CN102145110A - Oral medicine composition for clinically nursing high fever caused by infantile respiratory tract infection and preparation method of oral medicine composition - Google Patents
Oral medicine composition for clinically nursing high fever caused by infantile respiratory tract infection and preparation method of oral medicine composition Download PDFInfo
- Publication number
- CN102145110A CN102145110A CN2011100720282A CN201110072028A CN102145110A CN 102145110 A CN102145110 A CN 102145110A CN 2011100720282 A CN2011100720282 A CN 2011100720282A CN 201110072028 A CN201110072028 A CN 201110072028A CN 102145110 A CN102145110 A CN 102145110A
- Authority
- CN
- China
- Prior art keywords
- parts
- medicine composition
- medicine
- preparation
- respiratory tract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an oral medicine composition for clinically nursing high fever caused by infantile respiratory tract infection and a preparation method of the oral medicine composition. The medicine is prepared into decoction by the raw materials in parts by weight: 3 parts of gypsum, 5 parts of rhizoma anemarrhenae, 1 part of orpiment, 6 parts of radix scrophulariae, 11 parts of liquorice, 10 parts of isatis root, 5 parts of the root bark of the peony tree, 6 parts of radix bupleuri, 1 part of cicada cypress, 3 parts of peppermint, 8 parts of cordate houttuynia, 3 parts of microcos paniculata leaf, 2 parts of chrysanthemum and 9 parts of ardisiae japonica. The medicine composition of the invention can safely and effectively cure the high fever caused by respiratory tract infection caused by parainfluenza virus; the medicine is more effective than the normal western medicine treating method, and can be used as the good fever-lowering medicine.
Description
Technical field
The invention belongs to the clinical care field, relate to combination of oral medication and preparation method that a kind of clinical care infantile respiratory tract infection causes hyperpyrexia, relate in particular to a kind of combination of oral medication and preparation method that causes hyperpyrexia by human parainfluenza virus (HPIVs) infection children's bronchial.
Background technology
Child's internal organs are tender and lovely, each biorgan to the resistance of disease a little less than, respiratory tract infection is more common disease, relates in particular to the respiratory tract infectious disease that the human parainfluenza virus causes, and its clinical manifestation has hyperpyrexia, headache, dizziness, cough, limbs fatigue etc.Heating is body defence disease and adapts to a kind of compensatory response that internal and external environment temperature anomaly changes, is a kind of performance that body is resisted disease.But heating has certain limit, if hyperpyrexia continued then can produce harmful effect to body for a long time.So-called hyperpyrexia is meant body temperature at 39 ℃～40 ℃, surpasses 40 ℃ and is called excessive heat.Lasting hyperpyrexia can cause tic, cerebral anoxia.Therefore, for the serious body injury that prevents that hyperpyrexia from bringing, at first should take suitable nursing intervention, comprise giving the patient certain drug for abating fever, this is particularly important to follow-up clinical treatment.
The human parainfluenza virus is a kind of virus that usually causes childrens respiratory tract infection, relates in particular to child's bronchial infection, its pathogenic respiratory syncytial virus (RSV) that is only second to.The same with RSV, the human parainfluenza virus can cause the lower respiratory illness (as pneumonia, bronchitis and bronchiolitis) of serious repeated infection, particularly child and old people and have among the immunodeficiency crowd.
In the prior art: Chang Yong drug for abating fever is an aspirin clinically, the heating of human body is because endogenous pyrogen activates the hypothalamus prostaglandin synthetase, make the synthetic and release increase of prostaglandin, and prostaglandin E is extremely strong pyrogenicsubstance, and the effect of aspirin is distinguished the synthetic of prostaglandin and is strengthened the heat radiation process in passing through just to suppress, thus the generation refrigeration function.But there is huge side effect in this medicine to children's, as anaphylaxis, gastric mucosa damage, hepatic injury, hemorrhage, haemolysis, hematopoietic disorder, renal damage, neural mental symptom etc.Acetaminophen can effectively be treated by symptoms such as the caused fevers of respiratory tract infection, because its determined curative effect, and to aspirin allergy, do not tolerate or inapplicable patient all can take, be to treat the respiratory tract infection curative effect at present to cause hyperpyrexia one of medicine preferably, if but take acetaminophen for a long time in a large number liver, kidney are all had infringement.
