ester and polyoxyethylene sorbitan fatty acid ester is mixture that 1:4 forms in mass ratio;
Described organic additive is sorbitol;
Described inorganic additive is sodium chloride.
5. a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil as claimed in claim 2, is characterized in that counting by weight percentage, its raw material composition and content as follows:
Fructus Citri Limoniae quintessence oil 12%
Oils and fats 10%
Emulsifying agent 13%
Organic additive 5%
Inorganic additive 0.05%
Surplus is deionized water;
Described Fructus Citri Limoniae quintessence oil;
Described oils and fats is Vegetable oil lipoprotein, and described Vegetable oil lipoprotein is Jojoba oil;
Described emulsifying agent is solid state emulsifying agent, and described solid state emulsifying agent is ceteareth-20 with PEG-8 Cera Flava is mixture that 3:2 forms in mass ratio;
Described organic additive is 1,2-butanediol;
Described inorganic additive is magnesium sulfate.
6. a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil as claimed in claim 2, is characterized in that counting by weight percentage, its raw material composition and content as follows:
Fructus Citri Limoniae quintessence oil 15%
Oils and fats 13%
Emulsifying agent 16%
Organic additive 8%
Inorganic additive 1%
Surplus is deionized water;
Described Fructus Citri Limoniae quintessence oil;
Described oils and fats is artificial oil, and described artificial oil is squalane;
Described emulsifying agent is liquid milk agent, and described liquid milk agent is Polyethylene Glycol-7-castor oil hydrogenated;
Described organic additive is glycerol;
Described inorganic additive is potassium chloride.
7. a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil as claimed in claim 2, is characterized in that counting by weight percentage, its raw material composition and content as follows:
Fructus Citri Limoniae quintessence oil 23%
Oils and fats 18%
Emulsifying agent 25%
Organic additive 10%
Inorganic additive 1.5%
Surplus is deionized water;
Described Fructus Citri Limoniae quintessence oil;
Described oils and fats is mineral grease, and described mineral grease is white oil;
Described emulsifying agent is solid state emulsifying agent, and described solid state emulsifying agent is ceteareth-20;
Described organic additive is glycerol and 1, and 3 butanediols are the mixture of 1:1 composition by volume;
Described inorganic additive is potassium chloride.
8. a kind of O/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil as claimed in claim 2, is characterized in that counting by weight percentage, its raw material composition and content as follows:
Fructus Citri Limoniae quintessence oil 30%
Oils and fats 20%
Emulsifying agent 30%
Organic additive 10%
Inorganic additive 2%
Surplus is deionized water;
Described Fructus Citri Limoniae quintessence oil;
Described oils and fats is Vegetable oil lipoprotein, and described Vegetable oil lipoprotein is Jojoba oil and macadimia nut oil is the mixture of 1:1 composition in mass ratio;
Described emulsifying agent is the mixture of solid state emulsifying agent and liquid milk agent composition, and in mixture, solid emulsifier ceteareth-30 and liquid milk agent caprylic/capric polyethyleneglycol glyceride are 1:2 in mass ratio;
Described organic additive is glycerol and 1, and 3 butanediols are the mixture of 1:1 composition by volume;
Described inorganic additive is sodium chloride.
9. as described in claims 1,2,3,4 or 5, contain the preparation method of the O/W type nanoemulsions of Fructus Citri Limoniae quintessence oil, it is characterized in that specifically comprising the steps:
(1), emulsifying agent and oils and fats mixing post-heating to 80 ~ 85 DEG C are obtained finely dispersed oil phase component;
(2), organic additive, inorganic additive and water mixing post-heating to 80 ~ 85 DEG C are obtained finely dispersed water phase components;
(3), take speed as the water phase components of 5000 ~ 13000rpm homogenizing step (2) gained, the oil phase component of step (1) gained is added wherein simultaneously, emulsion is obtained after homogenizing 2 ~ 4min, then controlling rotating speed is that to be stirred to emulsion temperature be after 45 ~ 50 DEG C to 300 ~ 800rpm, Fructus Citri Limoniae quintessence oil is added wherein to continue to control rotating speed be 300 ~ 800 thick emulsions of 0/W type stirring that 30min obtain containing Fructus Citri Limoniae quintessence oil;
(4) is 40 ~ 200MPa containing the thick emulsion of 0/W type of Fructus Citri Limoniae quintessence oil at pressure, by step (3) gained, circulates 1 ~ 5 time, obtains the 0/W type nanoemulsions containing Fructus Citri Limoniae quintessence oil.
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| CN106262581A (en) * | 2016-08-08 | 2017-01-04 | 华中农业大学 | A kind of Citrus characteristic perfume nano-emulsion and preparation method thereof |
| CN107028881A (en) * | 2015-10-23 | 2017-08-11 | 长春纳米生技公司 | With reversible continuous and dispersed phase nanoemulsions |
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