CN102131765A - 口服活性类姜黄素化合物 - Google Patents

口服活性类姜黄素化合物 Download PDF

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Publication number
CN102131765A
CN102131765A CN2009801136580A CN200980113658A CN102131765A CN 102131765 A CN102131765 A CN 102131765A CN 2009801136580 A CN2009801136580 A CN 2009801136580A CN 200980113658 A CN200980113658 A CN 200980113658A CN 102131765 A CN102131765 A CN 102131765A
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CN
China
Prior art keywords
formula
compound
acid
compounds
molecular formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801136580A
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English (en)
Chinese (zh)
Inventor
R·N·钱尼伊尔帕拉姆普
安妮莎·克里斯南·奈尔
阿努伊·卡普尔
B·姬兰
拉玛·拉株·高卡拉吉
冈咖·拉珠·高卡拉吉
T·高拉柯蒂
V·索美帕里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laila Pharmaceuticals Pvt Ltd
Original Assignee
Laila Pharmaceuticals Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laila Pharmaceuticals Pvt Ltd filed Critical Laila Pharmaceuticals Pvt Ltd
Publication of CN102131765A publication Critical patent/CN102131765A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/293—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2009801136580A 2008-07-07 2009-07-06 口服活性类姜黄素化合物 Pending CN102131765A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1641/CHE/2008 2008-07-07
IN1641CH2008 2008-07-07
PCT/IN2009/000382 WO2010004579A2 (en) 2008-07-07 2009-07-06 Orally active curcuminoid compounds

Publications (1)

Publication Number Publication Date
CN102131765A true CN102131765A (zh) 2011-07-20

Family

ID=41507515

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801136580A Pending CN102131765A (zh) 2008-07-07 2009-07-06 口服活性类姜黄素化合物

Country Status (6)

Country Link
US (1) US8680143B2 (https=)
EP (1) EP2294049A4 (https=)
JP (1) JP2011527340A (https=)
CN (1) CN102131765A (https=)
AU (1) AU2009269530A1 (https=)
WO (1) WO2010004579A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110292571A (zh) * 2018-03-23 2019-10-01 美力龄生医股份有限公司 姜黄素衍生物的用途
CN112315953A (zh) * 2020-11-06 2021-02-05 中国海洋大学 一种姜黄素酯在改善急性肾损伤制品中的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015186144A2 (en) * 2014-06-07 2015-12-10 Laila Pharmaceuticals Pvt. Ltd. Method of inhibition of beta-secretase by using bis-o-demethylcurcumin for the prevention, management and treatment of neurodegenerative diseases
US10085951B2 (en) 2014-12-11 2018-10-02 Designs For Health, Inc. Curcuminoid formulations and related methods of treatment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031122A1 (de) * 2002-10-01 2004-04-15 Dr. André Rieks - Labor Für Enzymtechnologie Gmbh Neue curcumin/tetrahydrocurcumin-derivate für den einsatz in kosmetika, pharmazeutika und bei der ernährung
EP1876908A1 (en) * 2005-05-03 2008-01-16 DSMIP Assets B.V. Aryl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives
WO2007103435A2 (en) * 2006-03-06 2007-09-13 The Regents Of The University Of California Bioavailable curcuminoid formulations for treating alzheimer's disease and other age-related disorders
EP1999097B1 (en) * 2006-03-29 2011-12-21 DSM IP Assets B.V. Curcumin synthesis
CA2665916C (en) * 2006-10-12 2015-12-08 The Research Foundation Of The City University Of New York Novel curcumin and tetrahydrocurcumin derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110292571A (zh) * 2018-03-23 2019-10-01 美力龄生医股份有限公司 姜黄素衍生物的用途
US11135185B2 (en) 2018-03-23 2021-10-05 Merry Life Biomedical Company, Ltd. Uses of curcumin derivative
CN110292571B (zh) * 2018-03-23 2022-03-08 美力龄生医股份有限公司 姜黄素衍生物的用途
CN112315953A (zh) * 2020-11-06 2021-02-05 中国海洋大学 一种姜黄素酯在改善急性肾损伤制品中的应用
CN112315953B (zh) * 2020-11-06 2023-03-07 中国海洋大学 一种姜黄素酯在改善急性肾损伤制品中的应用

Also Published As

Publication number Publication date
WO2010004579A3 (en) 2011-01-27
US8680143B2 (en) 2014-03-25
EP2294049A4 (en) 2011-06-22
AU2009269530A1 (en) 2010-01-14
EP2294049A2 (en) 2011-03-16
US20110112190A1 (en) 2011-05-12
WO2010004579A2 (en) 2010-01-14
JP2011527340A (ja) 2011-10-27

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20110720