CN102149703B - 抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症 - Google Patents

抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症 Download PDF

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Publication number
CN102149703B
CN102149703B CN200980135652.3A CN200980135652A CN102149703B CN 102149703 B CN102149703 B CN 102149703B CN 200980135652 A CN200980135652 A CN 200980135652A CN 102149703 B CN102149703 B CN 102149703B
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CN
China
Prior art keywords
compound
dimethylamino
mixture
diazenyl
thiophene
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Expired - Fee Related
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CN200980135652.3A
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English (en)
Chinese (zh)
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CN102149703A (zh
Inventor
G·R·古卡拉吉
S·卡斯娜
R·R·古卡拉吉
T·吉拉考提
V·索门帕利
S·柯瑞莎鲁
K·布湖帕瑟拉吉
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Laila Nutraceuticals
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Laila Nutraceuticals
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN200980135652.3A 2008-09-15 2009-09-14 抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症 Expired - Fee Related CN102149703B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2230CH2008 2008-09-15
IN2230/CHE/08 2008-09-15
PCT/IN2009/000504 WO2010029577A2 (en) 2008-09-15 2009-09-14 Anti-cancer drugs and uses relating thereto for metastatic malignant melanoma and other cancers

Publications (2)

Publication Number Publication Date
CN102149703A CN102149703A (zh) 2011-08-10
CN102149703B true CN102149703B (zh) 2014-09-10

Family

ID=41565903

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980135652.3A Expired - Fee Related CN102149703B (zh) 2008-09-15 2009-09-14 抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症

Country Status (11)

Country Link
US (1) US8258119B2 (https=)
EP (1) EP2324006B1 (https=)
JP (1) JP2012502900A (https=)
KR (1) KR20110063537A (https=)
CN (1) CN102149703B (https=)
AU (1) AU2009290365B2 (https=)
BR (1) BRPI0913485A2 (https=)
CA (1) CA2736732A1 (https=)
IL (1) IL211366A0 (https=)
NZ (1) NZ591394A (https=)
WO (1) WO2010029577A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2424351B1 (en) * 2009-04-27 2015-10-21 Kasina Laila Innova Pharmaceuticals Private Ltd. Anti-cancer drugs, and uses relating for malignant melanoma and other cancers
NO2686520T3 (https=) 2011-06-06 2018-03-17
WO2012170439A1 (en) * 2011-06-06 2012-12-13 The Ohio State University Methods for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
JP2016521747A (ja) 2013-06-13 2016-07-25 アケビア セラピューティクス インコーポレイテッドＡｋｅｂｉａ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 貧血治療のための組成物及び方法
US9593095B2 (en) 2013-06-14 2017-03-14 Duke University Methods for the treatment of bacterial infections
DE112014006766T5 (de) * 2014-06-27 2017-04-27 Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto Herstellung und medizinische Verwendung von Triazenen
US10150734B2 (en) 2015-01-23 2018-12-11 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
US11324734B2 (en) 2015-04-01 2022-05-10 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
AU2016265922B2 (en) 2015-05-18 2021-05-20 Syn-Nat Products Enterprise LLC A pharmaceutical co-crystal and use thereof
BR112017027277A2 (pt) * 2015-06-19 2018-09-04 Syn Nat Products Entpr Llc ?método para o tratamento ou prevenção de uma doença e métodos para matar uma célula?
BR112017027285A2 (pt) 2015-06-19 2018-09-11 Syn Nat Products Entpr Llc ?cocristal, composição farmacêutica e método para o tratamento de uma doença?
US10428099B2 (en) 2015-06-25 2019-10-01 Syn-Nat Products Enterprise LLC Pharmaceutical co-crystal composition and use thereof
US11713298B2 (en) 2018-05-09 2023-08-01 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
WO2021117767A1 (ja) 2019-12-10 2021-06-17 田辺三菱製薬株式会社 含窒素ヘテロアリールカルボキサミド酢酸誘導体の製造方法
KR102648781B1 (ko) 2021-11-09 2024-03-19 국립공주대학교 산학협력단 항암 활성을 갖는 인데노피라졸론 유도체 화합물, 그의 제조방법 및 그의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1020641B (de) 1955-10-15 1957-12-12 Basf Ag Verfahren zur Herstellung von Derivaten der 3-Oxythiophen-2-carbonsaeure
CA968347A (en) * 1968-09-09 1975-05-27 John F. Gerster Substituted pyrazoles and process

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Synthesis and Cytostatic Activity of 4-Substituted Derivatives of Isoxazolyltriazenes;E. Wagner, et al.;《Polish J. Chem.》;20031231;第77卷(第8期);1001-1006 *
The Chemistry of 1,1-Dithiolates;L. Henriksen, et al.;《ACTA CHEMICA SCANDINAVICA》;19721231;第26卷(第8期);3342-3346 *

Also Published As

Publication number Publication date
CN102149703A (zh) 2011-08-10
US20100068178A1 (en) 2010-03-18
EP2324006A2 (en) 2011-05-25
WO2010029577A3 (en) 2010-05-06
AU2009290365A1 (en) 2010-03-18
WO2010029577A2 (en) 2010-03-18
JP2012502900A (ja) 2012-02-02
BRPI0913485A2 (pt) 2016-06-07
KR20110063537A (ko) 2011-06-10
NZ591394A (en) 2013-03-28
US8258119B2 (en) 2012-09-04
EP2324006B1 (en) 2014-08-13
IL211366A0 (en) 2011-04-28
CA2736732A1 (en) 2010-03-18
AU2009290365B2 (en) 2014-08-14

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