CN102139034A

CN102139034A - Medicament for treating chloasma

Info

Publication number: CN102139034A
Application number: CN 201110086630
Authority: CN
Inventors: 王勇勤
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-04-07
Filing date: 2011-04-07
Publication date: 2011-08-03

Abstract

The invention discloses a medicament for treating chloasma, which is prepared by taking acetic bupleurum, angelica, white peony root, red sage root, tuckahoe, bighead atractylodes rhizome, green orange leaf, prepared rhizoma cyperi and mint as raw medicines. The medicament can be prepared into any one of pharmaceutical oral preparations such as tablets, pills, powder, capsules and the like. The medicament disclosed by the invention has a better effect on treating chloasma, does not have toxic side effects, and especially has an obvious effect on treating liver depression and qi stagnation type chloasma.

Description

A kind of medicine for the treatment of chloasma

Technical field

The present invention relates to a kind of medicine, specifically relate to a kind of medicine for the treatment of chloasma.

Background technology

Chloasma is meant that the patch that area differs in size appears in face, is also referred to as chloasma hepaticum and butterfly spot, and is little of the coin size, big face such as the map of being abound with, and color is yellowish-brown or light black, divides on skin, and that touches is not in the way.Chloasma is symmetrically distributed in around cheekbone, cheek, volume, nose, mouthful week, the eye socket more, and the boundary line is obvious, and that presses is colour-fast, smooth surface, and no squama does not have the pain of itching.Chloasma cause of disease complexity mainly contains following several respects factor: 1) endocrine disturbance, lack of proper care as the serum estrogen level that gynaecopathia causes; 2) long-term psychentonia or oppressive stimulates acth secretion too much; 3) a certain position or organ disease in the body cause the organism metabolism dysequilibrium; 4) some endo-medicine also can bring out chloasma as medicine, sedation-analgesia and the antibiotic that contains hormone; 5) skin care item and cosmetics are selected improperly, use inferior, expired, zest or contain the cosmetics of hormone, lead, hydrargyrum, arsenic etc., not only can stay pigmentation through ultraviolet radiation, also can make mottle reach skin corium deeply; 6) long-term habitual constipation makes vivotoxin can not and advance to get rid of external, and the savings of especially unnecessary day hormone has quickened the secretion and the precipitation of melanin granule; 7) inherited genetic factors, new theory think that the formation of chloasma is relevant with cytogene heredity.Because chloasma pathogeny complexity, in therapeutic process often because of emotion changes, disease in the body, multiple factor such as Exposure to Sunlight very easily causes mottle refractory, rebound phenomena.The method of present treatment chloasma has a variety of, and laser therapy, Chinese medicine are nursed one's health, spent speckle product, beauty treatment, health care medicine etc. outward, but therapeutic effect is all not obvious.

The Chinese traditional treatment chloasma has long history, has certain advantage, but chloasma is a kind of disease with complicated cause of disease, no matter be basic research, or clinical treatment, still there is not at present theoretical direction clear and definite, system, therefore, remain further to be improved the research of aspects such as the basis of chloasma, clinical, treatment.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of chloasma, therapeutic effect is apparent in view, without any side effects.

Medicine of the present invention is to be the medicament that crude drug prepares with following parts by weight of traditional Chinese medicines:

Radix Bupleuri (processed with vinegar) 10-15, Radix Angelicae Sinensis 8-12, Radix Paeoniae Alba 8-12, Radix Salviae Miltiorrhizae 12-16, Poria 10-15, Rhizoma Atractylodis Macrocephalae 8-12, blue or green Folium Citri tangerinae 5-8, Rhizoma Cyperi (processed) 8-12, Herba Menthae 2-5.

The preferred parts by weight of each crude drug are in the medicine of the present invention:

Radix Bupleuri (processed with vinegar) 13-15, Radix Angelicae Sinensis 10-12, Radix Paeoniae Alba 8-10, Radix Salviae Miltiorrhizae 12-14, Poria 13-15, Rhizoma Atractylodis Macrocephalae 8-10, blue or green Folium Citri tangerinae 7-8, Rhizoma Cyperi (processed) 8-10, Herba Menthae 2-3.

The present invention makes any peroral dosage form on the pharmaceutics with the above-mentioned raw materials medicine, and as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.