Summary of the invention
The object of the present invention is to provide the clinical care infantile respiratory tract infection to cause the combination of oral medication and the preparation method of hyperpyrexia, relate in particular to a kind of combination of oral medication and preparation method that causes hyperpyrexia by human parainfluenza virus (HPIVs) infection children's bronchial.This medication effect is good, and side effect can be reduced to minimum.
Medicine of the present invention is obtained by following materials of weight proportions medicine compatibility: the medicine of following each component can be made the various medicaments of clinical practice.The pharmacology of each medicine of the present invention is: Gypsum Fibrosum: meridian distribution of property and flavor: Great Cold; Hot, sweet; Attach to the lung and stomach meridians.Function cures mainly: clearing away heat-fire, relieving restlessness is quenched the thirst.The Rhizoma Anemarrhenae: meridian distribution of property and flavor: cold; Bitter, sweet; Return lung, stomach, kidney channel.Function cures mainly: clearing away heat-fire, promote the production of body fluid and moisturize.Realgar: suffering, temperature.Poisonous.Return liver, large intestine channel, function cures mainly: dampness, dispel the wind parasite killing, detoxifcation.Radix Scrophulariae: meridian distribution of property and flavor: be slightly cold; Sweet, bitter, salty; Return lung, stomach, kidney channel.Function cures mainly: removing heat from blood YIN nourishing, eliminating fire and detoxication.Radix Glycyrrhizae: meridian distribution of property and flavor: flat; Sweet; GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Radix Isatidis: bitter, salty, Great Cold, go into the heart, stomach warp, the heat-clearing and toxic substances removing removing heat from blood.Cortex Moutan: hot, bitter, be slightly cold, go into the heart, liver, kidney channel, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Radix Bupleuri: bitter, hot, be slightly cold, go into liver, gallbladder, pericardium, tri-jiao channel, conciliate summer-heat.Periostracum Cicadae: sweet, cold.Return lung, Liver Channel.The function wind heat extraction that looses, sore-throat relieving, rash, nebula removing, spasmolytic.Be used for anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, convulsion with spasms, tetanus.Herba Menthae is hot cold sweating and heat resolving medicine, controls influenza, headache, conjunctival congestion, fever of the body, throat, dental bed disease such as swell and ache.The Herba Houttuyniae cold nature, bitter in the mouth; Function: heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; Inducing diuresis for treating stranguria syndrome.Folium Microcoris paniculatae: light, little acid, flat.Heat clearing away disappears stagnant, and the dampness removing jaundice eliminating reduces phlegm.Be used for flu, the abdominal pain of damp and hot dyspepsia, lack of appetite is had loose bowels, jaundice due to damp-heat.Flos Chrysanthemi: acrid in the mouth, sweet, hardship; Cold nature.Return lung, Liver Channel.Function cures mainly, the wind heat clearing away of loosing, and suppressing the hyperactive liver makes eye bright.PINGDIMU: property is flat, acrid in the mouth, little hardship; Return lung, Liver Channel.Curing mainly new chronic cough coughs; Sputum mixed with blood is damp and hotly made a psychological attack.
Calculate according to composition by weight: this pharmaceutical composition is prepared from by Gypsum Fibrosum 3, the Rhizoma Anemarrhenae 5, Realgar 1, Radix Scrophulariae 6, Radix Glycyrrhizae 11, Radix Isatidis 10, Cortex Moutan 5, Radix Bupleuri 6, Periostracum Cicadae 1, Herba Menthae 3, Herba Houttuyniae 8, Folium Microcoris paniculatae 3, Flos Chrysanthemi 2, PINGDIMU 9.
