CN102123980B - 用于制备对映异构纯胺的方法 - Google Patents

用于制备对映异构纯胺的方法 Download PDF

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Publication number
CN102123980B
CN102123980B CN200980129438.7A CN200980129438A CN102123980B CN 102123980 B CN102123980 B CN 102123980B CN 200980129438 A CN200980129438 A CN 200980129438A CN 102123980 B CN102123980 B CN 102123980B
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China
Prior art keywords
acid
rasagiline
aminoindan
organic solvent
water
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Expired - Fee Related
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CN200980129438.7A
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English (en)
Chinese (zh)
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CN102123980A (zh
Inventor
维纳亚克·戈雷
宾杜·马诺杰库马
桑迪普·索娜瓦内
达塔特雷·科卡内
辛德帕尔·汤克
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Generics UK Ltd
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Generics UK Ltd
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Priority to CN201410143892.0A priority Critical patent/CN103896779B/zh
Publication of CN102123980A publication Critical patent/CN102123980A/zh
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Publication of CN102123980B publication Critical patent/CN102123980B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200980129438.7A 2008-06-02 2009-06-02 用于制备对映异构纯胺的方法 Expired - Fee Related CN102123980B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410143892.0A CN103896779B (zh) 2008-06-02 2009-06-02 用于制备对映异构纯胺的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN973/KOL/2008 2008-06-02
IN973KO2008 2008-06-02
PCT/GB2009/050608 WO2009147430A1 (en) 2008-06-02 2009-06-02 A process for the preparation of enantiomerically pure amines

Related Child Applications (1)

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CN201410143892.0A Division CN103896779B (zh) 2008-06-02 2009-06-02 用于制备对映异构纯胺的方法

Publications (2)

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CN102123980A CN102123980A (zh) 2011-07-13
CN102123980B true CN102123980B (zh) 2014-05-07

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CN200980129438.7A Expired - Fee Related CN102123980B (zh) 2008-06-02 2009-06-02 用于制备对映异构纯胺的方法
CN201410143892.0A Expired - Fee Related CN103896779B (zh) 2008-06-02 2009-06-02 用于制备对映异构纯胺的方法

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Country Status (10)

Country Link
US (2) US8569545B2 (cg-RX-API-DMAC10.html)
EP (1) EP2285769B1 (cg-RX-API-DMAC10.html)
JP (1) JP5487440B2 (cg-RX-API-DMAC10.html)
CN (2) CN102123980B (cg-RX-API-DMAC10.html)
AU (1) AU2009254927B2 (cg-RX-API-DMAC10.html)
CA (2) CA2723869C (cg-RX-API-DMAC10.html)
CY (1) CY1115577T1 (cg-RX-API-DMAC10.html)
NZ (1) NZ589486A (cg-RX-API-DMAC10.html)
PL (1) PL2285769T3 (cg-RX-API-DMAC10.html)
WO (1) WO2009147430A1 (cg-RX-API-DMAC10.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2285769T3 (pl) * 2008-06-02 2015-01-30 Generics Uk Ltd Sposób otrzymywania enancjomerycznie czystych amin
EP2681186B1 (en) 2011-03-03 2016-05-11 Synthon BV Process of resolution of 1-aminoindan
WO2015033261A1 (en) 2013-09-03 2015-03-12 Universidade De Évora Process for preparing cyclic chiral amines and alcohols by intramolecular catalytic arylation of boronic acid or ester aldehydes and imine substrates
CN104326920B (zh) * 2014-10-13 2016-03-16 江苏清泉化学股份有限公司 一种去除间苯二甲胺中杂质的方法
CN105018560B (zh) * 2015-08-13 2018-09-14 陈永军 动态动力学拆分制备(s)-6-甲氧基-1-氨基茚满
CN105087742B (zh) * 2015-08-18 2018-09-14 陈永军 动态动力学拆分制备r-6-羟基-1-氨基茚满
CN105063161B (zh) * 2015-08-18 2018-11-09 陈永军 一种r-1-氨基茚满的制备方法
CN105177103B (zh) * 2015-08-19 2019-03-12 陈永军 一种r-6-羟基-1-氨基茚满的制备方法
AR110150A1 (es) 2016-11-09 2019-02-27 Roivant Sciences Gmbh Procesos para la preparación de inhibidores de tph1

Citations (8)

* Cited by examiner, † Cited by third party
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US3855227A (en) * 1972-05-08 1974-12-17 C Hollander ({31 )-di-o-isopropylidene-2-keto-l-gulonates
US3912761A (en) * 1972-05-08 1975-10-14 Hoffmann La Roche (-)-Di-O-isopropylidene-2-keto-L-gulonates
EP0235590A2 (en) * 1986-02-03 1987-09-09 Warner-Lambert Company Improved process for the resolution of 1-aminoindanes
CN1062900A (zh) * 1991-01-02 1992-07-22 奥韦特有限公司 N-炔丙基-1-氨基茚满的r-对映体、其制法及含它的药物组合物
WO1995011016A1 (en) * 1993-10-18 1995-04-27 Teva Pharmaceutical Industries Ltd. R-enantiomer of n-propargyl-1-aminoindan, salts, compositions and uses thereof
WO1996037199A1 (en) * 1995-05-22 1996-11-28 Teva Pharmaceutical Industries, Ltd. Use of r-enantiomer of n-propargyl-1-aminoindan, salts, and compositions thereof
US5994408A (en) * 1994-01-10 1999-11-30 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
WO2002068376A1 (en) * 2001-02-27 2002-09-06 Finetech Laboratories Ltd. Process for the preparation of rasagiline and its salts