The preparation method of medicine of the present invention being made capsule is as follows:

1) Radix Bupleuri is sprayed with Radix Bupleuri weight 0.1-0.2 vinegar doubly mixes thoroughly, put in the pot to fry to vinegar and exhaust and little doing, take out, dry that to make Radix Bupleuri (processed with vinegar) standby with slow fire;

2) Rhizoma Cyperi is pulverized put into container, pour into and mix thoroughly with each 0.2-0.25 of Rhizoma Cyperi weight yellow wine and rice vinegar doubly, it is standby to make Rhizoma Cyperi (processed);

3) the various crude drug addings with above-mentioned parts by weight double in the water of crude drug weight, decoct 20-30 minute, filter, and decoct three times, collecting decoction is condensed into the thick paste of relative density 1.20～1.24, drying after the filtration, be ground into fine powder, incapsulate, make capsule.

The using method of medicine capsule of the present invention is: take every day 3 times, each oral 4, one month is a course of treatment.

The present invention treats the medicine of chloasma, and the Radix Bupleuri reconciling superficies and interior is soothing the liver, and yang invigorating has effects such as reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI and elevate a turnable ladder yang-energy, is monarch drug.Radix Angelicae Sinensis is warm in nature, and sweet in the mouth, suffering are returned liver, the heart, spleen channel, and enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation is used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Paeoniae Alba picric acid, liver, spleen channel are gone in cold, nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant, controls breast abdominal rib pain, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.The Radix Salviae Miltiorrhizae bitter in the mouth, cold nature, GUIXIN, Liver Channel, promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.The Poria nature and flavor are sweet, light, and are flat, GUIXIN warp, lung meridian, spleen channel, kidney channel, diuretic, eliminating dampness by diuresis, diuresis.Rhizoma Atractylodis Macrocephalae hardship, sweet, temperature is returned spleen, stomach warp, invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive, be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Folium Citri tangerinae hardship, flat, soothing the liver, circulation of qi promoting is reduced phlegm, the detumescence poison.The little hardship of Rhizoma Cyperi is sweet, and is flat, goes into liver, tri-jiao channel, the resolving depression of regulating the flow of vital energy, pain relieving regulating menstruation.The Herba Menthae suffering, lung, Liver Channel are gone in cold, dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.Above medicament composing prescription is main effect with dispersing the stagnated live-QI to relieve the stagnation of QI, and treatment chloasma effect is better, without any side effects, and is particularly evident to the therapeutic effect of stagnation of liver-qi type chloasma.

The specific embodiment

Embodiment 1

1) gets 1.5 kilograms of Radix Bupleuri decoction pieces, 0.18 kilogram vinegar is sprayed on the decoction pieces mixes thoroughly, put in the pot to fry to vinegar and exhaust and little doing, take out, dry that to make Radix Bupleuri (processed with vinegar) standby with slow fire;

2) get Rhizoma Cyperi and put into cylinder for 1 kilogram, pour 0.2 kilogram of yellow wine into and 0.2 kilogram of rice vinegar is mixed thoroughly, it is standby to make Rhizoma Cyperi (processed);

3) get 1.5 kilograms of Radix Bupleuri (processed with vinegar), 1 kilogram of Rhizoma Cyperi (processed), 1.2 kilograms of Radix Angelicae Sinensis, 1 kilogram of the Radix Paeoniae Alba, 1.4 kilograms of Radix Salviae Miltiorrhizaes, 1.5 kilograms in Poria, 1 kilogram of the Rhizoma Atractylodis Macrocephalae, 0.8 kilogram of blue or green Folium Citri tangerinae, 0.3 kilogram of Herba Menthae, add 19.5 kilograms in water, heat, decocted 30 minutes to boiling point, filter out liquid, decoct three times so continuously, merge 3 times decocting liquid, be condensed into the thick paste of relative density 1.22 after the filtration, dry, be ground into fine powder, incapsulate, every heavy 0.5g.

Carried out the clinical observation on the therapeutic effect of treatment chloasma with the capsule of present embodiment preparation.

The clinical diagnosis standard: 1) facial filbert to dark brown, well-defined patch, symmetry distributes usually, NIP performance and squama; 2) there is not obvious subjective symptoms; 3) women's pilosity, mainly occur in adolescence after; 4) state of an illness can have seasonality, and the Chang Xiachong winter is light; 5) do not have obvious endocrinopathy, and get rid of the pigmentation that other disease causes; 6) average optical of pigmented area is greater than self more than 20% of facial average optical density value.