The preparation technology of preparation of the present invention is:
1) decoct: above-mentioned all medicines are put into marmite by a certain percentage, add hydrology fire by 1: 2 of crude drug gross weight and decoct, boiled back 100 minutes, medicinal liquid is leached, 1: 1 by the crude drug gross weight adds the fiery decoction of the hydrology again, boils back 50 minutes, and medicinal liquid is leached;
2) adjust pH: will add hydrochloric acid solution behind twice filtrate mixing, wherein the volume ratio of filtrate and hydrochloric acid solution is 10: 1, and the regulator solution pH value is 5, places precipitation 10 hours, filters and collects filtrate;
3) bottling sterilization: with above-mentioned steps 2) filtrate that obtains is packed in advance, and the disinfectant bottle is interior seals, and the medicinal liquid bottle is put into pressure cooker sterilize, and promptly gets Chinese medicine drug oral preparation of the present invention.
The invention belongs to prepared from traditional Chinese medicines and form, is a kind of Chinese medicine for oral administration, more obvious for the hyperpyrexia hyperpyrexia therapeutic effect that the treatment infantile respiratory tract infection causes.In order to understand better and to implement the present invention, further specify the present invention below in conjunction with embodiment.
Embodiment
Embodiment 1, animal acute toxicity test:
1, experiment material: laboratory animal is healthy male BABC/L mice, body weight 22 ± 1g, every group of 10 mices.The experiment medicine is with pharmaceutical composition of the present invention, aspirin (Aspirin Enteric-coated Tablets, specification 100mg/ sheet, manufacturer Bayer pharmaceutical factory).Experiment material is that ATL measures test kit, and manufacturer is Tianjin Kang'erke Bioscience Co., Ltd..
2, method and result:
Oral administration determines that the oral medicine optimal dose of the present invention of experimental group is 10ml/kg, every day sooner or later each once, totally 7 days, matched group was taken aspirin medicine 5mg/kg, every day sooner or later each once, totally 7 days.Blank group is taken the normal saline of same amount every day.After 7 days, mouse orbit is got blood, separation of serum. measure serum ALT activities. and as shown in Table 4, aspirin control group mice serum ALT activities is apparently higher than test group P＜0.01.
The influence of table 1 mice serum ALT content
Annotate: compare with matched group, * represents P＜0.01.
Discuss: according to above experimental result as can be known, compare with the conventional medicine aspirin, the pharmaceutical composition among the application can reduce the degree of injury to liver greatly.
Simultaneously, the kidney injury detection has also been carried out in this experiment: light microscopy checking: the visible glomerule of matched group nephridial tissue light microscopy checking obviously increases, the GCBM diffuse thickening, and substrate increases, the slight hypertrophy of mesangial cell, the near-end renal cells presents a large amount of vacuolar degenerations.Matter is not seen tangible pathological change between experimental group and blank group mice glomerule and tubule.
Discuss: according to above experimental result as can be known, compare with the conventional medicine aspirin, the pharmaceutical composition among the application can reduce the degree of injury to kidney greatly.
Embodiment 2, animal pharmacodynamics test
One, experiment material
1, medicine adopts pharmaceutical composition of the present invention and aspirin, and dosage is the same.
2, laboratory animal is selected normal KM mice for use, is provided by No.1 Military Medical Univ.; Parainfluenza virus KM mouse model, preparation method is with reference to " Chinese comparative medicine magazine, the foundation of parainfluenza mouse model and pathological research ".
Two, method and result
1, oral administration, the oral medicine 10ml/kg of the present invention of experimental group, every day, respectively once, totally 7 days, matched group was taken aspirin medicine 5mg/kg sooner or later.Blank group is taken the normal saline of same amount every day.Take medicine back one hour every day with body temperature instrumentation anus temperature 3 times, continuous 7 days.Three each 20 mices of group.Experimental data adopts the t check to handle.
The result: pharmaceutical composition of the present invention obviously reduces the body temperature of heating mice.Compare with matched group, P＜0.001 sees Table 2.