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US3728388A (en) 1970-08-10 1973-04-17 Sterling Drug Inc 1-amino-2,3-disubstituted cyclopropenylium salts
US3928621A (en) 1974-10-10 1975-12-23 Hoffmann La Roche Antiinflammatory 2-(2-aminoalkylamino)-1,2-diphenylethanols
JPS5283938A (en) 1976-01-01 1977-07-13 Hoffmann La Roche Antiiinflammation agent and process for preparing same
HU187775B (en) 1982-07-14 1986-02-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu New process for producing propargile-amines of pharmaceutical activity
AU607437B2 (en) 1986-09-02 1991-03-07 Du Pont Pharmaceuticals Company Resolution of dl-methyl 3-(4-(2-hydroxy-3-isopropylamino) propoxy)phenylpropionate((dl-esmolol))
CS269271B1 (en) 1988-05-30 1990-04-11 Hajicek Josef Method of selegiline's hydrochloride production
IL92952A (en) 1990-01-03 1994-06-24 Teva Pharma R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them
US5030725A (en) 1990-02-06 1991-07-09 Eli Lilly And Company Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one using (-)-DAG
EP0738149B1 (en) 1994-01-10 2006-11-29 Teva Pharmaceutical Industries, Ltd. 1-aminoindan derivatives and compositions thereof
JP2840560B2 (ja) 1994-11-22 1998-12-24 キノイン・ジヨージセル・エーシユ・ベジエーセテイ・テルメーケク・ジヤーラ・エル・テー 塩化プロパルギルアンモニウム誘導体の製造方法
AR044007A1 (es) * 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
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US7491847B2 (en) 2005-11-17 2009-02-17 Teva Pharmaceutical Industries, Ltd. Methods for isolating propargylated aminoindans
CN101062897B (zh) 2006-04-25 2011-11-23 重庆医药工业研究院有限责任公司 一种制备2，3-二氢-1h-茚-1-胺及其衍生物的改进方法
AU2007334428B2 (en) 2006-12-14 2014-05-29 Teva Pharmaceutical Industries, Ltd. Crystalline solid rasagiline base
EP1987816A1 (de) 2007-04-30 2008-11-05 Ratiopharm GmbH Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff
PL2285769T3 (pl) * 2008-06-02 2015-01-30 Generics Uk Ltd Sposób otrzymywania enancjomerycznie czystych amin
AU2009254929B2 (en) 2008-06-02 2014-03-13 Generics [Uk] Limited An improved process for the preparation of amines
AU2009275665A1 (en) 2008-07-30 2010-02-04 Generics [Uk] Limited Polymorphic form of rasagiline mesylate

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3855227A (en) * 1972-05-08 1974-12-17 C Hollander ({31 )-di-o-isopropylidene-2-keto-l-gulonates
US3912761A (en) * 1972-05-08 1975-10-14 Hoffmann La Roche (-)-Di-O-isopropylidene-2-keto-L-gulonates
EP0235590A2 (en) * 1986-02-03 1987-09-09 Warner-Lambert Company Improved process for the resolution of 1-aminoindanes
CN1062900A (zh) * 1991-01-02 1992-07-22 奥韦特有限公司 N-炔丙基-1-氨基茚满的r-对映体、其制法及含它的药物组合物
WO1995011016A1 (en) * 1993-10-18 1995-04-27 Teva Pharmaceutical Industries Ltd. R-enantiomer of n-propargyl-1-aminoindan, salts, compositions and uses thereof
US20030065038A1 (en) * 1993-10-18 2003-04-03 Teva Pharmaceutical Industries, Ltd. Use of r-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof
US5994408A (en) * 1994-01-10 1999-11-30 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
WO1996037199A1 (en) * 1995-05-22 1996-11-28 Teva Pharmaceutical Industries, Ltd. Use of r-enantiomer of n-propargyl-1-aminoindan, salts, and compositions thereof
WO2002068376A1 (en) * 2001-02-27 2002-09-06 Finetech Laboratories Ltd. Process for the preparation of rasagiline and its salts

Also Published As

Publication number Publication date
US8809589B2 (en) 2014-08-19
CA2723869A1 (en) 2009-12-10
JP5487440B2 (ja) 2014-05-07
CN103896779A (zh) 2014-07-02
PL2285769T3 (pl) 2015-01-30
US20110251288A1 (en) 2011-10-13
JP2011522023A (ja) 2011-07-28
CN103896779B (zh) 2015-12-30
NZ589486A (en) 2012-08-31
US8569545B2 (en) 2013-10-29
EP2285769A1 (en) 2011-02-23
EP2285769B1 (en) 2014-08-13
US20130303741A1 (en) 2013-11-14
CA2812006C (en) 2016-07-26
CA2812006A1 (en) 2009-12-10
CY1115577T1 (el) 2017-01-04
AU2009254927B2 (en) 2014-03-13
AU2009254927A1 (en) 2009-12-10
WO2009147430A1 (en) 2009-12-10
CA2723869C (en) 2013-07-16
CN102123980A (zh) 2011-07-13

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