Test case standard: 1) include the case standard in: the patient who meets the clinical diagnosis standard.2) get rid of the case standard: the A age below 23 one full year of life or more than 50 one full year of life, trimester of pregnancy or women breast-feeding their children, to this medicine allergy sufferers; B is associated with serious primary disease such as liver, kidney and hemopoietic system, psychotic; The all standards of including in that do not meet of C, not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment or safety judgement person.

Curative effect determinate standard: the basic healing: naked eyes are looked the mottle area and are disappeared〉90%, color disappears substantially; Cannot see tangible speckle apart from naked eyes for 1 meter; Produce effects: naked eyes look the mottle area and disappear＞and 60%, color is obviously thin out; Take a turn for the better: naked eyes are looked the mottle area and are disappeared greater than 30%, and color is thin out; Invalid: naked eyes look the mottle area and disappear＜and 30%, change color is not obvious.

Determine that according to clinical experience the medicament instructions of taking is: take every day 3 times, each oral 4, one month is a course of treatment.

The female patient of Pass Test case standard is totally 67 examples, 32.12 ± 6.31 one full year of life of mean age, and average medical history 4.67 ± 2.32 years, therapeutic effect such as table 1:

Table 1 chloasma therapeutic effect

Curative effect determinate standard	The basic healing	Produce effects	Take a turn for the better	Invalid	Add up to
						Case load	7	15	19	26	67
Percentage ratio	10.45	22.39	28.36	38.81	100

Present embodiment reaches 71.19% to the treatment total effective rate (basic healing, produce effects and improvement) of chloasma, is the reasonable medicine of Chinese traditional treatment chloasma effect.

Embodiment 2

Get 1.3 kilograms of Radix Bupleuri (processed with vinegar), 0.8 kilogram of Rhizoma Cyperi (processed), 1 kilogram of Radix Angelicae Sinensis, 0.8 kilogram of the Radix Paeoniae Alba, 1.2 kilograms of Radix Salviae Miltiorrhizaes, 1.3 kilograms in Poria, 0.8 kilogram of the Rhizoma Atractylodis Macrocephalae, 0.7 kilogram of blue or green Folium Citri tangerinae, 0.2 kilogram of Herba Menthae, add 16.2 kilograms in water, heat to boiling point, decocted 20 minutes, filter out liquid, decoct three times so continuously, merge 3 times decocting liquid, be condensed into the thick paste of relative density 1.24 after the filtration, drying, be ground into fine powder, incapsulate.

Embodiment 3

Get 1 kilogram of Radix Bupleuri (processed with vinegar), 1.2 kilograms of Rhizoma Cyperi (processed), 0.8 kilogram of Radix Angelicae Sinensis, 0.8 kilogram of the Radix Paeoniae Alba, 1.6 kilograms of Radix Salviae Miltiorrhizaes, 1 kilogram in Poria, 1.2 kilograms of the Rhizoma Atractylodis Macrocephalaes, 0.5 kilogram of blue or green Folium Citri tangerinae, 0.5 kilogram of Herba Menthae, add 17.2 kilograms in water, heat to boiling point, decocted 25 minutes, filter out liquid, decoct three times so continuously, merge 3 times decocting liquid, be condensed into the thick paste of relative density 1.20 after the filtration, drying, be ground into fine powder, incapsulate.

Claims

1. a medicine for the treatment of chloasma is characterized in that by following parts by weight of traditional Chinese medicines be the medicament that crude drug prepares: Radix Bupleuri (processed with vinegar) 10-15, Radix Angelicae Sinensis 8-12, Radix Paeoniae Alba 8-12, Radix Salviae Miltiorrhizae 12-16, Poria 10-15, Rhizoma Atractylodis Macrocephalae 8-12, blue or green Folium Citri tangerinae 5-8, Rhizoma Cyperi (processed) 8-12, Herba Menthae 2-5.

2. the medicine of treatment chloasma according to claim 1 is characterized in that the parts by weight of each crude drug are: Radix Bupleuri (processed with vinegar) 13-15, Radix Angelicae Sinensis 10-12, Radix Paeoniae Alba 8-10, Radix Salviae Miltiorrhizae 12-14, Poria 13-15, Rhizoma Atractylodis Macrocephalae 8-10, blue or green Folium Citri tangerinae 7-8, Rhizoma Cyperi (processed) 8-10, Herba Menthae 2-3.