Table 2 pharmaceutical composition of the present invention is to the X ± SD that influences of mouse temperature
In addition, also detected mice three weeks of back of taking medicine with interior survival rate, referring to table 3:
| Group | 7 days survival rate % | 14 days survival rate % | 21 days survival rate % |
| Blank group | -- | -- | -- |
| The treatment group | 80 | 75 | 75 |
| Matched group | 50 | 35 | 30 |
Discuss: pharmaceutical composition of the present invention can effectively be alleviated the hyperpyrexia that respiratory tract infection causes, and is better than general routine.
Embodiment 3: the Clinical detection test
Diagnostic criteria: detect through clinical and laboratory, the patient is the respiratory tract infection that parainfluenza virus causes, and comparatively serious bronchitis all occurs, and the fever temperature is all more than 39 ℃.
The case grouping: be divided into three groups at random, wherein 23 examples are organized in treatment, wherein male 12 examples, women 11 examples; Age 2-5 year, average 3.5 years old; Matched group: 22 examples, wherein male 14 examples, women 8 examples; Age 2-5 year, average 3.4 years old.All cases were not all used other antibiotic medicine before treatment.
The clinical efficacy of medicine composite for curing respiratory tract infection of the present invention and safety.Bronchitis patient 45 examples that the acute respiratory infection that method is made a definite diagnosis causes, wherein 23 examples are organized in treatment, oral pharmaceutical composition of the present invention, 100ml is each, and every day is sooner or later respectively once; Matched group 22 examples are taken Aspirin Enteric-coated Tablets, specification 100mg/ sheet, and manufacturer Bayer pharmaceutical factory, every day is each a slice sooner or later; Above-mentioned two groups are 3 days the course of treatment.After the single medication as a result, treatment group and matched group antipyretic effective percentage are respectively 82.6% (19/23) and 77.3% (17/22) (P＜0.05).Take efficacy analysis after a course of treatment, treatment group and matched group effective percentage are respectively 95.6% (22/23) and 90.9% (20/22).Two groups relatively have remarkable significant difference (P＜0.05).Two groups of all lower and no difference of science of statistics of adverse reaction rate.
Conclusion: pharmaceutical composition of the present invention can be treated the hyperpyrexia heating that respiratory tract infection that parainfluenza virus causes causes safely and effectively, and more effective than conventional western medicine means, can be used as a kind of good drug for abating fever.
Claims (2)
1. a pharmaceutical composition is characterized in that this pharmaceutical composition is the decoction of being made by following raw materials by weight proportions: Gypsum Fibrosum 3, the Rhizoma Anemarrhenae 5, Realgar 1, Radix Scrophulariae 6, Radix Glycyrrhizae 11, Radix Isatidis 10, Cortex Moutan 5, Radix Bupleuri 6, Periostracum Cicadae 1, Herba Menthae 3, Herba Houttuyniae 8, Folium Microcoris paniculatae 3, Flos Chrysanthemi 2, PINGDIMU 9.
2. preparation of drug combination method as claimed in claim 1 is characterized in that this preparation method finishes by following step:
1) decoct: above-mentioned each crude drug is put into marmite by a certain percentage, add hydrology fire by 1: 2 of crude drug gross weight and decoct, boiled back 100 minutes, medicinal liquid is leached, 1: 1 by the crude drug gross weight adds the fiery decoction of the hydrology again, boils back 50 minutes, and medicinal liquid is leached.
2) adjust pH: will add hydrochloric acid solution behind the medicinal liquid mixing that leach for twice, the regulator solution pH value is 5, and the volume ratio of its herb liquid and hydrochloric acid solution is 10: 1, places precipitation about 10 hours then, filters to collect and considers liquid.
