CN102112176B - 超声介导的药物递送 - Google Patents

超声介导的药物递送 Download PDF

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Publication number
CN102112176B
CN102112176B CN200980128390.8A CN200980128390A CN102112176B CN 102112176 B CN102112176 B CN 102112176B CN 200980128390 A CN200980128390 A CN 200980128390A CN 102112176 B CN102112176 B CN 102112176B
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CN
China
Prior art keywords
ultrasound
ultrasonic
particles
granule
agents
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Application number
CN200980128390.8A
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English (en)
Chinese (zh)
Other versions
CN102112176A (zh
Inventor
W·史
C·T·陈
C·霍尔
B·拉朱
M·博默
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Koninklijke Philips NV
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Koninklijke Philips Electronics NV
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Publication of CN102112176A publication Critical patent/CN102112176A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
CN200980128390.8A 2008-07-23 2009-06-09 超声介导的药物递送 Active CN102112176B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6169008P 2008-07-23 2008-07-23
US61/061,690 2008-07-23
PCT/IB2009/052449 WO2010010473A1 (en) 2008-07-23 2009-06-09 Ultrasound mediated drug delivery

Publications (2)

Publication Number Publication Date
CN102112176A CN102112176A (zh) 2011-06-29
CN102112176B true CN102112176B (zh) 2015-08-12

Family

ID=40848700

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980128390.8A Active CN102112176B (zh) 2008-07-23 2009-06-09 超声介导的药物递送

Country Status (5)

Country Link
US (1) US20110125080A1 (enExample)
EP (1) EP2318086B1 (enExample)
JP (1) JP5689416B2 (enExample)
CN (1) CN102112176B (enExample)
WO (1) WO2010010473A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5241714B2 (ja) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス， インコーポレイテッド スマートな非経口送達システム
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
WO2009067463A1 (en) 2007-11-19 2009-05-28 Proteus Biomedical, Inc. Body-associated fluid transport structure evaluation devices
EP2531096A4 (en) 2010-02-01 2013-09-11 Proteus Digital Health Inc DATA COLLECTION SYSTEM FOR TWO WRIST
SG182825A1 (en) 2010-02-01 2012-09-27 Proteus Biomedical Inc Data gathering system
CN103826692B (zh) * 2011-09-28 2016-06-22 皇家飞利浦有限公司 自动化超声介导递送
JP6313705B2 (ja) * 2011-09-29 2018-04-18 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 重要臓器保護を伴う超音波媒介送達
TWI405583B (zh) * 2011-11-03 2013-08-21 Taipei City Hospital Contrast Agent Enhances the Quantification of Ultrasound in Drug Delivery
CN103055302B (zh) * 2013-01-08 2014-05-14 福建医科大学附属协和医院 一种超声生物效应介导的重组人血管内皮抑制素控释制剂
US20180008534A1 (en) * 2014-12-08 2018-01-11 Robert B. Lomerson Method for preventing, treating, and curing cancer
EP3302443A4 (en) 2015-06-01 2019-02-13 The Trustees Of The University Of Pennsylvania MECHANO SENSITIVE MICRO CAPSULES FOR DRUG DELIVERY
WO2016210136A2 (en) * 2015-06-23 2016-12-29 Advanced Csf Therapies, Llc Methods and system for ultrasonic targeted drug delivery in cystic fluids, such as the cerebrospinal fluid, using buoyancy specific drug carriers
JP7053463B2 (ja) * 2015-11-11 2022-04-12 ナビフス コーポレーション リミテッド 超音波システムを使用して脳腫瘍を治療するための方法及びキット
US11369810B2 (en) * 2016-12-19 2022-06-28 Michalakis Averkiou Method and apparatus for ultrasonic mediation of drug delivery using microbubbles
JP7289061B2 (ja) * 2017-06-29 2023-06-09 インサイテック リミテッド シミュレーションベースの薬物処置計画
US12121597B2 (en) 2018-10-19 2024-10-22 The Board Of Trustees Of The University Of Illinois High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers
US11786215B2 (en) * 2019-01-23 2023-10-17 Washington University Methods of detecting, measuring, or imaging a concentration or location of a therapeutic agent
CA3177232A1 (en) * 2020-06-15 2021-12-23 Bracco Suisse Sa Improvements in ultrasound-mediated therapy
CN112263789B (zh) * 2020-09-18 2025-08-05 北京万孛力医疗器械有限公司 一种调节雄性哺乳动物睾酮水平的装置
WO2025129071A1 (en) * 2023-12-14 2025-06-19 Sonothera, Inc. Methods and systems for improved nucleic acid delivery via ultrasound

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4027036A (en) * 1973-04-12 1977-05-31 Lilly Industries, Ltd. 3-Substituted propanoic acid derivatives and pharmaceutical composition
WO1997017018A1 (en) * 1995-11-09 1997-05-15 Brigham & Women's Hospital Aperiodic ultrasound phased array
WO2006131840A2 (en) * 2005-06-07 2006-12-14 Koninklijke Philips Electronics, N.V. Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids
US7232431B1 (en) * 2001-01-29 2007-06-19 Ultra-Sonic Technologies, L.L.C. Intradermal incorporation of microparticles containing encapsulated drugs using low frequency ultrasound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618275A (en) * 1995-10-27 1997-04-08 Sonex International Corporation Ultrasonic method and apparatus for cosmetic and dermatological applications
GB9701237D0 (en) * 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US6322532B1 (en) * 1998-06-24 2001-11-27 3M Innovative Properties Company Sonophoresis method and apparatus
JP4070339B2 (ja) * 1999-01-20 2008-04-02 ジーイー横河メディカルシステム株式会社 超音波撮像装置
US6716168B2 (en) 2002-04-30 2004-04-06 Siemens Medical Solutions Usa, Inc. Ultrasound drug delivery enhancement and imaging systems and methods
US7695515B2 (en) 2003-07-15 2010-04-13 Spinal Generations, Llc Spinal disc prosthesis system
CN1909931B (zh) * 2004-01-15 2011-01-12 皇家飞利浦电子股份有限公司 用于分子成像的超声造影剂
US20080019904A1 (en) * 2004-06-29 2008-01-24 Koninklijke Philips Electronics, N.V. System For Manufacturing Micro-Sheres
JPWO2008081556A1 (ja) * 2007-01-05 2010-04-30 株式会社島津製作所 超音波装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4027036A (en) * 1973-04-12 1977-05-31 Lilly Industries, Ltd. 3-Substituted propanoic acid derivatives and pharmaceutical composition
WO1997017018A1 (en) * 1995-11-09 1997-05-15 Brigham & Women's Hospital Aperiodic ultrasound phased array
US7232431B1 (en) * 2001-01-29 2007-06-19 Ultra-Sonic Technologies, L.L.C. Intradermal incorporation of microparticles containing encapsulated drugs using low frequency ultrasound
WO2006131840A2 (en) * 2005-06-07 2006-12-14 Koninklijke Philips Electronics, N.V. Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Multifunctional Nanoparticles for Combining Ultrasonic Tumor Imaging and Targeted Chemotherapy;natalya Rapoport,Zhonggao Gao,Anne Kennedy;《J Natl Cancer Inst》;20070718;第99卷(第14期);第1097页，第1100-1101页 *

Also Published As

Publication number Publication date
JP2011529039A (ja) 2011-12-01
EP2318086B1 (en) 2016-04-13
JP5689416B2 (ja) 2015-03-25
EP2318086A1 (en) 2011-05-11
WO2010010473A1 (en) 2010-01-28
CN102112176A (zh) 2011-06-29
US20110125080A1 (en) 2011-05-26

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