CN102149703B - 抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症 - Google Patents

抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症 Download PDF

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Publication number
CN102149703B
CN102149703B CN200980135652.3A CN200980135652A CN102149703B CN 102149703 B CN102149703 B CN 102149703B CN 200980135652 A CN200980135652 A CN 200980135652A CN 102149703 B CN102149703 B CN 102149703B
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CN
China
Prior art keywords
compound
dimethylamino
mixture
diazenyl
thiophene
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200980135652.3A
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English (en)
Chinese (zh)
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CN102149703A (zh
Inventor
G·R·古卡拉吉
S·卡斯娜
R·R·古卡拉吉
T·吉拉考提
V·索门帕利
S·柯瑞莎鲁
K·布湖帕瑟拉吉
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Kasina Laila Innova Pharmaceuticals Pvt Ltd
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Kasina Laila Innova Pharmaceuticals Pvt Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN200980135652.3A 2008-09-15 2009-09-14 抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症 Expired - Fee Related CN102149703B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2230CH2008 2008-09-15
IN2230/CHE/08 2008-09-15
PCT/IN2009/000504 WO2010029577A2 (en) 2008-09-15 2009-09-14 Anti-cancer drugs and uses relating thereto for metastatic malignant melanoma and other cancers

Publications (2)

Publication Number Publication Date
CN102149703A CN102149703A (zh) 2011-08-10
CN102149703B true CN102149703B (zh) 2014-09-10

Family

ID=41565903

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980135652.3A Expired - Fee Related CN102149703B (zh) 2008-09-15 2009-09-14 抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症

Country Status (11)

Country Link
US (1) US8258119B2 (enExample)
EP (1) EP2324006B1 (enExample)
JP (1) JP2012502900A (enExample)
KR (1) KR20110063537A (enExample)
CN (1) CN102149703B (enExample)
AU (1) AU2009290365B2 (enExample)
BR (1) BRPI0913485A2 (enExample)
CA (1) CA2736732A1 (enExample)
IL (1) IL211366A0 (enExample)
NZ (1) NZ591394A (enExample)
WO (1) WO2010029577A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI1006651A2 (pt) * 2009-04-27 2015-08-25 Kasina Laila Innova Pharmaceuticals Private Ltd Medicamentos anticancer e usos relacionados para melanome maligno e outros canceres
NO2686520T3 (enExample) 2011-06-06 2018-03-17
CN103717214A (zh) * 2011-06-06 2014-04-09 阿克比治疗有限公司 用于稳定低氧诱导因子-2α作为治疗癌症的方法的化合物和组合物
HUE066123T2 (hu) 2013-06-13 2024-07-28 Akebia Therapeutics Inc Készítmények és módszerek anémia kezelésére
US9593095B2 (en) 2013-06-14 2017-03-14 Duke University Methods for the treatment of bacterial infections
DE112014006766T5 (de) * 2014-06-27 2017-04-27 Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto Herstellung und medizinische Verwendung von Triazenen
CA2974691A1 (en) 2015-01-23 2016-07-28 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
NZ735973A (en) 2015-04-01 2023-06-30 Akebia Therapeutics Inc Compositions and methods for treating anemia
KR20180008594A (ko) 2015-05-18 2018-01-24 신-낫 프로덕츠 엔터프라이즈 엘엘씨 약제학적 공-결정 및 그의 용도
JP6768716B2 (ja) 2015-06-19 2020-10-14 シン−ナット プロダクツ エンタープライズ エルエルシー カルボプラチンベースの共結晶の医薬組成物及びその用途
EP3297440A4 (en) * 2015-06-19 2019-04-10 Syn-Nat Products Enterprise LLC COMPOSITION WITH CARBOPLATIN AND USE
KR20180021805A (ko) 2015-06-25 2018-03-05 신-낫 프로덕츠 엔터프라이즈 엘엘씨 약제학적 공-결정 조성물 및 이의 용도
US11713298B2 (en) 2018-05-09 2023-08-01 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US12612367B2 (en) 2019-12-10 2026-04-28 Akebia Therapeutics, Inc. Method for producing nitrogen-containing heteroarylcarboxamide acetic acid derivative
WO2021216530A1 (en) 2020-04-20 2021-10-28 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer
KR102648781B1 (ko) 2021-11-09 2024-03-19 국립공주대학교 산학협력단 항암 활성을 갖는 인데노피라졸론 유도체 화합물, 그의 제조방법 및 그의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1020641B (de) 1955-10-15 1957-12-12 Basf Ag Verfahren zur Herstellung von Derivaten der 3-Oxythiophen-2-carbonsaeure
CA968347A (en) * 1968-09-09 1975-05-27 John F. Gerster Substituted pyrazoles and process

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Synthesis and Cytostatic Activity of 4-Substituted Derivatives of Isoxazolyltriazenes;E. Wagner, et al.;《Polish J. Chem.》;20031231;第77卷(第8期);1001-1006 *
The Chemistry of 1,1-Dithiolates;L. Henriksen, et al.;《ACTA CHEMICA SCANDINAVICA》;19721231;第26卷(第8期);3342-3346 *

Also Published As

Publication number Publication date
US20100068178A1 (en) 2010-03-18
IL211366A0 (en) 2011-04-28
CN102149703A (zh) 2011-08-10
JP2012502900A (ja) 2012-02-02
CA2736732A1 (en) 2010-03-18
KR20110063537A (ko) 2011-06-10
EP2324006B1 (en) 2014-08-13
WO2010029577A2 (en) 2010-03-18
WO2010029577A3 (en) 2010-05-06
BRPI0913485A2 (pt) 2016-06-07
AU2009290365B2 (en) 2014-08-14
US8258119B2 (en) 2012-09-04
EP2324006A2 (en) 2011-05-25
NZ591394A (en) 2013-03-28
AU2009290365A1 (en) 2010-03-18

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