3) sealing in the disinfectant bottle of packing in advance of the final worry liquid of collecting is put into pressure cooker with the medicinal liquid bottle and is sterilized bottling sterilization: with step 2), promptly gets the described pharmaceutical composition of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100720282A CN102145110B (en) | 2011-03-24 | 2011-03-24 | Oral medicine composition for clinically nursing high fever caused by infantile respiratory tract infection and preparation method of oral medicine composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100720282A CN102145110B (en) | 2011-03-24 | 2011-03-24 | Oral medicine composition for clinically nursing high fever caused by infantile respiratory tract infection and preparation method of oral medicine composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102145110A true CN102145110A (en) | 2011-08-10 |
| CN102145110B CN102145110B (en) | 2012-06-13 |
Family
ID=44419711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100720282A Expired - Fee Related CN102145110B (en) | 2011-03-24 | 2011-03-24 | Oral medicine composition for clinically nursing high fever caused by infantile respiratory tract infection and preparation method of oral medicine composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102145110B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1840065A (en) * | 2006-01-05 | 2006-10-04 | 李瑞庆 | Dispersible tablet for eliminating inflammation and preparation method thereof |
-
2011
- 2011-03-24 CN CN2011100720282A patent/CN102145110B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1840065A (en) * | 2006-01-05 | 2006-10-04 | 李瑞庆 | Dispersible tablet for eliminating inflammation and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 《广西中医药》 19961231 蒙定水 《中药治疗感染性高热近况》 47-49 1-2 第19卷, 第1期 2 * |
| 《江西中医药》 20050831 康立媛 《益气养阴法治疗小儿发热30例》 26 1-2 , 第8期 2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102145110B (en) | 2012-06-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102058767B (en) | Chinese medicine for treating senile chronic bronchitis and method for preparing pills thereof | |
| CN103463609A (en) | Traditional Chinese medicine oral decoction for treating upper respiratory infection and preparation method for Chinese patent medicine of traditional Chinese medicine oral decoction | |
| CN103110844B (en) | Traditional Chinese medicine for treating acute tonsillitis | |
| CN103394070A (en) | Chinese medicine preparation for treating influenza | |
| CN103861046A (en) | Traditional Chinese medicine for treating prosopalgia | |
| CN101502626A (en) | Medicine for treating influenza and preparation method thereof | |
| CN103585401A (en) | Traditional Chinese medicine composition for treating bird flu and preparation method therefor. | |
| CN104208473A (en) | Traditional Chinese medicine composition for treating wind-heat type cough and asthma and use thereof | |
| CN1317004C (en) | Chinese medicine prepn for treating infantile respiratory tract infection | |
| CN102145110B (en) | Oral medicine composition for clinically nursing high fever caused by infantile respiratory tract infection and preparation method of oral medicine composition | |
| CN102205037B (en) | Oral medicinal composition for treating infantile bronchitis caused by bacterial infection and preparation method thereof | |
| CN105477201A (en) | Traditional Chinese medicine preparation for treating influenza and preparation method of traditional Chinese medicine preparation for treating influenza | |
| CN105327182A (en) | Medicine for treating child pertussis and preparation method thereof | |
| CN103494968A (en) | Traditional Chinese medicine preparation for treating epidemic parotitis and preparation method thereof | |
| CN103768153A (en) | Traditional Chinese medicine composition for treating air sacculitis of poultry and preparation method thereof | |
| CN103536851A (en) | Traditional Chinese medicine composition for treating alcoholic fatty liver | |
| CN103816521B (en) | A kind of Chinese medicine for the treatment of syndrome of wind-toxicity invading collaterals type Tetanus | |
| CN105920208A (en) | Medicinal composition for treating infantile wind-heat type common cold | |
| CN105477414A (en) | Traditional Chinese medicinal preparation for treating viral cold | |
| CN105250746A (en) | Heat clearing and toxin removing oral liquid and preparation method thereof | |
| CN105147909A (en) | Chinese herb decoction for treating meningitis and preparation method thereof | |
| CN105250624A (en) | Medicine for treating ascariasis and preparation method of medicine | |
| CN105596929A (en) | Preparing method for traditional Chinese medicine preparation for treating phlegm-heat excessive accumulation type chronic cough | |
| CN104958530A (en) | Traditional Chinese medicinal composition for treating infantile pneumonia | |
| CN104998045A (en) | Traditional Chinese medicine preparation for treating pleurisy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120613 Termination date: 20130324 |