CN102144966A - 克林霉素磷酸酯注射液的制备方法 - Google Patents
克林霉素磷酸酯注射液的制备方法 Download PDFInfo
- Publication number
- CN102144966A CN102144966A CN 201110086780 CN201110086780A CN102144966A CN 102144966 A CN102144966 A CN 102144966A CN 201110086780 CN201110086780 CN 201110086780 CN 201110086780 A CN201110086780 A CN 201110086780A CN 102144966 A CN102144966 A CN 102144966A
- Authority
- CN
- China
- Prior art keywords
- clindamycin phosphate
- injection
- preparation
- sodium hydroxide
- filter membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UFUVLHLTWXBHGZ-MGZQPHGTSA-N [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1 UFUVLHLTWXBHGZ-MGZQPHGTSA-N 0.000 title claims abstract description 48
- 229960002291 clindamycin phosphate Drugs 0.000 title claims abstract description 48
- 238000002347 injection Methods 0.000 title claims abstract description 35
- 239000007924 injection Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 63
- 239000012528 membrane Substances 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000001914 filtration Methods 0.000 claims abstract description 10
- 239000000243 solution Substances 0.000 claims abstract description 8
- 239000008215 water for injection Substances 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 abstract description 10
- 229940079593 drug Drugs 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 8
- 239000000126 substance Substances 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 13
- 238000005516 engineering process Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 229960002227 clindamycin Drugs 0.000 description 4
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 3
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 2
- 229960005287 lincomycin Drugs 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000011021 bench scale process Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
| 供试品 | 收率数据 |
| 实施例1注射液 | 99.8% |
| 实施例2注射液 | 99.5% |
| 实施例3注射液 | 99.2% |
| 专利方法注射液 | 75% |
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110086780 CN102144966B (zh) | 2011-04-08 | 2011-04-08 | 克林霉素磷酸酯注射液的制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110086780 CN102144966B (zh) | 2011-04-08 | 2011-04-08 | 克林霉素磷酸酯注射液的制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102144966A true CN102144966A (zh) | 2011-08-10 |
| CN102144966B CN102144966B (zh) | 2013-03-20 |
Family
ID=44419571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110086780 Active CN102144966B (zh) | 2011-04-08 | 2011-04-08 | 克林霉素磷酸酯注射液的制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102144966B (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103072932A (zh) * | 2013-01-15 | 2013-05-01 | 江苏大红鹰恒顺药业有限公司 | 克林霉素磷酸酯注射液的无菌包装方法 |
| CN103565755A (zh) * | 2012-08-02 | 2014-02-12 | 江苏金丝利药业有限公司 | 克林霉素磷酸酯注射液组合物及其制备方法 |
| CN104666253A (zh) * | 2015-03-23 | 2015-06-03 | 山东北大高科华泰制药有限公司 | 注射用克林霉素磷酸酯粉针剂药物组合物和制法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969875A (zh) * | 2006-12-01 | 2007-05-30 | 沈阳金峰医药科技有限公司 | 克林霉素磷酸酯注射液的制剂工艺 |
| CN101874770A (zh) * | 2009-04-30 | 2010-11-03 | 华北制药集团制剂有限公司 | 一种克林霉素磷酸酯注射液及其制备方法 |
-
2011
- 2011-04-08 CN CN 201110086780 patent/CN102144966B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969875A (zh) * | 2006-12-01 | 2007-05-30 | 沈阳金峰医药科技有限公司 | 克林霉素磷酸酯注射液的制剂工艺 |
| CN101874770A (zh) * | 2009-04-30 | 2010-11-03 | 华北制药集团制剂有限公司 | 一种克林霉素磷酸酯注射液及其制备方法 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103565755A (zh) * | 2012-08-02 | 2014-02-12 | 江苏金丝利药业有限公司 | 克林霉素磷酸酯注射液组合物及其制备方法 |
| CN103072932A (zh) * | 2013-01-15 | 2013-05-01 | 江苏大红鹰恒顺药业有限公司 | 克林霉素磷酸酯注射液的无菌包装方法 |
| CN104666253A (zh) * | 2015-03-23 | 2015-06-03 | 山东北大高科华泰制药有限公司 | 注射用克林霉素磷酸酯粉针剂药物组合物和制法 |
| CN104666253B (zh) * | 2015-03-23 | 2018-04-20 | 山东北大高科华泰制药有限公司 | 注射用克林霉素磷酸酯粉针剂药物组合物和制法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102144966B (zh) | 2013-03-20 |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: LIAONING GELIN BIOLOGY PHARMACY CO., LTD. Free format text: FORMER NAME: SHENYANG GELIN PHARMACEUTICAL CO., LTD. Owner name: LIAONING GELIN BIOLOGICAL PHARMACEUTICAL GROUP CO. Free format text: FORMER NAME: LIAONING GELIN BIOLOGY PHARMACY CO., LTD. |
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| CP01 | Change in the name or title of a patent holder |
Address after: Shen North Road Shenbei New Area Huishan Economic Development Zone of Shenyang city of Liaoning Province, No. 176 110164 Patentee after: LIAONING GREEN BIO-PHARMACEUTICAL GROUP Co.,Ltd. Address before: Shen North Road Shenbei New Area Huishan Economic Development Zone of Shenyang city of Liaoning Province, No. 176 110164 Patentee before: Liaoning Green Biological Pharmaceutical Co.,Ltd. Address after: Shen North Road Shenbei New Area Huishan Economic Development Zone of Shenyang city of Liaoning Province, No. 176 110164 Patentee after: Liaoning Green Biological Pharmaceutical Co.,Ltd. Address before: Shen North Road Shenbei New Area Huishan Economic Development Zone of Shenyang city of Liaoning Province, No. 176 110164 Patentee before: Shenyang Green Pharmaceutical Co.,Ltd. |
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| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Shen North Road Shenbei New Area Huishan Economic Development Zone of Shenyang city of Liaoning Province, No. 176 110164 Patentee after: LIAONING GREEN BIOLOGICAL PHARMACEUTICAL GROUP Co.,Ltd. Address before: Shen North Road Shenbei New Area Huishan Economic Development Zone of Shenyang city of Liaoning Province, No. 176 110164 Patentee before: LIAONING GREEN BIO-PHARMACEUTICAL GROUP Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder |
Address after: Shen North Road Shenbei New Area Huishan Economic Development Zone of Shenyang city of Liaoning Province, No. 176 110164 Patentee after: Yuanyan Yaogang Biopharmaceutical (Shenyang) Co.,Ltd. Address before: Shen North Road Shenbei New Area Huishan Economic Development Zone of Shenyang city of Liaoning Province, No. 176 110164 Patentee before: Yuanyan Pharmaceutical Port Bioindustry (Liaoning) Group Co.,Ltd. Address after: Shen North Road Shenbei New Area Huishan Economic Development Zone of Shenyang city of Liaoning Province, No. 176 110164 Patentee after: Yuanyan Pharmaceutical Port Bioindustry (Liaoning) Group Co.,Ltd. Address before: Shen North Road Shenbei New Area Huishan Economic Development Zone of Shenyang city of Liaoning Province, No. 176 110164 Patentee before: LIAONING GREEN BIOLOGICAL PHARMACEUTICAL GROUP Co.,Ltd. |
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