CN102149703B - 抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症 - Google Patents

抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症 Download PDF

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Publication number
CN102149703B
CN102149703B CN200980135652.3A CN200980135652A CN102149703B CN 102149703 B CN102149703 B CN 102149703B CN 200980135652 A CN200980135652 A CN 200980135652A CN 102149703 B CN102149703 B CN 102149703B
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CN
China
Prior art keywords
compound
dimethylamino
mixture
diazenyl
thiophene
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200980135652.3A
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English (en)
Chinese (zh)
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CN102149703A (zh
Inventor
G·R·古卡拉吉
S·卡斯娜
R·R·古卡拉吉
T·吉拉考提
V·索门帕利
S·柯瑞莎鲁
K·布湖帕瑟拉吉
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Laila Nutraceuticals
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Laila Nutraceuticals
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Publication of CN102149703A publication Critical patent/CN102149703A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200980135652.3A 2008-09-15 2009-09-14 抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症 Expired - Fee Related CN102149703B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2230/CHE/08 2008-09-15
IN2230CH2008 2008-09-15
PCT/IN2009/000504 WO2010029577A2 (en) 2008-09-15 2009-09-14 Anti-cancer drugs and uses relating thereto for metastatic malignant melanoma and other cancers

Publications (2)

Publication Number Publication Date
CN102149703A CN102149703A (zh) 2011-08-10
CN102149703B true CN102149703B (zh) 2014-09-10

Family

ID=41565903

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980135652.3A Expired - Fee Related CN102149703B (zh) 2008-09-15 2009-09-14 抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症

Country Status (11)

Country Link
US (1) US8258119B2 (https=)
EP (1) EP2324006B1 (https=)
JP (1) JP2012502900A (https=)
KR (1) KR20110063537A (https=)
CN (1) CN102149703B (https=)
AU (1) AU2009290365B2 (https=)
BR (1) BRPI0913485A2 (https=)
CA (1) CA2736732A1 (https=)
IL (1) IL211366A0 (https=)
NZ (1) NZ591394A (https=)
WO (1) WO2010029577A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120006554A (ko) * 2009-04-27 2012-01-18 카시나 라일라 이노바 파마슈티칼스 프라이빗 리미티드 항암 약물, 및 악성 흑색종 및 다른 암에 대한 용도
NO2686520T3 (https=) 2011-06-06 2018-03-17
EP2717870B1 (en) * 2011-06-06 2017-09-27 Akebia Therapeutics Inc. Composition for stabilizing hypoxia inducible factor-2 alpha useful for treating cancer
SG10201910773VA (en) 2013-06-13 2020-01-30 Akebia Therapeutics Inc Compositions and methods for treating anemia
US9593095B2 (en) 2013-06-14 2017-03-14 Duke University Methods for the treatment of bacterial infections
US10221198B2 (en) 2014-06-27 2019-03-05 Ecole Polytechnique Federale De Lausanne (Epfl) Preparation and medical use of triazenes
AU2016209126A1 (en) 2015-01-23 2017-08-10 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
US11324734B2 (en) 2015-04-01 2022-05-10 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
EP3297624B1 (en) 2015-05-18 2021-03-03 Syn-Nat Products Enterprise LLC A pharmaceutical co-crystal and use thereof
KR20180018800A (ko) 2015-06-19 2018-02-21 신-낫 프로덕츠 엔터프라이즈 엘엘씨 카보플라틴 계 공-결정의 약제학적 조성물 및 이의 용도
BR112017027277A2 (pt) 2015-06-19 2018-09-04 Syn Nat Products Entpr Llc ?método para o tratamento ou prevenção de uma doença e métodos para matar uma célula?
CA2989001A1 (en) 2015-06-25 2016-12-29 Syn-Nat Products Enterprise LLC Pharmaceutical co-crystal composition and use thereof
EP3790863A1 (en) 2018-05-09 2021-03-17 Akebia Therapeutics Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
KR102648781B1 (ko) 2021-11-09 2024-03-19 국립공주대학교 산학협력단 항암 활성을 갖는 인데노피라졸론 유도체 화합물, 그의 제조방법 및 그의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1020641B (de) 1955-10-15 1957-12-12 Basf Ag Verfahren zur Herstellung von Derivaten der 3-Oxythiophen-2-carbonsaeure
CA968347A (en) 1968-09-09 1975-05-27 John F. Gerster Substituted pyrazoles and process

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Synthesis and Cytostatic Activity of 4-Substituted Derivatives of Isoxazolyltriazenes;E. Wagner, et al.;《Polish J. Chem.》;20031231;第77卷(第8期);1001-1006 *
The Chemistry of 1,1-Dithiolates;L. Henriksen, et al.;《ACTA CHEMICA SCANDINAVICA》;19721231;第26卷(第8期);3342-3346 *

Also Published As

Publication number Publication date
WO2010029577A2 (en) 2010-03-18
US8258119B2 (en) 2012-09-04
WO2010029577A3 (en) 2010-05-06
EP2324006A2 (en) 2011-05-25
KR20110063537A (ko) 2011-06-10
EP2324006B1 (en) 2014-08-13
CA2736732A1 (en) 2010-03-18
AU2009290365B2 (en) 2014-08-14
AU2009290365A1 (en) 2010-03-18
NZ591394A (en) 2013-03-28
CN102149703A (zh) 2011-08-10
IL211366A0 (en) 2011-04-28
JP2012502900A (ja) 2012-02-02
BRPI0913485A2 (pt) 2016-06-07
US20100068178A1 (en) 2010-03-18

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